Cited by 43Antifungal resistance and susceptibilityNanoparticles: synthesis and applicationsNanoparticle-Based Drug Delivery

Recent developments on using nanomaterials to combat Candida albicans

Open access
Li, Bingxin, Pan, Luyao, Zhang, Haofeng, Xie, Lingping, Wang, Xi, Shou, Jiahui, Qi, Yu, Yan, Xiaojian·2021·Frontiers in Chemistry

Abstract

Vaginal candidiasis (VC) is a common disease of women and the main pathogen is Candida albicans (C. albicans). C. albicans infection incidence especially its drug resistance have become a global health threat due to the existence of C. albicans biofilms and the low bioavailability of traditional antifungal drugs. In recent years, nanomaterials have made great progresses in the field of antifungal applications. Some researchers have treated fungal infections with inorganic nanoparticles, represented by silver nanoparticles (AgNPs) with antifungal properties. Liposomes, polymeric nanoparticles, metal-organic frameworks (MOFs), and covalent organic frameworks (COFs) were also used to improve the bioavailability of antifungal drugs. Herein, we briefly introduced the recent developments on using above nanomaterials to combat C. albicans in antifungal applications.

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Crossref · 10.3389/fchem.2021.813973

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  • The inhibitory activity of a variety of nanomaterials against Candida biofilms has been evaluated during approximately the last 10-15 years, with the majority of research on metal nanoparticles, more specifically silver nanoparticles.

    “The inhibitory activity of a variety of nanomaterials against Candida biofilms has been evaluated during approximately the last 10–15 years, with the majority of research being on metal nanoparticles, and more specifically silver nanoparticles (AgNPs), synthesized by different methods.”

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Authors
Li, B., Pan, L., Zhang, H., Xie, L., Wang, X., Shou, J., Qi, Y., & Yan, X.
Affiliations
  • First Affiliated Hospital of Wenzhou Medical University (CN)
  • Wenzhou Institute, University of Chinese Academy of Sciences (CN)
Corresponding author
  • Qi, Yu
  • Yan, Xiaojian
Venue
Frontiers in Chemistry
Published
2021-12-23
Volume
9
Pages
813973-813973
ISSN
2296-2646 (ISSN-L)
OpenAlex
W4200183210
Cited by
43
References
48
Citations by year
2026: 1 · 2025: 18 · 2024: 10 · 2023: 10 · 2022: 4
FWCI
0.70
Type
journal article
Language
en
Open access
Locations
  • Frontiers in Chemistry (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
  • Wenzhou Medical University
  • National Natural Science Foundation of China (22005019)
  • Wenzhou Municipal Science and Technology Bureau (Y20190014)
  • Natural Science Foundation of Zhejiang Province (LY21H160058)
  • Science and Technology Program of Zhejiang Province
Topics
  • Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
  • Physical Sciences › Materials Science › Materials Chemistry › Nanoparticles: synthesis and applications
  • Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
Keywords
Candida albicans, vaginal candidiasis, silver nanoparticles, liposomes, polymeric nanoparticles, metal-organic frameworks, covalent organic frameworks, antifungal drug delivery, drug bioavailability, antifungal resistance, fungal biofilms

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