Probiotic Pediococcus pentosaceus ameliorates MPTP-induced oxidative stress via regulating the gut microbiota–gut–brain axis
Open accessAbstract
Recent evidence demonstrated that functional bacteria were involved in the regulation of Parkinson’s disease (PD). However, the mechanism of probiotics in improving PD was unclear. Here the antioxidant effect and the mechanism of probiotics Pediococcus pentosaceus (PP) on PD were studied by regulating the gut–brain axis. In this study, male C57BL/6J mice were injected with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) intraperitoneally to establish a PD model and were then treated with PP for 4 weeks. Subsequently, a series of neurobehavioral tests to evaluate the motor function of the mice was performed. Additionally, degeneration of dopaminergic neurons, accumulation of α-synuclein, the production of an oxidative stress response, and the expression of nuclear factor erythroid 2-related factor 2 (Nrf2) pathway-related proteins were evaluated. Moreover, the gut microbial composition and the level of metabolite γ-aminobutyric acid (GABA) were assessed. The results showed that PP treatment could improve MPTP-induced motor deficits, the degeneration of dopaminergic neurons, and the accumulation of α-synuclein. Moreover, PP treatment significantly increased the levels of SOD1, Gpx1, and Nrf2, while it decreased the levels of Keap1 in the brain of MPTP-induced mice. Notably, PP treatment improved the gut microbial dysbiosis and increased the level of GABA in MPTP-induced mice. These findings indicated that PP might represent a promising candidate, due to the metabolite of GABA, that could be used for the treatment of PD.
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Gut microbiota manipulation affects GABA levels, and probiotic Pediococcus pentosaceus and prebiotic polymannuronic acid reduce GABA levels in brains of MPTP-induced mice, ameliorating motor dysfunction and neuronal degeneration.
“The administration of probiotic Pediococcus pentosaceus and prebiotic polymannuronic acid has shown promise in alleviating gut dysbiosis and reducing GABA levels in the brains of MPTP-induced mice, resulting in the amelioration of motor dysfunction and neuronal degeneration.490,511”
From Microbiota–gut–brain axis and its therapeutic applications in neurodegenerative diseases (2024) · cites this paper as [511]
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Microbiota–gut–brain axis and its therapeutic applications in neurodegenerative diseases
Loh, J. S., Mak, W. Q., Tan, L. K. S., Ng, C. X., Chan, H. H., Yeow, S. H., Foo, J. B., Ong, Y. S., How, C. W., & Khaw, K. Y. (2024) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-024-01743-1 · Cited by 1,193 · see citing works
- Authors
- Pan, S., Wei, H., Yuan, S., Kong, Y., Yang, H., Zhang, Y., Cui, X., Chen, W., Liu, J., & Zhang, Y.
- Affiliations
- First Affiliated Hospital of Wenzhou Medical University (CN)
- Wenzhou Medical University (CN)
- Corresponding author
- Liu, Jiaming
- Zhang, Yang
- Venue
- Frontiers in Cellular and Infection Microbiology
- Publisher
- Frontiers Media SA
- Published
- 2022-11-09
- Volume
- 12
- Pages
- 1022879-1022879
- ISSN
- 2235-2988 (ISSN-L)
- PMC
- PMC9682001
- OpenAlex
- W4308720768
- Cited by
- 51
- References
- 64
- Citations by year
- 2026: 11 · 2025: 15 · 2024: 21 · 2023: 4
- FWCI
- 5.26
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Frontiers in Cellular and Infection Microbiology (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Natural Science Foundation of Zhejiang Province
- Topics
- Health Sciences › Medicine › Neurology › Parkinson's Disease Mechanisms and Treatments
- Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Keywords
- Pediococcus pentosaceus, probiotics, Parkinson's disease, MPTP-induced neurotoxicity, gut-brain axis, gut dysbiosis, oxidative stress, Nrf2 signaling, dopaminergic neuron loss, alpha-synuclein, GABA, motor impairment, antioxidant activity
- MeSH terms
- Gastrointestinal Microbiome, Pediococcus pentosaceus, Kelch-Like ECH-Associated Protein 1, Brain-Gut Axis, Animals, gamma-Aminobutyric Acid, Male, Mice, Inbred C57BL, Parkinson Disease, 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine, Oxidative Stress, Probiotics, NF-E2-Related Factor 2, Mice, alpha-Synuclein
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