Unraveling Adipocytes and Cancer Links: Is There a Role for Senescence?
Open accessAbstract
Senescence is characterized by a permanent cell cycle arrest that is elicited in response to different stresses. In addition, senescent cells undergo multiple other phenotypic alterations, such as autophagy modulation, metabolic reprogramming, and the senescence-associated secretory phenotype (SASP). These senescence-related and inflammatory effects prevail within tumors and are strongly controlled by cancer properties, and inflammatory mediators further maintain and propagate the senescence process to adjacent cells. It is important to consider these detrimental effects that may drive tumorigenesis or cancer relapse. Importantly, cancer-associated adipocytes (CAAs) are one of the primary stromal cells in various tumor microenvironments and favor tumor progression by releasing various factors that can mediate local and systemic effects. However, it remains unclear whether CAAs possess senescent features. In this review, we discuss the complex relationship between senescence and CAAs and highlight important considerations for therapeutics.
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Within the tumor microenvironment, adipocytes exhibit a markedly altered phenotype compared to normal tissue, including reduced cell size, expanded interstitial spacing, and decreased intracellular lipid content.
“Within the TME, these adipocytes exhibit a markedly altered phenotype compared to their counterparts in normal tissue [59]. Morphological changes include reduced cell size, expanded interstitial spacing, and a pronounced decrease in intracellular lipid content [59].”
From Modeling Tumor Microenvironment Complexity In Vitro: Spheroids as Physiologically Relevant Tumor Models and Strategies for Their Analysis (2025) · cites this paper as [59]
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4 retracted
Kaur, A., Webster, M. R., Marchbank, K., Behera, R., Ndoye, A., Kugel, C. H., Dang, V. M., Appleton, J., O’Connell, M. P., Cheng, P., et al. (2016) · Nature · doi:10.1038/nature17392 · Cited by 398 · see citing works
RetractedWu, Q., Li, J., Li, Z., Sun, S., Zhu, S., Wang, L., Wu, J., Yuan, J., Zhang, Y., Sun, S., et al. (2019) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-019-1210-3 · Cited by 137 · see citing works
Self-citationRetractedWu, Q., Sun, S., Li, Z., Yang, Q., Li, B., Zhu, S., Wang, L., Wu, J., Yuan, J., Yang, C., et al. (2018) · Molecular Cancer · doi:10.1186/s12943-018-0899-5 · Cited by 103 · see citing works
Self-citationRetractedWu, Q., Sun, S., Li, Z., Yang, Q., Li, B., Zhu, S., Wang, L., Wu, J., Yuan, J., Wang, C., et al. (2018) · Adipocyte · doi:10.1080/21623945.2018.1551688 · Cited by 70 · see citing works
Self-citationRetractedOncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a
Serrano, M., Lin, A. W., McCurrach, M. E., Beach, D., & Lowe, S. W. (1997) · Cell · doi:10.1016/s0092-8674(00)81902-9 · Cited by 5,178 · see citing works
Batlle, E., & Clevers, H. (2017) · Nature Medicine · doi:10.1038/nm.4409 · Cited by 2,769 · see citing works
Adipocytes promote ovarian cancer metastasis and provide energy for rapid tumor growth
Nieman, K. M., Kenny, H. A., Penicka, C. V., Ladanyi, A., Buell-Gutbrod, R., Zillhardt, M. R., Romero, I. L., Carey, M. S., Mills, G. B., Hotamisligil, G. S., et al. (2011) · Nature Medicine · doi:10.1038/nm.2492 · Cited by 2,279 · see citing works
A complex secretory program orchestrated by the inflammasome controls paracrine senescence
Acosta, J. C., Banito, A., Wuestefeld, T., Georgilis, A., Janich, P., Morton, J. P., Athineos, D., Kang, T.-W., Lasitschka, F., Andrulis, M., et al. (2013) · Nature Cell Biology · doi:10.1038/ncb2784 · Cited by 2,278 · see citing works
Four faces of cellular senescence
Rodier, F., & Campisi, J. (2011) · Journal of Cell Biology · doi:10.1083/jcb.201009094 · Cited by 2,016 · see citing works
Chemokine signaling via the CXCR2 receptor reinforces senescence
Acosta, J. C., O'Loghlen, A., Banito, A., Guijarro, M. V., Augert, A., Raguz, S., Fumagalli, M., Da Costa, M., Brown, C., Popov, N., et al. (2008) · Cell · doi:10.1016/j.cell.2008.03.038 · Cited by 1,801 · see citing works
Krtolica, A., Parrinello, S., Lockett, S., Desprez, P.-Y., & Campisi, J. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.211053698 · Cited by 1,730 · see citing works
Cytoplasmic chromatin triggers inflammation in senescence and cancer
Dou, Z., Ghosh, K., Vizioli, M. G., Zhu, J., Sen, P., Wangensteen, K. J., Simithy, J., Lan, Y., Lin, Y., Zhou, Z., et al. (2017) · Nature · doi:10.1038/nature24050 · Cited by 1,335 · see citing works
Mechanisms and functions of cellular senescence
Herranz, N., & Gil, J. (2018) · Journal of Clinical Investigation · doi:10.1172/jci95148 · Cited by 1,232 · see citing works
Cancer-associated adipocytes exhibit an activated phenotype and contribute to breast cancer invasion
Dirat, B., Bochet, L., Dabek, M., Daviaud, D., Dauvillier, S., Majed, B., Wang, Y. Y., Meulle, A., Salles, B., Le Gonidec, S., et al. (2011) · Cancer Research · doi:10.1158/0008-5472.can-10-3323 · Cited by 1,134 · see citing works
Senescence-associated reprogramming promotes cancer stemness
Milanovic, M., Fan, D. N. Y., Belenki, D., Däbritz, J. H. M., Zhao, Z., Yu, Y., Dörr, J. R., Dimitrova, L., Lenze, D., Monteiro Barbosa, I. A., et al. (2018) · Nature · doi:10.1038/nature25167 · Cited by 1,131 · see citing works
Fat tissue, aging, and cellular senescence
Tchkonia, T., Morbeck, D. E., Von Zglinicki, T., Van Deursen, J., Lustgarten, J., Scrable, H., Khosla, S., Jensen, M. D., & Kirkland, J. L. (2010) · Aging Cell · doi:10.1111/j.1474-9726.2010.00608.x · Cited by 1,094 · see citing works
Autophagy mediates the mitotic senescence transition
Young, A. R. J., Narita, M., Ferreira, M., Kirschner, K., Sadaie, M., Darot, J. F. J., Tavaré, S., Arakawa, S., Shimizu, S., Watt, F. M., et al. (2009) · Genes & Development · doi:10.1101/gad.519709 · Cited by 1,078 · see citing works
cGAS is essential for cellular senescence
Yang, H., Wang, H., Ren, J., Chen, Q., & Chen, Z. J. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1705499114 · Cited by 1,009 · see citing works
A senescent cell bystander effect: senescence‐induced senescence
Nelson, G., Wordsworth, J., Wang, C., Jurk, D., Lawless, C., Martin‐Ruiz, C., & von Zglinicki, T. (2012) · Aging Cell · doi:10.1111/j.1474-9726.2012.00795.x · Cited by 755 · see citing works
A Switch from White to Brown Fat Increases Energy Expenditure in Cancer-Associated Cachexia
Petruzzelli, M., Schweiger, M., Schreiber, R., Campos‐Olivas, R., Tsoli, M., Allen, J., Swarbrick, M. M., Rose‐John, S., Rincón, M., Robertson, G. R., et al. (2014) · Cell Metabolism · doi:10.1016/j.cmet.2014.06.011 · Cited by 752 · see citing works
Parrinello, S., Coppe, J.-P., Krtolica, A., & Campisi, J. (2005) · Journal of Cell Science · doi:10.1242/jcs.01635 · Cited by 631 · see citing works
Breast cancer stem cells, cytokine networks, and the tumor microenvironment
Körkaya, H., Liu, S., & Wicha, M. S. (2011) · Journal of Clinical Investigation · doi:10.1172/jci57099 · Cited by 616 · see citing works
Secretion of vascular endothelial growth factor by primary human fibroblasts at senescence
Coppé, J.-P., Kauser, K., Campisi, J., & Beauséjour, C. M. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m603307200 · Cited by 604 · see citing works
Linking cellular stress responses to systemic homeostasis
Galluzzi, L., Yamazaki, T., & Kroemer, G. (2018) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-018-0068-0 · Cited by 529 · see citing works
Adipocyte-induced CD36 expression drives ovarian cancer progression and metastasis
Ladányi, A., Mukherjee, A., Kenny, H. A., Johnson, A., Mitra, A. K., Sundaresan, S., Nieman, K. M., Pascual, G., Benitah, S. A., MONTAG, A. G., et al. (2018) · Oncogene · doi:10.1038/s41388-017-0093-z · Cited by 522 · see citing works
Stromal senescence establishes an immunosuppressive microenvironment that drives tumorigenesis
Ruhland, M. K., Loza, A. J., Capietto, A.-H., Luo, X., Knolhoff, B. L., Flanagan, K. C., Belt, B. A., Alspach, E., Leahy, K., Luo, J., et al. (2016) · Nature Communications · doi:10.1038/ncomms11762 · Cited by 496 · see citing works
Cancer-associated adipocytes: key players in breast cancer progression
Wu, Q., Li, B., Li, Z., Li, J., Sun, S., & Sun, S. (2019) · Journal of Hematology & Oncology · doi:10.1186/s13045-019-0778-6 · Cited by 462 · see citing works
Self-citationBavik, C., Coleman, I., Dean, J. P., Knudsen, B., Plymate, S., & Nelson, P. S. (2006) · Cancer Research · doi:10.1158/0008-5472.can-05-1716 · Cited by 453 · see citing works
Ortiz-Montero, P., Londoño-Vallejo, A., & Vernot, J.-P. (2017) · Cell Communication and Signaling · doi:10.1186/s12964-017-0172-3 · Cited by 428 · see citing works
Monitoring Tumorigenesis and Senescence In Vivo with a p16INK4a-Luciferase Model
Burd, C. E., Sorrentino, J. A., Clark, K. S., Darr, D. B., Krishnamurthy, J., Deal, A. M., Bardeesy, N., Castrillon, D. H., Beach, D. H., & Sharpless, N. E. (2013) · Cell · doi:10.1016/j.cell.2012.12.010 · Cited by 419 · see citing works
Tsuyada, A., Chow, A., Wu, J., Somlo, G., Chu, P. G., Loera, S., Luu, T. H., Li, A. X., Wu, X., Ye, W., et al. (2012) · Cancer Research · doi:10.1158/0008-5472.can-11-3567 · Cited by 408 · see citing works
Senescence-associated inflammatory responses: aging and cancer perspectives
Lasry, A., & Ben-Neriah, Y. (2015) · Trends in Immunology · doi:10.1016/j.it.2015.02.009 · Cited by 408 · see citing works
Autophagy in cancer associated fibroblasts promotes tumor cell survival
Martinez‐Outschoorn, U., Trimmer, C., Zhao, L., Whitaker‐Menezes, D., Chiavarina, B., Zhou, J., Wang, C., Pavlides, S., Cantarin, M. P. M., Capozza, F., et al. (2010) · Cell Cycle · doi:10.4161/cc.9.17.12928 · Cited by 406 · see citing works
Alimonti, A., Nardella, C., Chen, Z., Clohessy, J. G., Carracedo, A., Trotman, L. C., Cheng, K., Varmeh, S., Kozma, S. C., Thomas, G., et al. (2010) · Journal of Clinical Investigation · doi:10.1172/jci40535 · Cited by 374 · see citing works
Yang, G., Rosen, D. G., Zhang, Z., Bast, R. C., Mills, G. B., Colacino, J. A., Mercado-Uribe, I., & Liu, J. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0605752103 · Cited by 341 · see citing works
Coppé, J.-P., Patil, C. K., Rodier, F., Sun, Y., Muñoz, D. P., Goldstein, J., Nelson, P. S., Desprez, P.-Y., & Campisi, J. (2008) · PLoS Biology · doi:10.1371/journal.pbio.0060301 · Cited by 302 · see citing works
Kiyono, K., Suzuki, H. I., Matsuyama, H., Morishita, Y., Komuro, A., Kano, M. R., Sugimoto, K., & Miyazono, K. (2009) · Cancer Research · doi:10.1158/0008-5472.can-08-4401 · Cited by 285 · see citing works
Witkiewicz, A. K., Dasgupta, A., Sotgia, F., Mercier, I., Pestell, R. G., Sabel, M. S., Kleer, C. G., Brody, J. R., & Lisanti, M. P. (2009) · American Journal Of Pathology · doi:10.2353/ajpath.2009.080873 · Cited by 283 · see citing works
The senescent bystander effect is caused by ROS-activated NF-κB signalling
Nelson, G., Kucheryavenko, O., Wordsworth, J., & von Zglinicki, T. (2017) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2017.08.005 · Cited by 280 · see citing works
Oncogene-induced senescence: the bright and dark side of the response
Gorgoulis, V. G., & Halazonetis, T. D. (2010) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2010.07.013 · Cited by 257 · see citing works
Microvesicles containing miRNAs promote muscle cell death in cancer cachexia via TLR7
He, W. A., Calore, F., Londhe, P., Canella, A., D, D. C. G., & Croce, C. M. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1402714111 · Cited by 251 · see citing works
VHL loss actuates a HIF-independent senescence programme mediated by Rb and p400
Young, A. P., Schlisio, S., Minamishima, Y. A., Zhang, Q., Li, L., Grisanzio, C., Signoretti, S., & Kaelin, W. G. (2008) · Nature Cell Biology · doi:10.1038/ncb1699 · Cited by 239 · see citing works
Capparelli, C., Guido, C., Whitaker‐Menezes, D., Bonuccelli, G., Balliet, R. M., Pestell, T. G., Goldberg, A. F., Pestell, R. G., Howell, A., Sneddon, S., et al. (2012) · Cell Cycle · doi:10.4161/cc.20718 · Cited by 235 · see citing works
Two-Step Senescence-Focused Cancer Therapies
Sieben, C. J., Sturmlechner, I., van de Sluis, B., & van Deursen, J. M. (2018) · Trends in Cell Biology · doi:10.1016/j.tcb.2018.04.006 · Cited by 222 · see citing works
Rowan, B. G., Gimble, J. M., Sheng, M., Anbalagan, M., Jones, R. K., Frazier, T. P., Asher, M., Lacayo, E. A., Friedlander, P. L., Kutner, R., et al. (2014) · PLoS ONE · doi:10.1371/journal.pone.0089595 · Cited by 174 · see citing works
Lapeire, L., Hendrix, A., Lambein, K., Bockstal, M. V., Braems, G., den Broecke, R. V., Limame, R., Mestdagh, P., Vandesompele, J., Vanhove, C., et al. (2014) · Cancer Research · doi:10.1158/0008-5472.can-14-0160 · Cited by 147 · see citing works
Diedrich, J. D., Rajagurubandara, E. N., Herroon, M. K., Mahapatra, G., Hüttemann, M., & Podgorski, I. (2016) · Oncotarget · doi:10.18632/oncotarget.11712 · Cited by 127 · see citing works
Hassona, Y. M., Cirillo, N., Lim, K. P., Herman, A., Mellone, M., Thomas, G. J., Pitiyage, G. N., Parkinson, E. K., & Prime, S. S. (2013) · Carcinogenesis · doi:10.1093/carcin/bgt035 · Cited by 110 · see citing works
Elevated Endoplasmic Reticulum Stress Response Contributes to Adipose Tissue Inflammation in Aging
Ghosh, A. K., Garg, S. K., Mau, T., O’Brien, M., Liu, J., & Yung, R. L. (2014) · The Journals of Gerontology Series A · doi:10.1093/gerona/glu186 · Cited by 96 · see citing works
Impaired autophagy activity is linked to elevated ER-stress and inflammation in aging adipose tissue
Ghosh, A. K., Mau, T., O’Brien, M., Garg, S., & Yung, R. L. (2016) · Aging · doi:10.18632/aging.101083 · Cited by 88 · see citing works
Martyniak, K., & Masternak, M. M. (2016) · Experimental Gerontology · doi:10.1016/j.exger.2016.12.007 · Cited by 75 · see citing works
Caveolin‐1: An Oxidative Stress‐Related Target for Cancer Prevention
Wang, S., Wang, N., Zheng, Y., Zhang, J., Zhang, F., & Wang, Z. (2017) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2017/7454031 · Cited by 74 · see citing works
Adipose Tissue Senescence and Inflammation in Aging is Reversed by the Young Milieu
Ghosh, A. K., O’Brien, M., Mau, T., Qi, N., & Yung, R. L. (2018) · The Journals of Gerontology Series A · doi:10.1093/gerona/gly290 · Cited by 72 · see citing works
Song, Y. H., Warncke, C., Choi, S. J., Choi, S., Chiou, A. E., Lu, L., Liu, H., Daniel, S., Antonyak, M. A., Cerione, R. A., et al. (2016) · Matrix Biology · doi:10.1016/j.matbio.2016.11.008 · Cited by 68 · see citing works
Caveolin‐1 deficiency induces premature senescence with mitochondrial dysfunction
Yu, D., Jung, S. H., An, H., Lee, S., Hong, J. H., Park, J. S., Lee, H., Lee, H., Bahn, M., Lee, H. C., et al. (2017) · Aging Cell · doi:10.1111/acel.12606 · Cited by 66 · see citing works
Buratta, S., Urbanelli, L., Sagini, K., Giovagnoli, S., Caponi, S., Fioretto, D., Mitro, N., Caruso, D., & Emiliani, C. (2017) · PLoS ONE · doi:10.1371/journal.pone.0188840 · Cited by 66 · see citing works
Guerrero, J., Tobar, N., Cáceres, M., Espinoza, L., Escobar, P., Dotor, J., Smith, P. C., & Martı́nez, J. (2009) · Breast Cancer Research and Treatment · doi:10.1007/s10549-009-0491-1 · Cited by 49 · see citing works
Senescence and the Pro-tumorigenic Stroma
Alspach, E., Fu, Y., & Stewart, S. A. (2013) · Critical Reviews in Oncogenesis · doi:10.1615/critrevoncog.2014010630 · Cited by 47 · see citing works
Expression of cancer-associated fibroblast-related proteins in adipose stroma of breast cancer
Jung, Y. Y., Lee, Y. K., & Koo, J. S. (2015) · Tumor Biology · doi:10.1007/s13277-015-3594-9 · Cited by 45 · see citing works
Adipocytes Promote Early Steps of Breast Cancer Cell Dissemination via Interleukin-8
Rodriguez, G. V., Abrahamsson, A. E., Jensen, L. D., & Dabrosin, C. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.01767 · Cited by 38 · see citing works
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Cancer-associated adipocytes: emerging supporters in breast cancer
Zhao, C., Wu, M., Zeng, N., Xiong, M., Hu, W., Lv, W., Yi, Y., Zhang, Q., & Wu, Y. (2020) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-020-01666-z · Cited by 170 · see citing works
Cancer-associated adipocytes as immunomodulators in cancer
Wu, Q., Li, B., Li, J., Sun, S., Yuan, J., & Sun, S. (2021) · Biomarker Research · doi:10.1186/s40364-020-00257-6 · Cited by 105 · see citing works
Self-citationTumor Microenvironment—A Short Review of Cellular and Interaction Diversity
Bożyk, A., Wojas‐Krawczyk, K., Krawczyk, P. A., & Milanowski, J. (2022) · Biology · doi:10.3390/biology11060929 · Cited by 104 · see citing works
Multi‑faceted role of cancer‑associated adipocytes in the tumor microenvironment (Review)
Yao, H., & He, S. (2021) · Molecular Medicine Reports · doi:10.3892/mmr.2021.12506 · Cited by 88 · see citing works
Shah, S., & D’Souza, G. G. M. (2025) · Cells · doi:10.3390/cells14100732 · Cited by 66 · see citing works
“Morphological changes include reduced cell size, expanded interstitial spacing, and a pronounced decrease in intracellular lipid content [59].”
Ravi, K., Manoharan, T. J. M., Wang, K.-C., Pockaj, B. A., & Nikkhah, M. (2023) · Biomaterials · doi:10.1016/j.biomaterials.2023.122428 · Cited by 42 · see citing works
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Gaggianesi, M., Franco, S. D., Pantina, V. D., Porcelli, G., D’Accardo, C., Verona, F., Veschi, V., Colarossi, L., Faldetta, N., Pistone, G., et al. (2021) · Frontiers in Oncology · doi:10.3389/fonc.2021.702642 · Cited by 40 · see citing works
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Self-citationSato, S., Hiruma, T., Koizumi, M., Yoshihara, M., Nakamura, Y., Tadokoro, H., Motomatsu, S., Yamanaka, T., Washimi, K., Okubo, Y., et al. (2023) · Cancer Science · doi:10.1111/cas.15786 · Cited by 28 · see citing works
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Immune mediated support of metastasis: Implication for bone invasion
Xin, Z., Qin, L., Tang, Y., Guo, S., Li, F., Yuan, F., Li, G., Yao, Y., Zheng, B., Zhang, B., et al. (2024) · 癌症：英文版 · doi:10.1002/cac2.12584 · Cited by 17 · see citing works
Zhang, C., Gu, X., Pan, M., Yuan, Q., & Cheng, H. (2021) · Clinical & Translational Oncology · doi:10.1007/s12094-020-02516-2 · Cited by 16 · see citing works
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Trivanović, D. I., Vujačić, M., Labella, R., Djordjević, I. O., Cazic, M., Chernak, B. J., & Jauković, A. (2024) · Current Osteoporosis Reports · doi:10.1007/s11914-024-00879-x · Cited by 6 · see citing works
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- Authors
- Wu, Q., Li, B., Sun, S., & Sun, S.
- Affiliations
- Université Paris-Sud (FR)
- Renmin Hospital of Wuhan University (CN)
- Corresponding author
- Sun, Si
- Sun, Shengrong
- Venue
- Frontiers in Cell and Developmental Biology
- Publisher
- Frontiers Media SA
- Published
- 2020-04-28
- Volume
- 8
- Pages
- 282-282
- ISSN
- 2296-634X (ISSN-L)
- PMC
- PMC7198697
- OpenAlex
- W3021809956
- Cited by
- 24
- References
- 60
- Citations by year
- 2026: 1 · 2025: 6 · 2024: 2 · 2023: 5 · 2022: 3 · 2021: 6 · 2020: 1
- FWCI
- 0.48
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Frontiers in Cell and Developmental Biology (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- National Natural Science Foundation of China (81471781, 81903166)
- Health and Family Planning Commission of Hubei Province (WJ2019Q044)
- Topics
- Health Sciences › Medicine › Physiology › Telomeres, Telomerase, and Senescence
- Health Sciences › Medicine › Physiology › Adipose Tissue and Metabolism
- Life Sciences › Immunology and Microbiology › Immunology › Immune cells in cancer
- Keywords
- cellular senescence, cancer-associated adipocytes, adipocytes, tumor microenvironment, senescence-associated secretory phenotype, inflammation, autophagy, metabolic reprogramming, cell cycle arrest, carcinogenesis, tumor recurrence, senescence therapy
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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