Cited by 202Genomics and Phylogenetic StudiesMicrobial Community Ecology and PhysiologyMicrobial Natural Products and Biosynthesis

A Review of bioinformatics tools for bio-prospecting from metagenomic sequence data

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Roumpeka, Despoina D., Wallace, R. John, Escalettes, Frank, Fotheringham, Ian, Watson, Mick·2017·Frontiers in Genetics

Abstract

The microbiome can be defined as the community of microorganisms that live in a particular environment. Metagenomics is the practice of sequencing DNA from the genomes of all organisms present in a particular sample, and has become a common method for the study of microbiome population structure and function. Increasingly, researchers are finding novel genes encoded within metagenomes, many of which may be of interest to the biotechnology and pharmaceutical industries. However, such "bioprospecting" requires a suite of sophisticated bioinformatics tools to make sense of the data. This review summarizes the most commonly used bioinformatics tools for the assembly and annotation of metagenomic sequence data with the aim of discovering novel genes.

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Authors
Roumpeka, D. D., Wallace, R. J., Escalettes, F., Fotheringham, I., & Watson, M.
Affiliations
  • Roslin Institute (GB)
  • University of Aberdeen (GB)
  • Ingenza (United Kingdom) (GB)
Corresponding author
Roumpeka, Despoina D.
Venue
Frontiers in Genetics
Published
2017-03-06
Volume
8
Pages
23-23
ISSN
1664-8021 (ISSN-L)
OpenAlex
W2595593998
Cited by
199
References
74
Citations by year
2026: 14 · 2025: 18 · 2024: 23 · 2023: 14 · 2022: 24 · 2021: 34 · 2020: 19 · 2019: 25 · 2018: 22 · 2017: 5 · 2015: 1
FWCI
1.89
Type
journal article
Language
en
Open access
Licence
cc-by
Locations
  • Frontiers in Genetics (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • Edinburgh Research Explorer (University of Edinburgh) (submittedVersion, cc-by)
Funders
Biotechnology and Biological Sciences Research Council (BBS/E/D/20310000, BB/J004243/1, BB/L016389/1)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Phylogenetic Studies
  • Physical Sciences › Environmental Science › Ecology › Microbial Community Ecology and Physiology
  • Health Sciences › Medicine › Pharmacology › Microbial Natural Products and Biosynthesis
Keywords
metagenomics, bioinformatics software, bioprospecting, microbiome, metagenome assembly, metagenome annotation, gene discovery, microbial community structure

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