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Cited by 29Genomics and Chromatin DynamicsChromatin Remodeling and CancerChromosomal and Genetic Variations

Mechanisms of enhancer-promoter communication and chromosomal architecture in mammals and Drosophila

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Kyrchanova, Olga V., Bylino, Oleg V., Georgiev, Pavel G.·2022·Frontiers in Genetics
DOI 10.3389/fgene.2022.1081088PMC PMC9751008
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Abstract

The spatial organization of chromosomes is involved in regulating the majority of intranuclear processes in higher eukaryotes, including gene expression. Drosophila was used as a model to discover many transcription factors whose homologs play a key role in regulation of gene expression in mammals. According to modern views, a cohesin complex mostly determines the architecture of mammalian chromosomes by forming chromatin loops on anchors created by the CTCF DNA-binding architectural protein. The role of the cohesin complex in chromosome architecture is poorly understood in Drosophila, and CTCF is merely one of many Drosophila architectural proteins with a proven potential to organize specific long-range interactions between regulatory elements in the genome. The review compares the mechanisms responsible for long-range interactions and chromosome architecture between mammals and Drosophila.

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  • Contacts between architectural proteins can modulate the spatial organization of the genome, including keeping enhancers close to promoters.

    “In model experiments, it was convincingly shown that contacts between these proteins can modulate the spatial organization of the genome, including keeping enhancers close to promoters [84,91,92].”

    From Enhancer Function in the 3D Genome (2023) · cites this paper as [84]

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Authors
Kyrchanova, O. V., Bylino, O. V., & Georgiev, P. G.
Affiliations
Russian Academy of Sciences (RU)
Corresponding author
Georgiev, Pavel G.
ORCID
Venue
Frontiers in Genetics
Publisher
Frontiers Media SA
Published
2022-12-01
Volume
13
Pages
1081088-1081088
ISSN
1664-8021 (ISSN-L)
DOI
10.3389/fgene.2022.1081088
PMC
PMC9751008
OpenAlex
W4310490335
Cited by
29
References
8
Citations by year
2026: 1 · 2025: 8 · 2024: 11 · 2023: 9
FWCI
0.73
Type
journal article
Language
en
Open access
Licence
Locations
  • Frontiers in Genetics (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
Russian Science Foundation
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Chromatin Remodeling and Cancer
  • Life Sciences › Agricultural and Biological Sciences › Plant Science › Chromosomal and Genetic Variations
Keywords
enhancer-promoter interactions, chromatin structure, long-range interactions, cohesin, CTCF, architectural proteins, chromatin looping, gene expression regulation, Drosophila, mammals, comparative genomics

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

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