The DOI matches its Crossref record; 19 of the 19 references it cites were found in a registry or an index.
Dissemination of Carbapenemases (KPC, NDM, OXA-48, IMP, and VIM) Among Carbapenem-Resistant Enterobacteriaceae Isolated From Adult and Children Patients in China
Open accessAbstract
This study aimed to investigate the dissemination and characteristics of blaKPC, blaNDM, blaOXA-48, blaIMP, and blaVIM among the carbapenem-resistant Enterobacteriaceae (CRE) strains isolated from adult and children patients. A total of 935 nonduplicate CRE strains were collected from 36 hospitals in 24 provinces or cities across China from 2016 to 2018. Antimicrobial susceptibility testing was performed by broth microdilution method and carbapenemase genes blaKPC, blaNDM, blaOXA-48-like, blaIMP, and blaVIM were screened by PCR and confirmed by DNA sequencing. Overall, carbapenemases were produced in 97.4% (911/935) of CRE strains, including KPC-2 (51.6%, 482/935), NDM (35.7%, 334/935), and OXA-48-like carbapenemases (7.3%, 68/935). Overall, the most prevalent carbapenemase gene was blaKPC-2 among Klebsiella pneumoniae (64.6%, 457/709) and the CRE strains isolated from adult patients (70.3%, 307/437), and blaNDM among Escherichia coli (96.0%, 143/149) and the CRE strains from children (49.0%, 247/498). The blaOXA-232-positive carbapenem-resistant K. pneumoniae (9.3%, 66/709) were all isolated from children. Sixteen strains were positive for blaIMP and 9 strains produced multiple carbapenemases. No strain was positive for blaVIM. Most of the CRE strains (> 90%) were resistant to cephalosporins and carbapenems, more than half (> 50%) were resistant to aminoglycosides and fluoroquinolones, but the majority (95.8% and 98.4%) were susceptible to polymyxin B and tigecycline. Ceftazidime-avibactam showed excellent in vitro activity against blaKPC-2 and blaOXA-48-like positive strains (100% susceptible). In China, KPC-2, NDM, and OXA-48-like carbapenemases were predominant among CRE clinical isolates. The most prevalent carbapenemase gene was blaKPC-2 among K. pneumoniae isolates from adult patients, and blaNDM among E. coli isolates from children.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Liu, Y.-Y., Wang, Y., Walsh, T. R., Yi, L.-X., Zhang, R., Spencer, J., Doi, Y., Tian, G., Dong, B., Huang, X., et al. (2016) · The Lancet Infectious Diseases · doi:10.1016/s1473-3099(15)00424-7 · Cited by 5,398
Self-citationYong, D., Toleman, M. A., Giske, C. G., Cho, H. S., Sundman, K., Lee, K., & Walsh, T. R. (2009) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.00774-09 · Cited by 2,519
Multiplex PCR for detection of acquired carbapenemase genes
Poirel, L., Walsh, T. R., Cuvillier, V., & Nordmann, P. (2011) · Diagnostic Microbiology and Infectious Disease · doi:10.1016/j.diagmicrobio.2010.12.002 · Cited by 1,991
Carbapenem resistance in Enterobacteriaceae: here is the storm!
Nordmann, P., Dortet, L., & Poirel, L. (2012) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2012.03.003 · Cited by 1,038
The global epidemiology of carbapenemase-producing Enterobacteriaceae
van Duin, D., & Doi, Y. (2017) · Virulence · doi:10.1080/21505594.2016.1222343 · Cited by 1,004
Grundmann, H., Glasner, C., Albiger, B., Aanensen, D. M., Tomlinson, C. T., Andrasević, A. T., Cantón, R., Carmeli, Y., Friedrich, A. W., Giske, C. G., et al. (2017) · The Lancet Infectious Diseases · doi:10.1016/s1473-3099(16)30257-2 · Cited by 662
Nationwide Surveillance of Clinical Carbapenem-resistant Enterobacteriaceae (CRE) Strains in China
Zhang, R., Liu, L., Zhou, H., Chan, E. W., Li, J., Fang, Y., Li, Y., Liao, K., & Chen, S. (2017) · EBioMedicine · doi:10.1016/j.ebiom.2017.04.032 · Cited by 542
Self-citationDeaths Attributable to Carbapenem-Resistant Enterobacteriaceae Infections
Falagas, M. E., Tansarli, G. S., Karageorgopoulos, D. E., & Vardakas, K. Z. (2014) · Emerging Infectious Diseases · doi:10.3201/eid2007.121004 · Cited by 514
Albiger, B., Glasner, C., Struelens, M. J., Grundmann, H., Monnet, D. L., & the European Survey of Carbapenemase-Producing Enterobacteriaceae (EuSCAPE) working group (2015) · Eurosurveillance · doi:10.2807/1560-7917.es.2015.20.45.30062 · Cited by 422
Wang, Q., Wang, X., Wang, J., Ouyang, P., Jin, C., Wang, R., Zhang, Y., Jin, L., Chen, H., Wang, Z., et al. (2018) · Clinical Infectious Diseases · doi:10.1093/cid/ciy660 · Cited by 349
Cited by
Ma, J., Song, X., Li, M., Yu, Z., Cheng, W., Yu, Z., Zhang, W., Zhang, Y., Shen, A., Sun, H., et al. (2023) · Microbiological Research · doi:10.1016/j.micres.2022.127249 · Cited by 308
Klebsiella pneumoniae carbapenemase variants: the new threat to global public health
Ding, L., Shen, S., Chen, J., Tian, Z., Shi, Q., Han, R., Guo, Y., & Hu, F. (2023) · Clinical Microbiology Reviews · doi:10.1128/cmr.00008-23 · Cited by 222
Self-citationHussein, M., Sun, Z., Hawkey, J., Allobawi, R., Judd, L. M., Carbone, V., Sharma, R., Thombare, V., Baker, M., Rao, G. G., et al. (2024) · mSystems · doi:10.1128/msystems.00972-23 · Cited by 14
IncX3 plasmid-mediated spread of blaNDM gene in Enterobacteriaceae among children in China
Qin, J., Wang, Z., Xu, H., Li, Y., Zhou, J., Yaxier, N., Wang, C., & Fu, P. (2024) · Journal of Global Antimicrobial Resistance · doi:10.1016/j.jgar.2024.03.021 · Cited by 14
Li, D., Li, P., Peng, M., Zhao, X., Jiang, X., Wang, D., Yuan, Y., Guo, Q., Wang, M., Xu, X., et al. (2022) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/dkab489 · Cited by 12
Self-citation
Metadata
- Authors
- Han, R., Shi, Q., Wu, S., Yin, D., Peng, M., Dong, D., Zheng, Y., Guo, Y., Zhang, R., Hu, F., & China Antimicrobial Surveillance Network (CHINET) Study Group
- Venue
- Frontiers in Cellular and Infection Microbiology
- Publisher
- Frontiers Media SA
- Published
- 2020-07-03
- Volume
- 10
- Pages
- 314-314
- ISSN
- 2235-2988 (ISSN-L)
- OpenAlex
- W3040267688
- Cited by
- 386
- References
- 19
- FWCI
- 13.90
- Type
- journal article
- Language
- en
- Open access
- gold
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Dissemination of Carbapenemases (KPC, NDM, OXA-48, IMP, and VIM) Among Carbapenem-Resistant Enterobacteriaceae Isolated From Adult and Children Patients in China. https://app.cochat.ai/papers/10.3389/fcimb.2020.00314
- The paper
- Han, R., Shi, Q., Wu, S., Yin, D., Peng, M., Dong, D., Zheng, Y., Guo, Y., Zhang, R., Hu, F., & China Antimicrobial Surveillance Network (CHINET) Study Group. (2020). Dissemination of Carbapenemases (KPC, NDM, OXA-48, IMP, and VIM) Among Carbapenem-Resistant Enterobacteriaceae Isolated From Adult and Children Patients in China. Frontiers in Cellular and Infection Microbiology. https://doi.org/10.3389/fcimb.2020.00314
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
