Clinical Evaluation of the Trophic Effect of Polydeoxyribonucleotide (PDRN) in Patients Undergoing Skin Explants. A Pilot Study
Abstract
Objective The purpose of this double-blind, randomised, placebo-controlled study was to assess the effects of intramuscular and subcutaneous PDRN in favouring the wound-healing process in donor sites of grafts. Methods 26 adult patients of both sexes (15 males and 11 females; mean age: 68.2 +/- 16.1 years) subjected to skin explants due to plastic surgery were eligible to participate in this double-blind, placebo-controlled study. Patients were randomly allocated into the PDRN group (14 subjects) or the placebo group (12 subjects). PDRN (5625 mg/vial) or placebo were administered by the intramuscular route once daily, associated with a subcutaneous administration of the same dosage form (2 vials every 3 days) for 10 consecutive days. The primary end point for efficacy was the evolution of wound healing in donor sites, which was evaluated measuring wound surface area and then calculating percentage re-epithelialisation. Secondary end points were local subjective symptoms, such as pain and itching, and objective signs such as perilesional erythema and blisters. Signs and symptoms were quantified through an analogue scale. Results At day 7 of the treatment period, the difference in percentage of re-epithelialisation was statistically significant (p Conclusions The findings of our study demonstrated that PDRN is able to modify positively the repair processes in donor sites of autologous skin grafts. This could improve the clinical outcome and decrease the need for additional ther…
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PDRN injections have not been clinically associated with serious adverse effects or persistent skin abnormalities.
“To date, PDRN injections have not been clinically associated with serious adverse effects or persistent skin abnormalities [148].”
From Comparison of Polynucleotide and Polydeoxyribonucleotide in Dermatology: Molecular Mechanisms and Clinical Perspectives (2025) · cites this paper as [148]
The commercialization of Placentex® catalyzed advancements in DNA purification technologies.
“and catalyzed advancements in DNA purification technologies [147,148,168].”
From Comparison of Polynucleotide and Polydeoxyribonucleotide in Dermatology: Molecular Mechanisms and Clinical Perspectives (2025) · cites this paper as [148]
The commercialization of Placentex® in the early 1990s marked a significant milestone in the therapeutic use of PDRN.
“The commercialization of Placentex® in the early 1990s marked a significant milestone in the therapeutic use of PDRN”
From Comparison of Polynucleotide and Polydeoxyribonucleotide in Dermatology: Molecular Mechanisms and Clinical Perspectives (2025) · cites this paper as [148]
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- Authors
- Rubegni, P., De Aloe, G., Mazzatenta, C., Cattarini, L., & Fimiani, M.
- Affiliations
- University of Siena (IT)
- Mastelli (Italy) (IT)
- Venue
- Current Medical Research and Opinion
- Publisher
- Informa Healthcare
- Published
- 2001-01
- Volume
- 17
- Issue
- 2
- Pages
- 128-131
- ISSN
- 0300-7995 (ISSN-L)
- 1473-4877
- OpenAlex
- W2155587700
- Cited by
- 56
- References
- 11
- Citations by year
- 2026: 3 · 2025: 4 · 2024: 6 · 2023: 5 · 2022: 2 · 2021: 1 · 2020: 4 · 2019: 1 · 2018: 2 · 2017: 3 · 2016: 3 · 2015: 3 · 2014: 5 · 2013: 2 · 2012: 1
- FWCI
- 0.80
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Current Medical Research and Opinion (publishedVersion)
- PubMed (publishedVersion)
- Use Siena air (University of Siena) (submittedVersion)
- Topics
- Health Sciences › Medicine › Rehabilitation › Wound Healing and Treatments
- Health Sciences › Medicine › Dermatology › Dermatologic Treatments and Research
- Health Sciences › Medicine › Urology › Periodontal Regeneration and Treatments
- Keywords
- polydeoxyribonucleotide, wound healing, donor site, skin grafts, re-epithelialization, trophic effects, intramuscular administration, subcutaneous administration, autologous skin grafting, plastic surgery
- MeSH terms
- Aged, Double-Blind Method, Evaluation Studies as Topic, Female, Humans, Length of Stay, Male, Middle Aged, Pilot Projects, Polydeoxyribonucleotides, Wound Healing, Skin Transplantation, Treatment Outcome
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