Central nervous system control of metabolism

Positional cloning of the mouse obese gene and its human homologue

Zhang, Y., Proenca, R., Maffei, M., Barone, M., Leopold, L., & Friedman, J. M. (1994) · Nature · doi:10.1038/372425a0 · Cited by 13,419 · see citing works

Targeted disruption of the melanocortin-4 receptor results in obesity in mice

Huszar, D., Lynch, C. A., Fairchild-Huntress, V., Dunmore, J. H., Fang, Q., Berkemeier, L. R., Gu, W., Kesterson, R. A., Boston, B. A., Cone, R. D., et al. (1997) · Cell · doi:10.1016/s0092-8674(00)81865-6 · Cited by 3,030 · see citing works

AMP-kinase regulates food intake by responding to hormonal and nutrient signals in the hypothalamus

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Hypothalamic mTOR Signaling Regulates Food Intake

Cota, D., Proulx, K., Smith, K. A. B., Kozma, S. C., Thomas, G., Woods, S. C., & Seeley, R. J. (2006) · Science · doi:10.1126/science.1124147 · Cited by 1,278 · see citing works

Leptin-Replacement Therapy for Lipodystrophy

Oral, E. A., Simha, V., Ruiz, E., Andewelt, A., Premkumar, A., Snell, P., Wagner, A. J., DePaoli, A. M., Reitman, M. L., Taylor, S. I., et al. (2002) · New England Journal of Medicine · doi:10.1056/nejmoa012437 · Cited by 1,247 · see citing works

Leptin Action on GABAergic Neurons Prevents Obesity and Reduces Inhibitory Tone to POMC Neurons

Vong, L., Ye, C., Yang, Z., Choi, B. J., Chua, S. C., & Lowell, B. B. (2011) · Neuron · doi:10.1016/j.neuron.2011.05.028 · Cited by 1,238 · see citing works

Stress-induced hyperglycemia

McCowen, K. C., Malhotra, A., & Bistrian, B. R. (2001) · Critical Care Clinics · doi:10.1016/s0749-0704(05)70154-8 · Cited by 1,170 · see citing works

Divergence of Melanocortin Pathways in the Control of Food Intake and Energy Expenditure

Balthasar, N., Dalgaard, L. T., Lee, C. E., Yu, J. H., Funahashi, H., Williams, T. B., Ferreira, M. A. R., Tang, V., McGovern, R. A., Kenny, C. D., et al. (2005) · Cell · doi:10.1016/j.cell.2005.08.035 · Cited by 1,122 · see citing works

Leptin reverses insulin resistance and diabetes mellitus in mice with congenital lipodystrophy

Shimomura, I., Hammer, R. E., Ikemoto, S., Brown, M. S., & Goldstein, J. L. (1999) · Nature · doi:10.1038/43448 · Cited by 1,038 · see citing works

STAT3 signalling is required for leptin regulation of energy balance but not reproduction

Bates, S. H., Stearns, W. H., Dundon, T. A., Schubert, M., Tso, A. W. K., Wang, Y., Banks, A. S., Lavery, H. J., Haq, A. K., Maratos-Flier, E., et al. (2003) · Nature · doi:10.1038/nature01388 · Cited by 1,010 · see citing works

Hypothalamic insulin signaling is required for inhibition of glucose production

Obici, S., Zhang, B. B., Karkanias, G., & Rossetti, L. (2002) · Nature Medicine · doi:10.1038/nm1202-798 · Cited by 904 · see citing works

Inactivation of the mouse melanocortin-3 receptor results in increased fat mass and reduced lean body mass

Chen, A. S., Marsh, D. J., Trumbauer, M. E., Frazier, E. G., Guan, X.-M., Yu, H., Rosenblum, C. I., Vongs, A., Feng, Y., Cao, L., et al. (2000) · Nature Genetics · doi:10.1038/79254 · Cited by 896 · see citing works

Diabetes, Obesity, and the Brain

Schwartz, M. W., & Porte, D. (2005) · Science · doi:10.1126/science.1104344 · Cited by 841 · see citing works

Leptin directly activates SF1 neurons in the VMH, and this action by leptin is required for normal body-weight homeostasis

Dhillon, H., Zigman, J. M., Ye, C., Lee, C. E., McGovern, R. A., Tang, V., Kenny, C. D., Christiansen, L. M., White, R. D., Edelstein, E. A., et al. (2006) · Neuron · doi:10.1016/j.neuron.2005.12.021 · Cited by 791 · see citing works

A Unique Metalolic Sysdrone Causes Obesity in the Melanocortin-3 Receptor-Deficient Mouse

Butler, A. A., Kesteson, R. A., Khong, K., Cullen, M. J., Pelleymounter, M. A., DeKoning, J., Baetscher, M., & Cone, R. D. (2000) · Endocrinology · doi:10.1210/endo.141.9.7791 · Cited by 703 · see citing works

Melanocortin-4 Receptors Expressed by Cholinergic Neurons Regulate Energy Balance and Glucose Homeostasis

Rossi, J., Balthasar, N., Olson, D., Scott, M., Berglund, E., Lee, C. E., Choi, M. J., Lauzon, D., Lowell, B. B., & Elmquist, J. K. (2011) · Cell Metabolism · doi:10.1016/j.cmet.2011.01.010 · Cited by 672 · see citing works

Brain IRS2 Signaling Coordinates Life Span and Nutrient Homeostasis

Taguchi, A., Wartschow, L. M., & White, M. F. (2007) · Science · doi:10.1126/science.1142179 · Cited by 523 · see citing works

The hypothalamic arcuate nucleus: A key site for mediating leptin’s effects on glucose homeostasis and locomotor activity

Coppari, R., Ichinose, M., Lee, C. E., Pullen, A. E., Kenny, C. D., McGovern, R. A., Tang, V., Liu, S. M., Ludwig, T., Chua, S. C., et al. (2005) · Cell Metabolism · doi:10.1016/j.cmet.2004.12.004 · Cited by 457 · see citing works

Hypothalamic sensing of circulating fatty acids is required for glucose homeostasis

Lam, T. K. T., Pocai, A., Gutierrez-Juarez, R., Obici, S., Bryan, J., Aguilar-Bryan, L., Schwartz, G. J., & Rossetti, L. (2005) · Nature Medicine · doi:10.1038/nm1201 · Cited by 432 · see citing works

The central melanocortin system directly controls peripheral lipid metabolism

Nogueiras, R., Wiedmer, P., Perez-Tilve, D., Veyrat-Durebex, C., Keogh, J. M., Sutton, G. M., Pfluger, P. T., Castaneda, T. R., Neschen, S., Hofmann, S. M., et al. (2007) · Journal of Clinical Investigation · doi:10.1172/jci31743 · Cited by 396 · see citing works

A brain-liver circuit regulates glucose homeostasis

Pocai, A., Obici, S., Schwartz, G. J., & Rossetti, L. (2005) · Cell Metabolism · doi:10.1016/j.cmet.2004.11.001 · Cited by 392 · see citing works

Direct Insulin and Leptin Action on Pro-opiomelanocortin Neurons Is Required for Normal Glucose Homeostasis and Fertility

Hill, J. W., Elias, C. F., Fukuda, M., Williams, K. W., Berglund, E. D., Holland, W. L., Cho, Y.-R., Chuang, J.-C., Xu, Y., Choi, M., et al. (2010) · Cell Metabolism · doi:10.1016/j.cmet.2010.03.002 · Cited by 391 · see citing works

Neuronal Glucosensing

Levin, B. E., Routh, V. H., Kang, L., Sanders, N. M., & Dunn-Meynell, A. A. (2004) · Diabetes · doi:10.2337/diabetes.53.10.2521 · Cited by 370 · see citing works

A metabolic defect promotes obesity in mice lacking melanocortin-4 receptors

Ste. Marie, L., Miura, G. I., Marsh, D. J., Yagaloff, K., & Palmiter, R. D. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.220409497 · Cited by 366 · see citing works

Direct leptin action on POMC neurons regulates glucose homeostasis and hepatic insulin sensitivity in mice

Berglund, E. D., Vianna, C. R., Donato, J., Kim, M. H., Chuang, J.-C., Lee, C. E., Lauzon, D. A., Lin, P., Brule, L. J., Scott, M. M., et al. (2012) · Journal of Clinical Investigation · doi:10.1172/jci59816 · Cited by 352 · see citing works

Leptin therapy in insulin-deficient type I diabetes

Wang, M.-Y., Chen, L., Clark, G. O., Lee, Y., Stevens, R. D., Ilkayeva, O. R., Wenner, B. R., Bain, J. R., Charron, M. J., Newgard, C. B., et al. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0909422107 · Cited by 327 · see citing works

Pomc-expressing progenitors give rise to antagonistic neuronal populations in hypothalamic feeding circuits

Padilla, S. L., Carmody, J. S., & Zeltser, L. M. (2010) · Nature Medicine · doi:10.1038/nm.2126 · Cited by 312 · see citing works

Short Term Effects of Leptin on Hepatic Gluconeogenesis and in Vivo Insulin Action

Rossetti, L., Massillon, D., Barzilai, N., Vuguin, P., Chen, W., Hawkins, M., Wu, J., & Wang, J. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.44.27758 · Cited by 304 · see citing works

The Geometry of Leptin Action in the Brain: More Complicated Than a Simple ARC

Myers, M. G., Münzberg, H., Leinninger, G. M., & Leshan, R. L. (2009) · Cell Metabolism · doi:10.1016/j.cmet.2008.12.001 · Cited by 294 · see citing works

Leptin regulates insulin sensitivity via phosphatidylinositol-3-OH kinase signaling in mediobasal hypothalamic neurons

Morton, G. J., Gelling, R. W., Niswender, K. D., Morrison, C. D., Rhodes, C. J., & Schwartz, M. W. (2005) · Cell Metabolism · doi:10.1016/j.cmet.2005.10.009 · Cited by 292 · see citing works

Brainstem Application of Melanocortin Receptor Ligands Produces Long-Lasting Effects on Feeding and Body Weight

Grill, H. J., Ginsberg, A. B., Seeley, R. J., & Kaplan, J. M. (1998) · Journal of Neuroscience · doi:10.1523/jneurosci.18-23-10128.1998 · Cited by 277 · see citing works

Mouse models of insulin resistance

Hribal, M. L., Oriente, F., & Accili, D. (2002) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00561.2001 · Cited by 251 · see citing works

High-fat feeding promotes obesity via insulin receptor/PI3K-dependent inhibition of SF-1 VMH neurons

Klöckener, T., Heß, S., Belgardt, B., Paeger, L., Verhagen, L. A. W., Husch, A., Sohn, J., Hampel, B., Dhillon, H., Zigman, J. M., et al. (2011) · Nature Neuroscience · doi:10.1038/nn.2847 · Cited by 239 · see citing works

Critical role of STAT3 in leptin's metabolic actions

Buettner, C., Pocai, A., Muse, E. D., Etgen, A. M., Myers, M. G., & Rossetti, L. (2006) · Cell Metabolism · doi:10.1016/j.cmet.2006.04.014 · Cited by 228 · see citing works

Leptin-Dependent Control of Glucose Balance and Locomotor Activity by POMC Neurons

Huo, L., Gamber, K., Greeley, S., Silva, J., Huntoon, N., Leng, X.-H., & Bjørbæk, C. (2009) · Cell Metabolism · doi:10.1016/j.cmet.2009.05.003 · Cited by 226 · see citing works

Intracerebroventricular Leptin Regulates Hepatic but Not Peripheral Glucose Fluxes

Liu, L., Karkanias, G. B., Morales, J. C., Hawkins, M., Barzilai, N., Wang, J., & Rossetti, L. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.47.31160 · Cited by 222 · see citing works

Mitochondrial uncoupling protein 2 (UCP2) in glucose and lipid metabolism

Diano, S., & Horváth, T. L. (2011) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2011.08.003 · Cited by 216 · see citing works

Role of the sympathetic nervous system and insulin in enhancing glucose uptake in peripheral tissues after intrahypothalamic injection of leptin in rats

Haque, M. S., Minokoshi, Y., Hamai, M., Iwai, M., Horiuchi, M., & Shimazu, T. (1999) · Diabetes · doi:10.2337/diabetes.48.9.1706 · Cited by 215 · see citing works

Selective Loss of Leptin Receptors in the Ventromedial Hypothalamic Nucleus Results in Increased Adiposity and a Metabolic Syndrome

Bingham, N. C., Anderson, K. K., Reuter, A. L., Stallings, N. R., & Parker, K. L. (2008) · Endocrinology · doi:10.1210/en.2007-1200 · Cited by 213 · see citing works

The melanocortin system and energy balance

Butler, A. A. (2006) · Peptides · doi:10.1016/j.peptides.2005.02.029 · Cited by 196 · see citing works

Distributed Neural Control of Energy Balance: Contributions from Hindbrain and Hypothalamus

Grill, H. J. (2006) · Obesity · doi:10.1038/oby.2006.312 · Cited by 192 · see citing works

The Role of the Dorsal Vagal Complex and the Vagus Nerve in Feeding Effects of Melanocortin-3/4 Receptor Stimulation

Williams, D. L., Kaplan, J. M., & Grill, H. J. (2000) · Endocrinology · doi:10.1210/endo.141.4.7410 · Cited by 182 · see citing works

Glucokinase Is a Critical Regulator of Ventromedial Hypothalamic Neuronal Glucosensing

Kang, L., Dunn-Meynell, A. A., Routh, V. H., Gaspers, L. D., Nagata, Y., Nishimura, T., Eiki, J., Zhang, B. B., & Levin, B. E. (2006) · Diabetes · doi:10.2337/diabetes.55.02.06.db05-1229 · Cited by 181 · see citing works

Central actions of adipocyte hormones

Ahima, R. S. (2005) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2005.07.010 · Cited by 160 · see citing works

Leptin Deficiency Causes Insulin Resistance Induced by Uncontrolled Diabetes

German, J. P., Wisse, B. E., Thaler, J. P., Oh-I, S., Sarruf, D. A., Ogimoto, K., Kaiyala, K. J., Fischer, J. D., Matsen, M. E., Taborsky, G. J., et al. (2010) · Diabetes · doi:10.2337/db09-1918 · Cited by 159 · see citing works

Arcuate Nucleus-Specific Leptin Receptor Gene Therapy Attenuates the Obesity Phenotype of Koletsky (fak/fak) Rats

Morton, G. J., Niswender, K. D., Rhodes, C. J., Myers, M. G., Blevins, J. E., Baskin, D. G., & Schwartz, M. W. (2003) · Endocrinology · doi:10.1210/en.2002-0115 · Cited by 158 · see citing works

Central Leptin Acutely Reverses Diet-Induced Hepatic Insulin Resistance

Pocai, A., Morgan, K., Buettner, C., Gutierrez-Juarez, R., Obici, S., & Rossetti, L. (2005) · Diabetes · doi:10.2337/diabetes.54.11.3182 · Cited by 153 · see citing works

Divergent Regulation of Energy Expenditure and Hepatic Glucose Production by Insulin Receptor in Agouti-Related Protein and POMC Neurons

Lin, H. V., Plum, L., Ono, H., Juárez, R. G., Shanabrough, M., Borók, E., Horváth, T. L., Rossetti, L., & Accili, D. (2009) · Diabetes · doi:10.2337/db09-1303 · Cited by 152 · see citing works

Metabolic Sensing and the Brain: Who, What, Where, and How?

Levin, B. E., Magnan, C., Dunn-Meynell, A. A., & Foll, C. L. (2011) · Endocrinology · doi:10.1210/en.2011-0194 · Cited by 146 · see citing works

Central Nervous System Regulation of Food Intake

Schwartz, M. W. (2006) · Obesity · doi:10.1038/oby.2006.275 · Cited by 146 · see citing works

Diet-Genotype Interactions in the Development of the Obese, Insulin-Resistant Phenotype of C57BL/6J Mice Lacking Melanocortin-3 or -4 Receptors

Sutton, G. M., Trevaskis, J. L., Hulver, M. W., McMillan, R. P., Markward, N., Babin, M. J., Meyer, E. A., & Butler, A. A. (2006) · Endocrinology · doi:10.1210/en.2005-1209 · Cited by 139 · see citing works

FOXO1 in the ventromedial hypothalamus regulates energy balance

Kim, K. W., Donato, J., Berglund, E. D., Choi, Y., Kohno, D., Elias, C. F., DePinho, R. A., & Elmquist, J. K. (2012) · Journal of Clinical Investigation · doi:10.1172/jci62848 · Cited by 137 · see citing works

Central nervous control of energy and glucose balance: focus on the central melanocortin system

Xu, Y., Elmquist, J. K., & Fukuda, M. (2011) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2011.06248.x · Cited by 133 · see citing works

Metabolic Status Regulates Ghrelin Function on Energy Homeostasis

Briggs, D. I., & Andrews, Z. B. (2010) · Neuroendocrinology · doi:10.1159/000322589 · Cited by 123 · see citing works

Melanocortin-independent Effects of Leptin on Hepatic Glucose Fluxes

Gutiérrez-Juárez, R., Obici, S., & Rossetti, L. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m408665200 · Cited by 115 · see citing works

Hyperphagia and Weight Gain after Gold-Thioglucose: Relation to Hypothalamic Neuropeptide Y and Proopiomelanocortin**This work was supported by grants from the Children’s Hospital Research Foundation (to H.T.B.) and the NIH (DK-50110; to C.V.M.).

Bergen, H., Mizuno, T. M., Taylor, J., & Mobbs, C. V. (1998) · Endocrinology · doi:10.1210/endo.139.11.6324 · Cited by 114 · see citing works

Melanocortin signaling in the CNS directly regulates circulating cholesterol

Pérez–Tilve, D., Hofmann, S. M., Basford, J. E., Nogueiras, R., Pfluger, P. T., Patterson, J. T., Grant, E., Wilson, H., Granholm, N. A., Arnold, M., et al. (2010) · Nature Neuroscience · doi:10.1038/nn.2569 · Cited by 103 · see citing works

Modulation of the central melanocortin system by leptin, insulin, and serotonin: Co-ordinated actions in a dispersed neuronal network

Williams, K. W., Scott, M. M., & Elmquist, J. K. (2011) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2010.11.042 · Cited by 95 · see citing works

Acute psychological stress affects glucose concentrations in patients with type 1 diabetes following food intake but not in the fasting state

Wiesli, P., Schmid, C., Kerwer, O., Nigg-Koch, C., Klaghofer, R., Seifert, B., Spinas, G. A., & Schwegler, K. (2005) · Diabetes Care · doi:10.2337/diacare.28.8.1910 · Cited by 88 · see citing works

Phosphatidyl Inositol 3-Kinase Signaling in Hypothalamic Proopiomelanocortin Neurons Contributes to the Regulation of Glucose Homeostasis

Hill, J. W., Xu, Y., Preitner, F., Fukuda, M., Cho, Y.-R., Luo, J., Balthasar, N., Coppari, R., Cantley, L. C., Kahn, B. B., et al. (2009) · Endocrinology · doi:10.1210/en.2009-0454 · Cited by 88 · see citing works

Minireview: The Value of Looking Backward: The Essential Role of the Hindbrain in Counterregulatory Responses to Glucose Deficit

Ritter, S., Li, A., Wang, Q., & Dinh, T. T. (2011) · Endocrinology · doi:10.1210/en.2010-1458 · Cited by 81 · see citing works

ATP-Sensitive K+ Channels Regulate the Release of GABA in the Ventromedial Hypothalamus During Hypoglycemia

Chan, O. T. M., Lawson, M. A., Zhu, W., Beverly, J. L., & Sherwin, R. S. (2007) · Diabetes · doi:10.2337/db06-1102 · Cited by 77 · see citing works

CNS-targets in control of energy and glucose homeostasis

Kleinridders, A., Könner, A. C., & Brüning, J. C. (2009) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2009.10.006 · Cited by 72 · see citing works

Melanocortin activity in the amygdala controls appetite for dietary fat

Boghossian, S., Park, M., & York, D. A. (2009) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00591.2009 · Cited by 66 · see citing works

IRS2 Signaling in LepR-b Neurons Suppresses FoxO1 to Control Energy Balance Independently of Leptin Action

Sadagurski, M., Leshan, R. L., Patterson, C. M., Rozzo, A., Kuznetsova, A., Skorupski, J. C., Jones, J. C., DePinho, R. A., Myers, M. G., & White, M. F. (2012) · Cell Metabolism · doi:10.1016/j.cmet.2012.04.011 · Cited by 64 · see citing works

Tyrosine-dependent and -independent actions of leptin receptor in control of energy balance and glucose homeostasis

Jiang, L., You, J., Yu, X., Gonzalez, L., Yu, Y., Wang, Q. A., Yang, G., Li, W., Cai, L., & Liu, Y. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0804589105 · Cited by 62 · see citing works

Leptin action via LepR-b Tyr1077 contributes to the control of energy balance and female reproduction

Patterson, C. M., Villanueva, E. C., Greenwald-Yarnell, M. L., Rajala, M. W., Gonzalez, I. E., Saini, N., Jones, J. C., & Myers, M. G. (2012) · Molecular Metabolism · doi:10.1016/j.molmet.2012.05.001 · Cited by 60 · see citing works

Metabolic state signalling through central hypocretin/orexin neurons

Burdakov, D., & Alexopoulos, H. (2005) · Journal of Cellular and Molecular Medicine · doi:10.1111/j.1582-4934.2005.tb00380.x · Cited by 57 · see citing works

Melanocortin‐3 receptors are involved in adaptation to restricted feeding

Begriche, K., Marston, O. J., Rossi, J., Burke, L. K., McDonald, P. H., Heisler, L. K., & Butler, A. A. (2012) · Genes Brain & Behavior · doi:10.1111/j.1601-183x.2012.00766.x · Cited by 57 · see citing works

The role of hepatic insulin receptors in the regulation of glucose production

Cherrington, A. D. (2005) · Journal of Clinical Investigation · doi:10.1172/jci25152 · Cited by 57 · see citing works

The ghrelin O-acyltransferase–ghrelin system: a novel regulator of glucose metabolism

Heppner, K. M., Tong, J., Kirchner, H., Nass, R. M., & Tschöp, M. H. (2011) · Current Opinion in Endocrinology Diabetes and Obesity · doi:10.1097/med.0b013e328341e1d3 · Cited by 47 · see citing works

The role of hepatic insulin receptors in the regulation of glucose production

Cherrington, A. D. (2005) · Journal of Clinical Investigation · doi:10.1172/jci200525152 · Cited by 47 · see citing works

Intracerebroventricular leptin regulates hepatic cholesterol metabolism

VanPatten, S., Karkanias, G. B., Rossetti, L., & Cohen, D. E. (2004) · Biochemical Journal · doi:10.1042/bj20040134 · Cited by 44 · see citing works

New ways in which GLP-1 can regulate glucose homeostasis

D’Alessio, D. A. (2005) · Journal of Clinical Investigation · doi:10.1172/jci27207 · Cited by 42 · see citing works

Central melanocortin stimulation increases phosphorylated perilipin A and hormone-sensitive lipase in adipose tissues

Shrestha, Y. B., Vaughan, C. H., Smith, B. J., Song, C. K., Baro, D. J., & Bartness, T. J. (2010) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00535.2009 · Cited by 38 · see citing works

Islets Have a Lot of Nerve! Or Do They?

Taborsky, G. (2011) · Cell Metabolism · doi:10.1016/j.cmet.2011.06.004 · Cited by 36 · see citing works

Melanocortin receptor-mediated effects on obesity are distributed over specific hypothalamic regions

de Backer, M. W. A., la Fleur, S. E., Brans, M. A. D., van Rozen, A. J., Luijendijk, M. C. M., Merkestein, M., Garner, K. M., van der Zwaal, E. M., & Adan, R. A. H. (2010) · International Journal of Obesity · doi:10.1038/ijo.2010.169 · Cited by 33 · see citing works

Neuronal Glucose Sensing: Still a Physiological Orphan?

Levin, B. E. (2007) · Cell Metabolism · doi:10.1016/j.cmet.2007.09.005 · Cited by 31 · see citing works

Insufficiency of Janus Kinase 2–Autonomous Leptin Receptor Signals for Most Physiologic Leptin Actions

Robertson, S., Ishida-Takahashi, R., Tawara, I., Hu, J., Patterson, C. M., Jones, J. C., Kulkarni, R. N., & Myers, M. G. (2010) · Diabetes · doi:10.2337/db09-1556 · Cited by 30 · see citing works

Peripheral glucose homeostasis: does brain insulin matter?

Levin, B. E., & Sherwin, R. S. (2011) · Journal of Clinical Investigation · doi:10.1172/jci59653 · Cited by 22 · see citing works

Rate of fall in blood glucose and recurrent hypoglycemia affect glucose dynamics and noradrenergic activation in the ventromedial hypothalamus

Barnes, M. B., Lawson, M. A., & Beverly, J. L. (2011) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00171.2011 · Cited by 22 · see citing works

Geometry of rubrospinal, rubroolivary, and local circuit neurons in the macaque red nucleus

Burman, K. J., Darian‐Smith, C., & Darian-Smith, I. (2000) · The Journal of Comparative Neurology · doi:10.1002/1096-9861(20000724)423:2 · Cited by 16 · see citing works

Did a muscle fuel gauge conquer the brain?

Pocai, A., Muse, E. D., & Rossetti, L. (2006) · Nature Medicine · doi:10.1038/nm0106-50 · Cited by 9 · see citing works

Blood glucose and the brain in diabetes: Between a rock and a hard place?

Evans, M. L., & Sherwin, R. S. (2002) · Current Diabetes Reports · doi:10.1007/s11892-002-0065-7 · Cited by 5 · see citing works

Adipose tissue inflammation and metabolic dysfunction in obesity

Kawai, T., Autieri, M. V., & Scalia, R. (2021) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00379.2020 · Cited by 1,947 · see citing works

The PI3K/AKT Pathway in Obesity and Type 2 Diabetes

Huang, X., Liu, G., Guo, J., & Su, Z. (2018) · International Journal of Biological Sciences · doi:10.7150/ijbs.27173 · Cited by 1,673 · see citing works

Non-Homeostatic Body Weight Regulation Through a Brainstem-Restricted Receptor for GDF15

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