The DOI matches its Crossref record; 408 of the 412 references it cites were found in a registry or an index.
Neurosteroid Actions in Memory and Neurologic/Neuropsychiatric Disorders
Open accessAbstract
Memory dysfunction is a symptomatic feature of many neurologic and neuropsychiatric disorders; however, the basic underlying mechanisms of memory and altered states of circuitry function associated with disorders of memory remain a vast unexplored territory. The initial discovery of endogenous neurosteroids triggered a quest to elucidate their role as neuromodulators in normal and diseased brain function. In this review, based on the perspective of our own research, the advances leading to the discovery of positive and negative neurosteroid allosteric modulators of GABA type-A (GABAA), NMDA, and non-NMDA type glutamate receptors are brought together in a historical and conceptual framework. We extend the analysis toward a state-of-the art view of how neurosteroid modulation of neural circuitry function may affect memory and memory deficits. By aggregating the results from multiple laboratories using both animal models for disease and human clinical research on neuropsychiatric and age-related neurodegenerative disorders, elements of a circuitry level view begins to emerge. Lastly, the effects of both endogenously active and exogenously administered neurosteroids on neural networks across the life span of women and men point to a possible underlying pharmacological connectome by which these neuromodulators might act to modulate memory across diverse altered states of mind.
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“Such a prediction is consistent with reported correlations between neurosteroids and a series of neurological disorders, including migraine, postpartum-depression, epilepsy, anxiety, cognitive and psychiatric disorders [56,144,145].”
From Fibromyalgia pathogenesis explained by a neuroendocrine multistable model (2024) · cites this paper as [144]
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Promnestic effects of intranasally applied pregnenolone in rats
Abdel‐Hafiz, L., Chao, O. Y.-H., Huston, J. P., Nikolaus, S., Spieler, R. E., Silva, M. A. D. S., & Mattern, C. (2016) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2016.07.012 · Cited by 9
Innala, E., Bäckström, T. C., Poromaa, I. S., Andersson, C., & Bixo, M. (2012) · Acta Obstetricia Et Gynecologica Scandinavica · doi:10.1111/j.1600-0412.2012.01536.x · Cited by 8
Neuroactive steroids and the constraint of memory
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4 of the 412 references couldn’t be matched to a known paper.
Research works printed but not linked: 1
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Structure, Function, and Pharmacology of Glutamate Receptor Ion Channels
Hansen, K. B., Wollmuth, L. P., Bowie, D., Furukawa, H., Menniti, F. S., Sobolevsky, A. I., Swanson, G. T., Swanger, S. A., Greger, I. H., Nakagawa, T., et al. (2021) · Pharmacological Reviews · doi:10.1124/pharmrev.120.000131 · Cited by 686
Cutler, A. J., Mattingly, G. W., & Maletic, V. (2023) · Translational Psychiatry · doi:10.1038/s41398-023-02514-2 · Cited by 156
Realising the therapeutic potential of neuroactive steroid modulators of the GABAA receptor
Belelli, D., Hogenkamp, D., Gee, K. W., & Lambert, J. J. (2020) · Neurobiology of Stress · doi:10.1016/j.ynstr.2019.100207 · Cited by 67
Abnormal synaptic plasticity and impaired cognition in schizophrenia
Wu, X., Yan, Q., & Zhu, F. (2022) · World Journal of Psychiatry · doi:10.5498/wjp.v12.i4.541 · Cited by 47
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Metadata
- Authors
- Ratner, M. H., Kumaresan, V., & Farb, D. H.
- Affiliations
- Boston University (US)
- Corresponding author
- Farb, David H.
- Venue
- Frontiers in Endocrinology
- Publisher
- Frontiers Media SA
- Published
- 2019-04-09
- Volume
- 10
- Pages
- 169-169
- ISSN
- 1664-2392 (ISSN-L)
- PMC
- PMC6465949
- OpenAlex
- W2939309394
- Cited by
- 96
- References
- 412
- Citations by year
- 2026: 5 · 2025: 4 · 2024: 14 · 2023: 16 · 2022: 18 · 2021: 22 · 2020: 15 · 2019: 1
- FWCI
- 1.86
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Frontiers in Endocrinology (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- National Institute on Aging (R21AG056947)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
- Keywords
- neurosteroids, memory, GABAA receptor, NMDA receptor, non-NMDA receptors, allosteric modulation, neuromodulation, neural circuits, memory impairment, neuropsychiatric disorders, neurodegenerative diseases, sex differences
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