ROS: Really involved in Oxygen Sensing
Open accessAbstract
The role of reactive oxygen species (ROS) in the cellular response to cellular oxygen sensing has been controversial. Three papers in this issue of Cell Metabolism (Brunelle et al., Guzy et al., 2005; Mansfield et al., 2005) used genetic tools to establish that ROS produced by mitochondria are required for the normal induction of HIF (hypoxia-inducible factor), which is a master regulator of oxygen-sensitive gene expression, by low oxygen.
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PHD activity can be inhibited by reactive oxygen species produced by mitochondria.
“Additionally, PHD activity can be inhibited by reactive oxygen species (ROS) produced by the mitochondria”
From Hypoxic control of metastasis (2016) · cites this paper as [23]
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- Authors
- Kaelin, W. G.
- Affiliations
- Brigham and Women's Hospital (US)
- Corresponding author
- Kaelin, William G.
- ORCID
- Kaelin, William G.
- Venue
- Cell Metabolism
- Publisher
- Elsevier BV
- Published
- 2005-06
- Volume
- 1
- Issue
- 6
- Pages
- 357-358
- ISSN
- 1550-4131 (ISSN-L)
- OpenAlex
- W2051215275
- Cited by
- 173
- References
- 13
- Citations by year
- 2026: 1 · 2025: 7 · 2024: 4 · 2023: 3 · 2022: 6 · 2021: 10 · 2020: 6 · 2019: 7 · 2018: 4 · 2017: 11 · 2016: 6 · 2015: 6 · 2014: 10 · 2013: 11 · 2012: 7
- FWCI
- 4.38
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Cell Metabolism (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Hypoxia, and Metabolism
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroscience of respiration and sleep
- Keywords
- reactive oxygen species, oxygen sensing, hypoxia-inducible factor, mitochondrial reactive oxygen species, hypoxia
- MeSH terms
- Animals, DNA-Binding Proteins, Humans, Nuclear Proteins, Oxygen, Transcription Factors, Reactive Oxygen Species, Mice, Hypoxia-Inducible Factor 1, Hypoxia-Inducible Factor 1, alpha Subunit
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