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The Bone Marrow-Derived Stromal Cells: Commitment and Regulation of Adipogenesis
Open accessAbstract
Bone marrow (BM) microenvironment represents an important compartment of bone that regulates bone homeostasis and the balance between bone formation and bone resorption depending on the physiological needs of the organism. Abnormalities of BM microenvironmental dynamics can lead to metabolic bone diseases. BM stromal cells (also known as skeletal or mesenchymal stem cells) [bone marrow stromal stem cell (BMSC)] are multipotent stem cells located within BM stroma and give rise to osteoblasts and adipocytes. However, cellular and molecular mechanisms of BMSC lineage commitment to adipocytic lineage and regulation of BM adipocyte formation are not fully understood. In this review, we will discuss recent findings pertaining to identification and characterization of adipocyte progenitor cells in BM and the regulation of differentiation into mature adipocytes. We have also emphasized the clinical relevance of these findings.
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“Additionally BMPCs have also been reported to secrete factors and regulate metabolic function both in a paracrine and endocrine capacity. 238 , 239”
From The role of the androgen receptor in the pathogenesis of obesity and its utility as a target for obesity treatments (2022) · cites this paper as [239]
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Metadata
- Authors
- Tencerova, M., & Kassem, M.
- Affiliations
- University of Southern Denmark (DK)
- ORCID
- Kassem, Moustapha
- Venue
- Frontiers in Endocrinology
- Publisher
- Frontiers Media SA
- Published
- 2016-09-21
- Volume
- 7
- Pages
- 127-127
- ISSN
- 1664-2392 (ISSN-L)
- PMC
- PMC5030474
- OpenAlex
- W2521077735
- Cited by
- 149
- References
- 167
- Citations by year
- 2026: 8 · 2025: 15 · 2024: 20 · 2023: 17 · 2022: 28 · 2021: 15 · 2020: 14 · 2019: 13 · 2018: 14 · 2017: 3 · 2016: 1
- FWCI
- 1.21
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by
- Locations
- Frontiers in Endocrinology (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- University of Southern Denmark Research Portal (University of Southern Denmark) (submittedVersion, cc-by)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Novo Nordisk Fonden (NNF15OC0016284)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Mesenchymal stem cell research
- Health Sciences › Medicine › Physiology (medical) › Adipose Tissue and Metabolism
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bone Metabolism and Diseases
- Keywords
- mesenchymal stem cells, adipogenesis, adipose progenitor cells, lineage commitment, bone marrow microenvironment, bone homeostasis, metabolic bone disease, osteoblasts
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