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Cited by 14Birth, Development, and HealthAir Quality and Health ImpactsToxic Organic Pollutants Impact

Prenatal Pollutant Exposures and Hypothalamic Development: Early Life Disruption of Metabolic Programming

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Koshko, Lisa, Scofield, Sydney, Mor, Gil, Sadagurski, Marianna·2022·Frontiers in Endocrinology
DOI 10.3389/fendo.2022.938094PMC PMC9327615
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Abstract

Environmental contaminants in ambient air pollution pose a serious risk to long-term metabolic health. Strong evidence shows that prenatal exposure to pollutants can significantly increase the risk of Type II Diabetes (T2DM) in children and all ethnicities, even without the prevalence of obesity. The central nervous system (CNS) is critical in regulating whole-body metabolism. Within the CNS, the hypothalamus lies at the intersection of the neuroendocrine and autonomic systems and is primarily responsible for the regulation of energy homeostasis and satiety signals. The hypothalamus is particularly sensitive to insults during early neurodevelopmental periods and may be susceptible to alterations in the formation of neural metabolic circuitry. Although the precise molecular mechanism is not yet defined, alterations in hypothalamic developmental circuits may represent a leading cause of impaired metabolic programming. In this review, we present the current knowledge on the links between prenatal pollutant exposure and the hypothalamic programming of metabolism.

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  • Persistent pollutants are important in developmental origins research because exposure often begins in utero, and several compounds can disrupt endocrine and metabolic regulation during critical developmental windows.

    “Persistent pollutants are important in developmental origins research because exposure often begins in utero, and several compounds can disrupt endocrine and metabolic regulation during critical developmental windows [88,89].”

    From Placental Pathophysiology and Developmental Programming of Adult Cardiometabolic Risk: A Narrative Review of Pregnancy Exposures (2026) · cites this paper as [89]

    The Mechanisms section (page unavailable) identifies several pollutants that cross the placenta and discusses developmental effects on the hypothalamus and neuroendocrine system. The Conclusion and Future Perspectives section (page unavailable) links prenatal exposure to later metabolic impairment, but says the direct effect on hypothalamic development remains unclear. The paper does not establish that exposure to persistent pollutants often begins in utero or that several specific compounds directly disrupt endocrine and metabolic regulation. (LLM, conf=0.83)

    Experimental — accuracy not yet measured

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Cited by

Sorted by citations

Authors
Koshko, L., Scofield, S., Mor, G., & Sadagurski, M.
Affiliations
Wayne State University (US)
Corresponding author
Sadagurski, Marianna
ORCID
Venue
Frontiers in Endocrinology
Publisher
Frontiers Media SA
Published
2022-07-11
Volume
13
Pages
938094-938094
ISSN
1664-2392 (ISSN-L)
DOI
10.3389/fendo.2022.938094
PMC
PMC9327615
OpenAlex
W4285013290
Cited by
14
References
9
Citations by year
2026: 2 · 2025: 6 · 2024: 4 · 2023: 2
FWCI
0.77
Type
journal article
Language
en
Open access
Licence
Locations
  • Frontiers in Endocrinology (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
  • American Diabetes Association (1-lB-IDF-063, DK020572, lB-IDF-063, P30 ES020957)
  • National Institute of General Medical Sciences (T32GM142519)
  • National Institute of Diabetes and Digestive and Kidney Diseases (P30DK020572, R01DK129681)
  • National Institute of Environmental Health Sciences (P30ES020957, ES020957, R01ES033171, P42ES030991)
Topics
  • Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Birth, Development, and Health
  • Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Air Quality and Health Impacts
  • Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Toxic Organic Pollutants Impact
Keywords
air pollution, hypothalamus, hypothalamic development, metabolic programming, type 2 diabetes, energy homeostasis, satiety signals, brain development
MeSH terms
Air Pollution, Child, Diabetes Mellitus, Type 2, Environmental Pollutants, Female, Humans, Hypothalamus, Neurosecretory Systems, Pregnancy

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