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Obesity May Accelerate the Aging Process
Open accessAbstract
Lines of evidence from several studies have shown that increases in life expectancy are now accompanied by increased disability rate. The expanded lifespan of the aging population imposes a challenge on the continuous increase of chronic disease. The prevalence of overweight and obesity is increasing at an alarming rate in many parts of the world. Further to increasing the onset of metabolic imbalances, obesity leads to reduced life span and affects cellular and molecular processes in a fashion resembling aging. Nine key hallmarks of the aging process have been proposed. In this review, we will review these hallmarks and discuss pathophysiological changes that occur with obesity, that are similar to or contribute to those that occur during aging. We present and discuss the idea that obesity, in addition to having disease-specific effects, may accelerate the rate of aging affecting all aspects of physiology and thus shortening life span and health span.
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“Accordingly, obesity accelerates and exacerbates ageing, and has been associated with shortened lifespan71.”
From NAD+ metabolism and its roles in cellular processes during ageing (2021) · cites this paper as [71]
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Cites
López-Otín, C., Blasco, M. A., Partridge, L., Serrano, M., & Kroemer, G. (2013) · Cell · doi:10.1016/j.cell.2013.05.039 · Cited by 14,982
Ng, M., Fleming, T., Robinson, M., Thomson, B., Graetz, N., Margono, C., Mullany, E. C., Biryukov, S., Abbafati, C., Abera, S. F., et al. (2014) · The Lancet · doi:10.1016/s0140-6736(14)60460-8 · Cited by 11,952
DNA methylation age of human tissues and cell types
Horvath, S. (2013) · Genome Biology · doi:10.1186/gb-2013-14-10-r115 · Cited by 7,075
The limited in vitro lifetime of human diploid cell strains
Hayflick, L. (1965) · Experimental Cell Research · doi:10.1016/0014-4827(65)90211-9 · Cited by 5,876
Renehan, A. G., Tyson, M., Egger, M., Heller, R. F., & Zwahlen, M. (2008) · The Lancet · doi:10.1016/s0140-6736(08)60269-x · Cited by 5,219
Inflammation and insulin resistance
Shoelson, S. E. (2006) · Journal of Clinical Investigation · doi:10.1172/jci29069 · Cited by 4,769
The Epidemiologic Transition: A Theory of the Epidemiology of Population Change
Omran, A. R. (2005) · Milbank Quarterly · doi:10.1111/j.1468-0009.2005.00398.x · Cited by 3,986
Watterson, K. R., Bestow, D., Gallagher, J. R., Hamilton, D. L., Ashford, F. B., Meakin, P. J., & Ashford, M. L. J. (2012) · Neurosignals · doi:10.1159/000334144 · Cited by 3,395
Naturally occurring p16Ink4a-positive cells shorten healthy lifespan
Baker, D. J., Childs, B. G., Durik, M., Wijers, M. E., Sieben, C. J., Zhong, J., A. Saltness, R., Jeganathan, K. B., Verzosa, G. C., Pezeshki, A., et al. (2016) · Nature · doi:10.1038/nature16932 · Cited by 2,876
A Potential Decline in Life Expectancy in the United States in the 21st Century
Olshansky, S. J., Passaro, D. J., Hershow, R. C., Layden, J., Carnes, B. A., Brody, J., Hayflick, L., Butler, R. N., Allison, D. B., & Ludwig, D. S. (2005) · New England Journal of Medicine · doi:10.1056/nejmsr043743 · Cited by 2,612
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Aging and age‐related diseases: from mechanisms to therapeutic strategies
Li, Z., Zhang, Z., Ren, Y., Wang, Y., Fang, J., Yue, H., Ma, S., & Guan, F. (2021) · Biogerontology · doi:10.1007/s10522-021-09910-5 · Cited by 702
Chronic inflammation and the hallmarks of aging
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Barbé‐Tuana, F. M., Funchal, G. A., Schmitz, C. R. R., Maurmann, R. M., & Bauer, M. E. (2020) · Seminars in Immunopathology · doi:10.1007/s00281-020-00806-z · Cited by 389
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Cena, H., Chiovato, L., & Nappi, R. E. (2020) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/clinem/dgaa285 · Cited by 356
The aftermath of the interplay between the endoplasmic reticulum stress response and redox signaling
Bhattarai, K. R., Riaz, T. A., Kim, H., & Chae, H. (2021) · Experimental & Molecular Medicine · doi:10.1038/s12276-021-00560-8 · Cited by 356
ω-3 and ω-6 Polyunsaturated Fatty Acids, Obesity and Cancer
D’Angelo, S., Motti, M. L., & Meccariello, R. (2020) · Nutrients · doi:10.3390/nu12092751 · Cited by 250
Chaudhary, M. R., Chaudhary, S., Sharma, Y., Singh, T. A., Mishra, A. K., Sharma, S. G., & Mehdi, M. M. (2023) · Biogerontology · doi:10.1007/s10522-023-10050-1 · Cited by 218
Immunosenescence, Inflammaging, and Frailty: Role of Myeloid Cells in Age-Related Diseases
Bleve, A., Motta, F., Durante, B., Pandolfo, C., Selmi, C., & Sica, A. (2022) · Clinical Reviews in Allergy & Immunology · doi:10.1007/s12016-021-08909-7 · Cited by 185
Fitch, A., & Bays, H. E. (2022) · Obesity Pillars · doi:10.1016/j.obpill.2021.100004 · Cited by 145
Dietary Regulation of Immunity
Lee, A. H., & Dixit, V. D. (2020) · Immunity · doi:10.1016/j.immuni.2020.08.013 · Cited by 127
Capurso, C. A., Bellanti, F., Buglio, A. L., & Vendemiale, G. (2019) · Nutrients · doi:10.3390/nu12010035 · Cited by 124
Lee, G., Kim, Y. Y., Jang, H., Han, J. S., Nahmgoong, H., Park, Y. J., Han, S. M., Cho, C., Lim, S., Noh, J.-R., et al. (2022) · Cell Metabolism · doi:10.1016/j.cmet.2022.03.010 · Cited by 111
Monoamine oxidases in age-associated diseases: New perspectives for old enzymes
Santin, Y., Resta, J., Parini, A., & Mialet‐Perez, J. (2021) · Ageing Research Reviews · doi:10.1016/j.arr.2021.101256 · Cited by 110
Inflammation as A Precursor of Atherothrombosis, Diabetes and Early Vascular Aging
Barbu, E., Popescu, M.-R., Popescu, A.-C., & Balanescu, S. M. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23020963 · Cited by 96
Dantas, W. S., Zunica, E. R. M., Heintz, E. C., Vandanmagsar, B., Floyd, Z. E., Yu, Y., Fujioka, H., Hoppel, C. L., Belmont, K. P., Axelrod, C. L., et al. (2022) · Journal of Cachexia Sarcopenia and Muscle · doi:10.1002/jcsm.12982 · Cited by 84
Hypothalamic inflammation in metabolic disorders and aging
Bhusal, A., Rahman, M. H., & Suk, K. (2021) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-021-04019-x · Cited by 87
Lundgren, S., Kuitunen, S., Pietiläinen, K. H., Hurme, M., Kähönen, M. A. P., Männistö, S., Perola, M., Lehtimäki, T. J., Raitakari, O. T., Kaprio, J. A., et al. (2022) · Journal of Internal Medicine · doi:10.1111/joim.13528 · Cited by 84
The interplay between obesity, immunosenescence, and insulin resistance
Shimi, G., Sohouli, M. H., Ghorbani, A., Shakery, A., & Zand, H. (2024) · Immunity & Ageing · doi:10.1186/s12979-024-00414-7 · Cited by 79
Environmental and genetic predictors of human cardiovascular ageing
Shah, M., Inácio, M. H. D. A., Lu, C., Schiratti, P.-R., Zheng, S. L., Clement, A., de Marvao, A., Bai, W., King, A. P., Ware, J. S., et al. (2023) · Nature Communications · doi:10.1038/s41467-023-40566-6 · Cited by 64
Vivarelli, S., Falzone, L., Torino, F., Scandurra, G., Russo, G. L., Bordonaro, R., Pappalardo, F., Spandidos, D. A., Raciti, G., & Libra, M. (2020) · International Journal of Oncology · doi:10.3892/ijo.2020.5159 · Cited by 64
Obesity-associated changes in molecular biology of primary breast cancer
Nguyen, H.-L., Geukens, T., Maetens, M., Aparicio, S. A. J. R., Bassez, A., Borg, Å., Brock, J. E., Broeks, A., Caldas, C., Cardoso, F., et al. (2023) · Nature Communications · doi:10.1038/s41467-023-39996-z · Cited by 71
de Toro‐Martín, J., Guénard, F., Tchernof, A., Hould, F., Lebel, S., Julien, F., Marceau, S., & Vohl, M. (2019) · Clinical Epigenetics · doi:10.1186/s13148-019-0754-6 · Cited by 67
Fresán, U., Guevara, M., Elía, F., Albéniz, E., Burgui, C., Castilla, J., & for the Working Group for the Study of COVID‐19 in Navarra (2020) · Obesity · doi:10.1002/oby.23029 · Cited by 58
Obesity and accelerated epigenetic aging in a high-risk cohort of children
Etzel, L. C., Hastings, W. J., Hall, M. A., Heim, C. C., Meaney, M. J., Noll, J. G., O’Donnell, K. J., Pokhvisneva, I., Rose, E. J., Schreier, H. M. C., et al. (2022) · Scientific Reports · doi:10.1038/s41598-022-11562-5 · Cited by 57
Wu, N., Zheng, W., Zhou, Y., Tian, Y., Tang, M., Feng, X., Ashrafizadeh, M., Wang, Y. Z., Niu, X., Tambuwala, M. M., et al. (2024) · Ageing Research Reviews · doi:10.1016/j.arr.2024.102428 · Cited by 59
Aging, obese-insulin resistance, and bone remodeling
Imerb, N., Thonusin, C., Chattipakorn, N., & Chattipakorn, S. C. (2020) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2020.111335 · Cited by 54
Ryu, J. Y., Choi, H. M., Yang, H.-I., & Kim, K. S. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21186887 · Cited by 52
Mann, S. N., Hadad, N., Holte, M. N., Rothman, A. R., Sathiaseelan, R., Mondal, S. A., Agbaga, M., Unnikrishnan, A., Subramaniam, M., Hawse, J. R., et al. (2020) · eLife · doi:10.7554/elife.59616 · Cited by 52
Valencia, I., Vallejo, S., Dongil, P., Romero, A., Hipólito‐Luengo, Á. S., Shamoon, L., Posada-Ayala, M., García‐Olmo, D., Carraro, R., Erusalimsky, J. D., et al. (2022) · Hypertension · doi:10.1161/hypertensionaha.121.18477 · Cited by 46
Vyas, C. M., Ogata, S., Reynolds, C. F., Mischoulon, D., Chang, G., Cook, N. R., Manson, J. E., Crous‐Bou, M., Vivo, I. D., & Okereke, O. I. (2020) · PLoS ONE · doi:10.1371/journal.pone.0237235 · Cited by 44
Does diet influence aging? Evidence from animal studies
Couteur, D. G. L., Raubenheimer, D., Solon‐Biet, S. M., de Cabo, R., & Simpson, S. J. (2022) · Journal of Internal Medicine · doi:10.1111/joim.13530 · Cited by 46
Mandl, M., Viertler, H. P., Hatzmann, F. M., Brucker, C., Großmann, S., Waldegger, P., Rauchenwald, T., Mattesich, M., Zwierzina, M., Pierer, G., et al. (2022) · Adipocyte · doi:10.1080/21623945.2022.2044601 · Cited by 42
Zadeh, F. A., Bokov, D. O., Yasin, G., Vahdat, S., & Farhangi, M. A. (2021) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2021.1971155 · Cited by 41
Kumar, M., Orkaby, A. R., Tighe, C. A., Villareal, D. T., Billingsley, H., Nanna, M. G., Kwak, M. J., Rohant, N., Patel, S., Goyal, P., et al. (2023) · JACC Advances · doi:10.1016/j.jacadv.2023.100560 · Cited by 46
Obesity and risk of diseases associated with hallmarks of cellular ageing: a multicohort study
Mika Kivimaki, B., Frank, P., Pentti, J., Xu, X., Vahtera, J., Ervasti, J. M., Nyberg, S. T., Lindbohm, J. V., Jokela, M. M., & Partridge, L. (2024) · The Lancet Healthy Longevity · doi:10.1016/s2666-7568(24)00087-4 · Cited by 43
Brunelli, D. T., Boldrini, V. D. O., Bonfante, I. L. P., Duft, R. G., Mateus, K., Costa, L., Chacon-Mikahil, M. P. T., Teixeira, A. M., Farias, A. S., & Cavaglieri, C. R. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2021.806400 · Cited by 39
Arachidonic acid in aging: New roles for old players
Qian, C., Wang, Q., Qiao, Y., Xu, Z. Q., Zhang, L., Xiao, H.-X., Lin, Z., Wu, M., Xia, W., Yang, H., et al. (2024) · Journal of Advanced Research · doi:10.1016/j.jare.2024.05.003 · Cited by 41
Pallangyo, P., Mkojera, Z., Hemed, N. R., Swai, H. J., Misidai, N., Mgopa, L. R., Bhalia, S. V., Millinga, J., Mushi, T. L., Kabeya, L., et al. (2020) · BMC Endocrine Disorders · doi:10.1186/s12902-020-00631-3 · Cited by 38
Villareal, D. T. (2023) · The journal of nutrition health & aging · doi:10.1007/s12603-023-1922-0 · Cited by 43
Senolytic treatment reverses obesity-mediated senescent cell accumulation in the ovary
Hense, J. D., Garcia, D. N., Isola, J. V. V., Rincón, J. A. A., Zanini, B. M., Prosczek, J. B., Stout, M. B., Mason, J. B., Walsh, P. T., Brieño‐Enríquez, M. A., et al. (2022) · GeroScience · doi:10.1007/s11357-022-00573-9 · Cited by 37
Implications of inflammatory states on dysfunctional immune responses in aging and obesity
Thomas, A. L., Alarcon, P. C., Divanovic, S., Chougnet, C. A., Hildeman, D. A., & Moreno-Fernandez, M. E. (2021) · Frontiers in Aging · doi:10.3389/fragi.2021.732414 · Cited by 35
Russa, D. L., Marrone, A., Mandalà, M., Macirella, R., & Pellegrino, D. (2020) · Biomedicines · doi:10.3390/biomedicines8120532 · Cited by 36
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Grün, L. K., Maurmann, R. M., Scholl, J. N., Fogaça, M. E., Schmitz, C. R. R., Dias, C. K., Gasparotto, J., Padoin, A. V., Mottin, C. C., Klamt, F., et al. (2023) · Immunity & Ageing · doi:10.1186/s12979-023-00378-0 · Cited by 38
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Correa‐Burrows, P., Burrows, R. A., Cecilia Albala, B., Sepúlveda, C., Salech, F., Troncoso, R., Bunout, D. C., & González-Billault, C. E. (2025) · JAMA Network Open · doi:10.1001/jamanetworkopen.2025.20011 · Cited by 33
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Dias, I. R., SANTOS, C. D. S., Magalhães, C. O. D. E., de Oliveira, L. R. S., Dias‐Peixoto, M. F., Sousa, R. A. L. D., & Cassilhas, R. C. (2020) · IBRO Reports · doi:10.1016/j.ibror.2020.05.001 · Cited by 34
Genes in human obesity loci are causal obesity genes in C. elegans
Ke, W., Reed, J. N., Yang, C., Higgason, N. M., Rayyan, L., Wählby, C., Carpenter, A. E., Civelek, M., & O’Rourke, E. J. (2021) · PLoS Genetics · doi:10.1371/journal.pgen.1009736 · Cited by 32
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Fermín‐Martínez, C. A., Márquez‐Salinas, A., Guerra, E. C., Zavala‐Romero, L., Antonio‐Villa, N. E., Fernández‐Chirino, L., Sandoval-Colin, D. E., Barquera‐Guevara, D. A., Muñoz, A. C., Vargas‐Vázquez, A., et al. (2022) · Aging Cell · doi:10.1111/acel.13756 · Cited by 32
Kreiner, F. F., von Scholten, B. J., Kurtzhals, P., & Gough, S. C. L. (2023) · Aging Cell · doi:10.1111/acel.13818 · Cited by 27
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Gkouskou, K. K., Grammatikopoulou, M. G., Lazou, E., Vasilogiannakopoulou, T., Sanoudou, D., & Eliopoulos, A. G. (2024) · Human Genomics · doi:10.1186/s40246-024-00570-3 · Cited by 30
Kar, A., Alvarez, M., Garske, K. M., Huang, H., Lee, S. H., Deal, M., Das, S. S., Koka, A., Jamal, Z. N., Mohlke, K. L., et al. (2024) · Genome Medicine · doi:10.1186/s13073-024-01291-x · Cited by 28
Shibu, M. A., Wang, T., Wang, M.-F., & Lin, W. (2020) · Aging · doi:10.18632/aging.103081 · Cited by 28
Talukdar, F. R., Marcillo, D. I. E., Laskar, R. S., Novoloaca, A., Cuenin, C., Sbraccia, P., Nisticò, L., Guglielmi, V., Gheit, T., Tommasino, M., et al. (2022) · Clinical Epigenetics · doi:10.1186/s13148-022-01401-9 · Cited by 32
Targeting mitochondria for ovarian aging: new insights into mechanisms and therapeutic potential
Wang, Z., Wang, Z.-J., Liu, H.-C., Wang, C.-Y., Wang, Y., Yang, Y., Zhao, C., Wang, G., & Wan, J. (2024) · Frontiers in Endocrinology · doi:10.3389/fendo.2024.1417007 · Cited by 27
Cavaliere, G., Catapano, A., Trinchese, G., Cimmino, F., Menale, C., Petrella, L., & Mollica, M. P. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24032967 · Cited by 26
Levakov, G., Kaplan, A., Meir, A. Y., Rinott, E., Tsaban, G., Zelicha, H., Blüher, M., Ceglarek, U., Stümvoll, M., Shelef, I., et al. (2023) · eLife · doi:10.7554/elife.83604 · Cited by 27
Extracellular Vesicles as Potential Theranostic Platforms for Skin Diseases and Aging
Kim, H., Lee, J. W., Han, G., Kim, K., Yang, Y., & Kim, S. H. (2021) · Pharmaceutics · doi:10.3390/pharmaceutics13050760 · Cited by 24
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Lee, C., Wang, B. Y., Wong, S. H., Chen, Y., Cao, Q., Hsiao, A. W., Fung, S.-H., Chen, Y.-F., Wu, H.-H., Cheng, P.-Y., et al. (2025) · Nature Aging · doi:10.1038/s43587-024-00802-0 · Cited by 26
Visfatin Induces Senescence of Human Dental Pulp Cells
Ok, C. Y., Park, S., Jang, H., Takata, T., Bae, M., Kim, Y., Ryu, M. H., & Bae, S. (2020) · Cells · doi:10.3390/cells9010193 · Cited by 26
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Kern, C. C., & Gems, D. (2022) · Frontiers in Genetics · doi:10.3389/fgene.2022.880343 · Cited by 24
Khosravaniardakani, S., Bokov, D. O., Mahmudiono, T., Hashemi, S. S., Nikrad, N., Rabieemotmaen, S., & Farhangi, M. A. (2022) · Frontiers in Nutrition · doi:10.3389/fnut.2022.812846 · Cited by 24
RetractedPranoto, A., Rejeki, P. S., Miftahussurur, M., Setiawan, H. K., Yosika, G. F., Munir, M., Maesaroh, S., Purwoto, S. P., Waritsu, C., & Yamaoka, Y. (2023) · Journal of Basic and Clinical Physiology and Pharmacology · doi:10.1515/jbcpp-2022-0196 · Cited by 29
Tokarz, J., Möller, G., Artati, A., Huber, S., Zeigerer, A., Blaauw, B., Adamski, J., & Dyar, K. A. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22157958 · Cited by 24
D-galactose-induced aging aggravates obesity-induced bone dyshomeostasis
Imerb, N., Thonusin, C., Pratchayasakul, W., Arunsak, B., Nawara, W., Ongnok, B., Aeimlapa, R., Charoenphandhu, N., Chattipakorn, N., & Chattipakorn, S. C. (2022) · Scientific Reports · doi:10.1038/s41598-022-12206-4 · Cited by 29
Sammarraie, S. H. A. A., Ayaz‐Güner, Ş., Acar, M. B., Şimşek, A., Sınıksaran, B. S., Bozalan, H. D., Özkan, M., Saraymen, R., Dündar, M., & Özcan, S. (2024) · Scientific Reports · doi:10.1038/s41598-024-70127-w · Cited by 25
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Jankowski, C. S. R., Samarah, L. Z., MacArthur, M. R., Mitchell, S. J., Weilandt, D. R., Hunter, C. J., Zeng, X., McReynolds, M. R., & Rabinowitz, J. D. (2025) · Cell Metabolism · doi:10.1016/j.cmet.2025.09.009 · Cited by 19
Bang, S., Choi, S.-H., & Jeong, S. M. (2025) · Cells · doi:10.3390/cells14241956 · Cited by 22
The role of tRNA-derived small RNAs in aging
Ha, S. G., & Lee, S. (2023) · BMB Reports · doi:10.5483/bmbrep.2022-0199 · Cited by 20
The biological mechanism and emerging therapeutic interventions of liver aging
Wang, W., Xu, K., Shang, M., Li, X., Tong, X., Liu, Z., Zhou, L., & Zheng, S. (2023) · International Journal of Biological Sciences · doi:10.7150/ijbs.87679 · Cited by 20
Su, T., He, Y., Huang, Y., Ye, M., Guo, Q., Xiao, Y., Cai, G., Chen, L., Li, C., Zhou, H., et al. (2024) · Nature Communications · doi:10.1038/s41467-023-43787-x · Cited by 22
Yang, L., Lu, P., Qi, X., Yang, Q., Liu, L., Dou, T., Guan, Q., & Yu, C. (2023) · iScience · doi:10.1016/j.isci.2023.108082 · Cited by 20
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Paulo, S. L., Miranda‐Lourenço, C., Belo, R. F., Rodrigues, R. S., Fonseca‐Gomes, J., Tanqueiro, S. R., Geraldes, V., Rocha, I., Sebastião, A. M., Xapelli, S., et al. (2021) · Current Issues in Molecular Biology · doi:10.3390/cimb43030162 · Cited by 19
Musci, R. V., Andrie, K. M., Walsh, M., Valenti, Z. J., Linden, M. A., Afzali, M. F., Bork, S. B., Campbell, M. A., Johnson, T., Kail, T. E., et al. (2022) · The Journal of Physiology · doi:10.1113/jp282273 · Cited by 18
Henderson, Y. O., Bithi, N., Yang, J., Link, C., Zhang, A., Baron, B., Maina, E., & Hine, C. (2022) · GeroScience · doi:10.1007/s11357-022-00678-1 · Cited by 18
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Metadata
- Authors
- Salvestrini, V., Sell, C., & Lorenzini, A.
- Affiliations
- University of Bologna (IT)
- Drexel University (US)
- Corresponding author
- Lorenzini, Antonello
- Venue
- Frontiers in Endocrinology
- Publisher
- Frontiers Media SA
- Published
- 2019-05-03
- Volume
- 10
- Pages
- 266-266
- ISSN
- 1664-2392 (ISSN-L)
- PMC
- PMC6509231
- OpenAlex
- W2943656785
- Cited by
- 260
- References
- 218
- Citations by year
- 2026: 32 · 2025: 40 · 2024: 38 · 2023: 43 · 2022: 48 · 2021: 26 · 2020: 28 · 2019: 4
- FWCI
- 2.29
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Frontiers in Endocrinology (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Archivio istituzionale della ricerca (Alma Mater Studiorum Università di Bologna) (submittedVersion, other-oa)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- Funders
- Ministero dell’Istruzione, dell’Università e della Ricerca
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Telomeres, Telomerase, and Senescence
- Health Sciences › Medicine › Physiology (medical) › Nutrition and Health in Aging
- Keywords
- obesity, aging, hallmarks of aging, lifespan, healthspan, disability, chronic disease, metabolic imbalance, cellular aging, molecular aging
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