Cited by 173Cancer, Hypoxia, and MetabolismRedox biology and oxidative stressNeuroscience of respiration and sleep

ROS: Really involved in Oxygen Sensing

Open access
Kaelin, William G.·2005·Cell Metabolism

Abstract

The role of reactive oxygen species (ROS) in the cellular response to cellular oxygen sensing has been controversial. Three papers in this issue of Cell Metabolism (Brunelle et al., Guzy et al., 2005; Mansfield et al., 2005) used genetic tools to establish that ROS produced by mitochondria are required for the normal induction of HIF (hypoxia-inducible factor), which is a master regulator of oxygen-sensitive gene expression, by low oxygen.

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Crossref · 10.1016/j.cmet.2005.05.006

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13 of 13 references verified0 citation errors · 0 not checkable

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  • PHD activity can be inhibited by reactive oxygen species produced by mitochondria.

    “Additionally, PHD activity can be inhibited by reactive oxygen species (ROS) produced by the mitochondria”

    From Hypoxic control of metastasis (2016) · cites this paper as [23]

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Authors
Kaelin, W. G.
Affiliations
Brigham and Women's Hospital (US)
Corresponding author
Kaelin, William G.
Venue
Cell Metabolism
Publisher
Elsevier BV
Published
2005-06
Volume
1
Issue
6
Pages
357-358
ISSN
1550-4131 (ISSN-L)
OpenAlex
W2051215275
Cited by
173
References
13
Citations by year
2026: 1 · 2025: 7 · 2024: 4 · 2023: 3 · 2022: 6 · 2021: 10 · 2020: 6 · 2019: 7 · 2018: 4 · 2017: 11 · 2016: 6 · 2015: 6 · 2014: 10 · 2013: 11 · 2012: 7
FWCI
4.38
Type
journal article
Language
en
Open access
Locations
  • Cell Metabolism (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Hypoxia, and Metabolism
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
  • Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroscience of respiration and sleep
Keywords
reactive oxygen species, oxygen sensing, hypoxia-inducible factor, mitochondrial reactive oxygen species, hypoxia
MeSH terms
Animals, DNA-Binding Proteins, Humans, Nuclear Proteins, Oxygen, Transcription Factors, Reactive Oxygen Species, Mice, Hypoxia-Inducible Factor 1, Hypoxia-Inducible Factor 1, alpha Subunit

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