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Cited by 26CRISPR and Genetic EngineeringGenetically Modified Organisms ResearchAgricultural Productivity and Crop Improvement

The DOI matches its Crossref record; 211 of the 211 references it cites were found in a registry or an index.

CRISPR for accelerating genetic gains in under-utilized crops of the drylands: Progress and prospects

Open access
Sharma, Kiran K., Palakolanu, Sudhakar Reddy, Bhattacharya, Joorie, Shankhapal, Aishwarya R., Bhatnagar-Mathur, Pooja·2022·Frontiers in Genetics
DOI 10.3389/fgene.2022.999207PMC PMC9582247
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Abstract

Technologies and innovations are critical for addressing the future food system needs where genetic resources are an essential component of the change process. Advanced breeding tools like "genome editing" are vital for modernizing crop breeding to provide game-changing solutions to some of the "must needed" traits in agriculture. CRISPR/Cas-based tools have been rapidly repurposed for editing applications based on their improved efficiency, specificity and reduced off-target effects. Additionally, precise gene-editing tools such as base editing, prime editing, and multiplexing provide precision in stacking of multiple traits in an elite variety, and facilitating specific and targeted crop improvement. This has helped in advancing research and delivery of products in a short time span, thereby enhancing the rate of genetic gains. A special focus has been on food security in the drylands through crops including millets, teff, fonio, quinoa, Bambara groundnut, pigeonpea and cassava. While these crops contribute significantly to the agricultural economy and resilience of the dryland, improvement of several traits including increased stress tolerance, nutritional value, and yields are urgently required. Although CRISPR has potential to deliver disruptive innovations, prioritization of traits should consider breeding product profiles and market segments for designing and accelerating delivery of locally adapted and preferred crop varieties for the drylands. In this context, the scope of regulatory environment has been stated, implying the dire impacts of unreasonable scrutiny of genome-edited plants on the evolution and progress of much-needed technological advances.

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Crossref · 10.3389/fgene.2022.999207

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FIGURE 1 Schematic representation of the potential traits which can be explored in underutilized crops using gene editing technology.
FIGURE 1 Schematic representation of the potential traits which can be explored in underutilized crops using gene editing technology.CC BY · PubMed Central
FIGURE 2 Diagrammatic representation of the timeline of events highlighting the field trials and commercialization of gene edited crops globally.
FIGURE 2 Diagrammatic representation of the timeline of events highlighting the field trials and commercialization of gene edited crops globally.CC BY · PubMed Central
FIGURE 3 Diagrammatic representation of some of the major gene edited crops approved under the “Am I regulated?” process by the USDA.
FIGURE 3 Diagrammatic representation of some of the major gene edited crops approved under the “Am I regulated?” process by the USDA.CC BY · PubMed Central

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Show all 209 references

Research works printed but not linked: 6

  1. Chang, 2018, Genomic data of the Bambara groundnut (Vigna subterranea), GigaScience, 10, 1055
  2. Preliminary report -Review of food derived using new breeding techniques –consultation outcomes2018
  3. Laaninen, 2019, New plant-breeding techniques Applicability of EU GMO rules
  4. Ngalamu, 2015, Cowpea production handbook
  5. Rojas-Vasquez, 2020, Use of genome editing technologies for genetic improvement of crops of tropical origin, Plant Cell, Tissue and Organ Culture (PCTOC), 140, 215, 10.1111/pbi.13635 · DOI · Paper page
  6. Sharma, 2015, Biochemical characterization of pearl millet

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Metadata

Authors
Sharma, K. K., Palakolanu, S. R., Bhattacharya, J., Shankhapal, A. R., & Bhatnagar-Mathur, P.
Affiliations
  • Energy and Resources Institute (IN)
  • International Crops Research Institute for the Semi-Arid Tropics (IN)
  • University of Nottingham (GB)
Corresponding author
Sharma, Kiran K.
ORCID
Venue
Frontiers in Genetics
Publisher
Frontiers Media SA
Published
2022-10-06
Volume
13
Pages
999207-999207
ISSN
1664-8021 (ISSN-L)
DOI
10.3389/fgene.2022.999207
PMC
PMC9582247
OpenAlex
W4303192285
Cited by
24
References
209
Citations by year
2026: 6 · 2025: 10 · 2024: 5 · 2023: 2 · 2022: 1
FWCI
0.47
Type
journal article
Language
en
Open access
Licence
Locations
  • Frontiers in Genetics (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • Open Access Repository of ICRISAT (International Crops Research Institute for the Semi-Arid Tropics) (acceptedVersion)
  • Rothamsted Repository (Rothamsted Repository) (acceptedVersion, other-oa)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
Consortium of International Agricultural Research Centers
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › CRISPR and Genetic Engineering
  • Life Sciences › Agricultural and Biological Sciences › Plant Science › Genetically Modified Organisms Research
  • Life Sciences › Agricultural and Biological Sciences › Agronomy and Crop Science › Agricultural Productivity and Crop Improvement
Keywords
CRISPR/Cas genome editing, rainfed agriculture, genetic gain, base editing, prime editing, multiplex genome editing, millet, Eragrostis tef, fonio, quinoa, Vigna subterranea, Cajanus cajan, cassava, stress tolerance, nutritional improvement, yield improvement, food security

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