Innate Immune Programing by Endotoxin and Its Pathological Consequences

Exploring the full spectrum of macrophage activation

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Changes in gut microbiota control metabolic endotoxemia-induced inflammation in high-fat diet-induced obesity and diabetes in mice

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Systemic LPS causes chronic neuroinflammation and progressive neurodegeneration

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The Ras-ERK and PI3K-mTOR pathways: cross-talk and compensation

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MyD88 is an adaptor protein in the hToll/IL-1 receptor family signaling pathways.

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Trained Immunity: A Memory for Innate Host Defense

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Negative regulation of Toll-like receptor-mediated immune responses

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TLR signaling

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Endotoxin tolerance: new mechanisms, molecules and clinical significance

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Candida albicans Infection Affords Protection against Reinfection via Functional Reprogramming of Monocytes

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Recognition of lipopolysaccharide pattern by TLR4 complexes

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Toll-like receptor–mediated cytokine production is differentially regulated by glycogen synthase kinase 3

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CD14 Controls the LPS-Induced Endocytosis of Toll-like Receptor 4

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The Effects Of Obesity, Smoking, And Drinking On Medical Problems And Costs

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Inflammatory markers in population studies of aging

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Systems biology approaches identify ATF3 as a negative regulator of Toll-like receptor 4

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C-Reactive Protein and the Prediction of Cardiovascular Events Among Those at Intermediate Risk

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Nuclear receptor transrepression pathways that regulate inflammation in macrophages and T cells

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Functional Diversity and Regulation of Different Interleukin-1 Receptor-Associated Kinase (IRAK) Family Members

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Endotoxin tolerance: A review

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Association of endotoxemia with carotid atherosclerosis and cardiovascular disease

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Microbial Translocation Is Associated with Increased Monocyte Activation and Dementia in AIDS Patients

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Epigenetic regulation of the alternatively activated macrophage phenotype

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Prevalence of Doctor-Diagnosed Arthritis and Arthritis-Attributable Activity Limitation--United States, 2003-2005

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Gut Microbiota, Lipopolysaccharides, and Innate Immunity in the Pathogenesis of Obesity and Cardiovascular Risk

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Endotoxemia and gut barrier dysfunction in alcoholic liver disease†

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Obesity among adults in the United States: No statistically significant change since 2003-2004

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IFN-γ Suppresses IL-10 Production and Synergizes with TLR2 by Regulating GSK3 and CREB/AP-1 Proteins

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Systemic low-grade inflammation is related to both circulating and adipose tissue TNFα, leptin and IL-6 levels in obese women

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A comprehensive map of the toll‐like receptor signaling network

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Experimental Endotoxemia Induces Adipose Inflammation and Insulin Resistance in Humans

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Engulfment of Apoptotic Cells by Macrophages: A Role of MicroRNA-21 in the Resolution of Wound Inflammation

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Bruton's Tyrosine Kinase Is a Toll/Interleukin-1 Receptor Domain-binding Protein That Participates in Nuclear Factor κB Activation by Toll-like Receptor 4

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Crosstalk among Jak-STAT, Toll-like receptor, and ITAM-dependent pathways in macrophage activation

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Emulsified lipids increase endotoxemia: possible role in early postprandial low-grade inflammation

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Potential Role of Endotoxin as a Proinflammatory Mediator of Atherosclerosis

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A Marker of Endotoxemia Is Associated With Obesity and Related Metabolic Disorders in Apparently Healthy Chinese

Sun, L. D., Yu, Z., Ye, X., Zou, S., Li, H., Yu, D., Wu, H., Chen, Y., Dore, J. M., Clément, K., et al. (2010) · Diabetes Care · doi:10.2337/dc10-0340 · Cited by 277 · see citing works

Mammalian target of rapamycin and glycogen synthase kinase 3 differentially regulate lipopolysaccharide-induced interleukin-12 production in dendritic cells

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Src-family and Syk Kinases in Activating and Inhibitory Pathways in Innate Immune Cells: Signaling Cross TalkPreprint

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FoxO1 regulates Tlr4 inflammatory pathway signalling in macrophages

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Characterization of Interleukin-1 Receptor-associated Kinase in Normal and Endotoxin-tolerant Cells

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Inhibition of GSK-3 Selectively Reduces Glucose-6-Phosphatase and Phosphoenolpyruvate Carboxykinase Gene Expression

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Structure, function and regulation of the Toll/IL‐1 receptor adaptor proteins

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Endotoxemia is Related to Systemic Inflammation and Atherosclerosis in Peritoneal Dialysis Patients

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Interferon gamma, a mediator of lethal lipopolysaccharide-induced Shwartzman-like shock reactions in mice.

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Quercetin is equally or more effective than resveratrol in attenuating tumor necrosis factor-α–mediated inflammation and insulin resistance in primary human adipocytes

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Bruton’s Tyrosine Kinase Is Required for TLR2 and TLR4-Induced TNF, but Not IL-6, Production

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LPS preconditioning redirects TLR signaling following stroke: TRIF-IRF3 plays a seminal role in mediating tolerance to ischemic injury

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Low Doses of Lipopolysaccharide and Minimally Oxidized Low-Density Lipoprotein Cooperatively Activate Macrophages via Nuclear Factor κB and Activator Protein-1

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Lipopolysaccharide-activated microglia induce death of oligodendrocyte progenitor cells and impede their development

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Mammalian Target of Rapamycin Complex 2 (mTORC2) Negatively Regulates Toll-like Receptor 4-mediated Inflammatory Response via FoxO1

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Gamma Interferon and Granulocyte/Monocyte Colony-stimulating Factor Prevent Endotoxin Tolerance in Human Monocytes by Promoting Interleukin-1 Receptor-associated Kinase Expression and Its Association to MyD88 and Not by Modulating TLR4 Expression

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Molecular Mechanisms Responsible for the Selective and Low-Grade Induction of Proinflammatory Mediators in Murine Macrophages by Lipopolysaccharide

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B Cell–Specific Loss of Lyn Kinase Leads to Autoimmunity

Lamagna, C., Hu, Y., DeFranco, A. L., & Lowell, C. A. (2013) · The Journal of Immunology · doi:10.4049/jimmunol.1301979 · Cited by 143 · see citing works

Role of Epigenetics in Inflammation-Associated diseases

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CD14-Dependent Internalization of Bacterial Lipopolysaccharide (LPS) Is Strongly Influenced by LPS Aggregation But Not by Cellular Responses to LPS

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Molecular Mechanism Responsible for the Priming of Macrophage Activation

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IRAK1 Serves as a Novel Regulator Essential for Lipopolysaccharide-induced Interleukin-10 Gene Expression

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Endotoxin tolerance dysregulates MyD88- and Toll/IL-1R domain-containing adapter inducing IFN-β-dependent pathways and increases expression of negative regulators of TLR signaling

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Diverse microglial responses after intrahippocampal administration of lipopolysaccharide

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Endotoxin levels correlate positively with a sedentary lifestyle and negatively with highly trained subjects

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Myeloid cells, BAFF, and IFN-γ establish an inflammatory loop that exacerbates autoimmunity in Lyn-deficient mice

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Resuscitation with Ringer's Ethyl Pyruvate Solution Prolongs Survival and Modulates Plasma Cytokine and Nitrite/Nitrate Concentrations in a Rat Model of Lipopolysaccharide-Induced Shock

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Interleukin-10-induced gene expression and suppressive function are selectively modulated by the PI3K-Akt-GSK3 pathway

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Extrinsic and intrinsic control of macrophage inflammatory responses

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Endotoxin, TLR4 Signaling and Vascular Inflammation: Potential Therapeutic Targets in Cardiovascular Disease

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Hyperactivated MyD88 signaling in dendritic cells, through specific deletion of Lyn kinase, causes severe autoimmunity and inflammation

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Metabolic endotoxemia and saturated fat contribute to circulating NGAL concentrations in subjects with insulin resistance

Moreno‐Navarrete, J. M., Manco, M., Ibáñez, J., García‐Fuentes, E., Ortega, F. J., Gorostiaga, E. M., Vendrell, J. J., Izquierdo, M., Martínez, C., Nolfe, G., et al. (2009) · International Journal of Obesity · doi:10.1038/ijo.2009.242 · Cited by 98 · see citing works

A common pathway mediated through Toll-like receptors leads to T- and natural killer–cell immunosuppression

Vaknin, I., Blinder, L., Wang, L., Gazit, R., Shapira, E., Genina, O., Pines, M., Pikarsky, E., & Baniyash, M. (2007) · Blood · doi:10.1182/blood-2007-07-100404 · Cited by 98 · see citing works

Hck Tyrosine Kinase Regulates TLR4-Induced TNF and IL-6 Production via AP-1

Smolinska, M., Page, T. H., Urbaniak, A. M., Mutch, B. E., & Horwood, N. J. (2011) · The Journal of Immunology · doi:10.4049/jimmunol.1100967 · Cited by 96 · see citing works

GSK3: an in-Toll-erant protein kinase?

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Requirement for MyD88 Signaling in B Cells and Dendritic Cells for Germinal Center Anti-Nuclear Antibody Production in Lyn-Deficient Mice

Hua, Z., Gross, A. J., Lamagna, C., Ramos-Hernández, N., Scapini, P., Ji, M. H., Shao, H., Lowell, C. A., Hou, B., & DeFranco, A. L. (2013) · The Journal of Immunology · doi:10.4049/jimmunol.1300683 · Cited by 92 · see citing works

Lipopolysaccharide-induced endothelial barrier breakdown is cyclic adenosine monophosphate dependent in vivo and in vitro*

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B-cell adaptor for PI3K (BCAP) negatively regulates Toll-like receptor signaling through activation of PI3K

Ni, M., Macfarlane, A. W., Graham, M., Lowell, C. A., Campbell, K. S., & Hamerman, J. A. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1111957108 · Cited by 89 · see citing works

Phosphatidylinositol-3 Kinase/Akt and GSK-3 Mediated Cytoprotective Effect of Epigallocatechin Gallate on Oxidative Stress-Injured Neuronal-Differentiated N18D3 Cells

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IFN-β Production by TLR4-Stimulated Innate Immune Cells Is Negatively Regulated by GSK3-β

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The Src family kinase Hck regulates mast cell activation by suppressing an inhibitory Src family kinase Lyn

Hong, H., Kitaura, J., Xiao, W., Hořejšı́, V., Ra, C., Lowell, C. A., Kawakami, Y., & Kawakami, T. (2007) · Blood · doi:10.1182/blood-2007-01-066092 · Cited by 85 · see citing works

Phosphatidylinositol 3-Kinase Activation Attenuates the TLR2-Mediated Macrophage Proinflammatory Cytokine Response to Francisella tularensis Live Vaccine Strain

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Endotoxin levels in sera of elderly individuals

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Akt Regulates Basal and Induced Processing of NF-κB2 (p100) to p52

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The Role of JAK-3 in Regulating TLR-Mediated Inflammatory Cytokine Production in Innate Immune Cells

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Inhibition of glycogen synthase kinase 3 beta ameliorates liver ischemia reperfusion injury by way of an interleukin-10-mediated immune regulatory mechanism

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Lyn kinase controls TLR4-dependent IKK and MAPK activation modulating the activity of TRAF-6/TAK-1 protein complex in mast cells

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Glycogen Synthase Kinase-3 Represses Cyclic AMP Response Element-binding Protein (CREB)-targeted Immediate Early Genes in Quiescent Cells

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