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Adaptive evolution of antioxidase-related genes in hypoxia-tolerant mammals

Wang, Qiu-Ping, Luo, Chao-Yang, Xu, Xiong-Hui, Hu, Wen-Xian, Gai, Yu-Lin, Gong, You-Jing, Mu, Yuan·2024·Frontiers in Genetics
DOI 10.3389/fgene.2024.1315677PMC PMC11079137
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Abstract

To cope with the damage from oxidative stress caused by hypoxia, mammals have evolved a series of physiological and biochemical traits, including antioxidant ability. Although numerous research studies about the mechanisms of hypoxia evolution have been reported, the molecular mechanisms of antioxidase-related genes in mammals living in different environments are yet to be completely understood. In this study, we constructed a dataset comprising 7 antioxidase-related genes (CAT, SOD1, SOD2, SOD3, GPX1, GPX2, and GPX3) from 43 mammalian species to implement evolutionary analysis. The results showed that six genes (CAT, SOD1, SOD2, SOD3, GPX1, and GPX3) have undergone divergent evolution based on the free-ratio (M1) model. Furthermore, multi-ratio model analyses uncovered the divergent evolution between hypoxic and non-hypoxic lineages, as well as various hypoxic lineages. In addition, the branch-site model identified 9 positively selected branches in 6 genes (CAT, SOD1, SOD2, SOD3, GPX2, and GPX3) that contained 35 positively selected sites, among which 31 positively selected sites were identified in hypoxia-tolerant branches, accounting for 89% of the total number of positively selected sites. Interestingly, 65 parallel/convergent sites were identified in the 7 genes. In summary, antioxidase-related genes are subjected to different selective pressures among hypoxia-tolerant species living in different habitats. This study provides a valuable insight into the molecular evolution of antioxidase-related genes in hypoxia evolution in mammals.

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  • Evolved resistance to hypoxia has also been essential for mammals that have transitioned to subterranean or high altitude environments.

    “However, evolved resistance to hypoxia has also been essential for mammals that have transitioned to subterranean or high altitude environments, where oxygen availability is also limited (Wang et al. 2024) (Fig. 1).”

    From From Trees to Traits: A Review of Advances in PhyloG2P Methods and Future Directions (2025) · cites this paper as Wang et al. 2024

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Metadata

Authors
Wang, Q.-P., Luo, C.-Y., Xu, X.-H., Hu, W.-X., Gai, Y.-L., Gong, Y.-J., & Mu, Y.
Venue
Frontiers in Genetics
Publisher
Frontiers Media SA
Published
2024-04-25
Volume
15
ISSN
1664-8021
DOI
10.3389/fgene.2024.1315677
PMC
PMC11079137
Cited by
7
References
0
Licence
creativecommons.org/licenses/by/4.0/ (vor)

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