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Cited by 26Hemostasis and retained surgical itemsHydrogels: synthesis, properties, applicationsWound Healing and Treatments

Mussel-inspired nanoparticle composite hydrogels for hemostasis and wound healing

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Cui, Guihua, Guo, Xiaoyu, Su, Ping, Zhang, Tianshuo, Guan, Jiao, Wang, Chungang·2023·Frontiers in Chemistry
DOI 10.3389/fchem.2023.1154788PMC PMC10097955
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Abstract

Uncontrolled hemorrhage caused by trauma can easily lead to death. Efficient and safe hemostatic materials are an urgent and increasing need for hemostatic research. Following a trauma, wound healing is induced by various cellular mechanisms and proteins. Hemostatic biomaterials that can not only halt bleeding quickly but also provide an environment to promote wound healing have been the focus of research in recent years. Mussel-inspired nanoparticle composite hydrogels have been propelling the development of hemostatic materials owing to their unique advantages in adhesion, hemostasis, and bacteriostasis. This review summarizes the hemostatic and antimicrobial fundamentals of polydopamine (PDA)-based nanomaterials and emphasizes current developments in hemorrhage-related PDA nanomaterials. Moreover, it briefly discusses safety concerns and clinical application problems with PDA hemostatic nanomaterials.

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  • Nanomaterials, with their large surface area, generate nanoscale effects that significantly enhance blood absorption and cell adhesion.

    “Nanomaterials, with their large surface area, are capable of generating nanoscale effects that significantly enhance blood absorption and cell adhesion [119].”

    From Mussel-Inspired Injectable Adhesive Hydrogels for Biomedical Applications (2024) · cites this paper as [119]

  • The negative charges of polyphenols activate coagulation factor XII in vivo, initiating a cascade reaction that enhances coagulation.

    “Moreover, the negative charges of polyphenols are capable of activating coagulation factor XII in vivo, initiating a cascade reaction that enhances coagulation [119].”

    From Mussel-Inspired Injectable Adhesive Hydrogels for Biomedical Applications (2024) · cites this paper as [119]

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Cited by

Sorted by citations

Authors
Cui, G., Guo, X., Su, P., Zhang, T., Guan, J., & Wang, C.
Affiliations
  • Northeast Normal University (CN)
  • Jilin Vocational College of Industry and Technology (CN)
  • Jilin Medical University (CN)
Corresponding author
  • Cui, Guihua
  • Wang, Chungang
ORCID
Venue
Frontiers in Chemistry
Publisher
Frontiers Media SA
Published
2023-03-30
Volume
11
Pages
1154788-1154788
ISSN
2296-2646 (ISSN-L)
DOI
10.3389/fchem.2023.1154788
PMC
PMC10097955
OpenAlex
W4361277569
Cited by
26
References
1
Citations by year
2026: 8 · 2025: 6 · 2024: 9 · 2023: 3
FWCI
1.32
Type
journal article
Language
en
Open access
Licence
Locations
  • Frontiers in Chemistry (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
People's Government of Jilin Province
Topics
  • Health Sciences › Medicine › Hematology › Hemostasis and retained surgical items
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Hydrogels: synthesis, properties, applications
  • Health Sciences › Medicine › Rehabilitation › Wound Healing and Treatments
Keywords
mussel-inspired materials, polydopamine, hemostasis, wound healing, hemorrhage control, antimicrobial hydrogels, bacteriostatic activity, trauma (physical injury), biomaterial safety, clinical application

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