Cell Culture Based in vitro Test Systems for Anticancer Drug Screening
Open accessAbstract
The development of new high-tech systems for screening anticancer drugs is one of the main problems of preclinical screening. Poor correlation between preclinical in vitro and in vivo data with clinical trials remains a major concern. The choice of the correct tumor model at the stage of in vitro testing provides reduction in both financial and time costs during later stages due to the timely screening of ineffective agents. In view of the growing incidence of oncology, increasing the pace of the creation, development and testing of new antitumor agents, the improvement and expansion of new high-tech systems for preclinical in vitro screening, is becoming very important. The pharmaceutical industry presently relies on several widely used in vitro models, including two-dimensional models, three-dimensional models, microfluidic systems, Boyden's chamber and models created using 3D bioprinting. This review outlines and describes these tumor models including their use in research, in addition to their characteristics. This review therefore gives an insight into in vitro based testing which is of interest to researchers and clinicians from differing fields including pharmacy, preclinical studies and cell biology.
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Monolayer systems fall short in predicting in vivo therapeutic efficacy despite their utility in mechanistic studies and target validation.
“However, despite their utility in mechanistic studies and target validation, these models fall short in predicting in vivo therapeutic efficacy.”
From Modeling Tumor Microenvironment Complexity In Vitro: Spheroids as Physiologically Relevant Tumor Models and Strategies for Their Analysis (2025) · cites this paper as [169]
The Two-Dimensional Cultures section (page unavailable) says drugs effective in 2D models do not always work in oncology patients, partly because those cultures lack in vivo tissue architecture and interactions. It describes monolayers as useful for drug screening, but does not establish their utility specifically for mechanistic studies or target validation. (LLM, conf=0.86)
Experimental — accuracy not yet measuredNumerous anticancer compounds that demonstrate robust activity in monolayer cultures fail to reproduce such outcomes in vivo.
“Numerous anticancer compounds that demonstrate robust activity in monolayer cultures fail to reproduce such outcomes in vivo [168,169,170,171].”
From Modeling Tumor Microenvironment Complexity In Vitro: Spheroids as Physiologically Relevant Tumor Models and Strategies for Their Analysis (2025) · cites this paper as [169]
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Self-citation
- Authors
- Kitaeva, K. V., Rutland, C. S., Rizvanov, A. A., & Solovyeva, V. V.
- Affiliations
- Kazan Federal University (RU)
- University of Nottingham (GB)
- Corresponding author
- Solovyeva, Valeriya V.
- Venue
- Frontiers in Bioengineering and Biotechnology
- Publisher
- Frontiers Media SA
- Published
- 2020-04-09
- Volume
- 8
- Pages
- 322-322
- ISSN
- 2296-4185 (ISSN-L)
- PMC
- PMC7160228
- OpenAlex
- W3015928265
- Cited by
- 142
- References
- 69
- Citations by year
- 2026: 12 · 2025: 11 · 2024: 26 · 2023: 29 · 2022: 30 · 2021: 26 · 2020: 8
- FWCI
- 1.94
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Frontiers in Bioengineering and Biotechnology (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Repository@Nottingham (University of Nottingham) (publishedVersion, cc-by)
- Repository@Nottingham (University of Nottingham) (submittedVersion, cc-by)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- Funders
- Russian Foundation for Basic Research (18-04-01133)
- Kazan Federal University
- Topics
- Physical Sciences › Engineering › Biomedical Engineering › 3D Printing in Biomedical Research
- Health Sciences › Medicine › Oncology › Cancer Cells and Metastasis
- Health Sciences › Veterinary › Small Animals › Animal testing and alternatives
- Keywords
- anticancer drug screening, in vitro tumor model, preclinical drug testing, 3D cell culture models, microfluidics, Boyden chamber, 3D bioprinting, 2D cell culture, in vitro-in vivo correlation, anticancer agents
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