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New insights into FAK function and regulation during spermatogenesis.

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PACAP ameliorates fertility in obese male mice via PKA/CREB pathway‐dependent Sirt1 activation and p53 deacetylation

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Protection of apigenin against acrylonitrile-induced sperm and testis injury in rats: involvement of activation of ASK1-JNK/p38 signaling pathway

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Study on PREP localization in mouse seminal vesicles and its possible involvement during regulated exocytosis

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Mild Exercise Rescues Steroidogenesis and Spermatogenesis in Rats Submitted to Food Withdrawal

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Preliminary Investigation on the Ameliorative Role Exerted by D-Aspartic Acid in Counteracting Ethane Dimethane Sulfonate (EDS) Toxicity in the Rat Testis

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Coenzyme Q 10 alleviates testicular endocrine and spermatogenic dysfunction induced by high‐fat diet in male Wistar rats: Role of adipokines, oxidative stress and MAPK / ERK / JNK pathway

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PCP Protein Inversin Regulates Testis Function Through Changes in Cytoskeletal Organization of Actin and Microtubules

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Aucubin supplementation alleviate diabetes induced-disruption of blood-testis barrier and testicular damage via stabilizing cell junction integrity

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Dietary high‐fructose reduces barrier proteins and activates mitogenic signalling in the testis of a rat model: Regulatory effects of kefir supplementation

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Autophagy and mitochondrial damage in the testis of high-fat diet fed rats

Latino, D., Baccari, G. C., Fiore, M. M. D., Cioffi, F., Venditti, M., Giacco, A., & Santillo, A. (2022) · General and Comparative Endocrinology · doi:10.1016/j.ygcen.2022.114104 · Cited by 17 · see citing works

Role of estrogen receptors, P450 aromatase, PCNA and p53 in high-fat-induced impairment of spermatogenesis in rats

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The ameliorative effect of atorvastatin on serum testosterone and testicular oxidant/antioxidant system of HFD-fed male albino rats

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Bee bread mitigates downregulation of steroidogenic genes, decreased spermatogenesis, and epididymal oxidative stress in male rats fed with high-fat diet

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PACAP ameliorates the fertility of obese mice through PAC1/PKA/ERK/Nrf2 signal axis

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Expression of obesity-related genes in human spermatozoa affects the outcomes of reproductive treatments

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Aging and oxidative stress alter DNA repair mechanisms in male germ cells of superoxide dismutase-1 null mice

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Differential Expression and Localization of EHBP1L1 during the First Wave of Rat Spermatogenesis Suggest Its Involvement in Acrosome Biogenesis

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Effect of Paternal Body Mass Index on In Vitro Fertilization and Neonatal Outcomes among Oligozoospermia and Asthenospermia Patients

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Unacylated ghrelin stimulates steroidogenesis in lean rats and reverses reproductive dysfunction in high fat diet-fed rats

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Correlation of Obesity and Serum Vitamin D Levels with Sperm DNA Integrity, Sperm Quality, and Sperm Viability in Normozoospermia Men

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Effects of a high‐fat diet on rat epididymis

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A healthy diet, physical activity, or either in relation to cardiovascular and all-cause mortality: A prospective cohort study

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Liquid chromatography-tandem mass spectrometry reveals an active response to DNA damage in human spermatozoa

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Type 1 diabetes impairs the activity of rat testicular somatic and germ cells through NRF2/NLRP3 pathway-mediated oxidative stress

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Immune Microenvironment Dysregulation: A Contributing Factor to Obesity-Associated Male Infertility

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Protective effects of atorvastatin on testicular dysfunction and reduced sperm quality induced by high-fat diet in mice: The inhibitory mechanism of oxidative stress

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GLP-1 receptor agonists show no detrimental effect on sperm quality in mouse models and cell lines

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Obesity in reproduction: Mechanisms from fertilization to post‑uterine development (Review)

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Mechanisms of Traditional Chinese Medicine in regulating Nrf2-related signaling pathways for the treatment of Oligoasthenozoospermia: A review

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Dexamethasone regulates the SIRT1/NF-κB signaling pathway in neonatal rats with bronchopulmonary dysplasia to counteract NLRP3-inflammasome-induced pyroptosis and oxidative stress

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Er-Chen decoction alleviates spermatogenic dysfunction in obese mice by tuning the SIRT1/p53 axis

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Restoring NAD + -Sirtuins Signaling: A Novel Approach to Combat Male Reproductive Aging

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Unraveling the impact of semaglutide in a diabetic rat model of testicular dysfunction: Insights into spermatogenesis pathways and miRNA-148a-5p

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Effect of lycium barbarum polysaccharide on ameliorating high-fat diet-damaged spermatogenesis via PCSK9 and TLR4 signaling pathways in obese mice

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Mitochondrial quality control disorder: a potential mechanism of male infertility

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Clove-Chitosan Nanoparticles Alleviate Fertility Impairment and Reproductive Dysfunction in Obese Male Rat Model

Ahmed, S. Y., Mohamed, A. S., Dakrory, A. I., & Abdelaziz, M. H. (2026) · Reproductive Sciences · doi:10.1007/s43032-026-02076-w · Cited by 2 · see citing works

Obesity Triggers Dysregulation of Essential ABC Transporters in Rat Testis and Sperm

Szatmári, P., Kemény, K. K., Seres, A. B., & Ducza, E. (2026) · Nutrients · doi:10.3390/nu18111829 · Cited by 2 · see citing works

Gadolinium induces Sertoli cell damage: cellular and molecular mechanisms

Falvo, S., Grillo, G., Baccari, G. C., Petito, G., Venditti, M., Fiore, M. M. D., Cappello, T., Maisano, M. S., & Santillo, A. (2026) · Reproductive Toxicology · doi:10.1016/j.reprotox.2026.109301 · Cited by 2 · see citing works

Ginseng Soluble Dietary Fiber Enhances Spermatogenic Potential in Obese Mice via the MAPK Signaling Pathway

Zhang, Y., Yu, Y., Bai, C., Li, Z., Huo, X., Li, W., Sun, Y., & Sha, J. (2024) · Journal of Food Biochemistry · doi:10.1155/2024/6235198 · Cited by 2 · see citing works

Negative effects of sucrose ingestion in testis weight and epididymal fat of adult Wistar rats

da Silva, T. M. M. F., dos Santos, L. R., de Araújo, V. M. M., Silva, L. D., Lima, L. F. L., Rodrigues, V. S., & de Barros, C. A. V. (2025) · Research Society and Development · doi:10.33448/rsd-v14i10.49830 · Cited by 1 · see citing works

Dietary β-sitosterol alleviates reproductive toxicity induced by combined exposure of low-dose deoxynivalenol and high-fat diet in male C57BL/6J mice

Zhang, Y. E. L., Zhou, Y., Lin, Y., Ren, Y., Cao, W., Han, J., Fei, D., Wang, G., Li, F., Wu, S., et al. (2026) · Food & Function · doi:10.1039/d5fo05222j · Cited by 1 · see citing works

ALKBH5 facilitates Srgn stability via m6A demethylation to disrupt blood-testis barrier integrity in the high-fat diet mice

Du, T., Yao, L., Wang, W., Li, Z., Dong, J., Zhou, Z., Shi, C., Ge, X., Ma, R., Chen, L., et al. (2026) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-026-06189-y · Cited by 1 · see citing works

Ameliorative Effect of Policosanol on High‐Fat Diet‐Induced Testicular Dysfunction: Implications of ROS/SIRT1 and Apoptotic Signaling Pathways in Rats

Elseweidy, M. M., Elgammal, N. S., Kilany, M. S., El‐Aziz, R. M. A., & Elnagar, G. M. (2026) · Chemistry & Biodiversity · doi:10.1002/cbdv.71345 · Cited by 1 · see citing works

Human-relevant co-exposure to 6:2 Cl-PFESA and PFHxS impairs sperm motility and blood-testis barrier integrity in male mice: Evaluation of combined effects

Shi, L., Gao, T., Zhu, Z., Yang, F., Han, B., Lv, J., Tao, L., Gao, Y., Hua, R., Wu, H., et al. (2026) · Journal of Hazardous Materials · doi:10.1016/j.jhazmat.2026.143035 · Cited by 1 · see citing works

Prevention of Diet-Induced Obesity by Phytoecdysteroids 20-Hydroxyecdysone and Calonysterone—Unexpected Modulation of Androgen Balance in Normal and Obese Rats

Osman, A. A., Laczkó, D., Vágvölgyi, M., Tóth, N., Kemény, K. K., Szatmári, P., Seres-Bokor, A., Hunyadi, A., & Ducza, E. (2026) · Nutrients · doi:10.3390/nu18122023

Postnatal high-fat diet consumption by male rat offspring of obese mothers accentuates negative outcomes of reproductive function in young adults

Rodríguez-González, G. L., Méndez-Sánchez, D., Chirinos, M., Reyes‐Castro, L. A., Ibáñez, C. A., Lomas‐Soria, C., Hernández‐Silva, G., Santos, S. D. L., Canto, P., & Zambrano, E. (2025) · Biology of Reproduction · doi:10.1093/biolre/ioaf261

Vitamin D co-administration mitigates testicular and sperm dysfunction in high fat diet- induced obese mouse model

Tan, N. A. S., Giribabu, N., & Salleh, N. (2025) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2025.106910

Dialogue between nutrition and reproduction: preliminary exploration of sperm quality response to high-fat diet in mice

Jiang, Y., & Zhang, W. (2026) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2025.1640714

Experimental and molecular docking evidence for the protective role of Monascus purpureus red pigments against hydroxyapatite nanoparticle-induced testicular injury in male rats

Sadek, D., Yousef, M. I., El‐Tabakh, M. A. M., Hussein, A., Kamel, M. A. E.-N., & Wakil, A. E. (2026) · Scientific Reports · doi:10.1038/s41598-026-44061-y

Advances in immunological research on male infertility

Liu, Z., Yang, X., Ji, Y., Wang, S., & Wang, J. (2026) · Frontiers in Reproductive Health · doi:10.3389/frph.2026.1752758

Testicular degeneration and impaired epididymal spermatozoal quality in overweight and obese domestic cats

Mutluay, D., Akı, R. H., Yakut, S., Mart, F. N., Ayozger, L. E. O., Güngör, Ş., & TENEKECİ, G. Y. (2026) · Research in Veterinary Science · doi:10.1016/j.rvsc.2026.106328

Actin Cytoskeleton Dysregulation Links Testicular and Sperm Dysfunction in Type 1 Diabetes

Ambruosi, M. R., Biasi, A., Boccella, S., Romdhani, I., Falvo, S., Guida, F., Maione, S., Minucci, S., & Venditti, M. (2026) · International Journal of Molecular Sciences · doi:10.3390/ijms27167423

Glycerol supplementation attenuates testicular inflammation and miRNA dysregulation in obese rats

Nomanzadeh, A., Barazesh, F., Faramarzi, H., & Sadaghiani, Z. G. (2026) · Reproductive Toxicology · doi:10.1016/j.reprotox.2026.109380

Obesity impairs male fertility through long-term effects on spermatogenesis

Jia, Y.-F., Feng, Q., Ge, Z., Guo, Y., Zhou, F., Zhang, K., Wang, X., Lu, W.-H., Liang, X., & Gu, Y. (2018) · BMC Urology · doi:10.1186/s12894-018-0360-5 · Cited by 96 · see citing works

Testicular germ cell apoptosis and sperm defects in mice upon long‐term high fat diet feeding

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Restoring Impaired Fertility Through Diet: Observations of Switching From High-Fat Diet During Puberty to Normal Diet in Adulthood Among Obese Male Mice

Qi, X., Zhang, M., Sun, M., Luo, D., Guan, Q., & Yu, C. (2022) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.839034 · Cited by 10 · see citing works

Switching from high-fat diet to normal diet ameliorate BTB integrity and improve fertility potential in obese male mice

Zhang, W., Tian, Z., Qi, X., Chen, P., Yang, Q., Guan, Q., Ye, J., & Yu, C. (2023) · Scientific Reports · doi:10.1038/s41598-023-41291-2 · Cited by 31 · see citing works

Effects of Diet-Induced Obesity and Exercise Intervention on Testicular Germ Cell Health: Modulation of SIRT1/FoxO1 and SIRT1/PGC-1α Signaling Axes

Basu, S., Das, S., & Mukherjee, S. (2026) · Cell Biochemistry and Biophysics · doi:10.1007/s12013-026-02076-2 · Cited by 1 · see citing works