The DOI matches its Crossref record; 164 of the 164 references it cites were found in a registry or an index.
Salmonella Pathogenicity Island 1 (SPI-1) and Its Complex Regulatory Network
Open accessAbstract
Salmonella species can infect a diverse range of birds, reptiles and mammals, including humans. The type III protein secretion system (T3SS) encoded by Salmonella pathogenicity island 1 (SPI-1) delivers effector proteins required for intestinal invasion and the production of enteritis. The T3SS is regarded as the most important virulence factor of Salmonella. SPI-1 encodes transcription factors that regulate the expression of some virulence factors of Salmonella, while other transcription factors encoded outside SPI-1 participate in the expression of SPI-1-encoded genes. SPI-1 genes are responsible for the invasion of host cells, regulation of the host immune response, e.g., the host inflammatory response, immune cell recruitment, and apoptosis, and biofilm formation. The regulatory network of SPI-1 is very complex and crucial. Here, we review the function, effectors and regulation of SPI-1 genes and their contribution to the pathogenicity of Salmonella.
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Cites
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Self-citationH-NS Mediates the Silencing of Laterally Acquired Genes in Bacteria
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Depuydt, M. A. C., Prange, K. H. M., Slenders, L., Örd, T., Elbersen, D., Boltjes, A., de Jager, S. C. A., Asselbergs, F. W., de Borst, G. J., Aavik, E., et al. (2020) · Circulation Research · doi:10.1161/circresaha.120.316770 · Cited by 594
A bacterial effector counteracts host autophagy by promoting degradation of an autophagy component
Leong, J. X., Raffeiner, M., Spinti, D., Langin, G., Franz‐Wachtel, M., Guzman, A. R., Kim, J., Pandey, P., Minina, A. E., Macek, B., et al. (2022) · The EMBO Journal · doi:10.15252/embj.2021110352 · Cited by 89
Autoinducer-2 and bile salts induce c-di-GMP synthesis to repress the T3SS via a T3SS chaperone
Li, S., Sun, H., Li, J., Zhao, Y., Wang, R., Xu, L., Duan, C., Li, J., Wang, Z., Liu, Q., et al. (2022) · Nature Communications · doi:10.1038/s41467-022-34607-9 · Cited by 58
Self-citation(2024) · doi:10.1038/s41598-024-60991-x · Cited by 11
Metadata
- Authors
- Lou, L., Zhang, P., Piao, R., & Wang, Y.
- Venue
- Frontiers in Cellular and Infection Microbiology
- Publisher
- Frontiers Media SA
- Published
- 2019-07-31
- Volume
- 9
- Pages
- 270-270
- ISSN
- 2235-2988 (ISSN-L)
- OpenAlex
- W2961276096
- Cited by
- 373
- References
- 164
- FWCI
- 24.11
- Type
- journal article
- Language
- en
- Open access
- gold
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- Lou, L., Zhang, P., Piao, R., & Wang, Y. (2019). Salmonella Pathogenicity Island 1 (SPI-1) and Its Complex Regulatory Network. Frontiers in Cellular and Infection Microbiology. https://doi.org/10.3389/fcimb.2019.00270
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