The DOI matches its Crossref record; 240 of the 240 references it cites were found in a registry or an index.
Chronic Inflammation in Cancer Development
Open accessAbstract
Chronic inflammatory mediators exert pleiotropic effects in the development of cancer. On the one hand, inflammation favors carcinogenesis, malignant transformation, tumor growth, invasion, and metastatic spread; on the other hand inflammation can stimulate immune effector mechanisms that might limit tumor growth. The link between cancer and inflammation depends on intrinsic and extrinsic pathways. Both pathways result in the activation of transcription factors such as NF-κB, STAT-3, and HIF-1 and in accumulation of tumorigenic factors in tumor and microenvironment. STAT-3 and NF-κB interact at multiple levels and thereby boost tumor-associated inflammation which can suppress anti-tumor immune responses. These factors also promote tumor growth, progression, and metastatic spread. IL-1, IL-6, TNF, and PGHS-2 are key mediators of an inflammatory milieu by modulating the expression of tumor-promoting factors. In this review we concentrate on the crucial role of pro-inflammatory mediators in inflammation-driven carcinogenesis and outline molecular mechanisms of IL-1 signaling in tumors. In addition, we elucidate the dual roles of stress proteins as danger signals in the development of anti-cancer immunity and anti-apoptotic functions.
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Cites
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“Bacterial infection is one of the major causes of chronic inflammation which facilitates increased cell proliferation, mutagenesis, oncogene activation, and angiogenesis that lead to development of oral cancer.(6) Numerous bacterial species are involved in oral cancer.”
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Metadata
- Authors
- Multhoff, G., Molls, M., & Radons, J.
- Venue
- Frontiers in Immunology
- Publisher
- Frontiers Media SA
- Published
- 2012
- Volume
- 2
- Pages
- 98-98
- ISSN
- 1664-3224 (ISSN-L)
- OpenAlex
- W1984752955
- Cited by
- 576
- References
- 240
- FWCI
- 6.39
- Type
- journal article
- Language
- en
- Open access
- gold
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- Multhoff, G., Molls, M., & Radons, J. (2012). Chronic Inflammation in Cancer Development. Frontiers in Immunology. https://doi.org/10.3389/fimmu.2011.00098
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
