The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
False-Negative Results of Real-Time Reverse-Transcriptase Polymerase Chain Reaction for Severe Acute Respiratory Syndrome Coronavirus 2: Role of Deep-Learning-Based CT Diagnosis and Insights from Two Cases
Open accessAbstract
The epidemic of 2019 novel coronavirus, later named as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is still gradually spreading worldwide. The nucleic acid test or genetic sequencing serves as the gold standard method for confirmation of infection, yet several recent studies have reported false-negative results of real-time reverse-transcriptase polymerase chain reaction (rRT-PCR). Here, we report two representative false-negative cases and discuss the supplementary role of clinical data with rRT-PCR, including laboratory examination results and computed tomography features. Coinfection with SARS-COV-2 and other viruses has been discussed as well.
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A novel coronavirus from patients with pneumonia in China, 2019
Zhu, N., Zhang, D., Wang, W., Li, X., Yang, B., Song, J., Zhao, X., Huang, B., Shi, W., Lu, R., et al. (2020) · New England Journal of Medicine · doi:10.1056/nejmoa2001017 · Cited by 28,244
Self-citationCoronaviridae Study Group of the International Committee on Taxonomy of Viruses, Gorbalenya, A. E., Baker, S. C., Baric, R. S., de Groot, R. J., Drosten, C., Gulyaeva, A. A., Haagmans, B. L., Lauber, C., Leontovich, A. M., et al. (2020) · Nature Microbiology · doi:10.1038/s41564-020-0695-z · Cited by 8,403
CT Imaging Features of 2019 Novel Coronavirus (2019-nCoV)
Chung, M., Bernheim, A., Mei, X., Zhang, N., Huang, M., Zeng, X., Cui, J., Xu, W., Yang, Y., Fayad, Z. A., et al. (2020) · Radiology · doi:10.1148/radiol.2020200230 · Cited by 2,751
Xie, X., Zhong, Z., Zhao, W., Zheng, C., Wang, F., & Liu, J. (2020) · Radiology · doi:10.1148/radiol.2020200343 · Cited by 1,960 · cited 2×
“org underlying reasons for false-negative rRT-PCR results, a previous published study suggested that insufficient viral specimens and laboratory error might be responsible (3).”
BackgroundResult
Cited by
False-negative results of initial RT-PCR assays for COVID-19: A systematic review
Arevalo-Rodriguez, I., Buitrago-Garcia, D., Simancas-Racines, D., Zambrano-Achig, P., Del Campo, R., Ciapponi, A., Sued, O., Martinez-García, L., Rutjes, A. W., Low, N., et al. (2020) · PLOS ONE · doi:10.1371/journal.pone.0242958 · Cited by 656
Lai, C.-C., Wang, C.-Y., & Hsueh, P.-R. (2020) · Journal of Microbiology, Immunology and Infection · doi:10.1016/j.jmii.2020.05.013 · Cited by 489
COVID-19 diagnosis by routine blood tests using machine learning
Kukar, M., Gunčar, G., Vovko, T., Podnar, S., Černelč, P., Brvar, M., Zalaznik, M., Notar, M., Moškon, S., & Notar, M. (2021) · Scientific Reports · doi:10.1038/s41598-021-90265-9 · Cited by 179
Artificial Intelligence for COVID-19: Rapid Review
(2020) · doi:10.2196/21476 · Cited by 160
Metadata
- Authors
- Li, D., Wang, D., Dong, J., Wang, N., Huang, H., Xu, H., & Xia, C.
- Venue
- Korean Journal of Radiology
- Publisher
- XMLink
- Published
- 2020
- Volume
- 21
- Issue
- 4
- Pages
- 505
- ISSN
- 1229-6929 (ISSN-L)
- 2005-8330
- OpenAlex
- W3010522809
- Cited by
- 367
- References
- 4
- FWCI
- 10.56
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Li, D., Wang, D., Dong, J., Wang, N., Huang, H., Xu, H., & Xia, C. (2020). False-Negative Results of Real-Time Reverse-Transcriptase Polymerase Chain Reaction for Severe Acute Respiratory Syndrome Coronavirus 2: Role of Deep-Learning-Based CT Diagnosis and Insights from Two Cases. Korean Journal of Radiology. https://doi.org/10.3348/kjr.2020.0146
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