Cortical activity during tactile exploration of objects in blind and sighted humans
Abstract
PURPOSE: Recent studies show evidence of multisensory representation in the functionally normal visual cortex, but this idea remains controversial. Occipital cortex activation is often claimed to be a reflection of mental visual imagery processes triggered by other modalities. However, if the occipital cortex is genuinely active during touch, this might be the basis for the massive cross-modal plasticity observed in the congenitally blind. METHODS: To address these issues, we used fMRI to compare patterns of activation evoked by a tactile object recognition (TOR) task (right or left hand) in 8 sighted and 8 congenitally blind subjects, with several other control tasks. RESULTS: TOR robustly activated object selective regions in the lateral occipital complex (LOC/LOtv) in the blind (similar to the patterns of activation found in the sighted), indicating that object identification per se (i.e. in the absence of visual imagery) is sufficient to evoke responses in the LOC/LOtv. Importantly, there was negligible occipital activation for hand movements (imitating object palpations) in the occipital cortex, in both groups. Moreover, in both groups, TOR activation in the LOC/LOtv was bilateral, regardless of the palpating hand (similar to the lack of strong visual field preference in the LOC/LOtv for viewed objects). Finally, the most prominent enhancement in TOR activation in the congenitally blind (compared to their sighted peers) was found in the posterior occipital cortex. CONCLUSIONS: These findings suggest that visual imagery is not an obligatory condition for object activation in visual cortex. It also demonstrates the massive plasticity in visual cortex of the blind for tactile object recognition that involves both the ventral and dorsal occipital areas, probably to support the high demand for this function in the blind.
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ResultOrganization and Reorganization of Sensory-Deprived Cortex
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“One consistent finding from these studies was evidence for a region in lateral occipital cortex (Amedi et al., 2002, 2007, 2010) that responds significantly more strongly to exploration of objects than to exploration of textures, to hand movements, or to retrieval of object knowledge (e.g.,…”
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“Adapted from Amedi et al. 2007 Data adapted from Amedi et al. 2010 Data adapted from Amedi et al. 2001 RH Y = –59 Y = –58 Y = –57 Y = –71 Z = –7 Z = –9 Z = 9 LH LH RH RH”
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“…order areas when it comes to more complex stimulation as for tactile or sound objects recognition and localization or the use of vision substitution devices (Amedi et al., 2002, 2010; Renier et al., 2010; StriemAmit et al., 2012b; Striem-Amit and Amedi, 2014), beyond basic sensory processing.”
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“In the blind the high demand required by object recognition appears to also recruit ventral and dorsal occipital areas [7].”
BackgroundResultThe Development of Visual Areas Depends Differently on Visual Experience
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“Furthermore, increasing evidence has confirmed that CB subjects preserved functional organization in several higher-tier visual areas when performing non-visual sensory task, such as the dorsal stream specialized for spatial processing [25,26] and action control [27], the ventral stream for reading [28] and object rec…”
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“Cross-modal activations have been described in early and lateblind groups (Amedi et al., 2003, 2010; Buchel et al., 1998; Burton, 2003; Cheung et al., 2009; Merabet et al., 2007; Ptito et al., 2005; Sadato et al., 1996, 2004; Sathian, 2005).”
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“been extensively reported in these subjects (Liu et al. 2007; Amedi et al. 2010; Bedny et al. 2011) or the preserved functional specialization in most brain areas (Mohan et al.”
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“Additionally, assessment of responses in lower and higher tier visual areas from both hemispheres evaluated the hypothesis posed by Amedi and colleagues that left V1 particularly contributed to verbal recall processes (Amedi et al., 2003; Amedi et al., 2010; Raz et al., 2005).”
BackgroundDormal, G., Pelland, M., Rezk, M., Yakobov, E., Leporé, F., & Collignon, O. (2017) · Journal of Cognitive Neuroscience · doi:10.1162/jocn_a_01186 · Cited by 45 · see citing works
“Similar activation patterns with cross-modal responses extending posteriorly were reported in a previous study when congenitally blind participants performed a tactile recognition task (Amedi et al., 2010).”
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“The reason is that reorganization of other processes, such as auditory motion perception and tactile object recognition, appears to follow the topography of the functionally equivalent visual processes in the sighted brain (Ricciardi et al., 2007a; Amedi et al., 2010; Dormal et al., 2016).”
Active touch in orthopteroid insects: behaviours, multisensory substrates and evolution
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The future of sensory substitution, addition, and expansion via haptic devices
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“performed on trained subjects (blind or sighted), the motion of electrotactile shocks across the tongue activates the MT+ area of the visual cortex, an area which is normally involved in visual motion (Merabet et al., 2009; Amedi et al., 2010; Matteau et al., 2010).”
BackgroundCrossmodal plasticity in the fusiform gyrus of late blind individuals during voice recognition
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“…dorsal areas (e.g. Collignon et al., 2011; Renier et al., 2010), while the processing of auditory or tactile object identity has been found to activate ventral areas of the visual cortex in congenitally blind individuals (Amedi et al., 2007, 2010; Hölig et al., 2014; Pietrini et al., 2004).”
BackgroundMind-Object Identity: A Solution to the Hard Problem
Manzotti, R. (2019) · Frontiers in Psychology · doi:10.3389/fpsyg.2019.00063 · Cited by 39 · see citing works
“For instance, born blind subjects, contrary to common beliefs, have never reported any color in their dreams or during hallucinatory states (Kiekopf, 1968; Raz et al., 2005; Amedi et al., 2010).”
BackgroundEvolution of cortical geometry and its link to function, behaviour and ecology
Schwartz, E., Nenning, K., Heuer, K., Jeffery, N. S., Bertrand, O., Toro, R., Kasprian, G. J., Prayer, D., & Langs, G. (2023) · Nature Communications · doi:10.1038/s41467-023-37574-x · Cited by 38 · see citing works
“Studies in congenital blindness have repeatedly demonstrated the recruitment of these areas of the cortex for haptic processing 96 – 99 , underlining the integrative role of the structures of ventral pathway 100,101 .”
Cross-modal Processing in the Occipito-temporal Cortex: A TMS Study of the Müller-Lyer Illusion
Mancini, F., Bolognini, N., Bricolo, E., & Vallar, G. (2010) · Journal of Cognitive Neuroscience · doi:10.1162/jocn.2010.21561 · Cited by 38 · see citing works
Neural Pathways Conveying Novisual Information to the Visual Cortex
Qin, W., & Yu, C. (2013) · Neural Plasticity · doi:10.1155/2013/864920 · Cited by 39 · see citing works
“This claim was also supported by sensory substitution devices (SSD) studies that the visual cortex was also involved in processing nonvisual tasks after a short period of SSD training in sighted subject [50, 72, 186].”
Jóhannesson, Ó. I., Balan, O. C., Unnþórsson, R., Moldoveanu, A. D. B., & Kristjansson, A. K. (2016) · Brain Sciences · doi:10.3390/brainsci6030020 · Cited by 39 · see citing works
“[58] compared the patterns of activation generated by tactile object recognition tasks for eight sighted and congenitally blind subjects.”
BackgroundMethodBrain (re)organization following visual loss
Voss, P. (2018) · Wiley Interdisciplinary Reviews Cognitive Science · doi:10.1002/wcs.1468 · Cited by 39 · see citing works
Analyzing EEG Signals Using Decision Trees: A Study of Modulation of Amplitude
Bastos, N. S., Marques, B. P., Adamatti, D. F., et al. (2020) · Computational Intelligence and Neuroscience · doi:10.1155/2020/3598416 · Cited by 35 · see citing works
“…impaired) activated the O2 (occipital lobe) channel in the generated tree. relevance of the brain signals in the occipital area can be derived from the idea presented in [19] that the activation of the occipital cortex often reflects the processing of mental visual images triggered by other senses.”
BackgroundRepresenting shape in sight and touch
Green, E. J. (2020) · Mind & Language · doi:10.1111/mila.12352 · Cited by 32 · see citing works
Using structural and functional brain imaging to uncover how the brain adapts to blindness
Hirsch, G. V., Bauer, C. M., & Merabet, L. B. (2015) · Journal of Psychiatry and Brain Functions · doi:10.7243/2055-3447-2-7 · Cited by 33 · see citing works
“For example, the lateral occipital complex (LOC), which is implicated in visual shape perception, is also active when blind individuals explore complex tactile shapes [59].”
BackgroundCampus, C., Brayda, L. G., Carli, F. D., Chellali, R., Famà, F., Bruzzo, C., Lucagrossi, L., & Rodriguez, G. (2012) · Journal of Neurophysiology · doi:10.1152/jn.00624.2011 · Cited by 29 · see citing works
“If these expectations are met, one might argue that tactile stimulation can, under certain circumstances, activate supramodal brain circuits (Amedi et al. 2010).”
BackgroundResultInfluentialProperties of cross-modal occipital responses in early blindness: An ALE meta-analysis
Zhang, C., Lee, T. M. C., Fu, Y., Ren, C., Chan, C. C. H., & Tao, Q. (2019) · NeuroImage Clinical · doi:10.1016/j.nicl.2019.102041 · Cited by 30 · see citing works
“For instance, a strong correlation has been found between activation of V1 and performance on verbal memory and language-related tasks (Amedi et al., 2003).”
Xu, Y., Vignali, L., Sigismondi, F., Crepaldi, D., Bottini, R., & Collignon, O. (2023) · PLoS Biology · doi:10.1371/journal.pbio.3001930 · Cited by 31 · see citing works
“One study found ILOTC’s activation when contrasting a haptic object recognition task and a task imitating the grasping and exploration of objects [22].”
Konkle, T., & Caramazza, A. (2016) · Cerebral Cortex · doi:10.1093/cercor/bhw287 · Cited by 26 · see citing works
“…versus animals (Mahon et al. 2009), tools (Peelen et al. 2013), or large objects (He et al. 2013), by manually exploring objects (Pietrini et al. 2004; Amedi et al. 2010), or by hearing the shape of objects or bodies via auditory substitution (Striem-Amit et al. 2012; Striem-Amit and Amedi 2014).”
Compensatory Cross-Modal Plasticity Persists After Sight Restoration
Mowad, T. G., Willett, A. E., Mahmoudian, M., Lipin, M. Y., Heinecke, A., Maguire, A. M., Bennett, J., & Ashtari, M. (2020) · Frontiers in Neuroscience · doi:10.3389/fnins.2020.00291 · Cited by 28 · see citing works
Tal, Z., Geva, R., & Amedi, A. (2015) · NeuroImage · doi:10.1016/j.neuroimage.2015.11.058 · Cited by 24 · see citing works
“…and that haptic object recognition by touch or using visual-to-auditory substitution recruits the object related lateral occipital complex (LOC, Amedi et al., 2007, 2010), leading to the suggestion that this area is dedicated to deciphering the 3D shape of objects regardless of sensory…”
Kim, S., Stevenson, R. A., & James, T. W. (2011) · Journal of Cognitive Neuroscience · doi:10.1162/jocn_a_00176 · Cited by 23 · see citing works
The puzzle of cross‐modal shape experience
Green, E. J. (2021) · Noûs · doi:10.1111/nous.12384 · Cited by 23 · see citing works
Telerobotic Haptic Exploration in Art Galleries and Museums for Individuals with Visual Impairments
Park, C. H., Ryu, E., & Howard, A. M. (2015) · IEEE Transactions on Haptics · doi:10.1109/toh.2015.2460253 · Cited by 24 · see citing works
“Observing that individuals with VIs incorporate many tactile [4], [5]”
BackgroundHaptic 3D Surface Representation of Table-Based Data for People With Visual Impairments
Braier, J., Lattenkamp, K., Räthel, B., Schering, S., Wojatzki, M., & Weyers, B. (2014) · ACM Transactions on Accessible Computing · doi:10.1145/2700433 · Cited by 23 · see citing works
Mattioni, S., Rezk, M., Battal, C., Vadlamudi, J., & Collignon, O. (2022) · eLife · doi:10.7554/elife.79370 · Cited by 20 · see citing works
Improving spatial working memory in blind and sighted youngsters using programmable tactile displays
Leo, F., Tinti, C., Chiesa, S., Cavaglià, R., Schmidt, S., Cocchi, E., & Brayda, L. G. (2018) · SAGE Open Medicine · doi:10.1177/2050312118820028 · Cited by 21 · see citing works
Orchard-Mills, E., Alais, D., & der Burg, E. V. (2013) · Attention Perception & Psychophysics · doi:10.3758/s13414-013-0535-9 · Cited by 18 · see citing works
“Moreover, the existence of networks between vision and touch in normally sighted individuals is supported by neuroimaging studies; visual areas have been shown to be activated during tactile orientation discrimination (Sathian & Zangaladze, 2002; Sathian, Zangaladze, Epstein, & Grafton, 1999), haptic object recognitio…”
BackgroundEarly Cross-modal Plasticity in Adults
Verde, L. L., Morrone, M. C., & Lunghi, C. (2016) · Journal of Cognitive Neuroscience · doi:10.1162/jocn_a_01067 · Cited by 18 · see citing works
“For example, the occipital recruitment in blind people for tactile processing (Collignon et al., 2011; Amedi et al., 2010; Gougoux et al., 2005; Sathian, 2005; Hamilton & Pascual-Leone, 1998; Sadato et al., 1996) is explained as the request of the system to dedicate optimal processing to a modality that became critica…”
BackgroundNeural correlates of taste perception in congenital blindness
Gagnon, L., Kupers, R. C., & Ptito, M. (2015) · Neuropsychologia · doi:10.1016/j.neuropsychologia.2015.02.027 · Cited by 18 · see citing works
“, 2011), touch (Ptito et al., 2005, 2012; Amedi et al., 2010; Matteau et al., 2010) and audition (Gougoux et al.”
BackgroundEffects of congenital blindness on the subcortical representation of speech cues
Jafari, Z., & Malayeri, S. (2013) · Neuroscience · doi:10.1016/j.neuroscience.2013.11.027 · Cited by 18 · see citing works
Inborn and experience-dependent models of categorical brain organization. A position paper
Gainotti, G. (2015) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2015.00002 · Cited by 17 · see citing works
“, 2009; Amedi et al., 2010). In fact, they hold that the relevant finding for constraining models is not the format of the information that is represented but rather its organization. On the other hand, it can be objected that, to devise a task that could be performed by both sighted and blind individuals, Mahon et al…”
BackgroundResultInfluentialCrossmodal Processing of Haptic Inputs in Sighted and Blind Individuals
Voss, P., Alary, F., Lazzouni, L., Chapman, C. E., Goldstein, R., Bourgoin, P., & Leporé, F. (2016) · Frontiers in Systems Neuroscience · doi:10.3389/fnsys.2016.00062 · Cited by 16 · see citing works
“Similarly, Amedi et al. (2010) had their subjects explore objects tactually using both hands.”
BackgroundResultInfluentialde Borst, A. W., & de Gelder, B. (2018) · Cerebral Cortex · doi:10.1093/cercor/bhy151 · Cited by 18 · see citing works
“after visual deprivation makes it responsive to a large variety of haptic and auditory tasks (Rosler et al. 1993; Roder et al. 1997; Burton et al. 2003; Ricciardi et al. 2007; Amedi et al. 2010; Dietrich et al. 2013; Lewald and Getzmann 2013; Occelli et al. 2013; Watkins et al. 2013; Striem-Amit and Amedi 2014; Anurov…”
BackgroundPoly-L-lactic acid as a facial filler.
Sterling, J. B., & Hanke, C. W. (2005) · PubMed · Cited by 17 · see citing works
Ortiz, T., Santos, J. M., Terán, L. O., et al. (2015) · PLoS ONE · doi:10.1371/journal.pone.0124527 · Cited by 16 · see citing works
“However, the same structure is strongly activated during somatosensory object recognition in people with blindess, suggesting that visual imagery is not an obligatory condition for tactile object recognition in visual cortex [3, 4, 21, 40] and others.”
BackgroundLiu, L., Yuan, C., Ding, H., Xu, Y., Long, M., Li, Y., Liu, Y., Jiang, T., Qin, W., Shen, W., et al. (2017) · Scientific Reports · doi:10.1038/srep45675 · Cited by 16 · see citing works
Making Sense of the Chemical Senses
Gagnon, L., Kupers, R. C., & Ptito, M. (2014) · Multisensory Research · doi:10.1163/22134808-00002461 · Cited by 16 · see citing works
Core knowledge of geometry can develop independently of visual experience
Heimler, B., Behor, T., Dehaene, S., Véronique Izard, A., & Amedi, A. (2021) · Cognition · doi:10.1016/j.cognition.2021.104716 · Cited by 15 · see citing works
Rimmele, J. M., Gudi-Mindermann, H., Nolte, G., Röder, B., & Engel, A. K. (2019) · NeuroImage · doi:10.1016/j.neuroimage.2019.03.003 · Cited by 16 · see citing works
Visuo-spatial imagery in dreams of congenitally and early blind: a systematic review
Ilić, K., Bertani, R., Lapteva, N., Drakatos, P., Delogu, A., Raheel, K., Soteriou, M., Mutti, C., Steier, J. S., Carmichael, D. W., et al. (2023) · Frontiers in Integrative Neuroscience · doi:10.3389/fnint.2023.1204129 · Cited by 12 · see citing works
“In blind subjects, the occipital cortex is activated during haptic (Amedi et al., 2010) and auditory (Kujala et al.”
BackgroundWhere you look can influence haptic object recognition
Lawson, R., Boylan, A., & Edwards, L. L. (2013) · Attention Perception & Psychophysics · doi:10.3758/s13414-013-0579-x · Cited by 11 · see citing works
“D objects and so is less likely to rely on a visual recoding, image mediation strategy to identify them (Lederman et al., 1990; see also Amedi et al., 2010).”
Mental Imagery in Dreams of Congenitally Blind People
Kang, J., Bertani, R., Raheel, K., Soteriou, M., Rosenzweig, J., Valentı́n, A., Goadsby, P. J., Tahmasian, M., Moran, R., Ilić, K., et al. (2023) · Brain Sciences · doi:10.3390/brainsci13101394 · Cited by 11 · see citing works
“This model is supported, at least prima facie , by evidence of cross-modal neuroplasticity of the “blind visual cortex” and its involvement in episodic memory [28], language [18], and in auditory [21,22,27,29] and haptic [30] processing [5].”
MethodCunningham, S. I., Weiland, J. D., Bao, P., & Tjan, B. S. (2011) · Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC) · doi:10.1109/iembs.2011.6090785 · Cited by 10 · see citing works
“Tactile discrimination studies have shown increased activation of posterior occipital areas when compared to their sighted counterparts [1, 2].”
BackgroundThe speed of object recognition from a haptic glance: event-related potential evidence
Gurtubay-Antolín, A., Rodríguez‐Herreros, B., & Rodríguez‐Fornells, A. (2015) · Journal of Neurophysiology · doi:10.1152/jn.00836.2014 · Cited by 9 · see citing works
“However, previous studies have found shared visuotactile representations of shape between both modalities (Amedi et al. 2010; Lacey et al. 2009).”
BackgroundLawson, R. (2013) · Attention Perception & Psychophysics · doi:10.3758/s13414-013-0559-1 · Cited by 9 · see citing works
“…with claims that a supramodal or crossmodal object recognition system subserves both visual and haptic identification (Allen & Humphreys, 2009; Amedi et al., 2010; Lacey et al., 2009; Ricciardi & Pietrini, 2011) and extends it to include haptic inputs from invisible locations (behind the…”
BackgroundResultDai, R., Huang, Z., Tu, H., Wang, L., Tanabe, S., Weng, X., He, S., & Li, D. (2016) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2016.00632 · Cited by 8 · see citing works
“As well as, blind’s visual ventral stream activated during braille reading (Reich et al., 2011; StriemAmit et al., 2012; Abboud et al., 2015) and object recognition (Pietrini et al., 2004; Peltier et al., 2007;Mahon et al., 2009; Amedi et al., 2010; Striem-Amit and Amedi, 2014).”
BackgroundDevelopment and plasticity of multisensory functions
Röder, B., & Wallace, M. T. (2010) · Restorative Neurology and Neuroscience · doi:10.3233/rnn-2010-0536 · Cited by 8 · see citing works
Masson, H. L., Kang, H.-M., Petit, L., & Wallraven, C. (2017) · Brain Structure and Function · doi:10.1007/s00429-017-1510-3 · Cited by 7 · see citing works
“In contrast, evidence on LOC activation found in blind patients who could not exhibit visual imagery during haptic shape processing challenged the role of that particular area related to visual imagery (Amedi et al. 2010).”
ResultRotation-independent representations for haptic movements
Shioiri, S., Yamazaki, T., Matsumiya, K., & Kuriki, I. (2013) · Scientific Reports · doi:10.1038/srep02595 · Cited by 7 · see citing works
Neuroplasticity in the blind and sensory substitution for vision
Striem-Amit, E. (2014) · doi:10.13140/2.1.2640.2247 · Cited by 7 · see citing works
Crossmodal enhancement in the LOC for visuohaptic object recognition over development
Keehn, R. J. J., James, T. W., & James, K. H. (2015) · Neuropsychologia · doi:10.1016/j.neuropsychologia.2015.08.008 · Cited by 7 · see citing works
“…( mm ) 0.5 0.0 similar functional region of cortex (i.e., LOtv) as indicated by other studies to be involved in visuohaptic object recognition (e.g., Amedi et al., 2001, 2002; Amedi et al., 2010; Kim et al., 2012), and provides an adequate proxy for LOC ROIs de fi ned using a more standardized task.”
BackgroundMethodInfluentialSubcortical encoding of speech cues in children with congenital blindness
Jafari, Z., & Malayeri, S. (2016) · Restorative Neurology and Neuroscience · doi:10.3233/rnn-160639 · Cited by 8 · see citing works
“…to the environment and develop significant abilities resulting from changes that are made in the top-down and bottom-up interactions and related subcortical (Skoe and Kraus, 2010; Chandrasekaran et al., 2012) and cortical areas (Stevens and Weaver, 2009; Amedi et al., 2010; Focker et al., 2012).”
Dormal, G., Pelland, M., Rezk, M., Yakobov, E., Leporé, F., & Collignon, O. (2017) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/143776 · Cited by 8 · see citing works
“Similar activation patterns with cross-modal responses extending posteriorly were reported in a previous study when congenitally blind participants performed a tactile recognition task (Amedi et al., 2010).”
Vision matters for shape representation: Evidence from sculpturing and drawing in the blind
Tian, S., Chen, L., Wang, X., Li, G., Fu, Z., Ji, Y., Lu, J., Wang, X., Shan, S., & Bi, Y. (2024) · Cortex · doi:10.1016/j.cortex.2024.02.016 · Cited by 6 · see citing works
Visual Cortex Alterations in Early and Late Blind Subjects During Tactile Perception
Ankeeta, A., Kumaran, S. S., Saxena, R., Dwivedi, S. N., & Jagannathan, N. R. (2021) · Perception · doi:10.1177/0301006621991953 · Cited by 6 · see citing works
“Although study includes a reasonable sample size, SCs (especially in adolescent group) could not be age matched, as it was difficult to recruit willing adolescents.”
BackgroundResultInfluentialDecision Tree to Analyses EEG Signal: A Case Study Using Spatial Activities
Bastos, N. S., Adamatti, D. F., & Billa, C. Z. (2017) · Communications in computer and information science · doi:10.1007/978-3-319-71011-2_13 · Cited by 6 · see citing works
Spatially segregated responses to visuo-tactile stimuli in mouse neocortex during active sensationPreprint
Couto, J., Kandler, S., Mao, D., McNaughton, B., Arckens, L., & Bonin, V. (2019) · bioRxiv · doi:10.1101/199364 · Cited by 5 · see citing works
“Cross-modal plasticity following the loss of visual inputs has been shown to give rise of tactile signals in primary visual cortex (Amedi et al., 2010; Merabet and Pascual-Leone, 2010; Van Brussel et al., 2011).”
BackgroundHow learning to read Braille in visual and tactile domains reorganizes the sighted brain
Gaca, M., Olszewska, A. M., Droździel, D., Kulesza, A., Paplińska, M., Kossowski, B., Jednoróg, K., Matuszewski, J., Herman, A. M., & Marchewka, A. (2025) · Frontiers in Neuroscience · doi:10.3389/fnins.2024.1297344 · Cited by 5 · see citing works
Applying Plasticity to Visual Rehabilitation in Adulthood
Maidenbaum, S., & Amedi, A. (2012) · Cambridge University Press eBooks · doi:10.1017/cbo9781139136907.012 · Cited by 5 · see citing works
Atılgan, H., Koi, J. X. J., Wong, E., Laakso, I., Matilainen, N., Pasqualotto, A., Tanaka, S., Chen, S. A., & Kitada, R. (2023) · Cerebral Cortex Communications · doi:10.1093/texcom/tgad005 · Cited by 6 · see citing works
“Third, we did not include the texture as a control when examining object preferences (e.g. James et al. 2002; Amedi et al. 2010).”
MethodD’Angiulli, A., Wymark, D., Temi, S., Bahrami, S., & Telfer, A. (2024) · Cortex · doi:10.1016/j.cortex.2024.01.010 · Cited by 6 · see citing works
“…findings which show a large activation of Broca ' s network in CTB individuals and an increased functional long-range reciprocal connectivity be-tween this region and visual and frontal cortical areas (e.g., Alary et al., 2008; Amedi et al., 2010; Heine et al., 2015; Peltier et al., 2007).”
Arbel, R., Heimler, B., & Amedi, A. (2023) · Neuropsychologia · doi:10.1016/j.neuropsychologia.2023.108685 · Cited by 5 · see citing works
Ortiz, T., Poch, J., Santos, J. M., Martı́nez, A. M., Ortiz-Terán, L., Hernández, C. R., Barcia, J. A., de Erausquin, G. A., & Pascual‐Leone, Á. (2013) · Neurocase · doi:10.1080/13554794.2013.770878 · Cited by 5 · see citing works
“activity appears more in temporo-occipital areas (ventral pathway) than parieto-occipital (dorsal pathway) ones (Amedi et al., 2010; Kandel & Wurtz, 2000), except at the end of the training period, when they are re-routed towards occipital areas.”
BackgroundFinger representation in the cortex of the congenitally blindPreprint
Wesselink, D. B., Kikkert, S., Bridge, H., & Makin, T. R. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.03.16.435392 · Cited by 4 · see citing works
“…2014, Maidenbaum et al. 2014, Kupers and Ptito 2014) and many findings have accumulated supporting the principle for medium to high-level functions (e.g. Striem-Amit et al. 2012, Dormal et al. 2016, Peelen et al. 2013, Amedi et al. 2007, Amedi et al. 2010, Wolbers et al. 2011, Kitada et al. 2014).”
BackgroundTsutsui, A., Wang, X., Takagi, H., & Asakawa, C. (2025) · International ACM SIGACCESS Conference on Computers and Accessibility (ASSETS) · doi:10.1145/3663547.3746373 · Cited by 3 · see citing works
“While human guides can provide adaptive real-time feedback, they may compromise user autonomy [62].”
Tian, S., Chen, Y., Fu, Z., Wang, X., & Bi, Y. (2023) · Cerebral Cortex · doi:10.1093/cercor/bhad200 · Cited by 4 · see citing works
“Multimodal shape representation has been extensively studied at the object level (Amedi et al. 2001; Amedi et al. 2002; Amedi et al. 2007; Stilla and Sathian 2008; Lacey et al. 2009b; Amedi et al. 2010; Lacey and Sathian 2014; Lee Masson et al. 2016a).”
BackgroundBurton, H., Agato, A., & Sinclair, R. J. (2011) · Brain Research · doi:10.1016/j.brainres.2011.11.039 · Cited by 4 · see citing works
“In occipital cortex, blind would probably show effects throughout occipital cortex based on prior reports of activation with tactile stimulation in early blind (Amedi et al., 2010; Burton et al., 2004; © 2011 Elsevier B.V.”
BackgroundResultInfluentialParadoxical effects of sensory loss
Pascual‐Leone, Á., Obretenova, S. N., & Merabet, L. B. (2011) · Cambridge University Press eBooks · doi:10.1017/cbo9780511978098.004 · Cited by 4 · see citing works
Special issues in brain plasticity, repair and rehabilitation: 20 years of a publishing strategy
Sabel, B. A., Matzke, S., & Prilloff, S. (2010) · Restorative Neurology and Neuroscience · doi:10.3233/rnn-2010-0581 · Cited by 2 · see citing works
“These findings were supported by Amedi et al. (2010), who showed that visual imagery is not an obligatory condition for object activation in visual cortex.”
Background
- Authors
- Amedi, A., Raz, N., Azulay, H., Malach, R., & Zohary, E.
- Affiliations
- Hebrew University of Jerusalem (IL)
- Weizmann Institute of Science (IL)
- Corresponding author
- Amedi, Amir
- Venue
- Restorative Neurology and Neuroscience
- Publisher
- SAGE Publications
- Published
- 2010-04
- Volume
- 28
- Issue
- 2
- Pages
- 143-156
- ISSN
- 0922-6028 (ISSN-L)
- 1878-3627
- OpenAlex
- W2159773361
- Cited by
- 125
- References
- 48
- Citations by year
- 2026: 3 · 2025: 5 · 2024: 3 · 2023: 8 · 2022: 5 · 2021: 4 · 2020: 9 · 2019: 6 · 2018: 4 · 2017: 7 · 2016: 9 · 2015: 10 · 2014: 12 · 2013: 14 · 2012: 9
- FWCI
- 7.54
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Restorative Neurology and Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Tactile and Sensory Interactions
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Multisensory perception and integration
- Life Sciences › Neuroscience › Cognitive Neuroscience › Visual perception and processing mechanisms
- Keywords
- tactile object recognition, congenital blindness, cross-modal plasticity, lateral occipital complex, visual cortex, multisensory representation, visual imagery, bilateral activation
- MeSH terms
- Adult, Afferent Pathways, Analysis of Variance, Blindness, Brain Mapping, Cerebral Cortex, Female, Hand, Humans, Image Processing, Computer-Assisted, Functional Laterality, Magnetic Resonance Imaging, Male, Middle Aged, Oxygen, Physical Stimulation, Reaction Time, Touch, Recognition, Psychology, Young Adult
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