Physiological and Pathological Androgen Actions in the Ovary

Astapova, Olga; Minor, Briaunna M N; Hammes, Stephen R

doi:10.1210/en.2019-00101

Cited by 133Ovarian function and disordersReproductive Biology and FertilitySexual Differentiation and Disorders

Physiological and Pathological Androgen Actions in the Ovary

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Astapova, Olga, Minor, Briaunna M N, Hammes, Stephen R·2019·Endocrinology

DOI 10.1210/en.2019-00101PMC PMC6937455

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Abstract

Androgens, although traditionally thought to be male sex steroids, play important roles in female reproduction, both in healthy and pathological states. This mini-review focuses on recent advances in our knowledge of the role of androgens in the ovary. Androgen receptor (AR) is expressed in oocytes, granulosa cells, and theca cells, and is temporally regulated during follicular development. Mouse knockout studies have shown that AR expression in granulosa cells is critical for normal follicular development and subsequent ovulation. In addition, androgens are involved in regulating dynamic changes in ovarian steroidogenesis that are critical for normal cycling. Androgen effects on follicle development have been incorporated into clinical practice in women with diminished ovarian reserve, albeit with limited success in available literature. At the other extreme, androgen excess leads to disordered follicle development and anovulatory infertility known as polycystic ovary syndrome (PCOS), with studies suggesting that theca cell AR may mediate many of these negative effects. Finally, both prenatal and postnatal animal models of androgen excess have been developed and are being used to study the pathophysiology of PCOS both within the ovary and with regard to overall metabolic health. Taken together, current scientific consensus is that a careful balance of androgen activity in the ovary is necessary for reproductive health in women.

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These testosterone-induced alterations to female development are largely consistent across animal models.
“Importantly, these testosterone‐induced alterations to female development are largely consistent across animal models (Astapova et al., 2019; Roland & Moenter, 2014).”
From Endometriosis and polycystic ovary syndrome are diametric disorders (2021) · cites this paper as Astapova et al., 2019
High ovarian testosterone promotes early follicular growth, mediating recruitment of follicles from primordial to small pre-antral stage, and contributing to elevated antral follicle count, follicular arrest, anovulation, and cyst formation characteristic of PCOS.
“High ovarian testosterone promotes early follicular growth, mediating the recruitment of follicles from the primordial stage to the small, pre‐antral stage, and contributing to elevated antral follicle count, follicular arrest, anovulation, and the cyst formation characteristic of PCOS (Astapova et al., 2019).”
From Endometriosis and polycystic ovary syndrome are diametric disorders (2021) · cites this paper as Astapova et al., 2019

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Progesterone receptor mediates ovulatory transcription through RUNX transcription factor interactions and chromatin remodelling
Dinh, D. T., Breen, J., Nicol, B., Foot, N. J., Bersten, D. C., Emery, A., Smith, K. M., Wong, Y. Y., Barry, S. C., Yao, H. H., et al. (2023) · Nucleic Acids Research · doi:10.1093/nar/gkad271 · Cited by 42 · see citing works
Lactating exposure to microplastics at the dose of infants ingested during artificial feeding induced reproductive toxicity in female mice and their offspring
Dou, Y., Zhang, M., Zhang, H., Zhang, C., Feng, L., Hu, J., Gao, Y., Yuan, X.-Z., Zhao, Y., Zhao, H., et al. (2024) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2024.174972 · Cited by 40 · see citing works
Curcumin in Combination with Aerobic Exercise Improves Follicular Dysfunction via Inhibition of the Hyperandrogen‐Induced IRE1α/XBP1 Endoplasmic Reticulum Stress Pathway in PCOS‐Like Rats
Zhang, Y., Weng, Y., Wang, D., Wang, R., Wang, L., Zhou, J., Shen, S., Wang, H., & Wang, Y. (2021) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2021/7382900 · Cited by 38 · see citing works
Cellular, Extracellular and Extracellular Vesicular miRNA Profiles of Pre-Ovulatory Follicles Indicate Signaling Disturbances in Polycystic Ovaries
Rooda, I., Hasan, M. M., Roos, K., Viil, J., Andronowska, A., Smolander, O., Jaakma, Ü., Salumets, A., Fazeli, A., & Velthut‐Meikas, A. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21249550 · Cited by 39 · see citing works
Androgen Excess Induced Mitochondrial Abnormality in Ovarian Granulosa Cells in a Rat Model of Polycystic Ovary Syndrome
Song, L., Yu, J., Zhang, D., Li, X., Chen, L., Cai, Z., & Yu, C. (2022) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.789008 · Cited by 38 · see citing works
Effect of DHT-Induced Hyperandrogenism on the Pro-Inflammatory Cytokines in a Rat Model of Polycystic Ovary Morphology
Krishnan, A., Muthusami, S., Periyasamy, L., Stanley, J. A., Gopalakrishnan, V., & Ramachandran, I. (2020) · Medicina · doi:10.3390/medicina56030100 · Cited by 34 · see citing works
Metabolic and Molecular Mechanisms of Diet and Physical Exercise in the Management of Polycystic Ovarian Syndrome
Scarfò, G., Daniele, S., Fusi, J., Gesi, M., Martini, C., Franzoni, F., Cela, V., & Artini, P. G. (2022) · Biomedicines · doi:10.3390/biomedicines10061305 · Cited by 32 · see citing works
The consequence and mechanism of dietary flavonoids on androgen profiles and disorders amelioration
Hu, X., Li, X., Deng, P., Zhang, Y., Liu, R., Cai, D., Xu, Q., Jiang, X., Sun, J., & Bai, W. (2022) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2022.2090893 · Cited by 32 · see citing works
Role of Androgen Receptor for Reconsidering the “True” Polycystic Ovarian Morphology in PCOS
Gao, X., Liu, Y., Lv, Y., Huang, T., Lü, G., Liu, H., & Zhao, S. (2020) · Scientific Reports · doi:10.1038/s41598-020-65890-5 · Cited by 31 · see citing works
Research Progress on the Effect of Epilepsy and Antiseizure Medications on PCOS Through HPO Axis
Li, S., Zhang, L., Wei, N., Tai, Z., Yu, C., & Xu, Z. (2021) · Frontiers in Endocrinology · doi:10.3389/fendo.2021.787854 · Cited by 25 · see citing works
Impose of KNDy/GnRH neural circuit in PCOS, ageing, cancer and Alzheimer’s disease: StAR actions in prevention of neuroendocrine dysfunction
Panda, S. P., Kesharwani, A., Singh, G. D., Prasanth, D., Vatchavai, B. R., Kumari, P. V. K., Panda, S. K., & Mallick, S. P. (2023) · Ageing Research Reviews · doi:10.1016/j.arr.2023.102086 · Cited by 24 · see citing works
Ligand Binding Prolongs Androgen Receptor Protein Half-Life by Reducing its Degradation
Astapova, O., Seger, C., & Hammes, S. R. (2021) · Journal of the Endocrine Society · doi:10.1210/jendso/bvab035 · Cited by 23 · see citing works
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Long-term environmental exposure of darkness induces hyperandrogenism in PCOS via melatonin receptor 1A and aromatase reduction
Chu, W., Li, S., Geng, X., Wang, D., Zhai, J., Lü, G., Chan, W., Chen, Z., & Du, Y. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2022.954186 · Cited by 24 · see citing works
Androgen-induced exosomal miR-379-5p release determines granulosa cell fate: cellular mechanism involved in polycystic ovaries
Salehi, R., Wyse, B. A., Asare-Werehene, M., Esfandiarinezhad, F., Abedini, A., Pan, B., Urata, Y., Gutsol, A. A., Viñas, J. L., Jahangiri, S., et al. (2023) · Journal of Ovarian Research · doi:10.1186/s13048-023-01141-1 · Cited by 21 · see citing works
Bovine models for human ovarian diseases
Roberts, J. F., & Huang, C. J. (2022) · Progress in molecular biology and translational science · doi:10.1016/bs.pmbts.2022.02.001 · Cited by 19 · see citing works
Serum testosterone levels are positively associated with serum anti-mullerian hormone levels in infertile women
Lin, L., Li, C., & Tsui, K. (2021) · Scientific Reports · doi:10.1038/s41598-021-85915-x · Cited by 21 · see citing works
Sex Steroid Receptors in Polycystic Ovary Syndrome and Endometriosis: Insights from Laboratory Studies to Clinical Trials
Hamid, F. A., Abu, M., Karim, A. K. A., Ahmad, M., Aziz, N. A., Kamal, D. A. M., & Mokhtar, M. H. (2022) · Biomedicines · doi:10.3390/biomedicines10071705 · Cited by 17 · see citing works
Emodin improves glucose metabolism and ovarian function in PCOS mice via the HMGB1/TLR4/NF-κB molecular pathway
Otoo, A., Czika, A., Lamptey, J., Yang, J.-P., Feng, Q., Wang, M., Wang, Y., & Ding, Y. (2023) · Reproduction · doi:10.1530/rep-22-0449 · Cited by 17 · see citing works
Angiotensin-(1-7), Angiotensin-Converting Enzyme 2 and Mas Receptor in Rat Polycystic Ovaries
Pereira, V. M., dos Reis, F. M., Casalechi, M., & dos Reis, A. M. (2020) · Protein and Peptide Letters · doi:10.2174/0929866527666200826104410 · Cited by 16 · see citing works
Rbpms2 promotes female fate upstream of the nutrient sensing Gator2 complex component Mios
Wilson, M., Romano, S. N., Khatri, N., Aharon, D. A., Liu, Y., Kaufman, O. H., Draper, B. W., & Marlow, F. L. (2024) · Nature Communications · doi:10.1038/s41467-024-49613-2 · Cited by 14 · see citing works
Hyperandrogenic environment regulates the function of ovarian granulosa cells by modulating macrophage polarization in PCOS
Chen, X., Hong, L., Diao, L., Yin, T., & Liu, S. (2024) · American Journal of Reproductive Immunology · doi:10.1111/aji.13854 · Cited by 15 · see citing works
DNA methylation and its impact on ovarian steroidogenesis in women with polycystic ovary syndrome: insights from human and animal models
Zhong, Y., Ding, J., & Xia, F. (2025) · Archives of Gynecology and Obstetrics · doi:10.1007/s00404-025-08048-w · Cited by 16 · see citing works
Correlation between ovarian follicular development and Hippo pathway in polycystic ovary syndrome
Huang, Z., Xu, T., Liu, C., Wu, H., Weng, L., Cai, J., Liang, N., & Ge, H. (2024) · Journal of Ovarian Research · doi:10.1186/s13048-023-01305-z · Cited by 15 · see citing works
Cuproptosis is involved in decabromodiphenyl ether-induced ovarian dysfunction and the protective effect of melatonin
Wang, Z., Zhang, W., Huang, D., Kang, H., Wang, J., Liu, Z., Jiang, G., & Gao, A. (2024) · Environmental Pollution · doi:10.1016/j.envpol.2024.124100 · Cited by 15 · see citing works
Characteristics of polycystic ovary syndrome rat models induced by letrozole, testosterone propionate and high-fat diets
Hu, R., Huang, Y., Liu, Z., Dong, H., Ma, W., Song, K., Xu, X., Wu, X. W., Geng, Y., Li, F., et al. (2024) · Reproductive BioMedicine Online · doi:10.1016/j.rbmo.2024.104296 · Cited by 14 · see citing works
Testosterone mediates life‐history trade‐offs in female mammals
Crespi, B. J., Bushell, A., & Dinsdale, N. L. (2024) · Biological reviews/Biological reviews of the Cambridge Philosophical Society · doi:10.1111/brv.13166 · Cited by 15 · see citing works
The impact of isotretinoin on the pituitary-ovarian axis: An interpretative review of the literature
Abdelhamed, A., Eldawla, R. E., Karadağ, A. S., Agamia, N., & Melnik, B. C. (2021) · Reproductive Toxicology · doi:10.1016/j.reprotox.2021.06.017 · Cited by 16 · see citing works
Intertwined reproductive endocrinology: Puberty and polycystic ovary syndrome
Witchel, S. F., & Plant, T. M. (2020) · Current Opinion in Endocrine and Metabolic Research · doi:10.1016/j.coemr.2020.07.004 · Cited by 14 · see citing works
Clinical Manifestations and Challenges in Adolescent and Adult Females With Classic Congenital Adrenal Hyperplasia Due to 21-Hydroxylase Deficiency
Engberg, H., Nordenström, A., & Hirschberg, A. L. (2024) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/clinem/dgae696 · Cited by 13 · see citing works
Androgens improve ovarian follicle function impaired by glucocorticoids through an androgen-IGF1-FSH synergistic effect
Gao, L., Gao, H., & Wang, W. (2022) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.951928 · Cited by 14 · see citing works
Terazosin reduces steroidogenic factor 1 and upregulates heat shock protein 90 expression in LH-induced bovine ovarian theca cells
Tang, Z.-R., Deng, S., Lian, Z., & Yu, K. (2020) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2020.12.016 · Cited by 13 · see citing works
Female Reproductive Systems: Hormone Dependence and Receptor Expression
Kuan, K., & Saunders, P. T. K. (2022) · Advances in experimental medicine and biology · doi:10.1007/978-3-031-11836-4_2 · Cited by 12 · see citing works
Role of the mitophagy‐apoptosis axis in the pathogenesis of polycystic ovarian syndrome
Kobayashi, H., Shigetomi, H., Matsubara, S., Yoshimoto, C., & Imanaka, S. (2024) · Journal of obstetrics and gynaecology research · doi:10.1111/jog.15916 · Cited by 11 · see citing works
AOP key event relationship report: Linking decreased androgen receptor activation with decreased granulosa cell proliferation of gonadotropin-independent follicles
Panagiotou, E. M., Draskau, M. K., Li, T., Hirschberg, A. L., Svingen, T., & Damdimopoulou, P. (2022) · Reproductive Toxicology · doi:10.1016/j.reprotox.2022.07.004 · Cited by 11 · see citing works
Lifestyle intervention towards Mediterranean Diet, physical activity adherence and anthropometric parameters in normal weight women with Polycystic Ovary Syndrome or Hashimoto’s Thyroiditis – preliminary study
Kamińska-Skrzyńska, W., Wiśniewska, K., Okręglicka, K., Pazura, I., & Nitsch-Osuch, A. S. (2023) · Annals of Agricultural and Environmental Medicine · doi:10.26444/aaem/159156 · Cited by 9 · see citing works
Interference of pseudorabies virus infection on functions of porcine granulosa cells via apoptosis modulated by MAPK signaling pathways
Deng, L., Min, W., Guo, S., Deng, J., Wu, X., Tong, D., Yuan, A., & Yang, Q. (2024) · Virology Journal · doi:10.1186/s12985-024-02289-y · Cited by 9 · see citing works
Association of candidate gene (INSR & THADA) polymorphism with polycystic ovary syndrome: meta-analysis and statistical power analysis
Velmurugan, S., Pauline, R., & Subbaraj, G. K. (2024) · Journal of the Turkish-German Gynecological Association · doi:10.4274/jtgga.galenos.2024.2024-1-7 · Cited by 9 · see citing works
Association of SNPs in the FK-506 binding protein (FKBP5) gene among Han Chinese women with polycystic ovary syndrome
Ma, X., Wang, Z., Zhang, C., Bian, Y., Zhang, X., Liu, X., Cao, Y., & Zhao, Y. (2022) · BMC Medical Genomics · doi:10.1186/s12920-022-01301-0 · Cited by 9 · see citing works
The role of zinc in follicular development
Liao, X., Wu, L., Yin, D., Tian, D., Zhou, C., Liu, J., Li, S., Zhou, J., Nie, Y., Liao, H., et al. (2023) · Molecular Biology Reports · doi:10.1007/s11033-023-08331-6 · Cited by 8 · see citing works
Investigation of Fructus Ligustri Lucidi for Premature Ovarian Insufficiency based on a Network Pharmacology and Experiment Verifications
Cai, W.-Y., & Luo, X. (2024) · Combinatorial Chemistry & High Throughput Screening · doi:10.2174/0113862073321308240808075854 · Cited by 7 · see citing works
Glucocorticoid therapy in classic congenital adrenal hyperplasia: traditional and new treatment paradigms
Bancos, I., Kim, H., Cheng, H. K.-H., Rodrı́guez-Lee, M., Coope, H., Cicero, S., Goldsmith, H., Lin, V. H., & Jeha, G. S. (2025) · Expert Review of Endocrinology & Metabolism · doi:10.1080/17446651.2025.2450423 · Cited by 7 · see citing works
The State-of-the-Art Review on FSHR, LHCGR, AR, ESR1, and ESR2 Key Mutations and Their Impact on the Effectiveness of Infertility Therapies—What We Know So Far
Hristov, D., & Stojanov, D. (2025) · Receptors · doi:10.3390/receptors4030016 · Cited by 7 · see citing works
Exploring the Mechanism of Yi-Jing Decoction in Treating Polycystic Ovary Syndrome by Using Network Pharmacology
Lin, Y., Liu, X., Li, X., Tang, Q., Meng, F., & Chen, W. (2022) · Current Medicinal Chemistry · doi:10.2174/0929867329666220508180611 · Cited by 7 · see citing works
Follicular Fluid-Derived Small Extracellular Vesicles Alleviate DHEA-Induced Granulosa Cell Apoptosis by Delivering LINC00092
Zhou, Z., Zhang, Y., Zhang, X., Zhang, J., Yi, G., Wan, B., Li, Y., Lu, H., Tan, C., & Lu, W. (2023) · Reproductive Sciences · doi:10.1007/s43032-023-01251-7 · Cited by 6 · see citing works
Increased Oxidative and Nitrative Stress and Decreased Sex Steroid Relaxation in a Vitamin D-Deficient Hyperandrogenic Rodent Model—And a Validation of the Polycystic Ovary Syndrome Model
Sziva, R. E., Kollarics, R., Pál, É., Bányai, B., Korsós-Novák, Á., Fontányi, Z., Magyar, P., Süli, A., Nádasy, G. L., Ács, N., et al. (2025) · Nutrients · doi:10.3390/nu17020201 · Cited by 6 · see citing works
The Relationships Between Serum DHEA-S and AMH Levels in Infertile Women: A Retrospective Cross-Sectional Study
Lin, L., & Tsui, K. (2021) · Journal of Clinical Medicine · doi:10.3390/jcm10061211 · Cited by 6 · see citing works
Randomized Controlled Study of the Effects of DHEA on the Outcome of IVF in Endometriosis
Zhang, Y., Li, M., Li, L., Xiao, J., & Chen, Z. (2021) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2021/3569697 · Cited by 6 · see citing works
Retracted
Investigation of androgen receptor CAG repeats length in polycystic ovary syndrome diagnosed using the new international evidence-based guideline
Yan, X., Gao, X., Shang, Q., Yang, Z., Wang, Y., Liu, L., Liu, W., Liu, D., Cheng, F., Zhao, S., et al. (2023) · Journal of Ovarian Research · doi:10.1186/s13048-023-01295-y · Cited by 5 · see citing works
Clinicopathologic Characteristics of a Single-institution Cohort of Ovarian Adult Granulosa Cell Tumors, With Biomarker and Therapeutic Implications Utilizing the Detection of Androgen, Estrogen, and Progesterone Hormone Receptor Expression by Immunohistochemistry
Moh, M., Puzyrenko, A., Summey, R., Rader, J. S., Cano, G. E. H., Gavina, J. V., Rui, H., Sun, Y., & Hopp, E. E. (2024) · International Journal of Gynecological Pathology · doi:10.1097/pgp.0000000000001032 · Cited by 5 · see citing works
Paxillin regulates androgen receptor expression associated with granulosa cell focal adhesions
Weidner, A. E., Roy, A., Vann, K., Walczyk, A. C., & Astapova, O. (2024) · Molecular Human Reproduction · doi:10.1093/molehr/gaae018 · Cited by 5 · see citing works
Self-citation
Androgen Exhibits a Protective Role Against Focal Erosions in Murine TNF-induced Inflammatory Arthritis
Chen, K. L., Kenney, H. M., Schwarz, E. M., & Rahimi, H. (2024) · Journal of the Endocrine Society · doi:10.1210/jendso/bvae169 · Cited by 5 · see citing works
Salt-Inducible Kinases Regulate Androgen Synthesis in Theca Cells by Enhancing Creb Signaling
Esquivel, M. R., Hayes, E. T., Lakomy, O., Hassan, M., Foretz, M., & Stocco, C. O. (2023) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2023.112030 · Cited by 5 · see citing works
A meta-analysis: Effect of androgens on reproduction in sows
Guo, Z., Lv, L., Liu, D., Ma, H., & Radović, Č. (2023) · Frontiers in Endocrinology · doi:10.3389/fendo.2023.1094466 · Cited by 5 · see citing works
Mechanistic insight into nanomedicine for polycystic ovary syndrome
Butt, M. A., Tabassum, S., Hardy, R., & Kiyani, M. M. (2025) · Molecular Biology Reports · doi:10.1007/s11033-025-10709-7 · Cited by 11 · see citing works
Thyroid, Adrenal, PRL Impairments and Ovarian Function
Tomatis, V., Battipaglia, C., & Genazzani, A. D. (2021) · Endocrines · doi:10.3390/endocrines2030021 · Cited by 4 · see citing works
Overlapping action of melatonin and female reproductive hormones—Understand the impact in pregnancy and menopause
Mineiro, R., Cardoso, M. R., Pinheiro, J. V., Cipolla‐Neto, J., do Amaral, F. G., & Quintela, T. (2024) · Advances in protein chemistry and structural biology · doi:10.1016/bs.apcsb.2024.06.005 · Cited by 4 · see citing works
Therapeutic effects of stevia aqueous extract alone or in combination with metformin in induced polycystic ovary syndrome rats: Gene expression, hormonal balance, and metabolomics aspects
Saedi, A., Zarei, S., Vatanparast, M., Hajizadeh, M. R., Hosseiniara, R., Esmaeili, O. S., Mohammad-Sadeghipour, M., Mirzaei, Z., & Mahmoodi, M. (2024) · Annales Pharmaceutiques Françaises · doi:10.1016/j.pharma.2024.08.008 · Cited by 4 · see citing works
Neonatal androgenization in rats affects oocyte maturation
Anesetti, G., & Chávez‐Genaro, R. (2021) · Reproductive Sciences · doi:10.1007/s43032-021-00559-6 · Cited by 4 · see citing works
The way toward adulthood for females with nonclassic congenital adrenal hyperplasia
Ntali, G., Charisis, S., Kylafi, C. F., Vogiatzi, E., & Michala, L. (2021) · Endocrine · doi:10.1007/s12020-021-02715-z · Cited by 4 · see citing works
A 7-nt nucleotide sequence variant within the sheep KDM3B gene affects female reproduction traits
Kang, Y., Bi, Y., Tang, Q., Xu, H., Lan, X., Zhang, Q., & Pan, C. (2021) · Animal Biotechnology · doi:10.1080/10495398.2021.1929270 · Cited by 4 · see citing works
LH Priming Before Ovarian Stimulation in Poor Responders: Effects on Oocyte Recovery and Post ICSI/IVF Pregnancy Rates
Junior, J. B. (2024) · World Journal of Gynecology & Womens Health · doi:10.33552/wjgwh.2024.06.000632 · Cited by 2 · see citing works
Single-Cell RNA Sequencing Reveals That C5AR1 in Follicle Monocyte Cells Could Predict the Development of POI
Han, Y., Diao, J., Wang, X., Zhang, S., Yuan, L., Ping, Y., Zhang, Y., & Luo, H. (2024) · Journal of Inflammation Research · doi:10.2147/jir.s490996 · Cited by 3 · see citing works
Association between low basal serum total testosterone levels and the risk of recurrent pregnancy loss in women with infertility
Zhao, Y., He, F., Pan, P., Xu, W., Xu, H., Yang, D., & Zhao, X. (2025) · European Journal of Obstetrics & Gynecology and Reproductive Biology · doi:10.1016/j.ejogrb.2025.02.018 · Cited by 3 · see citing works
MiR-34b/c play a role in early sex differentiation of Amur sturgeon, Acipenser schrenckii
Zhang, X., Wu, W., Zhou, J., Li, L., Jiang, H., & Chen, J. (2022) · Frontiers in Zoology · doi:10.1186/s12983-022-00469-6 · Cited by 3 · see citing works
Spatial and temporal expression profile of sex steroid receptors and antioxidant enzymes in the maternal-fetal interface of domestic cats
Nascimento, A. E. D. J., Santos, L. C., Santos, B. R., Santos, E. O., Cunha, M. C. D. S. G., Snoeck, P. P. D. N., de Lavor, M. S. L., & Silva, J. F. (2023) · Theriogenology · doi:10.1016/j.theriogenology.2023.08.001 · Cited by 3 · see citing works
Letrozole cotreatment progestin‐primed ovarian stimulation in women undergoing controlled ovarian stimulation for in vitro fertilization
Wang, X., Zhang, Y., Diao, H., Jiang, S., & Zhang, C. (2024) · Journal of obstetrics and gynaecology research · doi:10.1111/jog.15911 · Cited by 3 · see citing works
Maternal aromatase inhibition via letrozole altered RFamide-related peptide-3 and gonadotropin-releasing hormone expression in pubertal female rats.
Shaaban, Z., Tamadon, A., Shirazi, M. R. J., Zamiri, M. J., & Derakhshanfar, A. (2022) · PubMed Central · doi:10.22038/ijbms.2022.60962.13499 · Cited by 3 · see citing works
Gender-Specific Association of Handgrip Strength with Type 2 Diabetes Mellitus in Chinese Han Older Adults
Huang, Q., Chen, X., Shen, H. Y., Zhou, J. M., Zhang, H. Q., Wang, L., Chen, R., Cheng, J., Zhang, Y., Zhang, D. M., et al. (2023) · Diabetes Metabolic Syndrome and Obesity · doi:10.2147/dmso.s400350 · Cited by 3 · see citing works
Significance of androgen receptor and its potential for anti-androgen/androgen receptor-antagonist therapy in ovarian cancers
Kim, T. H., Memarzadeh, S., Vahdatshariatpanahi, S., Ostrzega, N. L., Kang, Y., & Moatamed, N. A. (2025) · PLoS ONE · doi:10.1371/journal.pone.0322744 · Cited by 2 · see citing works
Laurolitsine ameliorates insulin resistance, ovarian dysfunction and gut microbiota dysbiosis in DHEA plus HFD-induced PCOS mice
Zhang, Y., Chen, M., Zhou, Z. G., Guo, Y., Zheng, L., Yu, Y., Liu, J., Zhou, Y., Lu, H., Yao, S., et al. (2025) · Frontiers in Endocrinology · doi:10.3389/fendo.2025.1517934 · Cited by 2 · see citing works
Adolescent hyperandrogenism: diagnostic challenges and therapeutic approaches
Concepción‐Zavaleta, M. J., Fuentes‐Mendoza, J. M., Zavaleta‐Gutiérrez, F. E., Arias-Cantor, B. Y., Figueredo-Rueda, M. V., Arroyo, J., & Paz‐Ibarra, J. (2025) · World Journal of Pediatrics · doi:10.1007/s12519-025-00972-w · Cited by 2 · see citing works
Correlation between follicular fluid hormonal levels in PCOS women and embryo development in ART cycles
Kongsomnuan, S., Niransuk, P., Singwongsa, A., & Satirapod, C. (2026) · PLoS ONE · doi:10.1371/journal.pone.0342463 · Cited by 2 · see citing works
Glucocorticoid reduction after starting crinecerfont in adult patients with classic CAH: practical perspectives
Hamidi, O., Auchus, R. J., Correa, R. R., Levine, A. C., Wierman, M. E., Hartzell, A. L., Lin, V. H., & Bancos, I. (2026) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/clinem/dgag147 · Cited by 2 · see citing works
What is the Role of Testosterone Therapy in Postmenopausal Women? A SWOT Analysis
Aktöz, F., Güneş, A. C., & Erel, C. T. (2023) · Clinical and Experimental Obstetrics & Gynecology · doi:10.31083/j.ceog5008159 · Cited by 2 · see citing works
Dynamic serum testosterone concentration may predict in vitro fertilization yield during ovarian stimulation by a gonadotrophin‐releasing hormone agonist long protocol in women with normal ovarian reserve
Zhao, Y., Jiao, X., Xu, J., Chu, C., Cao, Y., Xu, H., Xu, W., & Zhao, X. (2023) · Medicine Advances · doi:10.1002/med4.41 · Cited by 2 · see citing works
Hypothesis: Androgen receptor/Aurora A kinase/NF-κB signaling axis induce inflammatory response during polycystic ovarian syndrome progression
Kumar, M. (2024) · Medical Hypotheses · doi:10.1016/j.mehy.2024.111286 · Cited by 2 · see citing works
Successful pregnancy using oral DHEA treatment for hypoandrogenemia in a 30-year-old female with 5 recurrent miscarriages, including fetal demise at 24 weeks: a case report
Boyle, P. C., Pandalache, C., & Turczynski, C. (2024) · Frontiers in Medicine · doi:10.3389/fmed.2024.1358563 · Cited by 2 · see citing works
Association of Basal Serum Androgen Concentration with Follicles Number on the Day of Triggering Final Oocyte Maturation in Low Responders According to the Bologna Criteria: A Prospective Cohort Study
Bosdou, J. Κ., Venetis, C. A., Anagnostis, P. G., Savvaidou, D., Chatzimeletiou, K., Zepiridis, L. I., Goulis, D. G., Grimbizis, G., & Kolibianakis, E. M. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26041656 · Cited by 2 · see citing works
Multi- and Transgenerational Histological and Transcriptomic Outcomes of Developmental TCDD Exposure in Zebrafish (Danio rerio) Ovary
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Dysregulation of AR and ERα caused ovarian alterations in gerbils prenatally exposed to 17α-ethinylestradiol and pequi oil
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Authors: Astapova, O., Minor, B. M. N., & Hammes, S. R.
Affiliations: University of Rochester Medicine (US)
Corresponding author: Hammes, Stephen R
ORCID: Astapova, Olga
Minor, Briaunna M N
Hammes, Stephen R
Venue: Endocrinology
Publisher: The Endocrine Society
Published: 2019-03-26
Volume: 160
Issue: 5
Pages: 1166-1174
ISSN: 0013-7227 (ISSN-L)
1945-7170
DOI: 10.1210/en.2019-00101
PMC: PMC6937455
OpenAlex: W2923411756
Cited by: 133
References: 70
Citations by year: 2026: 9 · 2025: 17 · 2024: 30 · 2023: 26 · 2022: 21 · 2021: 18 · 2020: 10 · 2019: 2
FWCI: 1.80
Type: journal article
Language: en
Open access: hybrid
doi.org
Licence: cc-by
Locations: Endocrinology (publishedVersion, cc-by)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: National Department of Health (F32HD097939-01)
National Institutes of Health
Topics: Health Sciences › Medicine › Reproductive Medicine › Ovarian function and disorders
Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Reproductive Biology and Fertility
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Sexual Differentiation and Disorders
Keywords: androgens, androgen receptor, ovary, folliculogenesis, ovulation, ovarian steroidogenesis, menstrual cycle, diminished ovarian reserve, polycystic ovary syndrome, hyperandrogenism, theca cells, granulosa cells, oocytes, anovulatory infertility, reproductive health
MeSH terms: Androgens, Animals, Female, Ovarian Follicle, Granulosa Cells, Humans, Receptors, Androgen, Theca Cells, Gene Expression, Mice, Knockout

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Physiological and Pathological Androgen Actions in the Ovary

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