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Obesity May Accelerate the Aging Process
Open accessAbstract
Lines of evidence from several studies have shown that increases in life expectancy are now accompanied by increased disability rate. The expanded lifespan of the aging population imposes a challenge on the continuous increase of chronic disease. The prevalence of overweight and obesity is increasing at an alarming rate in many parts of the world. Further to increasing the onset of metabolic imbalances, obesity leads to reduced life span and affects cellular and molecular processes in a fashion resembling aging. Nine key hallmarks of the aging process have been proposed. In this review, we will review these hallmarks and discuss pathophysiological changes that occur with obesity, that are similar to or contribute to those that occur during aging. We present and discuss the idea that obesity, in addition to having disease-specific effects, may accelerate the rate of aging affecting all aspects of physiology and thus shortening life span and health span.
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“Accordingly, obesity accelerates and exacerbates ageing, and has been associated with shortened lifespan71.”
From NAD+ metabolism and its roles in cellular processes during ageing (2021) · cites this paper as [71]
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Othman, E. M., Kreissl, M. C., Kaiser, F. R., Arias-Loza, P.-A., & Stopper, H. (2013) · Endocrinology · doi:10.1210/en.2012-1768 · Cited by 28
DNA Damage Detection by 53BP1: Relationship to Species Longevity
Croco, E., Marchionni, S., Bocchini, M., Angeloni, C., Stamato, T. D., Stefanelli, C., Hrelia, S., Sell, C., & Lorenzini, A. (2016) · The Journals of Gerontology Series A · doi:10.1093/gerona/glw170 · Cited by 28
Self-citationKaushik, P., & Anderson, J. T. (2016) · BioMolecular Concepts · doi:10.1515/bmc-2016-0010 · Cited by 27
Bourg, É. L. (2018) · BioEssays · doi:10.1002/bies.201800111 · Cited by 26
Flagged first, then by citations
1 of the 218 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
NAD+ metabolism and its roles in cellular processes during ageing
Covarrubias, A. J., Perrone, R., Grozio, A., & Verdin, E. (2021) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-020-00313-x · Cited by 1,617
Aging and age‐related diseases: from mechanisms to therapeutic strategies
Li, Z., Zhang, Z., Ren, Y., Wang, Y., Fang, J., Yue, H., Ma, S., & Guan, F. (2021) · Biogerontology · doi:10.1007/s10522-021-09910-5 · Cited by 702
Chronic inflammation and the hallmarks of aging
Baechle, J. J., Chen, N., Makhijani, P., Winer, S., Furman, D., & Winer, D. A. (2023) · Molecular Metabolism · doi:10.1016/j.molmet.2023.101755 · Cited by 471
The interplay between immunosenescence and age-related diseases
Barbé‐Tuana, F. M., Funchal, G. A., Schmitz, C. R. R., Maurmann, R. M., & Bauer, M. E. (2020) · Seminars in Immunopathology · doi:10.1007/s00281-020-00806-z · Cited by 389
Obesity, Polycystic Ovary Syndrome, and Infertility: A New Avenue for GLP-1 Receptor Agonists
Cena, H., Chiovato, L., & Nappi, R. E. (2020) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/clinem/dgaa285 · Cited by 356
Metadata
- Authors
- Salvestrini, V., Sell, C., & Lorenzini, A.
- Affiliations
- University of Bologna (IT)
- Drexel University (US)
- Corresponding author
- Lorenzini, Antonello
- Venue
- Frontiers in Endocrinology
- Publisher
- Frontiers Media SA
- Published
- 2019-05-03
- Volume
- 10
- Pages
- 266-266
- ISSN
- 1664-2392 (ISSN-L)
- PMC
- PMC6509231
- OpenAlex
- W2943656785
- Cited by
- 260
- References
- 218
- Citations by year
- 2026: 32 · 2025: 40 · 2024: 38 · 2023: 43 · 2022: 48 · 2021: 26 · 2020: 28 · 2019: 4
- FWCI
- 2.29
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Frontiers in Endocrinology (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Archivio istituzionale della ricerca (Alma Mater Studiorum Università di Bologna) (submittedVersion, other-oa)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- Funders
- Ministero dell’Istruzione, dell’Università e della Ricerca
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Telomeres, Telomerase, and Senescence
- Health Sciences › Medicine › Physiology (medical) › Nutrition and Health in Aging
- Keywords
- obesity, aging, hallmarks of aging, lifespan, healthspan, disability, chronic disease, metabolic imbalance, cellular aging, molecular aging
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
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