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Circular RNA (circRNA) in Alzheimer’s disease (AD)
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GENERAL COMMENTARY article Front. Genet., 31 December 2013 | https://doi.org/10.3389/fgene.2013.00307
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![Figure 1 (A) Detection of circRNA for miRNA-7 (ciRS-7) in sporadic Alzheimer's disease (AD) and age-matched control hippocampal CA1 [control (C) N = 4; AD (A) N = 6]; the single upper ciRS-7 (~1400 nt) band contains ~70 selectively conserved miRNA-7 binding sites as previously described (Hansen et al., 2013); a lower 28S RNA served as an internal loading control; all samples depleted of rRNA were treated with 50 units of RNaseR prior to electrophoresis RNaseR is a processive, Mg++-dependent hydrolytic exoribonuclease that degrades linear but not circular RNA; see Hansen et al. (2013); predicted circular transcripts consistently resisted an RNaseR challenge; 30 ug total AD and control hippocampal CA1 RNA was separated on agarose gels, transferred and probed with biotinylated or radiolabeled miRNA-7 probes as previously described (Colangelo et al., 2002; Hansen et al., 2013); detection was performed using a nonisotopic BrightStar BioDetect Kit (Ambion, Austin, TX; detection limit ~100 fg) or by standard autoradiography (Lukiw et al., 1992); (B) AD ciRS-7 is significantly reduced to about 0.18-fold of control (con) in a study of 20 control and AD (AD) hippocampal CA1 samples; this implicates loss of miRNA-7 sponge effects, an ambient up-regulation of miRNA-7 (as is observed), and down-regulation of a family of miRNA-7-sensitive mRNAs in the sporadic AD brain; other circRNAs may be involved; there were no significant differences between age for control or AD tissues [mean ± 1 standard deviation (SD) = 75.4 ± 8.3 year vs. 77.5 ± 7.6 year]; all AD cases were for moderate-to-advanced stages of AD; all post-mortem intervals were 2.1 h or less (Colangelo et al., 2002); there were no significant differences in age, ApoE allele status, RNA quality (all RIN values were 8.1–9.0) or yield between the control or AD groups (p > 0.05, ANOVA); a dashed horizontal line at 1.0 indicates homeostatic (control) ciRS-7 levels for ease of comparison; *p < 0.001 (ANOVA).](/paper-figures/a4706fbfe0d3497e8b376957eb291493/circular-rna-circrna-in-alzheimers-disease-ad-figure-1.jpg)
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“In addition, dysregulation of ciRS-7 has been found in zebrafish with an impaired midbrain [71] and in the hippocampus of AD patients [45].”
From Circular RNAs in depression: Biogenesis, function, expression, and therapeutic potential (2021) · cites this paper as [45]
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Circular RNAs are a large class of animal RNAs with regulatory potency
Memczak, S., Jens, M., Elefsinioti, A., Torti, F., Krueger, J., Rybak, A., Maier, L., Mackowiak, S. D., Gregersen, L. H., Munschauer, M., et al. (2013) · Nature · doi:10.1038/nature11928 · Cited by 7,990 · cited 1×
“Intrinsically resistant to exonucleolytic RNA decay, circRNAs appear to be enriched in mammalian brain tissues (Hansen et al., 2013; Memczak et al., 2013).”
BackgroundNatural RNA circles function as efficient microRNA sponges
Hansen, T. B., Jensen, T. I., Clausen, B. H., Bramsen, J. B., Finsen, B., Damgaard, C. K., & Kjems, J. (2013) · Nature · doi:10.1038/nature11993 · Cited by 7,985
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“Recently characterized, traditional methods of RNA detection and analysis requiring a free 5′ or 3′ ribonucleotide terminus may have significantly underestimated circRNA abundance and significance in eukaryotic cells (Salzman et al., 2012; Wilusz and Sharp, 2013; unpublished observations).”
Cogswell, J. P., Ward, J., Taylor, I. A., Waters, M., Shi, Y., Cannon, B., Kelnar, K., Kemppainen, J., Brown, D., Chen, C., et al. (2008) · Journal of Alzheimer s Disease · doi:10.3233/jad-2008-14103 · Cited by 943 · cited 1×
“…or AD groups (p > 0.05, ANOVA); a dashed horizontal line at 1.0 indicates homeostatic (control) ciRS-7 levels for ease of comparison; ∗p < 0.001 (ANOVA). contribute to the down-regulation of selective miRNA-7-sensitive messenger RNA (mRNA) targets (Cogswell et al., 2008; unpublished observations).”
BackgroundInfluentialA Circuitous Route to Noncoding RNA
Wilusz, J. E., & Sharp, P. A. (2013) · Science · doi:10.1126/science.1238522 · Cited by 531 · cited 1×
“Recently characterized, traditional methods of RNA detection and analysis requiring a free 5′ or 3′ ribonucleotide terminus may have significantly underestimated circRNA abundance and significance in eukaryotic cells (Salzman et al., 2012; Wilusz and Sharp, 2013; unpublished observations).”
Colangelo, V., Schurr, J., Ball, M. J., Pelaez, R. P., Bazan, N. G., & Lukiw, W. J. (2002) · Journal of Neuroscience Research · doi:10.1002/jnr.10351 · Cited by 517
A Gene Expression Profile of Alzheimer's Disease
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“…systems” and ambient up-regulation of specific inducible miRNAs may help explain the widely observed, generalized and progressive down-regulation of gene expression that is characteristic of the sporadic AD brain (Loring et al., 2001; Colangelo et al., 2002; Ginsberg et al., 2012; Lukiw, 2013).”
BackgroundInfluentialDeconstruction for Reconstruction: The Role of Proteolysis in Neural Plasticity and Disease
Bingol, B., & Sheng, M. (2011) · Neuron · doi:10.1016/j.neuron.2010.11.006 · Cited by 275
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“, 2013); detection was performed using a nonisotopic BrightStar BioDetect Kit (Ambion, Austin, TX; detection limit ∼100 fg) or by standard autoradiography (Lukiw et al., 1992); (B) AD ciRS-7 is significantly reduced to about 0.”
MethodInfluentialMicroRNA in schizophrenia: Genetic and expression analysis of miR-130b (22q11)
Burmistrova, O., Goltsov, A. Y., Abramova, L. I., Каледа, В. Г., Александровна, О. В., & Rogaev, E. I. (2007) · Biochemistry (Moscow) · doi:10.1134/s0006297907050161 · Cited by 101 · cited 1×
“…but are also associated with a circRNA for miRNA-7 (ciRS-7), in the same tissues; ciRS-7 contains multiple, tandem anti-miRNA-7 sequences (Burmistrova et al., 2007; Hansen et al., 2013; Lukiw et al., 2013). ciRS-7 thereby acts as a kind of endogenous, competing, anti-complementary miRNA…”
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Items 201–300 of 647
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Zhou, W., Wang, H., Wu, X., Long, W., Zheng, F., Kong, J., & Yu, B. (2018) · Experimental Biology and Medicine · doi:10.1177/1535370218813525 · Cited by 54
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“Although the functions of several circRNAs have not been fully investigated, there is some evidence demonstrating that circRNAs are differentially expressed in a range of serious diseases, including cancer [11], Alzheimer’s disease [12], heart dysfunctions, [13] and endocrine dysfunctions such as type-2 diabetes melli…”
circMbl Functions in cis and in trans to Regulate Gene Expression With Impacts on Physiology
Pamudurti, N. R., Patop, I. L., Krishnamoorthy, A., Bartok, O., Maya, R., Lerner, N., Ashwal-Fluss, R., Konakondla, J. V. V., Beatus, T., & Kadener, S. (2021) · Cell Reports · doi:10.1016/j.celrep.2022.110740 · Cited by 54
“Moreover, circRNAs are involved in brain-related diseases and neurodegeneration (Hanan et al., 2020; Lukiw, 2013; Zimmerman et al., 2020).”
Hu, J., Peng, L., Song, Y., Ge, Y., Meng, X., Huang, C., Li, J., & Xu, T. (2017) · Journal of Cellular Physiology · doi:10.1002/jcp.26154 · Cited by 54
“Recent studies also demonstrated that circRNAs played significant roles in the progression of cerebrovascular and neurological diseases, such as atherosclerotic vascular disease (ASVD) and Alzheimer's disease (AD) (Holdt et al., 2016; Lukiw, 2013; Zhao, Alexandrov, Jaber, & Lukiw, 2016).”
BackgroundThe Integrative Regulatory Network of circRNA, microRNA, and mRNA in Atrial Fibrillation
Jiang, S., Guo, C., Zhang, W., Che, W., Zhang, J., Zhuang, S., Wang, Y., Zhang, Y., & Liu, B. (2019) · Frontiers in Genetics · doi:10.3389/fgene.2019.00526 · Cited by 54
“Some circRNAs contain microRNA sites and act as an endogenous microRNA “sponge” to adsorb and quench the normal biological functions of the microRNA (Lukiw, 2013).”
BackgroundNon-coding RNA biomarkers in pancreatic ductal adenocarcinoma
Sharma, G. G., Okada, Y., Hoff, D. D. V., & Goel, A. (2020) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2020.10.001 · Cited by 54
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He, J., Ren, M., Li, H., Yang, L., Wang, X., & Yang, Q. (2019) · Frontiers in Genetics · doi:10.3389/fgene.2019.00860 · Cited by 52
“…circular RNA (circRNA) carried in the exosomes, because of its lack of an exonuclease recognition site, is not easily degraded (Memczak et al., 2013); thus, circRNA is considered an ideal biomarker and can be used to monitor a variety of CNS diseases (Lukiw, 2013; Qu et al., 2015; Lu and Xu, 2016).”
BackgroundBlood circRNAs as biomarkers for the diagnosis of community‐acquired pneumonia
Zhao, T., Zheng, Y., Hao, D.-Z., Jin, X., Luo, Q., Guo, Y., Li, D., Xi, W., Xu, Y., Chen, Y., et al. (2019) · Journal of Cellular Biochemistry · doi:10.1002/jcb.28863 · Cited by 51
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Low expression of hsa_circ_0006633 in human gastric cancer and its clinical significances
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Zhong, R., Chen, Z., Mo, T., Li, Z., & Zhang, P. (2019) · Cancer Cell International · doi:10.1186/s12935-019-0985-9 · Cited by 50
“Some studies have shown that circRNAs play an important role in regulating physiological or pathological functions [20, 21].”
Li, S., Weng, J., Song, F., Li, L., Xiao, C. W., Yang, W., Zhu, Z., & Xu, J. (2019) · Cell Death and Disease · doi:10.1038/s41419-020-2616-8 · Cited by 51
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“Recent studies have shown that circRNA plays an important role in the pathological process of ischemic brain damage [7], Alzheimer’s disease [23], Parkinson’s disease [24], and brain tumors [25].”
BackgroundExploring the regulatory roles of circular RNAs in Alzheimer’s disease
Zhang, Y., Zhao, Y., Liu, Y., Wang, M., Yu, W., & Zhang, L. (2020) · Translational Neurodegeneration · doi:10.1186/s40035-020-00216-z · Cited by 47
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“With profound researches, circRNA plays a part in the regulation of transcriptional, post-transcriptional, and translational processes, such as RNA processing, genomic rearrangement, chromosome modification, and X chromosome silencing [11].”
BackgroundZhang, L.-D., & Wang, Z. (2020) · Virology Journal · doi:10.1186/s12985-020-01314-0 · Cited by 50
Reduction of A-to-I RNA editing in the failing human heart regulates formation of circular RNAs
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“168 The downregulation of circHIPK2 expression substan - tially decreased the activation of astrocytes via modulating autophagy and endoplasmic reticulum (ER) stress via addressing miR-124–2HG and SIGMAR.”
BackgroundMiR-34 and MiR-200: Regulator of Cell Fate Plasticity and Neural Development
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Vesicular Transport of Encapsulated microRNA between Glial and Neuronal Cells
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“…(ix) the role of circular RNA (circRNA) which have been shown in some cases to act as natural “anti-miRNA sponges” of specific miRNA activities (Lukiw 2013 [77]; Zhao et al., 2016 [78]; Fakhoury 2018 [53]; Pogue and Lukiw., 2018 [33]; Zhao and Lukiw, 2018 [59]; Avsar et al., 2020 [35]; Groot…”
BackgroundXiu, Y., Jiang, G., Zhou, S., Diao, J., Liu, H., Su, B., & Li, C. (2019) · Frontiers in Genetics · doi:10.3389/fgene.2019.00731 · Cited by 47
“, 2016), Alzheimer’s disease (Lukiw, 2013), neuronal diseases (Errichelli et al.”
BackgroundSun, Z., Yang, C., Huang, L., Mo, Z., Zhang, K., Fan, W., Wang, K., Wu, F., Wang, J., Meng, F.-L., et al. (2023) · Nucleic Acids Research · doi:10.1093/nar/gkad949 · Cited by 47
“As a circular RNA sponge for miR-7, ciRS-7 (CDR1as) has been found predominantly in human and mouse brains and associated with colorectal cancer ( 17 ), Alzheimer’s disease ( 18 ), esophageal squamous cell carcinoma ( 19 ) and oral squamous cell carcinomas ( 20 ), etc .”
BackgroundBiogenesis, Features, Functions, and Disease Relationships of a Specific Circular RNA: CDR1as
Guo, Z., Cao, Q., Zhao, Z., & Song, C. (2020) · Aging and Disease · doi:10.14336/ad.2019.0920 · Cited by 47
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Application of droplet digital PCR in quantitative detection of the cell-free circulating circRNAs
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Circular RNA Vav3 sponges gga-miR-375 to promote epithelial-mesenchymal transition
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“Previous studies have confirmed that circRNA sponging with miRNA can relieve the inhibition of miRNA target gene expression [5,60], then we assumed that it is the increase in the expression of the gga-miR-375 target gene-YAP1 that contributes to the EMT induction.”
BackgroundYang, X., Li, J., Wu, Y., Ni, B., & Zhang, B. (2019) · Scandinavian Journal of Clinical and Laboratory Investigation · doi:10.1080/00365513.2019.1674004 · Cited by 46
“To date, many circRNAs have been found to be involved in the initiation and progression of several diseases, such as cancer [14], Alzheimer’s disease [15] and pre-eclampsia [16].”
BackgroundEvolutionary conservation in noncoding genomic regions
Leypold, N. A., & Speicher, M. R. (2021) · Trends in Genetics · doi:10.1016/j.tig.2021.06.007 · Cited by 51
Huang, Z., Su, R., Qing, C., Peng, Y., Luo, Q., & Li, J. (2018) · Frontiers in Microbiology · doi:10.3389/fmicb.2018.02010 · Cited by 45
“, 2017), Alzheimer’s disease (Lukiw, 2013), and other diseases (Chen et al.”
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Diagnostic and Prognostic Value of Circulating CircRNAs in Cancer
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Functional roles of circular RNAs in Alzheimer’s disease
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Circular RNAs: Emblematic Players of Neurogenesis and Neurodegeneration
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“CDR1as/ciRS7 is the best-characterized and most highly expressed of mammalian circRNAs; it is also strongly dysregulated in the hippocampal CA1 region of AD patients (Lukiw, 2013).”
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Knockout of circRNAs by base editing back-splice sites of circularized exons
Gao, X., Ma, X.-K., Li, X., Li, G., Liu, C., Zhang, J., Wang, Y., Wei, J., Chen, J., Chen, L., et al. (2022) · Genome biology · doi:10.1186/s13059-021-02563-0 · Cited by 38
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“It was reported that ciRS-7 acts as a competitive endogenous miRNA sponge that inhibits the function of miRNA-7 in AD-affected brains (Lukiw, 2013).”
BackgroundCirc-Spidr enhances axon regeneration after peripheral nerve injury
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Perdoncin, M., Konrad, A., Wyner, J. R., Lohana, S., Pillai, S. S., Pereira, D. G., Lakhani, H. V., & Sodhi, K. (2021) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2021.756499 · Cited by 39
“…their enrichment in different sources of AD samples including patient blood serum, post-mortem brain tissues, etc. are highly sensitive to alterations in the biochemical, neurochemical, neuropathological, and/or cellular environment (Alexandrov et al., 2012; Lukiw, 2013a,b; Kumar and Reddy, 2020).”
BackgroundFan, X.-C., Liu, T.-L., Wang, Y., Wu, X., Wang, Y., Lai, P., Song, J.-K., & Zhao, G. (2020) · Parasites & Vectors · doi:10.1186/s13071-020-04047-9 · Cited by 36
Yang, R., Xu, B., Yang, B., Fu, J., Liu, L., Amjad, N., Cai, A., Tan, C., Chen, H., & Wang, X. (2018) · Molecular Therapy — Nucleic Acids · doi:10.1016/j.omtn.2018.10.013 · Cited by 35
Sekar, S., Cuyugan, L., Adkins, J. R., Geiger, P. A., & Liang, W. S. (2018) · BMC Genomics · doi:10.1186/s12864-018-4670-5 · Cited by 36
Wang, Y., Wu, C., Zhang, F., Zhang, Y., Ren, Z., Lammi, M. J., & Guo, X. (2019) · Genetic Testing and Molecular Biomarkers · doi:10.1089/gtmb.2019.0108 · Cited by 36
“In addition, it has been found that circRNAs entail the development of other diseases, such as atherosclerosis (Zhao et al ., 2017), Alzheimer’s disease (Lukiw, 2013), and rheumatoid arthritis (RA) (Zheng et al ., 2017).”
The biogenesis, biological functions and modification of Circular RNAs
Liu, S., Guo, X., Shang, Q. J., & Gao, P. (2023) · Experimental and Molecular Pathology · doi:10.1016/j.yexmp.2023.104861 · Cited by 37
The circRNA interactome-innovative hallmarks of the intra- and extracellular radiation response
O’Leary, V. B., Smida, J., Matjanovski, M., Brockhaus, C., Winkler, K., Moertl, S., Ovsepian, S. V., & Atkinson, M. J. (2017) · Oncotarget · doi:10.18632/oncotarget.19228 · Cited by 35
Altered expression of circular RNAs in Moyamoya disease
Zhao, M., Gao, F., Zhang, D., Wang, S., Zhang, Y., Wang, R., & Zhao, J. (2017) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2017.08.011 · Cited by 36
Non-Coding RNAs in the Brain-Heart Axis: The Case of Parkinson’s Disease
Acharya, S., Salgado‐Somoza, A., Stefanizzi, F. M., Lumley, A. I., Zhang, L., Glaab, E., May, P., & Devaux, Y. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21186513 · Cited by 33
Circular RNAs: Promising Biomarkers for Age-related Diseases
Pan, Y., Wu, W., & Xiong, X. (2020) · Aging and Disease · doi:10.14336/ad.2020.0309 · Cited by 36
Nguyen, L. D., Chau, R. K., & Krichevsky, A. M. (2021) · Genes · doi:10.3390/genes12122005 · Cited by 37
Filippenkov, I. B., Sudarkina, O. Y., Limborska, S. A., & Dergunova, L. V. (2015) · RNA Biology · doi:10.1080/15476286.2015.1076611 · Cited by 34
Microarray Expression Profile of Circular RNAs in Plasma from Primary Biliary Cholangitis Patients
Zheng, J., Li, Z., Wang, T., Zhao, Y., & Wang, Y. (2017) · Cellular Physiology and Biochemistry · doi:10.1159/000485487 · Cited by 34
Li, J., Shi, Q., Wang, Q., Tan, X., Pang, K., Liu, X., Zhu, S., Xi, K., Zhang, J., Gao, Q., et al. (2019) · Neuroscience Letters · doi:10.1016/j.neulet.2019.02.032 · Cited by 34
Huang, J., Zhao, J., Zheng, Q., Wang, S., Wei, X., Li, F., Shang, J., Lei, C., & Ma, Y. (2019) · Animals · doi:10.3390/ani9070403 · Cited by 33
Garlapati, P., Ling, J., Chiao, P. J., & Fu, J. (2021) · Cancer Cell International · doi:10.1186/s12935-021-02017-4 · Cited by 34
“Studies have shown that circRNAs are dysregulated in various diseases such as neurodegenerative disease, cardiovascular disease, viral infection, and most important to this paper, cancer [5-8].”
BackgroundRole of circRNAs in neurodevelopment and neurodegenerative diseases
Li, J., Sun, C., Cui, H., Sun, J., & Zhou, P. (2021) · Journal of Molecular Neuroscience · doi:10.1007/s12031-021-01882-y · Cited by 36
“Lukiw discovered that circCDR1-AS was downregulated in the hippocampus of AD patients (Lukiw, 2013), as it contains several miR-7-binding sites, and this binding interaction may contribute to AD progression.”
BackgroundHuang, Z., Su, R., Deng, Z., Xu, J., Peng, Y., Luo, Q., & Li, J. (2017) · Scientific Reports · doi:10.1038/s41598-017-13885-0 · Cited by 33
Zhang, P., Xu, H., Li, R., Wu, W., Chao, Z., Li, C., Xia, W., Wang, L., Yang, J., & Xu, Y. (2018) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2018.04.016 · Cited by 33
Circular RNA in Aging and Age-Related Diseases
Yang, D., Yang, K., & Yang, M. (2018) · Advances in experimental medicine and biology · doi:10.1007/978-981-13-1117-8_2 · Cited by 33
The circINTS4/miR-146b/CARMA3 axis promotes tumorigenesis in bladder cancer
Zhang, X., Liu, X., Jing, Z., Bi, J., Li, Z., Liu, X., Li, J., Li, Z., Zhang, Z., & Kong, C. (2019) · Cancer Gene Therapy · doi:10.1038/s41417-019-0085-y · Cited by 33
Fan, B., Chen, F., Li, Y., Wang, Z., Wang, Z., Lu, Y., Wu, Z., Jian, J., & Wang, B. (2019) · Molecular Omics · doi:10.1039/c9mo00025a · Cited by 33
Wang, Y., Wu, C., Zhang, Y., Yang, Y., Ren, Z., Lammi, M. J., & Guo, X. (2019) · Clinica Chimica Acta · doi:10.1016/j.cca.2019.10.026 · Cited by 34
Predicting novel CircRNA-disease associations based on random walk and logistic regression model
Ding, Y., Chen, B., Lei, X., Liao, B., & Wu, F. (2020) · Computational Biology and Chemistry · doi:10.1016/j.compbiolchem.2020.107287 · Cited by 34
Circular RNA DGKB Promotes the Progression of Neuroblastoma by Targeting miR-873/GLI1 Axis
Yang, J., Yu, L., Yan, J., Yu, X., Li, W., Xiao, J., Lei, J., Deng, X., Zhang, S., & Yu, X. (2020) · Frontiers in Oncology · doi:10.3389/fonc.2020.01104 · Cited by 32
Recent Advances of MicroRNAs, Long Non-coding RNAs, and Circular RNAs in Preeclampsia
Chen, A., Yu, R., Jiang, S., Xia, Y., & Chen, Y. (2021) · Frontiers in Physiology · doi:10.3389/fphys.2021.659638 · Cited by 34
“They competitively bind to miRNA, thereby affecting the regulatory function and gene expression of miRNA (Lukiw, 2013).”
BackgroundCircular RNAs in rat models of cardiovascular and renal diseases
Cheng, X., & Joe, B. (2017) · Physiological Genomics · doi:10.1152/physiolgenomics.00064.2017 · Cited by 32
Vidal, A. F., Ribeiro-dos-Santos, A. M., Vinasco‐Sandoval, T., de Magalhães, L. L., Pinto, P., Anaissi, A. K. M., Demachki, S., de Assumpção, P. P., dos Santos, S. E. B., & Ribeiro‐dos‐Santos, Â. (2017) · Scientific Reports · doi:10.1038/s41598-017-15061-w · Cited by 32
Circular RNAs in Cardiovascular Diseases
Wang, L., Meng, X., Li, G., Zhou, Q., & Xiao, J. (2018) · Advances in experimental medicine and biology · doi:10.1007/978-981-13-1426-1_15 · Cited by 32
Circular RNAs as Novel Biomarkers for Cardiovascular Diseases
Zhou, Q., Zhang, Z., Bei, Y., Li, G., & Wang, T. (2018) · Advances in experimental medicine and biology · doi:10.1007/978-981-13-1426-1_13 · Cited by 32
Wang, Y., Wu, C., Yang, Y., Ren, Z., Lammi, M. J., & Guo, X. (2019) · Genetic Testing and Molecular Biomarkers · doi:10.1089/gtmb.2019.0036 · Cited by 32
“…as dysfunction of circRNAs was related to the occurrence and progression of many different human diseases, for example, Alzheimer’s disease in the nervous system (Lukiw, 2013), coronary artery disease (Zhao et al ., 2017), rheumatoid arthritis (Zheng et al ., 2017), and tumor (Liu et al ., 2017).”
The Combined Effects of Circular RNA Methylation Promote Pulmonary Fibrosis
Wang, S., Luo, W., Huang, J., Chen, M., Ding, J., Cheng, Y., Zhang, W., Fang, S., Wang, J., & Chao, J. (2022) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2021-0379oc · Cited by 35
Zhou, M., Zhang, P., Zhao, Y., Liu, R., & Zhang, Y. (2021) · Journal of Cancer · doi:10.7150/jca.55794 · Cited by 31
“Studies have proved that circRNAs play crucial roles in diverse biological processes, including tumor genesis, metastasis and advancement [15, 16].”
BackgroundRNA sequencing reveals the circular RNA expression profiles of osteoarthritic synovium
Xiang, S., Zeng, L., Bian, Y., & Weng, X. (2019) · Journal of Cellular Biochemistry · doi:10.1002/jcb.29106 · Cited by 31
“Several studies have revealed the potential role of circRNAs in carcinogenesis and Alzheimer’s disease.(13,14) During the past few years, an increasing number of research works have focused on the expression and regulatory mechanisms of circRNAs in arthritic diseases, especially OA and rheumatoid arthritis (RA).”
BackgroundNon-Coding RNAs as Sensors of Oxidative Stress in Neurodegenerative Diseases
Gámez‐Valero, A., Guisado-Corcoll, A., Herrero‐Lorenzo, M., Solaguren‐Beascoa, M., & Martí, E. (2020) · Antioxidants · doi:10.3390/antiox9111095 · Cited by 34
Metadata
- Authors
- Lukiw, W. J.
- Affiliations
- Louisiana State University (US)
- Corresponding author
- Lukiw, Walter J.
- ORCID
- Lukiw, Walter J.
- Venue
- Frontiers in Genetics
- Publisher
- Frontiers Media SA
- Published
- 2013
- Volume
- 4
- Pages
- 307-307
- ISSN
- 1664-8021 (ISSN-L)
- PMC
- PMC3875874
- OpenAlex
- W2095799789
- Cited by
- 636
- References
- 14
- Citations by year
- 2026: 9 · 2025: 12 · 2024: 25 · 2023: 48 · 2022: 57 · 2021: 85 · 2020: 103 · 2019: 88 · 2018: 89 · 2017: 66 · 2016: 32 · 2015: 14 · 2014: 6
- FWCI
- 7.76
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by
- Locations
- Frontiers in Genetics (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Instytut Medycyny Doswiadczalnej i Klinicznej im. M. Mossakowskiego, Polskiej Akademii Nauk
- National Institute on Aging (AG038834, NIA AG038834, R01AG038834)
- National Eye Institute (NEI-EY-006311, R01EY006311, EY-006311)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Circular RNAs in diseases
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Keywords
- circular RNA, Alzheimer's disease, non-coding RNA, RNA circularization
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