Effects of polydeoxyribonucleotide in the treatment of pressure ulcers

At week 3, median wound surface area was 1.30 cm2 (range 0.30-5.00) in the PDRN group versus 5.70 cm2 (range 2.00-16.00) in the control group (p=0.001).

“at week 3, 1.30 cm² (range: 0.30-5.00) versus 5.70 cm² (range: 2.00-16.00; p=0.001)”

At week 2, median wound surface area was 2.30 cm2 (range 0.30-5.90) in the PDRN group versus 6.45 cm2 (range 3.00-16.00) in the control group (p=0.001).

“At week 2, values were 2.30 cm² (range: 0.30-5.90) versus 6.45 cm² (range: 3.00-16.00; p=0.001)”

In patients with stage 2-4 pressure ulcers, PDRN treatment produced progressive and statistically significant reductions in wound surface area at all weekly assessment time points compared with controls.

“Wound surface area, measured using VISITRAK Digital, demonstrated progressive and statistically significant reductions in the PDRN group at all weekly assessment time points compared with controls.”

At week 1, median wound surface area was 5.30 cm2 (range 2.50-8.70) in the PDRN group versus 9.52 cm2 (range 4.80-17.00) in the control group (p=0.007).

“At week 1, the median wound surface area was 5.30 cm² (range: 2.50-8.70) in the experimental group versus 9.52 cm² (range: 4.80-17.00) in the control group (p=0.007).”

At week 4, median wound surface area was 0.90 cm2 (range 0.20-4.50) in the PDRN group versus 4.25 cm2 (range 1.80-14.00) in the control group (p<0.001).

“and at week 4, 0.90 cm² (range: 0.20-4.50) versus 4.25 cm² (range: 1.80-14.00; p<0.001).”

At week 2, median PUSH scores were 10 (range 6-13) in the PDRN group versus 12.5 (range 10-14) in the control group (p=0.002).

“at week 2, 10 (range: 6-13) versus 12.5 (range: 10-14; p=0.002)”

At week 3, median PUSH scores were 8 (range 5-11) in the PDRN group versus 11 (range 8-14) in the control group (p=0.001).

“at week 3, 8 (range: 5-11) versus 11 (range: 8-14; p=0.001)”

At week 1, median PUSH scores were 11 (range 8-14) in the PDRN group versus 13 (range 10-15) in the control group (p=0.008).

“At week 1, the median PUSH scores were 11 (range: 8-14) versus 13 (range: 10-15; p=0.008)”

At week 4, median PUSH scores were 4 (range 2-10) in the PDRN group versus 11 (range 6-13) in the control group (p<0.001).

“and at week 4, 4 (range: 2-10) versus 11 (range: 6-13; p<0.001).”

In Kim et al. 2014, PDRN significantly reduced wound surface area.

“PDRN significantly reduced wound surface area and improved PUSH scores throughout follow-up”

In Kim et al. 2014, PDRN significantly improved PUSH scores throughout follow-up.

“PDRN significantly reduced wound surface area and improved PUSH scores throughout follow-up”

Studies judged as having some concerns included Hong et al. [11], Vera et al. [14], and Kim et al. [8], primarily because of insufficient reporting of allocation concealment, deviations from intended interventions, or incomplete reporting of prespecified analyses.

“Studies judged as having some concerns included Hong et al. [11], Vera et al. [14], and Kim et al. [8], primarily because of insufficient reporting of allocation concealment, deviations from intended interventions, or incomplete reporting of prespecified analyses.”

Pressure Ulcer Scale for Healing (PUSH Tool 3.0) scores were significantly lower in the PDRN group at each time point.

“Secondary outcome assessment using the Pressure Ulcer Scale for Healing (PUSH Tool 3.0) similarly demonstrated significantly lower scores in the experimental group at each time point.”

No adverse effects were reported throughout the PDRN pressure ulcer treatment period.

“no adverse effects were reported throughout the treatment period.”

Hematological examinations at week 4 revealed no abnormal findings in either group.

“Hematological examinations conducted at week 4 revealed no abnormal findings in either group”