Cited by 3613D Printing in Biomedical ResearchCellular Mechanics and InteractionsMicrofluidic and Capillary Electrophoresis Applications

Bioprinting for cancer research

Knowlton, Stephanie, Onal, Sevgi, Yu, Chu Hsiang, Zhao, Jean J., Tasoglu, Savas·2015·Trends in Biotechnology

Abstract

Bioprinting offers the ability to create highly complex 3D architectures with living cells. This cutting-edge technique has significantly gained popularity and applicability in several fields. Bioprinting methods have been developed to effectively and rapidly pattern living cells, biological macromolecules, and biomaterials. These technologies hold great potential for applications in cancer research. Bioprinted cancer models represent a significant improvement over previous 2D models by mimicking 3D complexity and facilitating physiologically relevant cell-cell and cell-matrix interactions. Here we review bioprinting methods based on inkjet, microextrusion, and laser technologies and compare 3D cancer models with 2D cancer models. We discuss bioprinted models that mimic the tumor microenvironment, providing a platform for deeper understanding of cancer pathology, anticancer drug screening, and cancer treatment development.

Integrity signals

Registry

Crossref · 10.1016/j.tibtech.2015.06.007

Cites

87 of 87 references verified0 citation errors · 0 not checkable

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  • Bioprinting technology based on layer-by-layer printing has been used for tumor-on-a-chip fabrication.

    “In recent years, bioprinting technology based on layer-by-layer printing has been used for tumor-on-a-chip fabrication (Fig. 3)132,145–147.”

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Authors
Knowlton, S., Onal, S., Yu, C. H., Zhao, J. J., & Tasoglu, S.
Affiliations
  • University of Connecticut (US)
  • Harvard University (US)
Venue
Trends in Biotechnology
Publisher
Elsevier BV
Published
2015-09
Volume
33
Issue
9
Pages
504-513
ISSN
0167-7799 (ISSN-L)
OpenAlex
W1926427589
Cited by
361
References
88
Citations by year
2026: 7 · 2025: 16 · 2024: 32 · 2023: 35 · 2022: 38 · 2021: 43 · 2020: 52 · 2019: 35 · 2018: 34 · 2017: 39 · 2016: 30
FWCI
2.66
Type
journal article
Language
en
Open access
closed
Locations
  • Trends in biotechnology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Physical Sciences › Engineering › Biomedical Engineering › 3D Printing in Biomedical Research
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular Mechanics and Interactions
  • Physical Sciences › Engineering › Biomedical Engineering › Microfluidic and Capillary Electrophoresis Applications
Keywords
bioprinting, 3D tumor models, tumor microenvironment, inkjet bioprinting, cell-matrix interactions, anticancer drug screening, cancer treatment development
MeSH terms
Humans, Models, Biological, Neoplasms, Biomedical Research, Bioprinting

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