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Obesity May Accelerate the Aging Process
Open accessAbstract
Lines of evidence from several studies have shown that increases in life expectancy are now accompanied by increased disability rate. The expanded lifespan of the aging population imposes a challenge on the continuous increase of chronic disease. The prevalence of overweight and obesity is increasing at an alarming rate in many parts of the world. Further to increasing the onset of metabolic imbalances, obesity leads to reduced life span and affects cellular and molecular processes in a fashion resembling aging. Nine key hallmarks of the aging process have been proposed. In this review, we will review these hallmarks and discuss pathophysiological changes that occur with obesity, that are similar to or contribute to those that occur during aging. We present and discuss the idea that obesity, in addition to having disease-specific effects, may accelerate the rate of aging affecting all aspects of physiology and thus shortening life span and health span.
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“Accordingly, obesity accelerates and exacerbates ageing, and has been associated with shortened lifespan71.”
From NAD+ metabolism and its roles in cellular processes during ageing (2021) · cites this paper as [71]
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Metadata
- Authors
- Salvestrini, V., Sell, C., & Lorenzini, A.
- Affiliations
- University of Bologna (IT)
- Drexel University (US)
- Corresponding author
- Lorenzini, Antonello
- Venue
- Frontiers in Endocrinology
- Publisher
- Frontiers Media SA
- Published
- 2019-05-03
- Volume
- 10
- Pages
- 266-266
- ISSN
- 1664-2392 (ISSN-L)
- PMC
- PMC6509231
- OpenAlex
- W2943656785
- Cited by
- 260
- References
- 218
- Citations by year
- 2026: 32 · 2025: 40 · 2024: 38 · 2023: 43 · 2022: 48 · 2021: 26 · 2020: 28 · 2019: 4
- FWCI
- 2.29
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Frontiers in Endocrinology (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Archivio istituzionale della ricerca (Alma Mater Studiorum Università di Bologna) (submittedVersion, other-oa)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- Funders
- Ministero dell’Istruzione, dell’Università e della Ricerca
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Telomeres, Telomerase, and Senescence
- Health Sciences › Medicine › Physiology (medical) › Nutrition and Health in Aging
- Keywords
- obesity, aging, hallmarks of aging, lifespan, healthspan, disability, chronic disease, metabolic imbalance, cellular aging, molecular aging
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