Cited by 219Immune responses and vaccinationsImmune Response and InflammationT-cell and B-cell Immunology

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The Role of Environmental Factors in Modulating Immune Responses in Early Life

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MacGillivray, Duncan M., Kollmann, Tobias R.·2014·Frontiers in Immunology

DOI 10.3389/fimmu.2014.00434PMC PMC4161944

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Abstract

The concept of immunological memory stipulates that past exposures shape present immune function. These exposures include not only specific antigens impacting adaptive immune memory but also conserved pathogen or danger associated molecular patterns that mold innate immune responses for prolonged periods of time. It should thus not come as a surprise that there is a vast range of external or environmental factors that impact immunity. The importance of environmental factors modulating immunity is most readily recognized in early life, a period of rapidly changing environments. We here summarize available data on the role of environment shaping immune development and from it derive an overarching hypothesis relating the underlying molecular mechanisms and evolutionary principles involved.

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Authors: MacGillivray, D. M., & Kollmann, T. R.
Affiliations: University of British Columbia (CA)
Corresponding author: Kollmann, Tobias R.
ORCID: Kollmann, Tobias R.
Venue: Frontiers in Immunology
Publisher: Frontiers Media SA
Published: 2014-09-12
Volume: 5
Pages: 434-434
ISSN: 1664-3224 (ISSN-L)
DOI: 10.3389/fimmu.2014.00434
PMC: PMC4161944
OpenAlex: W2077870918
Cited by: 219
References: 182
Citations by year: 2026: 15 · 2025: 27 · 2024: 19 · 2023: 22 · 2022: 24 · 2021: 33 · 2020: 22 · 2019: 17 · 2018: 13 · 2017: 14 · 2016: 6 · 2015: 7
FWCI: 0.88
Type: journal article
Language: en
Open access: gold
doi.org
Licence: cc-by
Locations: Frontiers in Immunology (publishedVersion, cc-by)
Europe PMC (PubMed Central) (publishedVersion, cc-by)
PubMed Central (publishedVersion, cc-by)
PubMed (publishedVersion)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders: Burroughs Wellcome Fund
Michael Smith Health Research BC
Topics: Life Sciences › Immunology and Microbiology › Immunology › Immune responses and vaccinations
Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
Keywords: environmental factors, immune system development, early life, immunological memory, innate immunity, adaptive immunity, pathogen-associated molecular patterns, damage-associated molecular patterns, evolutionary immunology, immune system evolution

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The Role of Environmental Factors in Modulating Immune Responses in Early Life

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