Bioprinting for cancer research
Abstract
Bioprinting offers the ability to create highly complex 3D architectures with living cells. This cutting-edge technique has significantly gained popularity and applicability in several fields. Bioprinting methods have been developed to effectively and rapidly pattern living cells, biological macromolecules, and biomaterials. These technologies hold great potential for applications in cancer research. Bioprinted cancer models represent a significant improvement over previous 2D models by mimicking 3D complexity and facilitating physiologically relevant cell-cell and cell-matrix interactions. Here we review bioprinting methods based on inkjet, microextrusion, and laser technologies and compare 3D cancer models with 2D cancer models. We discuss bioprinted models that mimic the tumor microenvironment, providing a platform for deeper understanding of cancer pathology, anticancer drug screening, and cancer treatment development.
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Bioprinting technology based on layer-by-layer printing has been used for tumor-on-a-chip fabrication.
“In recent years, bioprinting technology based on layer-by-layer printing has been used for tumor-on-a-chip fabrication (Fig. 3)132,145–147.”
From Tumor-on-a-chip: from bioinspired design to biomedical application (2021) · cites this paper as [146]
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Application areas of 3D bioprinting
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3D-printed microfluidic devices
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3D bioprinting for drug discovery and development in pharmaceutics
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Design and Printing Strategies in 3D Bioprinting of Cell‐Hydrogels: A Review
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3D bioprinted glioma stem cells for brain tumor model and applications of drug susceptibility
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3D neural tissue models: From spheroids to bioprinting
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Emerging Technologies in Multi‐Material Bioprinting
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Printing Technologies for Medical Applications
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Organ-Derived Decellularized Extracellular Matrix: A Game Changer for Bioink Manufacturing?
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A brief review of extrusion‐based tissue scaffold bio‐printing
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Review of 3D printable hydrogels and constructs
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3D Printing—Encompassing the Facets of Dentistry
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Bioprinting the Cancer Microenvironment
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3D-printed microneedles in biomedical applications
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Microvalve-based bioprinting – process, bio-inks and applications
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Bioprinting for Neural Tissue Engineering
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3D Bioprinted cancer models: Revolutionizing personalized cancer therapy
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Bioprinting towards physiologically relevant tissue models for pharmaceutics
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The arrival of commercial bioprinters – Towards 3D bioprinting revolution!
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3D bioprinting of structural proteins
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Bioprinting of Thermoresponsive Hydrogels for Next Generation Tissue Engineering: A Review
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Emerging tumor spheroids technologies for 3D in vitro cancer modeling
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Coaxial 3D bioprinting of self-assembled multicellular heterogeneous tumor fibers
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3D Tumor Models and Their Use for the Testing of Immunotherapies
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Engineering 3D Hydrogels for Personalized In Vitro Human Tissue Models
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3D Printed Tissue Models: Present and Future
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Biomaterials and 3D Bioprinting Strategies to Model Glioblastoma and the Blood–Brain Barrier
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Microfluidic bioprinting for organ-on-a-chip models
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3D printing biomimetic materials and structures for biomedical applications
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A Mathematical Model on the Resolution of Extrusion Bioprinting for the Development of New Bioinks
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Bioprinting and Differentiation of Stem Cells
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A Bioprinted Liver-on-a-Chip for Drug Screening Applications
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Cell Culture Based in vitro Test Systems for Anticancer Drug Screening
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Recent advances in 3D bioprinting of vascularized tissues
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Photopolymerization of Bio-Based Polymers in a Biomedical Engineering Perspective
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Breast Cancer Cell Invasion into a Three Dimensional Tumor-Stroma Microenvironment
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3D-printed microfluidic chips with patterned, cell-laden hydrogel constructs
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Self-citationCharacterization of Cell Damage and Proliferative Ability during and after Bioprinting
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Mimicking tumor microenvironment by 3D bioprinting: 3D cancer modeling
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Enabling personalized implant and controllable biosystem development through 3D printing
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Digital Light Processing Bioprinting Advances for Microtissue Models
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3D approaches to model the tumor microenvironment of pancreatic cancer
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Bioprintable tough hydrogels for tissue engineering applications
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3D-Printed Biosensor Arrays for Medical Diagnostics
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3D models in the new era of immune oncology: focus on T cells, CAF and ECM
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Photocrosslinking-based bioprinting: Examining crosslinking schemes
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Direct Writing of Tunable Living Inks for Bioprocess Intensification
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Drug screening in 3D in vitro tumor models: overcoming current pitfalls of efficacy read‐outs
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Tumor-like lung cancer model based on 3D bioprinting
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Addressing Unmet Clinical Needs with 3D Printing Technologies
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The emergence of 3D bioprinting in organ-on-chip systems
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Grafting of 3D Bioprinting to In Vitro Drug Screening: A Review
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Advancing 3D bioprinting through machine learning and artificial intelligence
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Machine learning-enabled optimization of extrusion-based 3D printing
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3D printing towards implementing Industry 4.0: sustainability aspects, barriers and challenges
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Innovations in 3D Tissue Models of Human Brain Physiology and Diseases
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- Authors
- Knowlton, S., Onal, S., Yu, C. H., Zhao, J. J., & Tasoglu, S.
- Affiliations
- University of Connecticut (US)
- Harvard University (US)
- ORCID
- Zhao, Jean J.
- Venue
- Trends in Biotechnology
- Publisher
- Elsevier BV
- Published
- 2015-09
- Volume
- 33
- Issue
- 9
- Pages
- 504-513
- ISSN
- 0167-7799 (ISSN-L)
- OpenAlex
- W1926427589
- Cited by
- 361
- References
- 88
- Citations by year
- 2026: 7 · 2025: 16 · 2024: 32 · 2023: 35 · 2022: 38 · 2021: 43 · 2020: 52 · 2019: 35 · 2018: 34 · 2017: 39 · 2016: 30
- FWCI
- 2.66
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Trends in biotechnology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Physical Sciences › Engineering › Biomedical Engineering › 3D Printing in Biomedical Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular Mechanics and Interactions
- Physical Sciences › Engineering › Biomedical Engineering › Microfluidic and Capillary Electrophoresis Applications
- Keywords
- bioprinting, 3D tumor models, tumor microenvironment, inkjet bioprinting, cell-matrix interactions, anticancer drug screening, cancer treatment development
- MeSH terms
- Humans, Models, Biological, Neoplasms, Biomedical Research, Bioprinting
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