Master Regulator Activating Transcription Factor 3 (ATF3) in Metabolic Homeostasis and Cancer
Open accessAbstract
Activating transcription factor 3 (ATF3) is a stress-induced transcription factor that plays vital roles in modulating metabolism, immunity, and oncogenesis. ATF3 acts as a hub of the cellular adaptive-response network. Multiple extracellular signals, such as endoplasmic reticulum (ER) stress, cytokines, chemokines, and LPS, are connected to ATF3 induction. The function of ATF3 as a regulator of metabolism and immunity has recently sparked intense attention. In this review, we describe how ATF3 can act as both a transcriptional activator and a repressor. We then focus on the role of ATF3 and ATF3-regulated signals in modulating metabolism, immunity, and oncogenesis. The roles of ATF3 in glucose metabolism and adipose tissue regulation are also explored. Next, we summarize how ATF3 regulates immunity and maintains normal host defense. In addition, we elaborate on the roles of ATF3 as a regulator of prostate, breast, colon, lung, and liver cancers. Further understanding of how ATF3 regulates signaling pathways involved in glucose metabolism, adipocyte metabolism, immuno-responsiveness, and oncogenesis in various cancers, including prostate, breast, colon, lung, and liver cancers, is then provided. Finally, we demonstrate that ATF3 acts as a master regulator of metabolic homeostasis and, therefore, may be an appealing target for the treatment of metabolic dyshomeostasis, immune disorders, and various cancers.
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ATF3 is considered a hub of the cellular adaptive-response network.
“ATF3 is considered a ‘’hub of the cellular adaptive-response network’’ [39]”
From 20-Hydroxyecdysone Boosts Energy Production and Biosynthetic Processes in Non-Transformed Mouse Cells (2024) · cites this paper as [39]
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Sørlie, T., Perou, C., Tibshirani, R., Aas, T., Geisler, S., Johnsen, H., Hastie, T., Eisen, M., van de Rijn, M., Jeffrey, S., et al. (2001) · Proceedings of the National Academy of Sciences of the United States of America · doi:10.1073/pnas.191367098 · Cited by 11,695 · see citing works
Gene expression profiling predicts clinical outcome of breast cancer
van 't Veer, L. J., Dai, H., van de Vijver, M. J., He, Y. D., Hart, A. A. M., Mao, M., Peterse, H. L., van der Kooy, K., Marton, M. J., Witteveen, A. T., et al. (2002) · Nature · doi:10.1038/415530a · Cited by 9,536 · see citing works
Binding of a nuclear protein to the cyclic-AMP response element of the somatostatin gene
Montminy, M., & Bilezikjian, L. M. (1987) · Nature · doi:10.1038/328175a0 · Cited by 1,390 · see citing works
Hai, T., & Curran, T. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.9.3720 · Cited by 1,321 · see citing works
Carver, B. S., Chapinski, C., Wongvipat, J., Hieronymus, H., Chen, Y., Chandarlapaty, S., Arora, V. K., Le, C. H., Koutcher, J. A., Scher, H. I., et al. (2011) · Cancer Cell · doi:10.1016/j.ccr.2011.04.008 · Cited by 1,197 · see citing works
Cyclic AMP and the induction of eukaryotic gene transcription.
Roesler, W. J., Vandenbark, G. R., & Hanson, R. W. (1988) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)76506-5 · Cited by 1,036 · see citing works
Hai, T., Liu, F., Coukos, W. J., & Green, M. R. (1989) · Genes & Development · doi:10.1101/gad.3.12b.2083 · Cited by 1,024 · see citing works
Systems biology approaches identify ATF3 as a negative regulator of Toll-like receptor 4
Gilchrist, M., Thórsson, V., Li, B., Rust, A. G., Korb, M., Kennedy, K., Hai, T., Bolouri, H., & Aderem, A. A. (2006) · Nature · doi:10.1038/nature04768 · Cited by 796 · see citing works
Cyclooxygenase-2 Inhibitors in Tumorigenesis (Part I)
Taketo, M. M. (1998) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/90.20.1529 · Cited by 755 · see citing works
Hai, T., Wolfgang, C. D., Marsee, D. K., Allen, A. E., & Sivaprasad, U. (1999) · Europe PMC (PubMed Central) · Cited by 629 · see citing works
Chemoprevention of Colorectal Cancer
Janne, P. A., & Mayer, R. J. (2000) · New England Journal of Medicine · doi:10.1056/nejm200006293422606 · Cited by 499 · see citing works
Tang, J., Feng, Y., Tsao, S., Wang, N., Curtain, R., & Wang, Y. (2009) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2009.08.009 · Cited by 491 · see citing works
Nardo, D. D., Labzin, L. I., Kono, H., Seki, R., Schmidt, S. V., Beyer, M., Xu, D., Zimmer, S., Lahrmann, C., Schildberg, F. A., et al. (2013) · Nature Immunology · doi:10.1038/ni.2784 · Cited by 463 · see citing works
Cyclooxygenase-2 Inhibitors in Tumorigenesis (Part II)
Taketo, M. M. (1998) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/90.21.1609 · Cited by 404 · see citing works
Role for Activating Transcription Factor 3 in Stress-Induced β-Cell Apoptosis
Hartman, M. G., Lü, D., Kim, M.-L., Kociba, G. J., Shukri, T., Buteau, J., Wang, X., Frankel, W. L., D, D. C. G., Prentki, M., et al. (2004) · Molecular and Cellular Biology · doi:10.1128/mcb.24.13.5721-5732.2004 · Cited by 313 · see citing works
Opposing roles for calcineurin and ATF3 in squamous skin cancer
Wu, X., Nguyen, B.-C., Dziunycz, P., Chang, S. E., Brooks, Y., Lefort, K., Hofbauer, G. F. L., & Dotto, G. P. (2010) · Nature · doi:10.1038/nature08996 · Cited by 301 · see citing works
Wang, N., Feng, Y., Zhu, M., Tsang, C., Man, K., Tong, Y., & Tsao, S. (2010) · Journal of Cellular Biochemistry · doi:10.1002/jcb.22869 · Cited by 287 · see citing works
Structural determinants for transcriptional activation by cAMP-responsive DNA elements.
Deutsch, P., Hoeffler, J. P., Jameson, J. L., Lin, J. C., & Habener, J. F. (1988) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)81381-9 · Cited by 257 · see citing works
Chen, B. P. C., Liang, G., Whelan, J., & Hai, T. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)40754-x · Cited by 249 · see citing works
Liang, G., Wolfgang, C. D., Chen, B. P. C., Chen, T.-H., & Hai, T. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.3.1695 · Cited by 231 · see citing works
Negative Regulation of TLR-Signaling Pathways by Activating Transcription Factor-3
Whitmore, M., Iparraguirre, A., Kubelka, L., Weninger, W., Hai, T., & Williams, B. R. G. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.179.6.3622 · Cited by 214 · see citing works
A potential dichotomous role of ATF3, an adaptive-response gene, in cancer development
Yin, X. H., DeWille, J. W., & Hai, T. (2007) · Oncogene · doi:10.1038/sj.onc.1210861 · Cited by 209 · see citing works
Activating Transcription Factor 3, a Stress-inducible Gene, Suppresses Ras-stimulated Tumorigenesis
Lü, D., Wolfgang, C. D., & Hai, T. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m509278200 · Cited by 202 · see citing works
Hoetzenecker, W., Echtenacher, B., Guenova, E., Höetzenecker, K., Woelbing, F., Brück, J., Teske, A., Valtcheva, N., Fuchs, K., Kneilling, M., et al. (2011) · Nature Medicine · doi:10.1038/nm.2557 · Cited by 195 · see citing works
Kim, J., Kwak, H. J., Cha, J.-Y., Jeong, Y.-S., Rhee, S. D., Kim, K. R., & Cheon, H. G. (2014) · Journal of Biological Chemistry · doi:10.1074/jbc.m114.577908 · Cited by 192 · see citing works
Activating Transcription Factor 3 and the Nervous System
Hunt, D., Raivich, G., & Anderson, P. N. (2012) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2012.00007 · Cited by 162 · cited 5× · see citing works
“Taketani et al. reported that the DR5 gene is a direct target of ATF3 upon DNA damage, and ATF3 plays a key role in apoptosis induced by camptothecin (CPT) /TRAIL co-treatment of human colorectal cancer cells (90).”
BackgroundInfluentialYin, X. H., Wolford, C. C., Chang, Y.-S., McConoughey, S. J., Ramsey, S. A., Aderem, A. A., & Hai, T. (2010) · Journal of Cell Science · doi:10.1242/jcs.064915 · Cited by 160 · see citing works
Chang, Y. S., Jalgaonkar, S. P., Middleton, J. D., & Hai, T. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1700455114 · Cited by 156 · see citing works
Gold, E. S., Ramsey, S. A., Sartain, M. J., Selinummi, J., Podolsky, I., Rodriguez, D. J., Moritz, R. L., & Aderem, A. A. (2012) · The Journal of Experimental Medicine · doi:10.1084/jem.20111202 · Cited by 154 · see citing works
gadd153/Chop10 , a Potential Target Gene of the Transcriptional Repressor ATF3
Wolfgang, C. D., Chen, B. P. C., Martindale, J. L., Holbrook, N. J., & Hai, T. (1997) · Molecular and Cellular Biology · doi:10.1128/mcb.17.11.6700 · Cited by 153 · see citing works
Rao, J., Qian, X., Li, G., Pan, X., Zhang, C., Zhang, F., Zhai, Y., Wang, X., & Lü, L. (2014) · American Journal of Transplantation · doi:10.1111/ajt.12954 · Cited by 138 · see citing works
KLF6 Induces Apoptosis in Prostate Cancer Cells through Up-regulation of ATF3
Huang, X., Li, X., & Guo, B. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m802515200 · Cited by 138 · see citing works
Transcription factor ATF3 links host adaptive response to breast cancer metastasis
Wolford, C. C., McConoughey, S. J., Jalgaonkar, S. P., Leon, M. E., Merchant, A. S., Dominick, J. L., Yin, X. H., Chang, Y.-S., Zmuda, E. J., O'Toole, S. A., et al. (2013) · Journal of Clinical Investigation · doi:10.1172/jci64410 · Cited by 127 · see citing works
ATF3 Is a Key Regulator of Macrophage IFN Responses
Labzin, L. I., Schmidt, S. V., Masters, S. L., Beyer, M., Krebs, W., Klee, K., Stahl, R., Lütjohann, D., Schultze, J. L., Latz, E., et al. (2015) · The Journal of Immunology · doi:10.4049/jimmunol.1500204 · Cited by 124 · see citing works
Edagawa, M., Kawauchi, J., Hirata, M., Goshima, H., Inoue, M., Okamoto, T., Murakami, A., Maehara, Y., & Kitajima, S. (2014) · Journal of Biological Chemistry · doi:10.1074/jbc.m114.558890 · Cited by 118 · see citing works
Rohini, M., Menon, A. H., & Selvamurugan, N. (2018) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2018.08.107 · Cited by 117 · see citing works
The Roles of ATF3 in Glucose Homeostasis
Allen-Jennings, A. E., Hartman, M. G., Kociba, G. J., & Hai, T. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m100986200 · Cited by 116 · see citing works
Bandyopadhyay, S., Wang, Y., Zhan, R., et al. (2006) · Cancer Research · doi:10.1158/0008-5472.can-06-0943 · Cited by 113 · see citing works
Pan, Y., Chen, H., Siu, F., & Kilberg, M. S. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m304574200 · Cited by 112 · see citing works
Activating Transcription Factor 3 Induces DNA Synthesis and Expression of Cyclin D1 in Hepatocytes
Allan, A. L., Albanese, C., Pestell, R. G., & LaMarre, J. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m103196200 · Cited by 112 · see citing works
NFATc4 and ATF3 Negatively Regulate Adiponectin Gene Expression in 3T3-L1 Adipocytes
Kim, H. B., Kong, M., Kim, T., et al. (2006) · Diabetes · doi:10.2337/db05-1507 · Cited by 108 · see citing works
Activating transcription factor 3 is a negative regulator of allergic pulmonary inflammation
Gilchrist, M., Henderson, W. R., Clark, A., Simmons, R. M., Ye, X., Smith, K. D., & Aderem, A. A. (2008) · The Journal of Experimental Medicine · doi:10.1084/jem.20072254 · Cited by 106 · see citing works
Activating transcription factor 3 (ATF3) represses the expression of CCL4 in murine macrophages
Khuu, C. H., Barrozo, R. M., Hai, T., & Weinstein, S. L. (2006) · Molecular Immunology · doi:10.1016/j.molimm.2006.08.006 · Cited by 102 · see citing works
Hashimoto, Y. (2002) · Nucleic Acids Research · doi:10.1093/nar/30.11.2398 · Cited by 94 · see citing works
Bottone, F. G., Moon, Y., Kim, J. S., et al. (2005) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-04-0337 · Cited by 92 · see citing works
Jan, Y., Tsai, H., Yang, C., Huang, M.-S., Yang, Y., Lai, T., Lee, C.-H., Jeng, Y., Huang, C. F., Su, J.-L., et al. (2012) · Cancer Research · doi:10.1158/0008-5472.can-12-1842 · Cited by 91 · see citing works
Zmuda, E. J., Qi, L., Zhu, M. X., Mirmira, R. G., Montminy, M., & Hai, T. (2010) · Molecular Endocrinology · doi:10.1210/me.2009-0463 · Cited by 90 · see citing works
Sha, H., Zhang, D., Zhang, Y., Wen, Y., & Wang, Y. (2017) · Molecular Medicine Reports · doi:10.3892/mmr.2017.6992 · Cited by 88 · see citing works
Liu, G., Su, L., Hao, X., Zhong, N., Zhong, D., Singhal, S. K., & Liu, X. (2011) · Journal of Cellular and Molecular Medicine · doi:10.1111/j.1582-4934.2011.01401.x · Cited by 87 · see citing works
Hackl, C., Lang, S. A., Moser, C., Mori, A., Fichtner‐Feigl, S., Hellerbrand, C., Dietmeier, W., Schlitt, H. J., Geissler, E. K., & Stoeltzing, O. (2010) · BMC Cancer · doi:10.1186/1471-2407-10-668 · Cited by 86 · see citing works
Allen-Jennings, A. E., Hartman, M. G., Kociba, G. J., & Hai, T. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m200727200 · Cited by 85 · see citing works
Germain, C. S., Niknejad, N., Ma, L., Garbuio, K., Hai, T., & Dimitroulakos, J. (2010) · Neoplasia · doi:10.1593/neo.92048 · Cited by 80 · see citing works
Key role of ATF3 in p53-dependent DR5 induction upon DNA damage of human colon cancer cells
Taketani, K., Kawauchi, J., Tanaka, M., Ishizaki, H., Tanaka, Y., Sakai, T., Miyoshi, J., Maehara, Y., & Kitajima, S. (2011) · Oncogene · doi:10.1038/onc.2011.397 · Cited by 79 · see citing works
Ho, H. H., Antoniv, T. T., Ji, J.-D., & Ivashkiv, L. B. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.181.7.5089 · Cited by 78 · see citing works
Pelzer, A. E., Bektić, J., Hååg, P., et al. (2006) · The Journal of Urology · doi:10.1016/s0022-5347(05)00651-8 · Cited by 78 · see citing works
ATF3 regulates MCMV infection in mice by modulating IFN-γ expression in natural killer cells
Rosenberger, C. M., Clark, A., Treuting, P. M., et al. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0712182105 · Cited by 74 · see citing works
ATF3 is a novel regulator of mouse neutrophil migration
Boespflug, N. D., Kumar, S., McAlees, J. W., Phelan, J. D., Grimes, H. L., Hoebe, K. H. N., Hai, T., Filippi, M., & Karp, C. L. (2014) · Blood · doi:10.1182/blood-2013-06-510909 · Cited by 74 · see citing works
Adipocyte browning and resistance to obesity in mice is induced by expression of ATF3
Cheng, C., Ku, H., Cheng, J., Chao, S.-W., Li, H., Lai, P., Chang, C., Don, M., Chen, H.-H., & Lin, H. (2019) · Communications Biology · doi:10.1038/s42003-019-0624-y · Cited by 71 · see citing works
Self-citationLoss of ATF3 promotes Akt activation and prostate cancer development in a Pten knockout mouse model
Wang, Z., Xu, D., Ding, H.-F., Kim, J., Zhang, J., Hai, T., & Yan, C. (2014) · Oncogene · doi:10.1038/onc.2014.426 · Cited by 69 · see citing works
Li, D., Yin, X. H., Zmuda, E. J., Wolford, C. C., Dong, X. C., White, M. F., & Hai, T. (2007) · Diabetes · doi:10.2337/db07-0717 · Cited by 68 · see citing works
Chen, C., Ge, C., Liu, Z., Li, L., Zhao, F., Tian, H., Chen, T., Li, H., Yao, M., & Li, J. (2018) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-018-0919-8 · Cited by 65 · see citing works
Bottone, F. G., Martinez, J. M., Collins, J. B., et al. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m301002200 · Cited by 64 · see citing works
Moser, C., Lang, S. A., Kainz, S., et al. (2007) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-07-0410 · Cited by 63 · see citing works
The transcription factor ATF3 acts as an oncogene in mouse mammary tumorigenesis
Wang, A., Arantes, S., Yan, L., Kiguchi, K., McArthur, M. J., Şahin, A. A., Thames, H. D., Aldaz, C. M., & MacLeod, M. C. (2008) · BMC Cancer · doi:10.1186/1471-2407-8-268 · Cited by 61 · see citing works
Naringenin-Mediated ATF3 Expression Contributes to Apoptosis in Human Colon Cancer
Song, H. M., Park, G. H., Eo, H. J., & Jeong, J. B. (2016) · Biomolecules & Therapeutics · doi:10.4062/biomolther.2015.109 · Cited by 61 · see citing works
Kalfon, R., Koren, L., Aviram, S., Schwartz, O., Hai, T., & Aronheim, A. (2016) · Cardiovascular Research · doi:10.1093/cvr/cvw228 · Cited by 59 · see citing works
ATF3 inhibits adipocyte differentiation of 3T3-L1 cells
Jang, M. K., Kim, C. H., Seong, J. K., & Jung, M. H. (2012) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2012.03.104 · Cited by 57 · see citing works
A critical role of STAT1 in streptozotocin-induced diabetic liver injury in mice: Controlled by ATF3
Kim, W., Lee, S. H., Song, E. H., Park, Y. M., Lim, J.-Y., Kim, D. J., Choi, K., Park, S. I., Gao, B., & Kim, W. (2009) · Cellular Signalling · doi:10.1016/j.cellsig.2009.07.011 · Cited by 57 · see citing works
Zmuda, E. J., Viapiano, M. S., Grey, S. T., Hadley, G. A., Garcı́a-Ocaña, A., & Hai, T. (2010) · Diabetologia · doi:10.1007/s00125-010-1696-x · Cited by 57 · see citing works
Miyazaki, K., Inoue, S., Yamada, K., Watanabe, M., Liu, Q., Watanabe, T., Adachi, M. T., Tanaka, Y., & Kitajima, S. (2009) · Nucleic Acids Research · doi:10.1093/nar/gkn1082 · Cited by 57 · see citing works
The ATF Transcription Factors in Cellular Adaptive Responses
Hai, T. (2007) · Springer eBooks · doi:10.1007/978-0-387-40049-5_20 · Cited by 56 · see citing works
Wei, S., Wang, H., Lu, C., Malmut, S., Zhang, J., Ren, S., Yu, G., Wang, W., Tang, D. D., & Yan, C. (2014) · Journal of Biological Chemistry · doi:10.1074/jbc.m113.503755 · Cited by 55 · see citing works
Gene modulation by Cox-1 and Cox-2 specific inhibitors in human colorectal carcinoma cancer cells
Bottone, F. G. (2003) · Carcinogenesis · doi:10.1093/carcin/bgh016 · Cited by 55 · see citing works
Activation of the Canonical Wnt/β-Catenin Pathway in ATF3-Induced Mammary Tumors
Yan, L., Coletta, L. D., Powell, K. L., et al. (2011) · PLoS ONE · doi:10.1371/journal.pone.0016515 · Cited by 53 · see citing works
Transcription factor ATF 3 mediates the radioresistance of breast cancer
Zhao, W., Sun, M., Li, S., et al. (2018) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.13688 · Cited by 52 · see citing works
Rohini, M., Gokulnath, M., Miranda, P. J., et al. (2018) · Biochimie · doi:10.1016/j.biochi.2018.07.023 · Cited by 51 · see citing works
Nguyen, C. T., Kim, E., Luong, T. T., Pyo, S., & Rhee, D. (2014) · Molecules and Cells · doi:10.14348/molcells.2015.2231 · Cited by 49 · see citing works
Wang, J., Cao, Y., & Steiner, D. F. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m305456200 · Cited by 49 · see citing works
Ishiguro, T., Nagawa, H., Naito, M., et al. (2000) · Japanese Journal of Cancer Research · doi:10.1111/j.1349-7006.2000.tb01021.x · Cited by 48 · see citing works
Activating transcription factor 3 promotes malignance of lung cancer cells in vitro
Li, X., Zhou, X., Li, Y., et al. (2017) · Thoracic Cancer · doi:10.1111/1759-7714.12421 · Cited by 47 · see citing works
Glal, D., Sudhakar, J. N., Lu, H.-H., Liu, M.-C. J., Chiang, H.-Y., Liu, Y., Cheng, C., & Shui, J. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.02522 · Cited by 47 · see citing works
Self-citationATF3 plays a role in adipocyte hypoxia-mediated mitochondria dysfunction in obesity
Jang, M.-K., Son, Y., & Jung, M. H. (2013) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2012.12.154 · Cited by 46 · see citing works
Hypothalamic ATF3 is involved in regulating glucose and energy metabolism in mice
Lee, Y., Sasaki, T., Kobayashi, M., Kikuchi, O., Kim, H.-J., Yokota‐Hashimoto, H., Shimpuku, M., Susanti, V. Y., Ido-Kitamura, Y., Kimura, K., et al. (2013) · Diabetologia · doi:10.1007/s00125-013-2879-z · Cited by 45 · see citing works
The Stress Response Mediator ATF3 Represses Androgen Signaling by Binding the Androgen Receptor
Wang, H., Jiang, M., Cui, H., Chen, M., Buttyan, R., Hayward, S. W., Hai, T., Wang, Z., & Yan, C. (2012) · Molecular and Cellular Biology · doi:10.1128/mcb.00159-12 · Cited by 44 · see citing works
ATF3 Protects against LPS-Induced Inflammation in Mice via Inhibiting HMGB1 Expression
Lai, P., Cheng, C., Lin, H., Tseng, T.-L., Chen, H.-H., & Chen, S.-H. (2013) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2013/716481 · Cited by 43 · see citing works
Self-citationAdipoR2 is transcriptionally regulated by ER stress‐inducible ATF3 in HepG2 human hepatocyte cells
Koh, I.-U., Lim, J. H., Joe, M. K., Kim, W., Jung, M. H., Yoon, J. B., & Song, J. (2010) · FEBS Journal · doi:10.1111/j.1742-4658.2010.07646.x · Cited by 42 · see citing works
Transcriptional activity of ATF3 in the stromal compartment of tumors promotes cancer progression
Buganim, Y., Madar, S., Rais, Y., et al. (2011) · Carcinogenesis · doi:10.1093/carcin/bgr203 · Cited by 41 · see citing works
Weng, S., Zhou, L., Deng, Q., et al. (2016) · BMC Gastroenterology · doi:10.1186/s12876-016-0442-3 · Cited by 40 · see citing works
Cao, Y., Yang, Q., Deng, H., Tang, J., Hu, J., Liu, H., Zhi, M., Ye, L., Zou, B., Liu, Y., et al. (2019) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1818164116 · Cited by 40 · see citing works
Kim, K., Lee, J., Park, Y., & Lee, S. (2015) · Biomolecules & Therapeutics · doi:10.4062/biomolther.2014.107 · Cited by 38 · see citing works
Runx2, a target gene for activating transcription factor-3 in human breast cancer cells
Gokulnath, M., Partridge, N. C., & Selvamurugan, N. (2014) · Tumor Biology · doi:10.1007/s13277-014-2796-x · Cited by 35 · see citing works
Chuang, T. Y., Wu, H. L., Min, J., Diamond, M. P., Azziz, R., & Chen, Y. (2017) · Cancer Cell International · doi:10.1186/s12935-017-0429-3 · Cited by 34 · see citing works
Contrasting patterns of expression of transcription factors in pancreatic α and β cells
Wang, J., Webb, G. C., Cao, Y., & Steiner, D. F. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1735286100 · Cited by 33 · see citing works
Lin, L., Yao, Z., Bhuvaneshwar, K., Gusev, Y., Kallakury, B., Yang, S., Shetty, K., & He, A. R. (2014) · Carcinogenesis · doi:10.1093/carcin/bgu163 · Cited by 33 · see citing works
ATF3 negatively regulates adiponectin receptor 1 expression
Park, H. J., Kang, Y. M., Kim, C. H., & Jung, M. H. (2010) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2010.08.011 · Cited by 32 · see citing works
Kwok, S., Rittling, S. R., Partridge, N. C., et al. (2009) · Journal of Cellular Biochemistry · doi:10.1002/jcb.22267 · Cited by 31 · see citing works
ATF-3/miR-590/GOLPH3 signaling pathway regulates proliferation of breast cancer
Song, Q., Qiu, C., Wang, Q., et al. (2018) · BMC Cancer · doi:10.1186/s12885-018-4031-4 · Cited by 31 · see citing works
ATF3 represses PPARγ expression and inhibits adipocyte differentiation
Jang, M.-K., & Jung, M. H. (2014) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2014.10.028 · Cited by 30 · see citing works
Favre, D., Gouill, E. L., Fahmi, D., Verdumo, C., Chinetti, G., Staels, B., Caiazzo, R. J., Pattou, F. N., Lê, K., Tappy, L., et al. (2011) · Diabetes · doi:10.2337/db10-1743 · Cited by 30 · see citing works
Activating Transcription Factor 3 as a Novel Regulator of Chemotherapy Response in Breast Cancer
Hasim, M. S., Nessim, C., Villeneuve, P. J., Vanderhyden, B. C., & Dimitroulakos, J. (2018) · Translational Oncology · doi:10.1016/j.tranon.2018.06.001 · Cited by 30 · see citing works
Lee, S., Kim, G., Kim, N. Y., Kim, S., Ghosh, P., & Rhee, D. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.01954 · Cited by 29 · see citing works
Activating transcription factor 3 promotes colon cancer metastasis
Wu, Z., Wei, Z., Sun, S., et al. (2014) · Tumor Biology · doi:10.1007/s13277-014-2044-4 · Cited by 28 · see citing works
Wang, C., & Yang, W. (2013) · International Journal of Molecular Sciences · doi:10.3390/ijms14048367 · Cited by 27 · see citing works
Liu, Y., Wei, J., Shi, M., Jiang, H., & Zhou, J. (2016) · Journal of Biological Chemistry · doi:10.1074/jbc.m116.726364 · Cited by 25 · see citing works
Lee, Y. M., Uhm, K.-O., Lee, E. S., et al. (2008) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2008.04.003 · Cited by 24 · see citing works
Atf3 induction is a therapeutic target for obesity and metabolic diseases
Kim, S., Song, N., Bahn, G., Chang, S., Yun, U. J., Ku, J., Jo, D., & Park, K. W. (2018) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2018.09.048 · Cited by 23 · see citing works
He, F., Zhou, M., Yu, T., et al. (2016) · Journal of Molecular Cell Biology · doi:10.1093/jmcb/mjw021 · Cited by 22 · see citing works
Expression and clinical significance of activating transcription factor 3 in human breast cancer.
Cao, H., Yang, Z.-X., & Jiang, G. (2013) · PubMed · Cited by 21 · see citing works
ATF3 Gene Regulates Cell Form and Migration Potential of HT29 Colon Cancer Cells
Ishiguro, T., & Nagawa, H. (2001) · Oncology Research Featuring Preclinical and Clinical Cancer Therapeutics · doi:10.3727/096504001108747792 · Cited by 20 · see citing works
Overexpression of activating transcription factor 3 exerts suppressive effects in HepG2 cells
Li, X., Zang, S., Cheng, H., et al. (2018) · Molecular Medicine Reports · doi:10.3892/mmr.2018.9707 · Cited by 20 · see citing works
Udayakumar, T. S., Stoyanova, R. S., Shareef, M. M., Mu, Z., Philip, S., Burnstein, K. L., & Pollack, A. S. (2016) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-15-0332 · Cited by 19 · see citing works
Shen, J., Lin, H. M., Li, G., et al. (2016) · Oncotarget · doi:10.18632/oncotarget.8525 · Cited by 17 · see citing works
Li, X., Shengbing, Z., Zhang, Y., et al. (2014) · Pathology - Research and Practice · doi:10.1016/j.prp.2014.03.013 · Cited by 14 · see citing works
Lee, Y., Kobayashi, M., Kikuchi, O., et al. (2013) · Endocrine Journal · doi:10.1507/endocrj.ej13-0383 · Cited by 13 · see citing works
Subamolide A Induces Mitotic Catastrophe Accompanied by Apoptosis in Human Lung Cancer Cells
Hung, J., Wen, C.-W., Hsu, Y., et al. (2013) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2013/828143 · Cited by 12 · see citing works
Thompson, M. R., Xu, D., & Williams, B. R. G. (2013) · Journal of Interferon & Cytokine Research · doi:10.1089/jir.2013.0007 · Cited by 11 · see citing works
Bottone, F. G., & Alston‐Mills, B. (2011) · Journal of Medicinal Food · doi:10.1089/jmf.2010.0110 · Cited by 9 · see citing works
Wang, Z., Yin, S., Tian, G., et al. (2016) · Open Life Sciences · doi:10.1515/biol-2016-0048 · Cited by 1 · see citing works
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Immunopathogenic mechanisms and immunoregulatory therapies in MASLD
He, Y., Chen, Y., Qian, S., van Der Merwe, S., Dhar, D., Brenner, D. A., & Tacke, F. (2025) · Cellular & Molecular Immunology · doi:10.1038/s41423-025-01307-5 · Cited by 81 · see citing works
“Activating transcription factor 3 (ATF3), a stress-induced transcription factor that binds to the cyclic AMP response element (CRE), plays a vital role in metabolic regulation and immunity [101].”
Zia, S., Hammond, B. P., Zirngibl, M., Sizov, A., Baaklini, C. S., Panda, S. P., Ho, M. F. S., Lee, K. V., Mainali, A., Burr, M. K., et al. (2022) · Molecular Neurodegeneration · doi:10.1186/s13024-022-00584-2 · Cited by 40 · see citing works
Wang, M., Lu, Y., Wang, H., Wu, Y., Xu, X., & Li, Y. (2021) · Frontiers in Oncology · doi:10.3389/fonc.2021.740120 · Cited by 36 · see citing works
Activating transcription factor 3, glucolipid metabolism, and metabolic diseases
Hu, S., Zhao, X., Li, R., Hu, C., Wu, H., Li, J., Zhang, Y., & Xu, Y. (2023) · Journal of Molecular Cell Biology · doi:10.1093/jmcb/mjac067 · Cited by 33 · see citing works
Smiljanić, K., Prodić, I., Trifunovic, S., Krstić Ristivojević, M., Aćimović, M., Stanković Jeremić, J., Lončar, B., & Tešević, V. (2023) · Antioxidants · doi:10.3390/antiox12111988 · Cited by 24 · see citing works
Shuvalov, O., Kirdeeva, Y., Fefilova, E., Daks, A., Fedorova, O., Parfenyev, S., Nazarov, A., Vlasova, Y., Krasnov, G. S., & Barlev, N. A. (2024) · Antioxidants · doi:10.3390/antiox13111349 · Cited by 9 · see citing works
- Authors
- Ku, H.-C., & Cheng, C.-F.
- Affiliations
- Taipei Tzu Chi Hospital (TW)
- Tzu Chi University (TW)
- Corresponding author
- Cheng, Ching-Feng
- Venue
- Frontiers in Endocrinology
- Publisher
- Frontiers Media SA
- Published
- 2020-08-14
- Volume
- 11
- Pages
- 556-556
- ISSN
- 1664-2392 (ISSN-L)
- PMC
- PMC7457002
- OpenAlex
- W3049724387
- Cited by
- 345
- References
- 118
- Citations by year
- 2026: 33 · 2025: 89 · 2024: 77 · 2023: 67 · 2022: 47 · 2021: 32
- FWCI
- 4.24
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Frontiers in Endocrinology (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Ministry of Science and Technology, Taiwan
- Taipei Tzu Chi Hospital
- Buddhist Tzu Chi Medical Foundation
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Endoplasmic Reticulum Stress and Disease
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics, phytochemicals, and oxidative stress
- Keywords
- ATF3, metabolic homeostasis, glucose metabolism, adipose tissue regulation, adipocyte metabolism, immunity, carcinogenesis, endoplasmic reticulum stress, cytokines, lipopolysaccharide, prostate cancer, breast cancer, colon cancer, lung cancer, liver cancer, transcriptional regulation, cancer therapy targets
- MeSH terms
- Animals, Energy Metabolism, Homeostasis, Humans, Neoplasms, Adipocytes, Activating Transcription Factor 3, Endoplasmic Reticulum Stress
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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