The DOI matches its Crossref record; 78 of the 78 references it cites were found in a registry or an index.
Androgen Action in the Ovary
Open accessAbstract
Androgen production by the ovary is an essential requirement for normal cyclical secretion of estradiol but its physiological role extends to important actions on both preantral and antral follicle development, including promotion of granulosa cell proliferation. It is likely only in mature antral follicles that androgens encourage apoptosis and consequent follicle atresia, and this may be an important mechanism to ensure mono-follicular ovulation in primates, including humans. Recent studies have provided new insight into the mechanism of androgen signaling in the ovary which involves both genomic and non-genomic effects that are complementary in effecting a cellular response. In polycystic ovary syndrome, a condition characterized by intra-ovarian androgen excess, aberrant development of both preantral and antral follicles is a salient feature. We present evidence that local action of androgens plays a part in such abnormalities. Finally, we review the role of androgens in follicle atresia and conclude that the effects are part of the normal physiology of follicle maturation.
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“Aberrant development during these earliest stages of follicular growth likely contributes to the ovarian aspects of PCOS [19].”
From Polycystic Ovary Syndrome: Pathophysiology, Presentation, and Treatment With Emphasis on Adolescent Girls (2019) · cites this paper as [19]
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Insulin Resistance and the Polycystic Ovary Syndrome: Mechanism and Implications for Pathogenesis
Dunaif, A. E. (1997) · Endocrine Reviews · doi:10.1210/edrv.18.6.0318 · Cited by 2,776
Franks, S. (1995) · New England Journal of Medicine · doi:10.1056/nejm199509283331307 · Cited by 2,463
Self-citationEhrmann, D. A. (2005) · New England Journal of Medicine · doi:10.1056/nejmra041536 · Cited by 1,920
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Androgens stimulate early stages of follicular growth in the primate ovary
Vendola, K. A., Zhou, J., Adesanya, O. O., Weil, S. J., & Bondy, C. A. (1998) · Journal of Clinical Investigation · doi:10.1172/jci2081 · Cited by 712
Transcriptional activation and nuclear targeting signals of the human androgen receptor.
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Follicle dynamics and anovulation in polycystic ovary syndrome
Franks, S., Stark, J., & Hardy, K. (2008) · Human Reproduction Update · doi:10.1093/humupd/dmn015 · Cited by 581
Self-citationDunaif, A. E., GRAF, M., Mandeli, J., Laumas, V., & Dobrjansky, A. (1987) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-65-3-499 · Cited by 577
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Joshi, S., Sharma, V., Bhandari, S., Joshi, P., & Mondal, S. (2024) · Research Square · doi:10.21203/rs.3.rs-4384391/v1
Zahn, L. A., Budine, T. D., Shirey-Rice, J. K., Joly, M. M., Wallis, R. S., Bernard, G. R., Holroyd, K. J., Pulley, J. M., & Jerome, R. N. (2025) · Frontiers in Pharmacology · doi:10.3389/fphar.2025.1562587
Urata, Y., Salehi, R., Wyse, B. A., Jahangiri, S., Librach, C. L., Tzeng, C.-R., Osuga, Y., & Tsang, B. K. (2023) · Figshare · doi:10.6084/m9.figshare.24070248
Dadaş, Y., Öner, G., Karaman, E., Ayan, D., Doganay, H. N., Bayram, E., Şanlıer, N. T., & Kulular, B. (2026) · Cancers · doi:10.3390/cancers18071142
Circadian misalignment in PCOS: role of sleep and light
Samaddar, S., Ghosh, S., Kumar, A., Yadav, P., Yadav, M., & Dahiya, R. (2026) · Biological Rhythm Research · doi:10.1080/09291016.2026.2651558 · Cited by 2
Devillers, M. M. (2021) · theses.fr (ABES) · doi:10.70675/66ce6604zc759z4b30z8361z93a93c0f2deb
Developmental and functional landscape of theca cells in ovarian biology
Haddadi, M., Adib, S., Amorim, C. A., Dalman, A., & Valojerdi, M. R. (2026) · Biological Research · doi:10.1186/s40659-026-00680-3 · Cited by 1
Tehrani, F. R., Mousavi, M. A., Naz, M. S. G., Farahmand, M., Jorjani, M., & Mahboobifard, F. (2026) · Endocrinology Diabetes & Metabolism · doi:10.1002/edm2.70287
Pan, M., Huang, J., Yan, J., Mo, J., Dong, K., Ding, Y., Zhang, G., Huang, W., Yang, Z., Wang, N., et al. (2026) · Bioorganic Chemistry · doi:10.1016/j.bioorg.2026.110474
Metadata
- Authors
- Franks, S., & Hardy, K.
- Affiliations
- Hammersmith Hospital (GB)
- Corresponding author
- Franks, Stephen
- ORCID
- Franks, Stephen
- Venue
- Frontiers in Endocrinology
- Publisher
- Frontiers Media SA
- Published
- 2018-08-10
- Volume
- 9
- Pages
- 452-452
- ISSN
- 1664-2392 (ISSN-L)
- PMC
- PMC6097027
- OpenAlex
- W2886792139
- Cited by
- 109
- References
- 78
- Citations by year
- 2026: 10 · 2025: 8 · 2024: 17 · 2023: 19 · 2022: 21 · 2021: 18 · 2020: 9 · 2019: 6 · 2018: 1
- FWCI
- 1.28
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Frontiers in Endocrinology (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Spiral (Imperial College London) (submittedVersion, other-oa)
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Ovarian function and disorders
- Health Sciences › Medicine › Reproductive Medicine › Reproductive Biology and Fertility
- Life Sciences › Agricultural and Biological Sciences › Animal Science and Zoology › Reproductive Physiology in Livestock
- Keywords
- androgens, ovary, androgen signaling, folliculogenesis, granulosa cell proliferation, follicular atresia, apoptosis, polycystic ovary syndrome, estradiol secretion, follicle maturation
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