Cited by 149Mesenchymal stem cell researchAdipose Tissue and MetabolismBone Metabolism and Diseases

The DOI matches its Crossref record; 167 of the 167 references it cites were found in a registry or an index.

The Bone Marrow-Derived Stromal Cells: Commitment and Regulation of Adipogenesis

Open access

Tencerova, Michaela, Kassem, Moustapha·2016·Frontiers in Endocrinology

DOI 10.3389/fendo.2016.00127PMC PMC5030474

Open this paper in CoChat — free account Open PDF

Abstract

Bone marrow (BM) microenvironment represents an important compartment of bone that regulates bone homeostasis and the balance between bone formation and bone resorption depending on the physiological needs of the organism. Abnormalities of BM microenvironmental dynamics can lead to metabolic bone diseases. BM stromal cells (also known as skeletal or mesenchymal stem cells) [bone marrow stromal stem cell (BMSC)] are multipotent stem cells located within BM stroma and give rise to osteoblasts and adipocytes. However, cellular and molecular mechanisms of BMSC lineage commitment to adipocytic lineage and regulation of BM adipocyte formation are not fully understood. In this review, we will discuss recent findings pertaining to identification and characterization of adipocyte progenitor cells in BM and the regulation of differentiation into mature adipocytes. We have also emphasized the clinical relevance of these findings.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.3389/fendo.2016.00127

Cites

167 of 167 references verified0 citation errors · 0 not checkable

Statistics

Figure 1 Regulation of bone marrow stem cells differentiation into adipocytes or osteoblasts. Bone marrow is a heterogeneous organ, which consists of different cell types participating in bone homeostasis. Among them, most abundant are hematopoietic stem cells (bone resorptive osteoclasts) and mesenchymal stem cells giving rise into bone forming osteoblasts or adipocytes. This process is regulated via several transcription factors and secreted molecules (e.g., PPARs, Wnt, adiponectin, leptin), which are produced locally or released from peripheral tissues, including BAT, WAT, skeletal muscle, liver, or CNS and affecting bone marrow niche through circulation. This multiorgan crosstalk between bone and peripheral tissues plays an important role in the regulation of bone and energy metabolism. Abbreviations: CNS, central nervous system; BAT, brown adipose tissue; WAT, white adipose tissue. Adapted from SERVIER Medical Art; http://www.servier.com/Powerpoint-image-bankCC BY · PubMed Central

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

1 retracted

Cytokines suppress adipogenesis and PPAR-γ function through the TAK1/TAB1/NIK cascade
Suzawa, M., Takada, I., Yanagisawa, J., Ohtake, F., Ogawa, S., Yamauchi, T., Kadowaki, T., Takeuchi, Y., Shibuyà, H., Gotoh, Y., et al. (2003) · Nature Cell Biology · doi:10.1038/ncb942 · Cited by 292
Retracted
Human Adipose Tissue Is a Source of Multipotent Stem Cells
Zuk, P. A., Zhu, M., Ashjian, P. H., Ugarte, D. A. D., Huang, J. I., Mizuno, H., Alfonso, Z. C., Fraser, J. K., Benhaim, P., & Hedrick, M. H. (2002) · Molecular Biology of the Cell · doi:10.1091/mbc.e02-02-0105 · Cited by 6,762
The Wnt Signaling Pathway in Development and Disease
Logan, C. Y., & Nusse, R. (2004) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.20.010403.113126 · Cited by 5,325
A PGC1-α-dependent myokine that drives brown-fat-like development of white fat and thermogenesis
Boström, P., Wu, J., Jedrychowski, M. P., Korde, A., Ye, L., Lo, J. C., Rasbach, K. A., Boström, E. A., Choi, J. H., Long, J. Z., et al. (2012) · Nature · doi:10.1038/nature10777 · Cited by 4,810
Sox9 Modulates Proliferation and Expression of Osteogenic Markers of Adipose-Derived Stem Cells (ASC)
Stöckl, S., Göttl, C., Grifka, J. K., & Grässel, S. (2013) · Cellular Physiology and Biochemistry · doi:10.1159/000350089 · Cited by 4,670
Mechanisms of fatty acid-induced inhibition of glucose uptake.
Boden, G., Chen, X., Ruiz, J., White, J. V., & Rossetti, L. (1994) · Journal of Clinical Investigation · doi:10.1172/jci117252 · Cited by 3,720
Mesenchymal and haematopoietic stem cells form a unique bone marrow niche
Méndez‐Ferrer, S., Michurina, T. V., Ferraro, F., Mazloom, A. R., MacArthur, B. D., Lira, S. A., Scadden, D. T., Ma’ayan, A., Enikolopov, G., & Frenette, P. S. (2010) · Nature · doi:10.1038/nature09262 · Cited by 3,381
Adipocyte differentiation from the inside out
Rosen, E. D., & MacDougald, O. A. (2006) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2066 · Cited by 2,607
Adipose-derived stem cells for regenerative medicine
Gimble, J. M., Katz, A. J., & Bunnell, B. A. (2007) · Circulation Research · doi:10.1161/01.res.0000265074.83288.09 · Cited by 2,332
Leptin Inhibits Bone Formation through a Hypothalamic Relay
Ducy, P., Amling, M., Takeda, S., Priemel, M., Schilling, A. F., Beil, F. T., Shen, J., Vinson, C., Rueger, J. M., & Karsenty, G. (2000) · Cell · doi:10.1016/s0092-8674(00)81558-5 · Cited by 2,077
C/EBPα induces adipogenesis through PPARγ: a unified pathwayPreprint
Rosen, E. D., Hsu, C.-H., Wang, X., Sakai, S., Freeman, M. W., Gonzalez, F. J., & Spiegelman, B. M. (2002) · Genes & Development · doi:10.1101/gad.948702 · Cited by 1,497
The epidemiology of corticosteroid-induced osteoporosis: a meta-analysis
Staa, T. P. V., Staa, T. P. V., Staa, T. P. V., Leufkens, H. G. M., & Cooper, C. (2002) · Osteoporosis International · doi:10.1007/s001980200108 · Cited by 1,294
Romosozumab in Postmenopausal Women with Low Bone Mineral Density
McClung, M. R., Grauer, A., Boonen, S., Bolognese, M. A., Brown, J. P., Diez-Perez, A., Langdahl, B. L., Reginster, J.-Y., Zanchetta, J. R., Wasserman, S. M., et al. (2014) · New England Journal of Medicine · doi:10.1056/nejmoa1305224 · Cited by 1,258
Comparison of Multi-Lineage Cells from Human Adipose Tissue and Bone Marrow
De Ugarte, D. A., Morizono, K., Elbarbary, A., Alfonso, Z., Zuk, P. A., Zhu, M., Dragoo, J. L., Ashjian, P., Thomas, B., Benhaim, P., et al. (2003) · Cells Tissues Organs · doi:10.1159/000071150 · Cited by 1,173
New role of bone morphogenetic protein 7 in brown adipogenesis and energy expenditure
Tseng, Y.-H., Kokkotou, E., Schulz, T. J., Huang, T. L., Winnay, J. N., Taniguchi, C. M., Tran, T. T., Suzuki, R., Espinoza, D. O., Yamamoto, Y., et al. (2008) · Nature · doi:10.1038/nature07221 · Cited by 1,099
TRANSCRIPTIONAL REGULATION OF GENE EXPRESSION DURING ADIPOCYTE DIFFERENTIATION
MacDougald, O. A., & Lane, M. D. (1995) · Annual Review of Biochemistry · doi:10.1146/annurev.bi.64.070195.002021 · Cited by 1,064
Sclerostin Is an Osteocyte-expressed Negative Regulator of Bone Formation, But Not a Classical BMP Antagonist
van Bezooijen, R. L., Roelen, B. A. J., Visser, A., van der Wee-Pals, L. J. A., de Wilt, E., Karperien, M., Hamersma, H. A., Papapoulos, S. E., ten Dijke, P., & Löwik, C. W. G. M. (2004) · The Journal of Experimental Medicine · doi:10.1084/jem.20031454 · Cited by 893
PPAR γ insufficiency enhances osteogenesis through osteoblast formation from bone marrow progenitors
Akune, T., Ohba, S., Kamekura, S., Yamaguchi, M., Chung, U., Kubota, N., Terauchi, Y., Harada, Y., Azuma, Y., Nakamura, K., et al. (2004) · Journal of Clinical Investigation · doi:10.1172/jci19900 · Cited by 869
Adipocyte tissue volume in bone marrow is increased with aging and in patients with osteoporosis
Justesen, J., Stenderup, K., Ebbesen, E., Mosekilde, L., Steiniche, T., & Kassem, M. (2004) · Biogerontology (Dordrecht) · doi:10.1023/a:1011513223894 · Cited by 847
Self-citation
Aging activates adipogenic and suppresses osteogenic programs in mesenchymal marrow stroma/stem cells: the role of PPAR‐γ2 transcription factor and TGF‐β/BMP signaling pathways
Moerman, E., Teng, K., Lipschitz, D., & Lecka-Czernik, B. (2004) · Aging Cell · doi:10.1111/j.1474-9728.2004.00127.x · Cited by 840
Defective adipocyte differentiation in mice lacking the C/EBPβ and/or C/EBPδ gene
Tanaka, T., Yoshida, N., Kishimoto, T., & Akira, S. (1997) · The EMBO Journal · doi:10.1093/emboj/16.24.7432 · Cited by 804
Identification and Specification of the Mouse Skeletal Stem Cell
Chan, C. K. F., Seo, E. Y., Chen, J. Y., Lo, D. D., McArdle, A., Sinha, R., Tevlin, R., Seita, J., Vincent-Tompkins, J., Wearda, T. L., et al. (2015) · Cell · doi:10.1016/j.cell.2014.12.002 · Cited by 763
Interleukin‐6 deficient mice are protected from bone loss caused by estrogen depletion.
Poli, V., Balena, R. F., Fattori, E., Markatos, A., Yamamoto, M., Tanaka, H., Ciliberto, G., Rodan, G. A., & Costantini, F. (1994) · The EMBO Journal · doi:10.1002/j.1460-2075.1994.tb06368.x · Cited by 745
Regulation of Wnt Signaling during Adipogenesis
Bennett, C. N., Ross, S. E., Longo, K. A., Bajnok, L., Hemati, N., Johnson, K. W., Harrison, S. D., & MacDougald, O. A. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m204527200 · Cited by 743
Irisin Stimulates Browning of White Adipocytes Through Mitogen-Activated Protein Kinase p38 MAP Kinase and ERK MAP Kinase Signaling
Zhang, Y., Li, R., Meng, Y., Li, S., Donelan, W., Zhao, Y., Qi, L., Zhang, M., Wang, X., Cui, T., et al. (2014) · Diabetes · doi:10.2337/db13-1106 · Cited by 733 · cited 2×
“Moreover, IL6 maintains BMSC in undifferentiated state through ERK1/2-mediated mechanism during bone fracture healing (123).”
Background
PPAR γ insufficiency enhances osteogenesis through osteoblast formation from bone marrow progenitors
Akune, T., Ohba, S., Kamekura, S., et al. (2004) · Journal of Clinical Investigation · doi:10.1172/jci200419900 · Cited by 730
Leptin Acts on Human Marrow Stromal Cells to Enhance Differentiation to Osteoblasts and to Inhibit Differentiation to Adipocytes1
Thomas, T., Gori, F., Khosla, S., Jensen, M. D., Burguera, B. G., & Riggs, B. L. (1999) · Endocrinology · doi:10.1210/endo.140.4.6637 · Cited by 725
The tenascin family of ECM glycoproteins: Structure, function, and regulation during embryonic development and tissue remodeling
Jones, F. S., & Jones, P. L. (2000) · Developmental Dynamics · doi:10.1002/(sici)1097-0177(200006)218:2 · Cited by 699
The bone morphogenetic protein family and osteogenesis
Wozney, J. M. (1992) · Molecular Reproduction and Development · doi:10.1002/mrd.1080320212 · Cited by 684
Gremlin 1 Identifies a Skeletal Stem Cell with Bone, Cartilage, and Reticular Stromal Potential
Worthley, D. L., Churchill, M., Compton, J. T., Tailor, Y. H., Rao, M., Si, Y., Levin, D. E., Schwartz, M. G., Uygur, A., Hayakawa, Y., et al. (2015) · Cell · doi:10.1016/j.cell.2014.11.042 · Cited by 645
Matrix IGF-1 maintains bone mass by activation of mTOR in mesenchymal stem cells
Xian, L., Wu, X., Pang, L., Lou, M., Rosen, C. J., Qiu, T., Crane, J., Frassica, F., Zhang, L., Rodriguez, J. P., et al. (2012) · Nature Medicine · doi:10.1038/nm.2793 · Cited by 631
Osteo-chondroprogenitor cells are derived from Sox9 expressing precursors
Akiyama, H., Kim, J., Nakashima, K., Balmes, G. C., Iwai, N., Deng, J. M., Zhang, Z., Martin, J. F., Behringer, R. R., Nakamura, T., et al. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0504750102 · Cited by 607
Fibroblast Growth Factor-21 Regulates PPARγ Activity and the Antidiabetic Actions of Thiazolidinediones
Dutchak, P. A., Katafuchi, T., Bookout, A. L., Choi, J. H., Yu, R. T., Mangelsdorf, D. J., & Kliewer, S. A. (2012) · Cell · doi:10.1016/j.cell.2011.11.062 · Cited by 537
The myokine irisin increases cortical bone mass
Colaianni, G., Cuscito, C., Mongelli, T., Pignataro, P., Buccoliero, C., Liu, P., Lü, P., Sartini, L., Comite, M. D., Mori, G., et al. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1516622112 · Cited by 521
Insulin-like growth factor-I is an essential regulator of the differentiation of 3T3-L1 adipocytes.
Smith, P. J., Wise, L. S., Berkowitz, R., Wan, C. F., & Rubin, C. S. (1988) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)76555-7 · Cited by 511
Playing with bone and fat
Gimble, J. M., Zvonic, S., Floyd, Z. E., Kassem, M. S., & NUTTALL, M. E. (2006) · Journal of Cellular Biochemistry · doi:10.1002/jcb.20777 · Cited by 508
Self-citation
Bone marrow adipose tissue is an endocrine organ that contributes to increased circulating adiponectin during caloric restriction
Cawthorn, W., Scheller, E., Learman, B. S., Parlee, S., Simon, B., Mori, H., Ning, X.-M., Bree, A. J., Schell, B. A., Broome, D. T., et al. (2014) · Cell Metabolism · doi:10.1016/j.cmet.2014.06.003 · Cited by 506
Leptin Receptor Promotes Adipogenesis and Reduces Osteogenesis by Regulating Mesenchymal Stromal Cells in Adult Bone Marrow
Yue, R., Zhou, B. O., Shimada, I. S., Zhao, Z., & Morrison, S. J. (2016) · Cell stem cell · doi:10.1016/j.stem.2016.02.015 · Cited by 495
Bone Morphogenetic Protein-2 Causes Commitment and Differentiation in C3Hl0T1/2 and 3T3 Cells
Wang, E. A., Israel, D. I., Kelly, S. J., & Luxenberg, D. P. (1993) · Growth Factors · doi:10.3109/08977199308991582 · Cited by 490
Deletion of PPARγ in adipose tissues of mice protects against high fat diet-induced obesity and insulin resistance
Jones, J. R., Barrick, C. J., Kim, K., Lindner, J., Blondeau, B., Fujimoto, Y., Shiota, M., Kesterson, R. A., Kahn, B. B., & Magnuson, M. A. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0306743102 · Cited by 487
Lrp5 functions in bone to regulate bone mass
Cui, Y., Niziolek, P., MacDonald, B. T., Diegel, C. R., Alenina, N. V., Robinson, D. R., Zhong, Z. A., Matthes, S., Jacobsen, C. M., Conlon, R. A., et al. (2011) · Nature Medicine · doi:10.1038/nm.2388 · Cited by 460
Bone Is a Target for the Antidiabetic Compound Rosiglitazone
Rzońca, S., Suva, L. J., Gaddy, D., Montague, D. C., & Lecka‐Czernik, B. (2003) · Endocrinology · doi:10.1210/en.2003-0746 · Cited by 455
Cartilage‐like gene expression in differentiated human stem cell spheroids: A comparison of bone marrow–derived and adipose tissue–derived stromal cells
Winter, A., Breit, S., Parsch, D., Benz, K., Steck, E., Hauner, H., Weber, R. M., Ewerbeck, V., & Richter, W. (2003) · Arthritis & Rheumatism · doi:10.1002/art.10767 · Cited by 454
MicroRNAs as Regulators of Differentiation and Cell Fate Decisions
Ivey, K. N., & Srivastava, D. (2010) · Cell Stem Cell · doi:10.1016/j.stem.2010.06.012 · Cited by 449
The function of adipocytes in the bone marrow stroma: an update
Gimble, J. M., Robinson, C. E., Wu, X., & Kelly, K. A. (1996) · Bone · doi:10.1016/s8756-3282(96)00258-x · Cited by 446
Identification of Common Pathways Mediating Differentiation of Bone Marrow- and Adipose Tissue-Derived Human Mesenchymal Stem Cells into Three Mesenchymal Lineages
Liu, T. M., Martina, M., Hutmacher, D. W., Hui, J. H. P., Lee, E. H., & Lim, B. (2006) · Stem Cells · doi:10.1634/stemcells.2006-0394 · Cited by 430
Fibroblast growth factor 21 promotes bone loss by potentiating the effects of peroxisome proliferator-activated receptor γ
Wei, W., Dutchak, P. A., Wang, X., Ding, X., Wang, X., Bookout, A. L., Goetz, R., Mohammadi, M., Gerard, R. D., Dechow, P. C., et al. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1200797109 · Cited by 426
Adiponectin increases bone mass by suppressing osteoclast and activating osteoblast
Oshima, K., Nampei, A., Matsuda, M., Iwaki, M., Fukuhara, A., Hashimoto, J., Yoshikawa, H., & Shimomura, I. (2005) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2005.03.210 · Cited by 403
Transdifferentiation potential of human mesenchymal stem cells derived from bone marrow
Song, L., & Tuan, R. S. (2004) · The FASEB Journal · doi:10.1096/fj.03-1100fje · Cited by 395
Increased Bone Marrow Fat in Anorexia Nervosa
Bredella, M. A., Fazeli, P. K., Miller, K. K., Misra, M., Torriani, M., Thomas, B. J., Ghomi, R. H., Rosen, C. J., & Klibanski, A. (2009) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2008-2532 · Cited by 387
Differential Roles for Bone Morphogenetic Protein (BMP) Receptor Type IB and IA in Differentiation and Specification of Mesenchymal Precursor Cells to Osteoblast and Adipocyte Lineages
Chen, D., Ji, X., Harris, M. A., Feng, J. Q., Karsenty, G., Celeste, A. J., Rosen, V., Mundy, G. R., & Harris, S. E. (1998) · The Journal of Cell Biology · doi:10.1083/jcb.142.1.295 · Cited by 382
Adipocytic cells cultured from marrow have osteogenic potential
Bennett, J. H., Joyner, C. J., Triffitt, J. T., & Owen, M. E. (1991) · Journal of Cell Science · doi:10.1242/jcs.99.1.131 · Cited by 361
Macrophages block insulin action in adipocytes by altering expression of signaling and glucose transport proteins
Lumeng, C. N., Deyoung, S. M., & Saltiel, A. R. (2007) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00284.2006 · Cited by 359
Marrow Fat and the Bone Microenvironment: Developmental, Functional, and Pathological Implications
Rosen, C. J., Ackert‐Bicknell, C. L., Rodriguez, J. P., & Pino, A. M. (2009) · Critical Reviews in Eukaryotic Gene Expression · doi:10.1615/critreveukargeneexpr.v19.i2.20 · Cited by 353
C/EBPα is required for differentiation of white, but not brown, adipose tissue
Linhart, H., Ishimura‐Oka, K., DeMayo, F. J., Kibe, T., Repka, D., Poindexter, B. J., Bick, R. J., & Darlington, G. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.211416898 · Cited by 349
Vertebral Bone Marrow Fat Is Positively Associated With Visceral Fat and Inversely Associated With IGF‐1 in Obese Women
Bredella, M. A., Torriani, M., Ghomi, R. H., Thomas, B. J., Brick, D. J., Gerweck, A. V., Rosen, C. J., Klibanski, A., & Miller, K. K. (2010) · Obesity · doi:10.1038/oby.2010.106 · Cited by 346
Transforming Growth Factor-β Inhibits Adipocyte Differentiation by Smad3 Interacting with CCAAT/Enhancer-binding Protein (C/EBP) and Repressing C/EBP Transactivation Function
Choy, L., & Derynck, R. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m212259200 · Cited by 343
Direct and indirect effects of leptin on adipocyte metabolism
Harris, R. B. S. (2013) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2013.05.009 · Cited by 333
Treatment of Obese Diabetic Mice With a Heme Oxygenase Inducer Reduces Visceral and Subcutaneous Adiposity, Increases Adiponectin Levels, and Improves Insulin Sensitivity and Glucose Tolerance
Li, M., Kim, D. H., Tsenovoy, P. L., Peterson, S. J., Rezzani, R., Rodella, L. F., Aronow, W. S., Ikehara, S., & Abraham, N. G. (2008) · Diabetes · doi:10.2337/db07-1764 · Cited by 313
Peroxisome proliferator-activated receptor-gamma activation by thiazolidinediones induces adipogenesis in bone marrow stromal cells.
Gimble, J. M., Robinson, C. E., Wu, X., Kelly, K. A., Rodriguez, B., Kliewer, S. A., Lehmann, J. M., & Morris, D. C. (1996) · Molecular Pharmacology · doi:10.1016/s0026-895x(25)09536-7 · Cited by 295
Interleukin‐6 maintains bone marrow‐derived mesenchymal stem cell stemness by an ERK1/2‐dependent mechanism
Pricola, K. L., Zahir, N., Haleem‐Smith, H., Song, Y., & Tuan, R. S. (2009) · Journal of Cellular Biochemistry · doi:10.1002/jcb.22289 · Cited by 290
Insulin signalling mechanisms for triacylglycerol storage
Czech, M., Tencerová, M., Pedersen, D. J., & Aouadi, M. (2013) · Diabetologia · doi:10.1007/s00125-013-2869-1 · Cited by 289
Native human adipose stromal cells: localization, morphology and phenotype
Maumus, M., Peyrafitte, J.-A., D’Angelo, R., Fournier‐Wirth, C., Bouloumié, A., Casteilla, L., Sengenès, C., & Bourin, P. (2011) · International Journal of Obesity · doi:10.1038/ijo.2010.269 · Cited by 283
Transcriptional networks and chromatin remodeling controlling adipogenesis
Siersbæk, R., Nielsen, R., & Mandrup, S. (2011) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2011.10.001 · Cited by 278
Cytokines Promote Wnt Signaling and Inflammation and Impair the Normal Differentiation and Lipid Accumulation in 3T3-L1 Preadipocytes
Gustafson, B., & Smith, U. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m512077200 · Cited by 273
Bone Loss and Increased Bone Adiposity in Spontaneous and Pharmacologically Induced Diabetic Mice
Boțolin, S., & McCabe, L. R. (2006) · Endocrinology · doi:10.1210/en.2006-1006 · Cited by 270
Bone marrow fat has brown adipose tissue characteristics, which are attenuated with aging and diabetes
Krings, A., Rahman, S., Huang, S., Lu, Y., Czernik, P. J., & Lecka‐Czernik, B. (2011) · Bone · doi:10.1016/j.bone.2011.06.016 · Cited by 266
Peripheral leptin regulates bone formation
Turner, R. T., Kalra, S. P., Wong, C. P., Philbrick, K. A., Lindenmaier, L. B., Boghossian, S., & Iwaniec, U. T. (2013) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.1734 · Cited by 264 · cited 2×
“The PPARγ-regulated adipokines: leptin and adiponectin are primarily secreted by adipocytes and can regulate adipogenesis (79, 80).”
Background
A bispecific antibody targeting sclerostin and DKK-1 promotes bone mass accrual and fracture repair
Florio, M., Gunasekaran, K., Stolina, M., Li, X., Liu, L., Tipton, B., Salimi-Moosavi, H., Asuncion, F., Li, C., Sun, B., et al. (2016) · Nature Communications · doi:10.1038/ncomms11505 · Cited by 262
Control of adipocyte differentiation
Smas, C. M., & Sul, H. S. (1995) · Biochemical Journal · doi:10.1042/bj3090697 · Cited by 255
Bone-specific insulin resistance disrupts whole-body glucose homeostasis via decreased osteocalcin activation
Wei, J., Ferron, M., Clarke, C. J., Hannun, Y. A., Jiang, H., Blaner, W. S., & Karsenty, G. (2014) · Journal of Clinical Investigation · doi:10.1172/jci72323 · Cited by 255
Adiponectin Regulates Bone Mass via Opposite Central and Peripheral Mechanisms through FoxO1
Kajimura, D., Lee, H. W., Riley, K. J., Arteaga‐Solis, E., Ferron, M., Zhou, B., Clarke, C. J., Hannun, Y. A., DePinho, R. A., Guo, X.-D. E., et al. (2013) · Cell Metabolism · doi:10.1016/j.cmet.2013.04.009 · Cited by 244
Osteocalcin Promotes β-Cell Proliferation During Development and Adulthood Through Gprc6a
Wei, J., Hanna, T., Suda, N., Karsenty, G., & Ducy, P. F. (2013) · Diabetes · doi:10.2337/db13-0887 · Cited by 237
Human Osteogenic Protein-1 Induces Chondroblastic, Osteoblastic, and/or Adipocytic Differentiation of Clonal Murine Target Cells
Asahina, I., Sampath, T. K., & Hauschka, P. V. (1996) · Experimental Cell Research · doi:10.1006/excr.1996.0005 · Cited by 236
Irisin Enhances Osteoblast DifferentiationIn Vitro
Colaianni, G., Cuscito, C., Mongelli, T., Oranger, A., Mori, G., Brunetti, G., Colucci, S. C., Cinti, S., & Grano, M. (2014) · International Journal of Endocrinology · doi:10.1155/2014/902186 · Cited by 231
Stable stem cell commitment to the adipocyte lineage by inhibition of DNA methylation: Role of the BMP-4 gene
Bowers, R. R., Kim, J. W., Otto, T. C., & Lane, M. D. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0605789103 · Cited by 228
Regulation of Human Skeletal Stem Cells Differentiation by Dlk1/Pref-1
Abdallah, B. M., Jensen, C. H., Gutierrez, G. E., Leslie, R. G. Q., Jensen, T. G., & Kassem, M. S. (2004) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.040118 · Cited by 228
Self-citation
BMP4 and BMP Antagonists Regulate Human White and Beige Adipogenesis
Gustafson, B., Hammarstedt, A., Hedjazifar, S., Hoffmann, J. M., Svensson, P., Grimsby, J. S., Rondinone, C. M., & Smith, U. (2015) · Diabetes · doi:10.2337/db14-1127 · Cited by 219
Activation of CCAAT/Enhancer-binding Protein (C/EBP) α Expression by C/EBPβ during Adipogenesis Requires a Peroxisome Proliferator-activated Receptor-γ-associated Repression of HDAC1 at the C/ebpα Gene Promoter
Zuo, Y., Qiang, L., & Farmer, S. R. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m510682200 · Cited by 205
Bone Morphogenetic Protein-2-induced Alkaline Phosphatase Expression Is Stimulated by Dlx5 and Repressed by Msx2
Kim, Y. J., Lee, M., Wozney, J. M., Cho, J., & Ryoo, H. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m404145200 · Cited by 202
FGF21 as a Hepatokine, Adipokine, and Myokine in Metabolism and Diseases
Itoh, N. (2014) · Frontiers in Endocrinology · doi:10.3389/fendo.2014.00107 · Cited by 198
Leptin Acts on Human Marrow Stromal Cells to Enhance Differentiation to Osteoblasts and to Inhibit Differentiation to Adipocytes
Thomas, T. (1999) · Endocrinology · doi:10.1210/en.140.4.1630 · Cited by 192
Regulating the Balance between Peroxisome Proliferator-activated Receptor γ and β-Catenin Signaling during Adipogenesis
Liu, J., & Farmer, S. R. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m407050200 · Cited by 187
Bone Loss in Diabetes: Use of Antidiabetic Thiazolidinediones and Secondary Osteoporosis
Lecka‐Czernik, B. (2010) · Current Osteoporosis Reports · doi:10.1007/s11914-010-0027-y · Cited by 187
IGF-1 regulation of key signaling pathways in bone
Guntur, A. R., & Rosen, C. J. (2013) · BoneKEy Reports · doi:10.1038/bonekey.2013.171 · Cited by 185
Bone Geometry, Volumetric Density, Microarchitecture, and Estimated Bone Strength Assessed by HR-pQCT in Adult Patients With Type 1 Diabetes Mellitus
Shanbhogue, V. V., Hansen, S., Frost, M., Jørgensen, N. R., Hermann, A. P., Henriksen, J. E., & Brixen, K. (2015) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.2573 · Cited by 183
Patients With High Bone Mass Phenotype Exhibit Enhanced Osteoblast Differentiation and Inhibition of Adipogenesis of Human Mesenchymal Stem Cells
Qiu, W., Andersen, T. E., Bollerslev, J., Mandrup, S., Abdallah, B. M., & Kassem, M. S. (2007) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.070721 · Cited by 182
Self-citation
Comparative investigation of the differentiation capability of bone-marrow- and adipose-derived mesenchymal stem cells by qualitative and quantitative analysis
Vishnubalaji, R., Al-Nbaheen, M. S., Kadalmani, B., Aldahmash, A. M., & Ramesh, T. (2012) · Cell and Tissue Research · doi:10.1007/s00441-011-1306-3 · Cited by 180
Krüppel-like Factor-6 Promotes Preadipocyte Differentiation through Histone Deacetylase 3-dependent Repression of DLK1
Li, D., Yea, S., Li, S., Zhu, C. X., Narla, G., Banck, M. S., Laborda, J., Tan, S., Friedman, J. M., Friedman, S. L., et al. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m500463200 · Cited by 177
Compromised cortical bone compartment in type 2 diabetes mellitus patients with microvascular disease
Shanbhogue, V. V., Hansen, S., Frost, M., Jørgensen, N. R., Hermann, A. P., Henriksen, J. E., & Brixen, K. (2015) · European Journal of Endocrinology · doi:10.1530/eje-15-0860 · Cited by 174
Effects of diabetes drugs on the skeleton
Meier, C., Schwartz, A. V., Egger, A., & Lecka‐Czernik, B. (2015) · Bone · doi:10.1016/j.bone.2015.04.026 · Cited by 174
Dkk1-induced inhibition of Wnt signaling in osteoblast differentiation is an underlying mechanism of bone loss in multiple myeloma
Qiang, Y., Barlogie, B., Rudikoff, S., & Shaughnessy, J. D. (2007) · Bone · doi:10.1016/j.bone.2007.12.006 · Cited by 169
Marrow fat metabolism is linked to the systemic energy metabolism
Lecka‐Czernik, B. (2011) · Bone · doi:10.1016/j.bone.2011.06.032 · Cited by 168
A comparison between osteogenic differentiation of human unrestricted somatic stem cells and mesenchymal stem cells from bone marrow and adipose tissue
Shafiee, A., Seyedjafari, E., Soleimani, M., Ahmadbeigi, N., Dinarvand, P., & Ghaemi, N. (2011) · Biotechnology Letters · doi:10.1007/s10529-011-0541-8 · Cited by 163
The role of the epidermal growth factor-like protein dlk in cell differentiation.
Laborda, J. (2000) · PubMed · doi:10.14670/hh-15.119 · Cited by 158
A Role for Bone Morphogenetic Protein-4 in Adipocyte Development
Bowers, R. R., & Lane, M. D. (2007) · Cell Cycle · doi:10.4161/cc.6.4.3804 · Cited by 153
The WNT Inhibitor Dickkopf 1 and Bone Morphogenetic Protein 4 Rescue Adipogenesis in Hypertrophic Obesity in Humans
Gustafson, B., & Smith, U. (2012) · Diabetes · doi:10.2337/db11-1419 · Cited by 147
Age-related Marrow Adipogenesis Is Linked to Increased Expression of RANKL
Takeshita, S., Fumoto, T., Naoe, Y., & Ikeda, K. (2014) · Journal of Biological Chemistry · doi:10.1074/jbc.m114.547919 · Cited by 146
Concise Review: MicroRNA Function in Multipotent Mesenchymal Stromal Cells
Clark, E. A., Kalomoiris, S., Nolta, J. A., & Fierro, F. A. (2013) · Stem Cells · doi:10.1002/stem.1623 · Cited by 146
Overexpression of Adiponectin Targeted to Adipose Tissue in Transgenic Mice: Impaired Adipocyte Differentiation
Bauche, I. B., Ait-El-Mkadem, S., Pottier, A.-M., Sènou, M., Many, M., Rezsöhazy, R., Pénicaud, L., Maeda, N., Funahashi, T., & Brichard, S. M. (2007) · Endocrinology · doi:10.1210/en.2006-0838 · Cited by 144
microRNA-320/RUNX2 axis regulates adipocytic differentiation of human mesenchymal (skeletal) stem cells
Hamam, D., Ali, D., Vishnubalaji, R., Hamam, R., Al-Nbaheen, M. S., Chen, L., Kassem, M. S., Aldahmash, A. M., & Alajez, N. M. (2014) · Cell Death and Disease · doi:10.1038/cddis.2014.462 · Cited by 144
Self-citation
Transforming Growth Factor β2 Inhibits Adipocyte Differentiation Induced by Skeletal Unloading in Rat Bone Marrow Stroma
Ahdjoudj, S., Lasmoles, F., Holy, X., Zérath, E., & Marie, P. J. (2002) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.2002.17.4.668 · Cited by 144
Paracrine regulation of fat cell formation in bone marrow cultures via adiponectin and prostaglandins
Yokota, T., Meka, C. S. R., Medina, K. L., Igarashi, H., Comp, P. C., Takahashi, M., Nishida, M., Oritani, K., Miyagawa, J.-I., Funahashi, T., et al. (2002) · Journal of Clinical Investigation · doi:10.1172/jci14506 · Cited by 141
Ectodomain Shedding of Preadipocyte Factor 1 (Pref-1) by Tumor Necrosis Factor Alpha Converting Enzyme (TACE) and Inhibition of Adipocyte Differentiation
Wang, Y., & Sul, H. S. (2006) · Molecular and Cellular Biology · doi:10.1128/mcb.02437-05 · Cited by 140
Adiponectin Stimulates Osteoblast Differentiation Through Induction of COX2 in Mesenchymal Progenitor Cells
Lee, H. W., Kim, S., Kim, A., Lee, E. J., Choi, J., & Kim, J. B. (2009) · Stem Cells · doi:10.1002/stem.144 · Cited by 139
Dissociation of the neuronal regulation of bone mass and energy metabolism by leptin in vivo
Shi, Y., Yadav, V. K., Suda, N., Liu, X. S., Guo, X.-D. E., Myers, M. G., & Karsenty, G. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0808701106 · Cited by 139
Role of Foxa-2 in adipocyte metabolism and differentiation
Wolfrum, C., Shih, D. Q., Kuwajima, S., Norris, A. W., Kahn, C. R., & Stoffel, M. (2003) · Journal of Clinical Investigation · doi:10.1172/jci18698 · Cited by 139
Demonstration of the presence of independent pre-osteoblastic and pre-adipocytic cell populations in bone marrow-derived mesenchymal stem cells
Post, S., Abdallah, B. M., Bentzon, J. F., & Kassem, M. S. (2008) · Bone · doi:10.1016/j.bone.2008.03.011 · Cited by 139
Self-citation
Diet‐induced obesity alters bone remodeling leading to decreased femoral trabecular bone mass in mice
Cao, J., Sun, L., & Gao, H. (2010) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2009.05252.x · Cited by 136
MECHANISMS IN ENDOCRINOLOGY: Micro-RNAs: targets for enhancing osteoblast differentiation and bone formation
Taipaleenmäki, H., Hokland, L. B., Chen, L., Kauppinen, S., & Kassem, M. S. (2011) · European Journal of Endocrinology · doi:10.1530/eje-11-0646 · Cited by 132
Self-citation
A comparison of adipose and bone marrow-derived mesenchymal stromal cell secreted factors in the treatment of systemic inflammation
Elman, J. S., Li, M., Wang, F., Gimble, J. M., & Parekkadan, B. (2014) · Journal of Inflammation · doi:10.1186/1476-9255-11-1 · Cited by 126
Paracrine regulation of fat cell formation in bone marrow cultures via adiponectin and prostaglandins
Yokota, T., Meka, C. S. R., Medina, K. L., Igarashi, H., Comp, P. C., Takahashi, M., Nishida, M., Oritani, K., Miyagawa, J., Funahashi, T., et al. (2002) · Journal of Clinical Investigation · doi:10.1172/jci0214506 · Cited by 125
New factors controlling the balance between osteoblastogenesis and adipogenesis
Abdallah, B. M., & Kassem, M. S. (2011) · Bone · doi:10.1016/j.bone.2011.06.030 · Cited by 124
Self-citation
The omega-6 arachidonic fatty acid, but not the omega-3 fatty acids, inhibits osteoblastogenesis and induces adipogenesis of human mesenchymal stem cells: potential implication in osteoporosis
Casado‐Díaz, A., Santiago‐Mora, R., Dorado, G., & Quesada‐Gómez, J. M. (2012) · Osteoporosis International · doi:10.1007/s00198-012-2138-z · Cited by 122
A conversation with Marc Feldmann
Neill, U. S. (2014) · Journal of Clinical Investigation · doi:10.1172/jci71860 · Cited by 120
Troglitazone Treatment Increases Bone Marrow Adipose Tissue Volume but Does not Affect Trabecular Bone Volume in Mice
Tornvig, L., Mosekilde, L., Justesen, J., Falk, E., & Kassem, M. S. (2001) · Calcified Tissue International · doi:10.1007/s002230020018 · Cited by 118
Self-citation
The KLF2 Transcription Factor Does Not Affect the Formation of Preadipocytes but Inhibits Their Differentiation into Adipocytes
Wu, J., Srinivasan, S. V., Neumann, J. C., & Lingrel, J. B. (2005) · Biochemistry · doi:10.1021/bi050166i · Cited by 117
Wnt signalling mediates the cross-talk between bone marrow derived pre-adipocytic and pre-osteoblastic cell populations
Taipaleenmäki, H., Abdallah, B. M., Aldahmash, A. M., Säämänen, A., & Kassem, M. S. (2011) · Experimental Cell Research · doi:10.1016/j.yexcr.2010.12.015 · Cited by 116
Self-citation
Characterization of adipocyte differentiation from human mesenchymal stem cells in bone marrow
Qian, S.-W., Li, X., Zhang, Y.-Y., Huang, H.-Y., Liu, Y., Sun, X., & Tang, Q.-Q. (2010) · BMC Developmental Biology · doi:10.1186/1471-213x-10-47 · Cited by 114
CCAAT/Enhancer-binding Protein β Promotes Osteoblast Differentiation by Enhancing Runx2 Activity with ATF4
Tominaga, H., Maeda, S., Hayashi, M., Takeda, S., Akira, S., Komiya, S., Nakamura, T., Akiyama, H., & Imamura, T. (2008) · Molecular Biology of the Cell · doi:10.1091/mbc.e08-03-0329 · Cited by 114
Disruption of the insulin-like growth factor-1 gene in osteocytes impairs developmental bone growth in mice
Sheng, M. H. ‐., Zhou, X.-D., Bonewald, L. F., Baylink, D. J., & Lau, K. ‐. W. (2012) · Bone · doi:10.1016/j.bone.2012.09.027 · Cited by 111
Conditional Deletion of Insulin-Like Growth Factor-I in Collagen Type 1α2-Expressing Cells Results in Postnatal Lethality and a Dramatic Reduction in Bone Accretion
Govoni, K. E., Wergedal, J. E., Florin, L., Angel, P. E., Baylink, D. J., & Mohan, S. (2007) · Endocrinology · doi:10.1210/en.2007-0608 · Cited by 109
Circulating levels of fibroblast growth factor-21 increase with age independently of body composition indices among healthy individuals
Hanks, L. J., Gutiérrez, O. M., Bamman, M. M., Ashraf, A., McCormick, K. L., & Casazza, K. (2015) · Journal of Clinical & Translational Endocrinology · doi:10.1016/j.jcte.2015.02.001 · Cited by 104
LRP5 Regulates Human Body Fat Distribution by Modulating Adipose Progenitor Biology in a Dose- and Depot-Specific Fashion
Loh, N. Y., Neville, M. J., Marinou, K., Hardcastle, S., Fielding, B. A., Duncan, E. L., McCarthy, M. I., Tobias, J. H., Gregson, C. L., Karpe, F., et al. (2015) · Cell Metabolism · doi:10.1016/j.cmet.2015.01.009 · Cited by 103
Secreted frizzled-related protein 1 regulates adipose tissue expansion and is dysregulated in severe obesity
Lagathu, C., Christodoulides, C., Tan, C. Y., Virtue, S., Laudes, M., Campbell, M., Ishikawa, K., Ortega, F. J., Tinahones, F. J., Fernández‐Real, J. M., et al. (2010) · International Journal of Obesity · doi:10.1038/ijo.2010.107 · Cited by 102
Macrophage-conditioned medium inhibits the differentiation of 3T3-L1 and human abdominal preadipocytes
Constant, V. A., Gagnon, A., Landry, A., & Sorisky, A. (2006) · Diabetologia · doi:10.1007/s00125-006-0253-0 · Cited by 101
CD146/MCAM defines functionality of human bone marrow stromal stem cell populations
Harkness, L., Zaher, W. A., Ditzel, N., Isa, A., & Kassem, M. S. (2016) · Stem Cell Research & Therapy · doi:10.1186/s13287-015-0266-z · Cited by 100
Self-citation
A study of bone marrow and subcutaneous fatty acid composition in subjects of varying bone mineral density
Griffith, J. F., Yeung, D. K. W., Ahuja, A. T., Choy, C. W. Y., Mei, W. Y., Lam, S. S. L., Lam, T. P., Chen, Z., & Leung, P. (2009) · Bone · doi:10.1016/j.bone.2009.02.022 · Cited by 98
Cross-talk between Insulin and Wnt Signaling in Preadipocytes
Palsgaard, J., Emanuelli, B., Winnay, J. N., Sumara, G., Karsenty, G., & Kahn, C. R. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.337048 · Cited by 98
Increased heme-oxygenase 1 expression in mesenchymal stem cell-derived adipocytes decreases differentiation and lipid accumulation via upregulation of the canonical Wnt signaling cascade
Vanella, L., Sodhi, K., Kim, D. H., Puri, N., Maheshwari, M., Hinds, T. D., Bellner, L., Goldstein, D. B., Peterson, S. J., Shapiro, J. I., et al. (2013) · Stem Cell Research & Therapy · doi:10.1186/scrt176 · Cited by 96
Molecular and functional characterization of human bone marrow adipocytes
Poloni, A., Maurizi, G., Serrani, F., Mancini, S., Zingaretti, M. C., Frontini, A., Cinti, S., Olivieri, A., & Leoni, P. (2013) · Experimental Hematology · doi:10.1016/j.exphem.2013.02.005 · Cited by 88
A CCAAT/Enhancer Binding Protein β Isoform, Liver-Enriched Inhibitory Protein, Regulates Commitment of Osteoblasts and Adipocytes
Hata, K., Nishimura, R., Ueda, M., Ikeda, F., Matsubara, T., Ichida, F., Hisada, K., Nokubi, T., Yamaguchi, A., & Yoneda, T. (2005) · Molecular and Cellular Biology · doi:10.1128/mcb.25.5.1971-1979.2005 · Cited by 87
Adiponectin Regulates Bone Marrow Mesenchymal Stem Cell Niche Through a Unique Signal Transduction Pathway: An Approach for Treating Bone Disease in Diabetes
Yu, L., Tu, Q., Han, Q., Zhang, L., Sui, L., Zheng, L., Meng, S., Tang, Y., Xuan, D., Zhang, J., et al. (2014) · Stem Cells · doi:10.1002/stem.1844 · Cited by 81
Treatment needs and current options for postmenopausal osteoporosis
Gennari, L., Rotatori, S., Bianciardi, S., Nuti, R., & Merlotti, D. (2016) · Expert Opinion on Pharmacotherapy · doi:10.1080/14656566.2016.1176147 · Cited by 81
Effect of Fatty Acids on Human Bone Marrow Mesenchymal Stem Cell Energy Metabolism and Survival
Fillmore, N., Huqi, A., Jaswal, J. S., Mori, J., Paulin, R., Haromy, A., Onay-Beşi̇kçi̇, A., Ionescu, L., Thébaud, B., Michelakis, E. D., et al. (2015) · PLoS ONE · doi:10.1371/journal.pone.0120257 · Cited by 75
Romosozumab in Postmenopausal Women with Osteopenia
Evenepoel, P., D'Haese, P., & Brandenburg, V. (2014) · New England Journal of Medicine · doi:10.1056/nejmc1402396 · Cited by 71
Dlk1/FA1 Is a Novel Endocrine Regulator of Bone and Fat Mass and Its Serum Level Is Modulated by Growth Hormone
Abdallah, B. M., Ding, M. L., Jensen, C. H., Ditzel, N., Flyvbjerg, A., Jensen, T. G., Dagnæs‐Hansen, F., Gasser, J. A., & Kassem, M. S. (2007) · Endocrinology · doi:10.1210/en.2007-0171 · Cited by 69
Self-citation
microRNAs as Regulators of Adipogenic Differentiation of Mesenchymal Stem Cells
Hamam, D., Ali, D., Kassem, M. S., Aldahmash, A. M., & Alajez, N. M. (2014) · Stem Cells and Development · doi:10.1089/scd.2014.0331 · Cited by 68
Self-citation
Human Stromal (Mesenchymal) Stem Cells: Basic Biology and Current Clinical Use for Tissue Regeneration
Aldahmash, A. M., Zaher, W. A., Al-Nbaheen, M. S., & Kassem, M. S. (2012) · Annals of Saudi Medicine · doi:10.5144/0256-4947.2012.68 · Cited by 67
Self-citation
Circulating Sclerostin Associated With Vertebral Bone Marrow Fat in Older Men But Not Women
Ma, Y.-H. V., Schwartz, A. V., Sigurdsson, S. O., Hue, T. F., Lang, T., Harris, T. B., Rosen, C. J., Vittinghoff, E., Eiríksdóttir, G., Hauksdóttir, A. M., et al. (2014) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2013-4493 · Cited by 66
Adiponectin receptor 1 regulates bone formation and osteoblast differentiation by GSK-3β/β-Catenin signaling in mice
Lin, Y., Chen, C., Chuang, T. Y., Lin, Y., Liu, H. Y., Mersmann, H. J., Wu, S., & Ding, S. (2014) · Bone · doi:10.1016/j.bone.2014.03.051 · Cited by 66
DLK1 Regulates Whole-Body Glucose Metabolism: A Negative Feedback Regulation of the Osteocalcin-Insulin Loop
Abdallah, B. M., Ditzel, N., Laborda, J., Karsenty, G., & Kassem, M. S. (2015) · Diabetes · doi:10.2337/db14-1642 · Cited by 63
Self-citation
Skeletal Stem Cells in Space and Time
Kassem, M. S., & Bianco, P. (2015) · Cell · doi:10.1016/j.cell.2014.12.034 · Cited by 62
Self-citation
The effects of thiazolidinediones on human bone marrow stromal cell differentiation in vitro and in thiazolidinedione-treated patients with type 2 diabetes
Beck, G. R., Khazai, N. B., Bouloux, G. F., Camalier, C. E., Lin, Y., Garneys, L. M., Siqueira, J., Peng, L., Pasquel, F. J., Umpierrez, D., et al. (2012) · Translational research · doi:10.1016/j.trsl.2012.08.006 · Cited by 61
Molecular Mechanisms of Adipocyte Differentiation and Inhibitory Action of Pref-1
Smas, C. M., & Sul, H. S. (1997) · Critical Reviews in Eukaryotic Gene Expression · doi:10.1615/critreveukargeneexpr.v7.i4.10 · Cited by 61
Sera of overweight people promote in vitro adipocyte differentiation of bone marrow stromal cells
Bernardo, G. D., Messina, G., Capasso, S., Gaudio, S. D., Cipollaro, M., Peluso, G., Casale, F., Monda, M., & Galderisi, U. (2014) · Stem Cell Research & Therapy · doi:10.1186/scrt393 · Cited by 57
Patients with high-bone-mass phenotype owing to Lrp5-T253I mutation have low plasma levels of serotonin
Frost, M., Andersen, T. E., Yadav, V. K., Brixen, K., Karsenty, G., & Kassem, M. S. (2010) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.44 · Cited by 56
Self-citation
A New Selective Estrogen Receptor Modulator with Potent Uterine Antagonist Activity, Agonist Activity in Bone, and Minimal Ovarian Stimulation
Geiser, A. G., Hummel, C. W., Draper, M. W., Henck, J. W., COHEN, I. R., Rudmann, D. G., Donnelly, K. B., Adrian, M. D., Shepherd, T. A., Wallace, O. B., et al. (2005) · Endocrinology · doi:10.1210/en.2005-0024 · Cited by 53
Microarray analyses of transdifferentiated mesenchymal stem cells
Schilling, T., Küffner, R., Klein‐Hitpaß, L., Zimmer, R., Jakob, F. J., & Schütze, N. (2007) · Journal of Cellular Biochemistry · doi:10.1002/jcb.21415 · Cited by 53
Lipid Profiling of In Vitro Cell Models of Adipogenic Differentiation: Relationships With Mouse Adipose Tissues
Liaw, L., Prudovsky, I. A., Koza, R. A., Anunciado-Koza, R. V. P., Siviski, M. E., Lindner, V., Friesel, R. E., Rosen, C. J., Baker, P. R. S., Simons, B. L., et al. (2016) · Journal of Cellular Biochemistry · doi:10.1002/jcb.25522 · Cited by 51
Pioglitazone increases bone marrow fat in type 2 diabetes: results from a randomized controlled trial
Grey, A. B., Beckley, V., Doyle, A., Fenwick, S., Horne, A. M., Gamble, G. D., & Bolland, M. J. (2012) · European Journal of Endocrinology · doi:10.1530/eje-11-1075 · Cited by 49
Energy Excess, Glucose Utilization, and Skeletal Remodeling: New Insights
Lecka‐Czernik, B., & Rosen, C. J. (2015) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.2574 · Cited by 48
Morphologic and transcriptomic comparison of adipose- and bone-marrow-derived porcine stem cells cultured in alginate hydrogels
Kim, D., Monaco, E. L., Maki, A. J., de Lima, A. S., Kong, H. J., Hurley, W. L., & Wheeler, M. B. (2010) · Cell and Tissue Research · doi:10.1007/s00441-010-1015-3 · Cited by 45
Effects of leptin on the differentiation and metabolism of human adipocytes
Aprath-Husmann, I., Röhrig, K., Gottschling-Zeller, H., Skurk, T., Scriba, D., Birgel, M., & Hauner, H. (2001) · International Journal of Obesity · doi:10.1038/sj.ijo.0801737 · Cited by 44
C/EBP regulates body composition, energy balance-related hormones and tumor growth
Staiger, J., Lueben, M. J., Berrigan, D. A., Malı́k, R., Perkins, S. N., Hursting, S. D., & Johnson, P. F. (2008) · Carcinogenesis · doi:10.1093/carcin/bgn273 · Cited by 42
Interleukin‐6 induces the lineage commitment of bone marrow‐derived mesenchymal multipotent cells through down‐regulation of Sox2 by osteogenic transcription factors
Yoon, D. S., Kim, Y. H., Lee, S., Lee, K., Park, K. H., Jang, Y., & Lee, J. W. (2014) · The FASEB Journal · doi:10.1096/fj.13-248567 · Cited by 41
Misexpression of CCAAT/enhancer binding protein beta causes osteopenia
Zanotti, S., Stadmeyer, L., Smerdel‐Ramoya, A., Durant, D., & CANALIS, E. M. (2009) · Journal of Endocrinology · doi:10.1677/joe-08-0514 · Cited by 38
CD34 defines an osteoprogenitor cell population in mouse bone marrow stromal cells
Abdallah, B. M., AL-Shammary, A. A., Skagen, P., Dawud, R. A., Adjaye, J., Aldahmash, A. M., & Kassem, M. S. (2015) · Stem Cell Research · doi:10.1016/j.scr.2015.09.005 · Cited by 37
Self-citation
Fetal antigen 1 (FA1), a circulating member of the epidermal growth factor (EGF) superfamily: ELISA development, physiology and metabolism in relation to renal function
Jensen, C. H., Krogh, T. N., Støving, R. K., Holmskov, U., & Teisner, B. (1997) · Clinica Chimica Acta · doi:10.1016/s0009-8981(97)00152-6 · Cited by 35
Identification of a Subpopulation of Marrow MSC-Derived Medullary Adipocytes That Express Osteoclast-Regulating Molecules: Marrow Adipocytes Express Osteoclast Mediators
Holt, V., Caplan, A. I., & Haynesworth, S. E. (2014) · PLoS ONE · doi:10.1371/journal.pone.0108920 · Cited by 33
Cell size and plamitate-1-14c turnover of rabbit marrow fat
Trubowitz, S., & Bathija, A. (1977) · Blood · doi:10.1182/blood.v49.4.599.599 · Cited by 29
Fatty Involution of Marrow and the Role of Adipose Tissue in Hemopoiesis
Tavassoli, M. (1989) · Humana Press eBooks · doi:10.1007/978-1-4612-4494-3_4 · Cited by 22
Diabetes and bone fracture: risk factors for old and young
Vestergaard, P. (2014) · Diabetologia · doi:10.1007/s00125-014-3338-1 · Cited by 20
Adipogenesis of the mesenchymal stromal cells and bone oedema in rheumatoid arthritis.
Okada, A., Yamasaki, S., Koga, T., Kawashiri, S., Tamai, M., Origuchi, T., Nakamura, H., Eguchi, K., & Kawakami, A. (2012) · PubMed · Cited by 18
Bone Loss and Inhaled Glucocorticoids
van Staa, T. P., Leufkens, B., & Cooper, C. C. (2002) · New England Journal of Medicine · doi:10.1056/nejm200202143460716 · Cited by 17
Impaired mitochondrial function and reduced viability in bone marrow cells of obese mice
de Oliveira, G. P., Cortez, E. A. C., Araujo, G. J., Sabino, K. C. C., Neves, F. A., Bernardo, A. F., de Carvalho, S. N., Moura, A. S., de Carvalho, L., & Thole, A. A. (2014) · Cell and Tissue Research · doi:10.1007/s00441-014-1857-1 · Cited by 16
Adipocytes Differentiated In Vitro from Rat Mesenchymal Stem Cells Lack Essential Free Fatty Acids Compared to Adult Adipocytes
Bojin, F. M., Lukinich-Gruia, A. T., Cristea, M. I., Ordodi, V. L., Păunescu, V., & Mic, F. A. (2011) · Stem Cells and Development · doi:10.1089/scd.2011.0491 · Cited by 14

Research works printed but not linked: 2

Grant, 2000, Col2-GFP reporter marks chondrocyte lineage and chondrogenesis during mouse skeletal development, Dev Dyn, 218, 394, 10.1002/(SICI)1097-0177(200006)218:2394::AID-DVDY123.0.CO;2-I · DOI
Yu-Hua, 2007, Bone morphogenetic proteins and adipocyte differentiation, Cell Sci Rev, 3, 1

Sorted by citations

The effect of cytokines on osteoblasts and osteoclasts in bone remodeling in osteoporosis: a review
Xu, J., Yu, L., Liu, F., Wan, L., & Deng, Z. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1222129 · Cited by 292
High‐Fat Diet–Induced Obesity Promotes Expansion of Bone Marrow Adipose Tissue and Impairs Skeletal Stem Cell Functions in Mice
Tencerova, M., Figeac, F., Ditzel, N., Taipaleenmäki, H., Nielsen, T., & Kassem, M. (2018) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.3408 · Cited by 218
Self-citation
Obesity-Associated Hypermetabolism and Accelerated Senescence of Bone Marrow Stromal Stem Cells Suggest a Potential Mechanism for Bone Fragility.
Tencerova, M., Frost, M., Figeac, F., Nielsen, T., Ali, D., Lauterlein, J., Andersen, T. L., Haakonsson, A., Rauch, A., Madsen, J. S., et al. (2019) · Cell Reports · doi:10.1016/j.celrep.2019.04.066 · Cited by 125
Self-citation
Bone Marrow Mesenchymal Stromal Cells: Identification, Classification, and Differentiation
Gao, Q., Wang, L., Wang, S., Huang, B., Jing, Y., & Su, J. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.787118 · Cited by 140
Defining osteoblast and adipocyte lineages in the bone marrow
Pierce, J. L., Begun, D. L., Westendorf, J. J., & McGee‐Lawrence, M. E. (2018) · Bone · doi:10.1016/j.bone.2018.05.019 · Cited by 134

See all 149

Authors: Tencerova, M., & Kassem, M.
Affiliations: University of Southern Denmark (DK)
ORCID: Kassem, Moustapha
Venue: Frontiers in Endocrinology
Publisher: Frontiers Media SA
Published: 2016-09-21
Volume: 7
Pages: 127-127
ISSN: 1664-2392 (ISSN-L)
DOI: 10.3389/fendo.2016.00127
PMC: PMC5030474
OpenAlex: W2521077735
Cited by: 149
References: 167
Citations by year: 2026: 8 · 2025: 15 · 2024: 20 · 2023: 17 · 2022: 28 · 2021: 15 · 2020: 14 · 2019: 13 · 2018: 14 · 2017: 3 · 2016: 1
FWCI: 1.21
Type: journal article
Language: en
Open access: gold
doi.org
Licence: cc-by
Locations: Frontiers in Endocrinology (publishedVersion, cc-by)
Europe PMC (PubMed Central) (publishedVersion, cc-by)
PubMed Central (publishedVersion, cc-by)
PubMed (publishedVersion)
University of Southern Denmark Research Portal (University of Southern Denmark) (submittedVersion, cc-by)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders: Novo Nordisk Fonden (NNF15OC0016284)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Mesenchymal stem cell research
Health Sciences › Medicine › Physiology (medical) › Adipose Tissue and Metabolism
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bone Metabolism and Diseases
Keywords: mesenchymal stem cells, adipogenesis, adipose progenitor cells, lineage commitment, bone marrow microenvironment, bone homeostasis, metabolic bone disease, osteoblasts

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

The Bone Marrow-Derived Stromal Cells: Commitment and Regulation of Adipogenesis

Abstract

Overview

Integrity signals

Figures

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks