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Cited by 109Ovarian function and disordersReproductive Biology and FertilityReproductive Physiology in Livestock

The DOI matches its Crossref record; 78 of the 78 references it cites were found in a registry or an index.

Androgen Action in the Ovary

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Franks, Stephen, Hardy, Kate·2018·Frontiers in Endocrinology
DOI 10.3389/fendo.2018.00452PMC PMC6097027
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Abstract

Androgen production by the ovary is an essential requirement for normal cyclical secretion of estradiol but its physiological role extends to important actions on both preantral and antral follicle development, including promotion of granulosa cell proliferation. It is likely only in mature antral follicles that androgens encourage apoptosis and consequent follicle atresia, and this may be an important mechanism to ensure mono-follicular ovulation in primates, including humans. Recent studies have provided new insight into the mechanism of androgen signaling in the ovary which involves both genomic and non-genomic effects that are complementary in effecting a cellular response. In polycystic ovary syndrome, a condition characterized by intra-ovarian androgen excess, aberrant development of both preantral and antral follicles is a salient feature. We present evidence that local action of androgens plays a part in such abnormalities. Finally, we review the role of androgens in follicle atresia and conclude that the effects are part of the normal physiology of follicle maturation.

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Figure 1 Immunohistochemical identification of androgen receptor (AR) protein in preantral follicles of women with and without PCOS. Bars represent the proportion of follicles that stain positive for AR protein. AR expression increased significantly with increasing stage of follicle development in both normal and PCOS (stage effect) but here was a significantly greater abundance of AR in PCO follicles (ovary effect). From Webber (12).
Figure 1 Immunohistochemical identification of androgen receptor (AR) protein in preantral follicles of women with and without PCOS. Bars represent the proportion of follicles that stain positive for AR protein. AR expression increased significantly with increasing stage of follicle development in both normal and PCOS (stage effect) but here was a significantly greater abundance of AR in PCO follicles (ovary effect). From Webber (12).CC BY · PubMed Central
Figure 2 Proposed pathways of androgen action on preantral follicle growth. Testosterone or DHT act via the androgen receptor, increasing granulosa cell proliferation. This may be mediated directly, or indirectly by increased FSHR (stimulating GC proliferation) or decreased AMH (reducing AMH inhibition). AMH can be further reduced by androgen-induced reduction of oocyte-specific BMP, which normally stimulates AMH levels. Inset box summarizes androgen-induced inhibition of TGFβ ligands, and type I and II TGFβ receptors, with the exception of Alk6 Laird et al. (20).
Figure 2 Proposed pathways of androgen action on preantral follicle growth. Testosterone or DHT act via the androgen receptor, increasing granulosa cell proliferation. This may be mediated directly, or indirectly by increased FSHR (stimulating GC proliferation) or decreased AMH (reducing AMH inhibition). AMH can be further reduced by androgen-induced reduction of oocyte-specific BMP, which normally stimulates AMH levels. Inset box summarizes androgen-induced inhibition of TGFβ ligands, and type I and II TGFβ receptors, with the exception of Alk6 Laird et al. (20).CC BY · PubMed Central

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Metadata

Authors
Franks, S., & Hardy, K.
Affiliations
Hammersmith Hospital (GB)
Corresponding author
Franks, Stephen
ORCID
Franks, Stephen
Venue
Frontiers in Endocrinology
Publisher
Frontiers Media SA
Published
2018-08-10
Volume
9
Pages
452-452
ISSN
1664-2392 (ISSN-L)
DOI
10.3389/fendo.2018.00452
PMC
PMC6097027
OpenAlex
W2886792139
Cited by
109
References
78
Citations by year
2026: 10 · 2025: 8 · 2024: 17 · 2023: 19 · 2022: 21 · 2021: 18 · 2020: 9 · 2019: 6 · 2018: 1
FWCI
1.28
Type
journal article
Language
en
Open access
Licence
Locations
  • Frontiers in Endocrinology (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
  • Spiral (Imperial College London) (submittedVersion, other-oa)
Topics
  • Health Sciences › Medicine › Reproductive Medicine › Ovarian function and disorders
  • Health Sciences › Medicine › Reproductive Medicine › Reproductive Biology and Fertility
  • Life Sciences › Agricultural and Biological Sciences › Animal Science and Zoology › Reproductive Physiology in Livestock
Keywords
androgens, ovary, androgen signaling, folliculogenesis, granulosa cell proliferation, follicular atresia, apoptosis, polycystic ovary syndrome, estradiol secretion, follicle maturation

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