The DOI matches its Crossref record; 14 of the 14 references it cites were found in a registry or an index.
Circular RNA (circRNA) in Alzheimer’s disease (AD)
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GENERAL COMMENTARY article Front. Genet., 31 December 2013 | https://doi.org/10.3389/fgene.2013.00307
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“In addition, dysregulation of ciRS-7 has been found in zebrafish with an impaired midbrain [71] and in the hippocampus of AD patients [45].”
From Circular RNAs in depression: Biogenesis, function, expression, and therapeutic potential (2021) · cites this paper as [45]
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Circular RNAs are a large class of animal RNAs with regulatory potency
Memczak, S., Jens, M., Elefsinioti, A., Torti, F., Krueger, J., Rybak, A., Maier, L., Mackowiak, S. D., Gregersen, L. H., Munschauer, M., et al. (2013) · Nature · doi:10.1038/nature11928 · Cited by 7,990 · cited 1×
“Intrinsically resistant to exonucleolytic RNA decay, circRNAs appear to be enriched in mammalian brain tissues (Hansen et al., 2013; Memczak et al., 2013).”
BackgroundNatural RNA circles function as efficient microRNA sponges
Hansen, T. B., Jensen, T. I., Clausen, B. H., Bramsen, J. B., Finsen, B., Damgaard, C. K., & Kjems, J. (2013) · Nature · doi:10.1038/nature11993 · Cited by 7,985
Salzman, J., Gawad, C., Wang, P. L., Lacayo, N., & Brown, P. O. (2012) · PLoS ONE · doi:10.1371/journal.pone.0030733 · Cited by 2,239 · cited 1×
“Recently characterized, traditional methods of RNA detection and analysis requiring a free 5′ or 3′ ribonucleotide terminus may have significantly underestimated circRNA abundance and significance in eukaryotic cells (Salzman et al., 2012; Wilusz and Sharp, 2013; unpublished observations).”
Cogswell, J. P., Ward, J., Taylor, I. A., Waters, M., Shi, Y., Cannon, B., Kelnar, K., Kemppainen, J., Brown, D., Chen, C., et al. (2008) · Journal of Alzheimer s Disease · doi:10.3233/jad-2008-14103 · Cited by 943 · cited 1×
“…or AD groups (p > 0.05, ANOVA); a dashed horizontal line at 1.0 indicates homeostatic (control) ciRS-7 levels for ease of comparison; ∗p < 0.001 (ANOVA). contribute to the down-regulation of selective miRNA-7-sensitive messenger RNA (mRNA) targets (Cogswell et al., 2008; unpublished observations).”
BackgroundInfluentialA Circuitous Route to Noncoding RNA
Wilusz, J. E., & Sharp, P. A. (2013) · Science · doi:10.1126/science.1238522 · Cited by 531 · cited 1×
“Recently characterized, traditional methods of RNA detection and analysis requiring a free 5′ or 3′ ribonucleotide terminus may have significantly underestimated circRNA abundance and significance in eukaryotic cells (Salzman et al., 2012; Wilusz and Sharp, 2013; unpublished observations).”
Colangelo, V., Schurr, J., Ball, M. J., Pelaez, R. P., Bazan, N. G., & Lukiw, W. J. (2002) · Journal of Neuroscience Research · doi:10.1002/jnr.10351 · Cited by 517
A Gene Expression Profile of Alzheimer's Disease
Loring, J. F., Wen, X., Lee, J. M., Seilhamer, J. J., & Somogyi, R. (2001) · DNA and Cell Biology · doi:10.1089/10445490152717541 · Cited by 300 · cited 2×
“…systems” and ambient up-regulation of specific inducible miRNAs may help explain the widely observed, generalized and progressive down-regulation of gene expression that is characteristic of the sporadic AD brain (Loring et al., 2001; Colangelo et al., 2002; Ginsberg et al., 2012; Lukiw, 2013).”
BackgroundInfluentialDeconstruction for Reconstruction: The Role of Proteolysis in Neural Plasticity and Disease
Bingol, B., & Sheng, M. (2011) · Neuron · doi:10.1016/j.neuron.2010.11.006 · Cited by 275
Lukiw, W. J., Handley, P., Wong, L. J., & McLachlan, D. R. C. (1992) · Neurochemical Research · doi:10.1007/bf00968788 · Cited by 125 · cited 2×
“, 2013); detection was performed using a nonisotopic BrightStar BioDetect Kit (Ambion, Austin, TX; detection limit ∼100 fg) or by standard autoradiography (Lukiw et al., 1992); (B) AD ciRS-7 is significantly reduced to about 0.”
MethodInfluentialMicroRNA in schizophrenia: Genetic and expression analysis of miR-130b (22q11)
Burmistrova, O., Goltsov, A. Y., Abramova, L. I., Каледа, В. Г., Александровна, О. В., & Rogaev, E. I. (2007) · Biochemistry (Moscow) · doi:10.1134/s0006297907050161 · Cited by 101 · cited 1×
“…but are also associated with a circRNA for miRNA-7 (ciRS-7), in the same tissues; ciRS-7 contains multiple, tandem anti-miRNA-7 sequences (Burmistrova et al., 2007; Hansen et al., 2013; Lukiw et al., 2013). ciRS-7 thereby acts as a kind of endogenous, competing, anti-complementary miRNA…”
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Diao, W., Wang, Y., Zhang, J., Shao, H., Huang, Y., & Jin, M. (2020) · doi:10.21203/rs.3.rs-90417/v1
Song, M., Chen, M., Huang, K., Zhong, D., Chen, Y., Fu, J., Jiang, M., Liu, Q., Shi, D., & Li, H. (2020) · doi:10.21203/rs.3.rs-23175/v1
“In addition, in mammalian brains and cancer cells, circRNA expression is often abnormally expressed, and some circRNAs have been reported to be associated with human neurodegenerative diseases and cancer progression (Lukiw, 2013; Agnieszka et al., 2015; M and Jeroen, 2017).”
Background(2018) · Elsevier eBooks · doi:10.1016/b978-0-12-814365-0.00024-5
Identificación de circRNAs como biomarcadores epigenéticos candidatos en la enfermedad de Alzheimer
Urdánoz‐Casado, A. (2022) · Academica-e (Universidad Pública de Navarra) · doi:10.48035/tesis/2454/43427
Epigenetics of Brain Disorders
Jawaid, A., Kremer, E. A., Carullo, N. V. N., & Mansuy, I. M. (2022) · Elsevier eBooks · doi:10.1016/b978-0-323-91909-8.00025-6
The CircRNAs for Diagnostic, Prognostic, and Therapy in Alzheimer’s Disease
Cabrera-Reyes, E. A., Jiménez-Acosta, M. A., Padilla-Cristerna, M. L., & Meraz‐Ríos, M. A. (2022) · Advances in Bioscience and Biotechnology · doi:10.4236/abb.2022.1312035
A Summary of Circular RNAs in Alzheimer's Disease
Xiao, R., Wu, H., & Chen, K. (2021) · Journal of Neurological Research And Therapy · doi:10.14302/issn.2470-5020.jnrt-20-3619
CircRNA-disease inference using deep ensemble model based on triple association
Fu, L., Du, H., Wang, Y., & Peng, Q. (2022) · China Automation Congress (CAC) · doi:10.1109/cac57257.2022.10055518
Chen, R., Wu, W., & Qiu, Y.-K. (2023) · PubMed Central · doi:10.12122/j.issn.1673-4254.2023.05.10
Additional file 3 of Knockout of circRNAs by base editing back-splice sites of circularized exons
Gao, X., Ma, X.-K., Li, X., Li, G., Liu, C., Zhang, J., Wang, Y., Wei, J., Chen, J., Chen, L., et al. (2022) · Figshare · doi:10.6084/m9.figshare.18132711
Additional file 2 of Knockout of circRNAs by base editing back-splice sites of circularized exons
Gao, X., Ma, X.-K., Li, X., Li, G., Liu, C., Zhang, J., Wang, Y., Wei, J., Chen, J., Chen, L., et al. (2022) · Figshare · doi:10.6084/m9.figshare.18132708
Circular RNAs in Heart Diseases
Yang, T., Spanos, M., Wan, W., & Xiao, J. (2025) · Advances in experimental medicine and biology · doi:10.1007/978-981-96-9428-0_17 · Cited by 1
Tang, G., Li, J., Yao, D., Zhan, X., & Li, X. (2025) · Current Bioinformatics · doi:10.2174/0115748936393849250830080429
Wang, A., & Chen, P. (2024) · Figshare · doi:10.6084/m9.figshare.26755765
Wang, A., & Chen, P. (2024) · Figshare · doi:10.6084/m9.figshare.26755780
Wang, A., & Chen, P. (2024) · Figshare · doi:10.6084/m9.figshare.26755783
Wang, A., & Chen, P. (2024) · Figshare · doi:10.6084/m9.figshare.26410004
Additional file 4 of Knockout of circRNAs by base editing back-splice sites of circularized exons
Gao, X., Ma, X.-K., Li, X., Li, G.-W., Liu, C.-X., Zhang, J., Wang, Y., Wei, J., Chen, J., Chen, L.-L., et al. (2022) · Figshare · doi:10.6084/m9.figshare.18132714
Additional file 1 of Knockout of circRNAs by base editing back-splice sites of circularized exons
Gao, X., Ma, X.-K., Li, X., Li, G.-W., Liu, C.-X., Zhang, J., Wang, Y., Wei, J., Chen, J., Chen, L.-L., et al. (2022) · Figshare · doi:10.6084/m9.figshare.18132705
Wang, A., & Chen, P. (2024) · Figshare · doi:10.6084/m9.figshare.26755771
Wang, A., & Chen, P. (2024) · Figshare · doi:10.6084/m9.figshare.26409880
Wang, A., & Chen, P. (2024) · Figshare · doi:10.6084/m9.figshare.26755768
Wang, A., & Chen, P. (2024) · Figshare · doi:10.6084/m9.figshare.26755774
Epigenetic Changes in Alzheimer’s Disease and Interventions for Therapy
Xu, M., Xiong, L., Qin, Z., Yu, X., Chen, T., Zhang, X., Jin, M., Wang, L., Cai, L., Wei, Y., et al. (2026) · Neuropsychiatric Disease and Treatment · doi:10.2147/ndt.s576404 · Cited by 1
“130 This is due mainly to the challenges associated with the molecular tools required for detecting, quantifying, and evaluating the functions of circular RNAs in physiological processes and diseases.”
Koley, R., De, S., Ghosh, A., Bhattacharjee, D., Mitra, A., Mondal, B., Pahari, A., Nandi, M., Kanri, R., Dasgupta, S., et al. (2026) · In vitro models · doi:10.1007/s44164-026-00111-3
Su, Y., Ren, H., Huang, S., & Hao, Y. (2026) · Alzheimer Disease & Associated Disorders · doi:10.1097/wad.0000000000000724
miR-125b Mediates Tau-induced Mitochondrial Dysfunction in a Cellular Model of Alzheimer’s Disease
Plano, L. M. D., Saitta, A., Minuti, A., Muscarà, C., Gasparo, I., Licitri, L., Sciuto, E. L., Sabrina Conoci, A., Schepici, G., Caccamo, A., et al. (2026) · Molecular Neurobiology · doi:10.1007/s12035-026-05982-x
“For example, it downregulates synapsin-2 and 15-lipoxygenase (15-LOX), impairing membrane remodeling and reducing the production of neuroprotective docosanoids [8].”
mmu_circ_0012122/mmu-miR-1843-5p/Sertad2 axis: A novel regulatory pathway in rabies virus infection
Ye, Q., Tang, X., Cai, H., Yuan, M., Ba, X., Tian, Y., Chen, J., Wang, X., & Xiang, R. (2026) · Virulence · doi:10.1080/21505594.2026.2690777
“Gene expression was calculated based on junction reads at circRNA back-splicing sites [35], and normalized by using the circRNA spliced reads per billion mapped reads (SRPBM).”
Soltani, I., Bahia, W., Slaymi, C., Khemissi, W., Rahali, N., Bougatef, H., Baazaoui, N., Ferchichi, S., & Almawi, W. Y. (2026) · Computational Biology and Chemistry · doi:10.1016/j.compbiolchem.2026.109445
FAIRsharing record for: PlantCircRNA
FAIRsharing Team, et al. (2024) · FAIRsharing.org · doi:10.25504/fairsharing.73bafe
Metadata
- Authors
- Lukiw, W. J.
- Affiliations
- Louisiana State University (US)
- Corresponding author
- Lukiw, Walter J.
- ORCID
- Lukiw, Walter J.
- Venue
- Frontiers in Genetics
- Publisher
- Frontiers Media SA
- Published
- 2013
- Volume
- 4
- Pages
- 307-307
- ISSN
- 1664-8021 (ISSN-L)
- PMC
- PMC3875874
- OpenAlex
- W2095799789
- Cited by
- 636
- References
- 14
- Citations by year
- 2026: 9 · 2025: 12 · 2024: 25 · 2023: 48 · 2022: 57 · 2021: 85 · 2020: 103 · 2019: 88 · 2018: 89 · 2017: 66 · 2016: 32 · 2015: 14 · 2014: 6
- FWCI
- 7.76
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by
- Locations
- Frontiers in Genetics (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Instytut Medycyny Doswiadczalnej i Klinicznej im. M. Mossakowskiego, Polskiej Akademii Nauk
- National Institute on Aging (AG038834, NIA AG038834, R01AG038834)
- National Eye Institute (NEI-EY-006311, R01EY006311, EY-006311)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Circular RNAs in diseases
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Keywords
- circular RNA, Alzheimer's disease, non-coding RNA, RNA circularization
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