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Cited by 408

The DOI matches its Crossref record; 111 of the 111 references it cites were found in a registry or an index.

Blood vessel replacement: 50 years of development and tissue engineering paradigms in vascular surgery

Open access
Chlupáč, J, Filová, E, Bačáková, L·2009·Physiological Research

Abstract

The gold standard material in bypass surgery of blood vessels remains the patient’s own artery or vein. However, this material may be unavailable, or may suffer vein graft disease. Currently available vascular prostheses, namely polyethylene terephthalate (PET, Dacron) and expanded polytetrafluoroethylene (ePTFE), perform well as large-caliber replacements, but their long-term patency is discouraging in small-caliber applications (<6 mm), such as in coronary, crural or microvessel surgery. This failure is mainly a result of an unfavorable healing process with surface thrombogenicity, due to lack of endothelial cells and anastomotic intimal hyperplasia caused by hemodynamic disturbances. An ideal small-diameter vascular graft has become a major focus of research. Novel biomaterials have been manufactured, and tissue-biomaterial interactions have been optimized. Tissue engineering technology has proven that the concept of partially or totally living blood vessels is feasible. The purpose of this review is to outline the vascular graft materials that are currently being implanted, taking into account cell-biomaterial physiology, tissue engineering approaches and the collective achievements of the authors.

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Crossref · 10.33549/physiolres.931918

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Metadata

Authors
Chlupáč, J., Filová, E., & Bačáková, L.
Venue
Physiological Research
Published
2009
Volume
58 Suppl 2
Pages
S119-S140
ISSN
  • 0862-8408 (ISSN-L)
  • 1802-9973
OpenAlex
W72375187
Cited by
408
References
111
FWCI
13.53
Type
journal article
Language
en
Open access
gold

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CoChat. (2026). Citation check: Blood vessel replacement: 50 years of development and tissue engineering paradigms in vascular surgery. https://app.cochat.ai/papers/10.33549/physiolres.931918
The paper
Chlupáč, J., Filová, E., & Bačáková, L. (2009). Blood vessel replacement: 50 years of development and tissue engineering paradigms in vascular surgery. Physiological Research. https://doi.org/10.33549/physiolres.931918

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.