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Cited by 487Neurogenesis and neuroplasticity mechanismsNeuroscience and Neuropharmacology ResearchDevelopmental Biology and Gene Regulation

NeuN As a Neuronal Nuclear Antigen and Neuron Differentiation Marker

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Gusel’nikova, V. V., Korzhevskiy, D. E.·2015·Acta Naturae
DOI 10.32607/20758251-2015-7-2-42-47PMC PMC4463411
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Abstract

The NeuN protein is localized in nuclei and perinuclear cytoplasm of most of the neurons in the central nervous system of mammals. Monoclonal antibodies to the NeuN protein have been actively used in the immunohistochemical research of neuronal differentiation to assess the functional state of neurons in norm and pathology for more than 20 years. Recently, NeuN antibodies have begun to be applied in the differential morphological diagnosis of cancer. However, the structure of the protein, which can be revealed by antibodies to NeuN, remained unknown until recently, and the functions of the protein are still not fully clear. In the present mini-review, data on NeuN accumulated so far are summarized and analyzed. Data on the structure and properties of the protein, its isoforms, intracellular localization, and hypothesized functions are reported. The application field of immunocytochemical detection of NeuN in scientific and clinical studies, as well as the difficulties in the interpretation of the obtained experimental data and their possible causes, is described in details.

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  • This set highlights many sensory, perceptual, and motor systems critical for fear conditioning.

    “Collectively, this set highlights many sensory, perceptual, and motor systems critical for fear conditioning54-57.”

    From Magnetic resonance microscopy maps widespread effects of Alzheimer’s disease on brain structures and behavior in mice (2026) · cites this paper as [54]

    The Introduction discusses NeuN as a neuronal marker and mentions some motor neurons, but it does not describe a set of sensory, perceptual, and motor systems or their role in fear conditioning. Searches for fear conditioning and for sensory and motor systems found no passage addressing that claim. (LLM, conf=0.76)

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Cited by

Sorted by citations

Authors
Gusel’nikova, V. V., & Korzhevskiy, D. E.
Affiliations
Institute of Experimental Medicine (RU)
Venue
Acta Naturae
Publisher
Acta Naturae Ltd
Published
2015-06-15
Volume
7
Issue
2
Pages
42-47
ISSN
  • 2075-8243 (ISSN-L)
  • 2075-8251
DOI
10.32607/20758251-2015-7-2-42-47
PMC
PMC4463411
OpenAlex
W890895450
Cited by
487
References
1
Citations by year
2026: 41 · 2025: 61 · 2024: 71 · 2023: 61 · 2022: 52 · 2021: 63 · 2020: 45 · 2019: 37 · 2018: 28 · 2017: 18 · 2016: 8 · 2015: 2
FWCI
7.54
Type
journal article
Language
en
Open access
Licence
Locations
  • Acta Naturae (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
Keywords
NeuN, monoclonal antibodies, protein structure, protein isoforms, subcellular localization, central nervous system neurons, immunocytochemistry

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