Cited by 212Effects and risks of endocrine disrupting chemicalsEpigenetics and DNA MethylationBirth, Development, and Health

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Phthalate Exposure and Long-Term Epigenomic Consequences: A Review

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Dutta, Sudipta, Haggerty, Diana K., Rappolee, Daniel A., Ruden, Douglas M.·2020·Frontiers in Genetics

DOI 10.3389/fgene.2020.00405PMC PMC7218126

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Abstract

Phthalates are esters of phthalic acid widely used as plasticizers to soften and increase the flexibility in polyvinyl chloride (PVC) plastics. They are also used in cosmetics and other daily personal care products. Phthalates are not covalently bound to plastics and easily leach into the environment and enter the human body by dermal absorption, ingestion or inhalation. Several in vitro and in vivo studies suggest that phthalates can act as endocrine disruptors and cause moderate reproductive and developmental toxicities. Furthermore, phthalates can cross the placental barrier and affect the developing fetus. Thus, phthalates are ubiquitous food and environmental contaminants with potential adverse health effects in humans. This review focusses on studies conducted in the field of toxicogenomics of phthalates and discusses possible transgenerational and multigenerational effects caused by phthalate exposure during any point of the life-cycle.

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Authors: Dutta, S., Haggerty, D. K., Rappolee, D. A., & Ruden, D. M.
Affiliations: University of Nebraska Medical Center (US)
Michigan State University (US)
Wayne State University (US)
Corresponding author: Ruden, Douglas M.
ORCID: Dutta, Sudipta
Haggerty, Diana K.
Rappolee, Daniel A.
Ruden, Douglas M.
Venue: Frontiers in Genetics
Publisher: Frontiers Media SA
Published: 2020-05-06
Volume: 11
Pages: 405-405
ISSN: 1664-8021 (ISSN-L)
DOI: 10.3389/fgene.2020.00405
PMC: PMC7218126
OpenAlex: W3023341510
Cited by: 212
References: 234
Citations by year: 2026: 29 · 2025: 49 · 2024: 35 · 2023: 38 · 2022: 35 · 2021: 25 · 2020: 1
FWCI: 2.14
Type: journal article
Language: en
Open access: gold
doi.org
Licence: cc-by
creativecommons.org/licenses/by/4.0/ (vor)
Locations: Frontiers in Genetics (publishedVersion, cc-by)
PubMed Central (publishedVersion, cc-by)
PubMed (publishedVersion)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders: Foundation for the National Institutes of Health
Topics: Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Effects and risks of endocrine disrupting chemicals
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Birth, Development, and Health
Keywords: phthalates, plasticizers, endocrine disruptors, epigenetics, toxicogenomics, transgenerational epigenetic inheritance, multigenerational effects, reproductive toxicity, developmental toxicity, placental transfer, dermal exposure, environmental pollutants, food contaminants

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Phthalate Exposure and Long-Term Epigenomic Consequences: A Review

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