Cited by 97Neuroscience and Neuropharmacology ResearchMemory and Neural MechanismsAlzheimer's disease research and treatments

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Neurosteroid Actions in Memory and Neurologic/Neuropsychiatric Disorders

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Ratner, Marcia H., Kumaresan, Vidhya, Farb, David H.·2019·Frontiers in Endocrinology

DOI 10.3389/fendo.2019.00169PMC PMC6465949

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Abstract

Memory dysfunction is a symptomatic feature of many neurologic and neuropsychiatric disorders; however, the basic underlying mechanisms of memory and altered states of circuitry function associated with disorders of memory remain a vast unexplored territory. The initial discovery of endogenous neurosteroids triggered a quest to elucidate their role as neuromodulators in normal and diseased brain function. In this review, based on the perspective of our own research, the advances leading to the discovery of positive and negative neurosteroid allosteric modulators of GABA type-A (GABAA), NMDA, and non-NMDA type glutamate receptors are brought together in a historical and conceptual framework. We extend the analysis toward a state-of-the art view of how neurosteroid modulation of neural circuitry function may affect memory and memory deficits. By aggregating the results from multiple laboratories using both animal models for disease and human clinical research on neuropsychiatric and age-related neurodegenerative disorders, elements of a circuitry level view begins to emerge. Lastly, the effects of both endogenously active and exogenously administered neurosteroids on neural networks across the life span of women and men point to a possible underlying pharmacological connectome by which these neuromodulators might act to modulate memory across diverse altered states of mind.

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Authors: Ratner, M. H., Kumaresan, V., & Farb, D. H.
Affiliations: Boston University (US)
Corresponding author: Farb, David H.
ORCID: Ratner, Marcia H.
Kumaresan, Vidhya
Farb, David H.
Venue: Frontiers in Endocrinology
Publisher: Frontiers Media SA
Published: 2019-04-09
Volume: 10
Pages: 169-169
ISSN: 1664-2392 (ISSN-L)
DOI: 10.3389/fendo.2019.00169
PMC: PMC6465949
OpenAlex: W2939309394
Cited by: 96
References: 412
Citations by year: 2026: 5 · 2025: 4 · 2024: 14 · 2023: 16 · 2022: 18 · 2021: 22 · 2020: 15 · 2019: 1
FWCI: 1.86
Type: journal article
Language: en
Open access: gold
doi.org
Licence: cc-by
creativecommons.org/licenses/by/4.0/ (vor)
Locations: Frontiers in Endocrinology (publishedVersion, cc-by)
Europe PMC (PubMed Central) (publishedVersion, cc-by)
PubMed Central (publishedVersion, cc-by)
PubMed (publishedVersion)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders: National Institute on Aging (R21AG056947)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
Keywords: neurosteroids, memory, GABAA receptor, NMDA receptor, non-NMDA receptors, allosteric modulation, neuromodulation, neural circuits, memory impairment, neuropsychiatric disorders, neurodegenerative diseases, sex differences

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Neurosteroid Actions in Memory and Neurologic/Neuropsychiatric Disorders

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