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Tissue specific origin, development, and pathological perspectives of pericytes

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Yamazaki, Tomoko, Mukouyama, Yoh-suke·2018·Frontiers in Cardiovascular Medicine
DOI 10.3389/fcvm.2018.00078PMC PMC6030356
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Abstract

Pericytes are mural cells surrounding blood vessels, adjacent to endothelial cells. Pericytes play critical roles in maturation and maintenance of vascular branching morphogenesis. In the central nervous system (CNS), pericytes are necessary for the formation and regulation of the blood-brain barrier (BBB) and pericyte deficiency accompanies CNS diseases including multiple sclerosis, diabetic retinopathy, neonatal intraventricular hemorrhage, and neurodegenerative disorders. Despite the importance of pericytes, their developmental origins and phenotypic diversity remain incompletely understood. Pericytes express multiple markers and the origin of pericytes differs by tissue, which may cause difficulty for the identification and understanding of the ontogeny of pericytes. Also, pericytes have the potential to give rise to different tissues in vitro but this is not clear in vivo. These studies indicate that pericytes are heterogeneous in a tissue- and context- dependent manner. This short review focuses on recent studies about identification of pericytes, heterogeneous origin of pericytes during development and in adults, and the differentiation capacity of pericytes, and pericytes in pathological settings.

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Cited by

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Authors
Yamazaki, T., & Mukouyama, Y.-S.
Affiliations
  • Providence Portland Medical Center (US)
  • National Heart, Lung, and Blood Institute (US)
Corresponding author
Mukouyama, Yoh-suke
ORCID
Venue
Frontiers in Cardiovascular Medicine
Publisher
Frontiers Media SA
Published
2018-06-27
Volume
5
Pages
78-78
ISSN
2297-055X (ISSN-L)
DOI
10.3389/fcvm.2018.00078
PMC
PMC6030356
OpenAlex
W2808298032
Cited by
175
References
6
Citations by year
2026: 9 · 2025: 17 · 2024: 29 · 2023: 27 · 2022: 29 · 2021: 33 · 2020: 21 · 2019: 10
FWCI
1.51
Type
journal article
Language
en
Open access
Licence
Locations
  • Frontiers in Cardiovascular Medicine (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
  • National Institutes of Health (HL005702-11)
  • Japan Society for the Promotion of Science
Topics
  • Life Sciences › Neuroscience › Neurology › Barrier Structure and Function Studies
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Angiogenesis and VEGF in Cancer
  • Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
Keywords
pericytes, pericyte heterogeneity, pericyte differentiation, blood-brain barrier, multiple sclerosis, diabetic retinopathy, neonatal intraventricular hemorrhage, neurodegenerative diseases

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