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Cited by 37Obstructive Sleep Apnea ResearchHormonal and reproductive studiesHypothalamic control of reproductive hormones

Effects of CPAP on Testosterone Levels in Patients With Obstructive Sleep Apnea: A Meta-Analysis Study

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Cignarelli, Angelo, Castellana, Marco, Castellana, Giorgio, Perrini, Sebastio, Brescia, Francesco, Natalicchio, Annalisa, Garruti, Gabriella, Laviola, Luigi +2 more·2019·Frontiers in Endocrinology
DOI 10.3389/fendo.2019.00551PMC PMC6712440
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Abstract

Background: Obstructive sleep apnea (OSA) represents a frequent complication among patients with obesity and has been associated with neuroendocrine changes, including hypogonadism. Objective: We conducted a systematic review and meta-analysis to evaluate the effects of Continuous Positive Airway Pressure (CPAP) on testosterone and gonadotropins in male patients with OSA. Methods: The review was registered on PROSPERO (CRD42018103164). PubMed, Scopus, CENTRAL and Clinicaltrials.gov were searched until June 2018. Studies reporting the effect of CPAP on total testosterone, free testosterone, SHBG, FSH, LH and prolactin were included. A subgroup analysis on hypogonadal versus eugonadal status at baseline was performed. Results: Out of 129 retrieved papers, ten prospective cohort and two randomized controlled studies were included in the review. 388 patients were included. CPAP use was not associated with a significant change in total testosterone levels (mean difference 1.08, 95% CI -0.48 to 2.64) or other outcomes. The subgroup analysis confirmed the overall results. Conclusions: The present review does not support the hypothesis of a direct interaction between OSA and testosterone. Strategies other than CPAP should therefore be considered in managing hypogonadism in patients with OSA.

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  • Two meta-analyses concluded that CPAP has no effect on testosterone in men with OSA.

    “the two available meta-analyses have not concluded that CPAP therapy increases testosterone in men with OSA, but have instead concluded that CPAP has no effect on testosterone [108, 109].”

    From Sleep, testosterone and cortisol balance, and ageing men (2022) · cites this paper as [109]

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Authors
Cignarelli, A., Castellana, M., Castellana, G., Perrini, S., Brescia, F., Natalicchio, A., Garruti, G., Laviola, L., Resta, O., & Giorgino, F.
Affiliations
  • University of Bari Aldo Moro (IT)
  • Istituti Clinici Scientifici Maugeri (IT)
Corresponding author
Giorgino, Francesco
ORCID
Venue
Frontiers in Endocrinology
Publisher
Frontiers Media SA
Published
2019-08-21
Volume
10
Pages
551-551
ISSN
1664-2392 (ISSN-L)
DOI
10.3389/fendo.2019.00551
PMC
PMC6712440
OpenAlex
W2962874202
Cited by
37
References
13
Citations by year
2026: 9 · 2025: 4 · 2024: 3 · 2023: 6 · 2022: 5 · 2021: 6 · 2020: 4
FWCI
0.44
Type
journal article
Language
en
Open access
Licence
Locations
  • Frontiers in Endocrinology (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
  • CINECA IRIS Institutional Research Information System (University of Bari Aldo Moro) (submittedVersion, other-oa)
Topics
  • Health Sciences › Medicine › Physiology › Obstructive Sleep Apnea Research
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
  • Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
Keywords
obstructive sleep apnea, continuous positive airway pressure, testosterone, hypogonadism, gonadotropins, free testosterone, sex hormone-binding globulin, prolactin, male patients, obesity

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