Putting CRISPR-Cas system in action: a golden window for efficient and precise genome editing for crop improvement

A Programmable Dual-RNA–Guided DNA Endonuclease in Adaptive Bacterial Immunity

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Multiplex Genome Engineering Using CRISPR/Cas Systems

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RNA-Guided Human Genome Engineering via Cas9

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Genome-scale CRISPR-Cas9 knockout screening in human cells

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Search-and-replace genome editing without double-strand breaks or donor DNA

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Cpf1 Is a Single RNA-Guided Endonuclease of a Class 2 CRISPR-Cas System

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CRISPR-Cas12a target binding unleashes indiscriminate single-stranded DNase activity

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Programmable base editing of A•T to G•C in genomic DNA without DNA cleavage

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High-Frequency off-Target Mutagenesis Induced by CRISPR-Cas Nucleases in Human Cells

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Cas9–crRNA ribonucleoprotein complex mediates specific DNA cleavage for adaptive immunity in bacteria

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In vivo genome editing using Staphylococcus aureus Cas9

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CRISPR RNA Maturation by Trans-Encoded Small RNA and Host Factor RNase III

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The CRISPR/Cas bacterial immune system cleaves bacteriophage and plasmid DNA

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Evolutionary classification of CRISPR–Cas systems: a burst of class 2 and derived variants

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Crystal structure of Cas9 in complex with guide RNA and target DNA

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Genome editing with CRISPR–Cas nucleases, base editors, transposases and prime editors

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Simultaneous editing of three homoeoalleles in hexaploid bread wheat confers heritable resistance to powdery mildew

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Targeting DNA Double-Strand Breaks with TAL Effector Nucleases

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CRISPR–Cas9 Structures and Mechanisms

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Targeted genome modification of crop plants using a CRISPR-Cas system

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Epigenome editing by a CRISPR-Cas9-based acetyltransferase activates genes from promoters and enhancers

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Targeted genome engineering in human cells with the Cas9 RNA-guided endonuclease

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A CRISPR/Cas9 toolkit for multiplex genome editing in plants

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CRISPR/Cas Genome Editing and Precision Plant Breeding in Agriculture

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Rational design of highly active sgRNAs for CRISPR-Cas9-mediated gene inactivation

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Diversity, classification and evolution of CRISPR-Cas systems

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Structures of Cas9 endonucleases reveal RNA-mediated conformational activation

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DNA-free genome editing in plants with preassembled CRISPR-Cas9 ribonucleoproteins

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Engineering Quantitative Trait Variation for Crop Improvement by Genome Editing

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Global Warming, Climate Change, and Environmental Pollution: Recipe for a Multifactorial Stress Combination Disaster

Zandalinas, S. I., Fritschi, F., & Mittler, R. (2021) · Trends in Plant Science · doi:10.1016/j.tplants.2021.02.011 · Cited by 1,133 · see citing works

Climate change impacts on crop yield, crop water productivity and food security—A review

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Optimized libraries for CRISPR-Cas9 genetic screens with multiple modalities

Sanson, K. R., Hanna, R. E., Hegde, M., Donovan, K. F., Strand, C., Sullender, M. E., Vaimberg, E. W., Goodale, A., Root, D. E., Piccioni, F., et al. (2018) · Nature Communications · doi:10.1038/s41467-018-07901-8 · Cited by 1,043 · see citing works

<scp>ARGOS</scp> 8 variants generated by <scp>CRISPR</scp> ‐Cas9 improve maize grain yield under field drought stress conditions

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Phage-assisted evolution of an adenine base editor with improved Cas domain compatibility and activity

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The Biology of CRISPR-Cas: Backward and Forward

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Redesigning photosynthesis to sustainably meet global food and bioenergy demand

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Multiplex gene editing by CRISPR–Cpf1 using a single crRNA array

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Efficient and transgene-free genome editing in wheat through transient expression of CRISPR/Cas9 DNA or RNA

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Development of broad virus resistance in non‐transgenic cucumber using CRISPR/Cas9 technology

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Applications of CRISPR–Cas in agriculture and plant biotechnology

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Broad-spectrum resistance to bacterial blight in rice using genome editing

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CRISPR-P 2.0: An Improved CRISPR-Cas9 Tool for Genome Editing in Plants

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De novo domestication of wild tomato using genome editing

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Genome editing in maize directed by CRISPR–Cas9 ribonucleoprotein complexes

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Enhanced Rice Blast Resistance by CRISPR/Cas9-Targeted Mutagenesis of the ERF Transcription Factor Gene OsERF922

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Targeted base editing in rice and tomato using a CRISPR-Cas9 cytidine deaminase fusion

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The CRISPR / C as9 system produces specific and homozygous targeted gene editing in rice in one generation

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Orthogonal Cas9 proteins for RNA-guided gene regulation and editing

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Rapid generation of a transgene-free powdery mildew resistant tomato by genome deletion

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Engineering canker‐resistant plants through CRISPR /Cas9‐targeted editing of the susceptibility gene Cs LOB 1 promoter in citrus

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In vivo genome editing with a small Cas9 orthologue derived from Campylobacter jejuni

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Principle and application of plant mutagenesis in crop improvement: a review

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Efficient genome engineering in human pluripotent stem cells using Cas9 from <i>Neisseria meningitidis</i>

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Genome-wide specificities of CRISPR-Cas Cpf1 nucleases in human cells

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Targeted Mutagenesis in Zea mays Using TALENs and the CRISPR/Cas System

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High-frequency, precise modification of the tomato genome

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Developing climate‐resilient crops: improving plant tolerance to stress combination

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Conformational control of DNA target cleavage by CRISPR–Cas9

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A Multifunctional AAV-CRISPR-Cas9 and Its Host Response

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Structures of a CRISPR-Cas9 R-loop complex primed for DNA cleavage

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Application of the CRISPR–Cas System for Efficient Genome Engineering in Plants

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Gene targeting by the TAL effector PthXo2 reveals cryptic resistance gene for bacterial blight of rice

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A Cas9–guide RNA complex preorganized for target DNA recognition

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Efficient targeted multiallelic mutagenesis in tetraploid potato (Solanum tuberosum) by transient CRISPR-Cas9 expression in protoplasts

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Simultaneous modification of three homoeologs of <i> Ta <scp>EDR</scp> 1 </i> by genome editing enhances powdery mildew resistance in wheat

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Rapid improvement of domestication traits in an orphan crop by genome editing

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Directed evolution of adenine base editors with increased activity and therapeutic application

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Functionally diverse type V CRISPR-Cas systems

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CRISPR/Cas9-mediated viral interference in plants

Ali, Z., Abulfaraj, A. A., Idris, A. M., Ali, S., Tashkandi, M., & Mahfouz, M. M. (2015) · Genome biology · doi:10.1186/s13059-015-0799-6 · Cited by 507 · see citing works

Expanded base editing in rice and wheat using a Cas9-adenosine deaminase fusion

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Genome editing of the disease susceptibility gene Cs LOB 1 in citrus confers resistance to citrus canker

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A male-expressed rice embryogenic trigger redirected for asexual propagation through seeds

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Am I ready for CRISPR? A user's guide to genetic screens

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Direct observation of R-loop formation by single RNA-guided Cas9 and Cascade effector complexes

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Specific elimination of mutant mitochondrial genomes in patient-derived cells by mitoTALENs

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Novel alleles of rice eIF4G generated by CRISPR/Cas9‐targeted mutagenesis confer resistance to Rice tungro spherical virus

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OsSAPK2 Confers Abscisic Acid Sensitivity and Tolerance to Drought Stress in Rice

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Targeted, random mutagenesis of plant genes with dual cytosine and adenine base editors

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Site-specific manipulation of Arabidopsis loci using CRISPR-Cas9 SunTag systems

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De Novo Domestication: An Alternative Route toward New Crops for the Future

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Precise plant genome editing using base editors and prime editors

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CRISPR/Cas: A powerful tool for gene function study and crop improvement

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CRISPR/cas9 genome editing in wheat

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Clonal seeds from hybrid rice by simultaneous genome engineering of meiosis and fertilization genes

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