Peptide-Based Functional Biomaterials for Soft-Tissue Repair
Open accessAbstract
Synthetically derived peptide-based biomaterials are in many instances capable of mimicking the structure and function of their full-length endogenous counterparts. Combine this with the fact that short mimetic peptides are easier to produce when compared to full length proteins, show enhanced processability and ease of modification, and have the ability to be prepared under well-defined and controlled conditions; it becomes obvious why there has been a recent push to develop regenerative biomaterials from these molecules. There is increasing evidence that the incorporation of peptides within regenerative scaffolds can result in the generation of structural recognition motifs that can enhance cell attachment or induce cell signaling pathways, improving cell infiltration or promote a variety of other modulatory biochemical responses. By highlighting the current approaches in the design and application of short mimetic peptides, we hope to demonstrate their potential in soft-tissue healing while at the same time drawing attention to the advances made to date and the problems which need to be overcome to advance these materials to the clinic for applications in heart, skin, and cornea repair.
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Peptide-based interventions and biomimetic materials complement PRP and MSC applications by enhancing infection control, promoting wound healing, and improving tissue integration.
“Peptide-based interventions and biomimetic materials, while emerging, introduce novel regenerative strategies that complement PRP and MSC applications by enhancing infection control, promoting wound healing, and improving tissue integration [7].”
From Advancements in Regenerative Therapies for Orthopedics: A Comprehensive Review of Platelet-Rich Plasma, Mesenchymal Stem Cells, Peptide Therapies, and Biomimetic Applications (2025) · cites this paper as [7]
The sections on cornea and skin therapeutics describe antimicrobial peptides that prevent infection and promote wound healing. The section on combination therapies with cells describes peptide-modified scaffolds that improve cell adhesion or retention, including in MSC applications. The cited passages do not establish that these materials complement PRP applications. (LLM, conf=0.86)
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- Authors
- Hosoyama, K., Lazurko, C., Muñoz, M., McTiernan, C. D., & Alarcon, E. I.
- Affiliations
- Ottawa Heart Institute (CA)
- University of Ottawa (CA)
- Corresponding author
- Alarcon, Emilio I.
- Venue
- Frontiers in Bioengineering and Biotechnology
- Publisher
- Frontiers Media SA
- Published
- 2019-08-23
- Volume
- 7
- Pages
- 205-205
- ISSN
- 2296-4185 (ISSN-L)
- PMC
- PMC6716508
- OpenAlex
- W2969179712
- Cited by
- 118
- References
- 162
- Citations by year
- 2026: 5 · 2025: 15 · 2024: 11 · 2023: 21 · 2022: 27 · 2021: 21 · 2020: 17 · 2019: 1
- FWCI
- 1.05
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Frontiers in Bioengineering and Biotechnology (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Natural Sciences and Engineering Research Council of Canada
- Canadian Institutes of Health Research
- Topics
- Physical Sciences › Materials Science › Biomaterials › Silk-based biomaterials and applications
- Physical Sciences › Materials Science › Biomaterials › Supramolecular Self-Assembly in Materials
- Health Sciences › Medicine › Surgery › Tissue Engineering and Regenerative Medicine
- Keywords
- peptide-based biomaterials, peptidomimetics, soft tissue repair, regenerative scaffolds, cell attachment, signal transduction, tissue engineering, cardiac repair, skin repair, synthetic peptides
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