The DOI matches its Crossref record; 206 of the 209 references it cites were found in a registry or an index.
Childhood Obesity: Immune Response and Nutritional Approaches
Open accessAbstract
Childhood obesity is characterized by a low-grade inflammation status depending on the multicellular release of cytokines, adipokines, and reactive oxygen species. In particular, the imbalance between anti-inflammatory T regulatory cells and inflammatory T helper 17 cells seems to sustain such a phlogistic condition. Alterations of gut microbiota since childhood also contribute to the maintenance of inflammation. Therefore, besides preventive measures and caloric restrictions, dietary intake of natural products endowed with anti-oxidant and anti-inflammatory activities may represent a valid interventional approach for preventing and/or attenuating the pathological consequences of obesity. In this regard, the use of prebiotics, probiotics, polyphenols, polyunsaturated fatty acids, vitamins, and melatonin in human clinical trials will be described.
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In the citing paper
“ageing and obesity are both associated with chronic low grade inflammation, immune impairment, and intestinal dysbiosis.”
From Antioxidant, Immunomodulating, and Microbial‐Modulating Activities of the Sustainable and Ecofriendly Spirulina (2017) · cites this paper as [141]
In the citing paper
“Obesity is associated with systemic inflammation and impaired immunity.”
From The influence of obesity on the effects of spirulina supplementation in the human metabolic response of Korean elderly (2016) · cites this paper as [30]
In the citing paper
“In obese individuals, visceral adipose tissue is the major source of proinflammatory cytokines [30].”
From The influence of obesity on the effects of spirulina supplementation in the human metabolic response of Korean elderly (2016) · cites this paper as [30]
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Items 201–206 of 206
Bacteria and their cell wall components uniformly co-activate interleukin-17-producing thymocytes
Weber, A., Zimmermann, C., Kieseier, B. C., Hartung, H., & Hofstetter, H. H. (2014) · Clinical & Experimental Immunology · doi:10.1111/cei.12414 · Cited by 10 · cited 1×
“IL-17 also plays a crucial role in host defense upon bacterial and fungal infections by recruiting neutrophils and producing antimicrobial peptides (AMPs) (48).”
BackgroundBautista-Castaño, I., Sangil-Monroy, M., & Serra‐Majem, L. (2004) · Medicina Clínica · doi:10.1016/s0025-7753(04)74668-0 · Cited by 10
Reactive nitrogen species; devastating intracellular players and melatonin as a defender
Korkmaz, A., & Manchester, L. C. (2011) · Journal of Experimental and Integrative Medicine · doi:10.5455/jeim.270311.ed.003 · Cited by 10 · cited 1×
“MELATONIN Melatonin is a pineal hormone endowed with anti-oxidant properties, thus, preventing nitro-oxidative stress mediated by peroxynitrites (179).”
BackgroundKorhonen, R., Kosonen, O., Hämäläinen, M., & Moilanen, E. (2008) · Basic & Clinical Pharmacology & Toxicology · doi:10.1111/j.1742-7843.2008.00275.x · Cited by 9 · cited 1×
“In this framework, it is worthwhile mentioning that post-prandial stress is associated to a condition of low-grade inflammation (63) with a massive increase of free radicals and pro-inflammatory cytokines (64).”
BackgroundMetabolic Syndrome, its Pathophysiology and the Role of Melatonin
Srinivasan, V., Ohta, Y., Espino, J., Pariente, J. A., Rodríguez, A., Mohamed, M., & Zakaria, R. (2012) · Recent Patents on Endocrine Metabolic & Immune Drug Discovery · doi:10.2174/1872214811307010011 · Cited by 8
Mechanistic insights into the cardiovascular benefits of a Mediterranean diet
Lim, G. B. (2014) · Nature Reviews Cardiology · doi:10.1038/nrcardio.2014.92 · Cited by 4 · cited 1×
“general recommendations associated to other recent dietary guidelines (55, 56) are primarily based on low intakes of saturated and trans fat, cholesterol, added sugar and salt, energy intake, and PA according to the Mediterranean diet (MedDiet) model (57, 58).”
Flagged first, then by citations
3 of the 209 references couldn’t be matched to a known paper.
Research works printed but not linked: 3
- International Association for the Study of Obesity, 2013, Obesity the Global Epidemic
- Bautista-Castaño, 2004, [Knowledge and gaps on the role of nutrition and physical activity on the onset of childhood obesity], Med Clin (Barc), 123, 782
- Califf, 2014, The human microbiome: getting personal, Microbe, 9, 410
Cited by
Sorted by citations
Cortellini, A., Bersanelli, M., Buti, S., Cannita, K., Santini, D., Perrone, F., Giusti, R., Tiseo, M., Michiara, M., Di Marino, P., et al. (2019) · Journal for ImmunoTherapy of Cancer · doi:10.1186/s40425-019-0527-y · Cited by 413
Morales, F., la Paz, S. M., León, M. J., & Rivero‐Pino, F. (2023) · Nutrients · doi:10.3390/nu16010001 · Cited by 452
“Overall, in the case of obese children needing to improve their health status, the dietary considerations include limiting the number of sugar-sweetened drinks and meals that include portions of fruits and vegetables consumed, avoiding fast food and promoting small serving sizes [80].”
BackgroundGut microbiota role in irritable bowel syndrome: New therapeutic strategies
Distrutti, E., Monaldi, L., Ricci, P., & Fiorucci, S. (2016) · World Journal of Gastroenterology · doi:10.3748/wjg.v22.i7.2219 · Cited by 320
Finamore, A., Palmery, M., Bensehaila, S., & Peluso, I. (2017) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2017/3247528 · Cited by 256
“In this context, ageing [140], obesity [141, 142], and metabolic syndrome [142] are associated not only to chronic low grade inflammation, but also to immune impairment (recurrent infection and low vaccine efficacy).”
BackgroundThe influence of diet on anti-cancer immune responsiveness
Soldati, L., Renzo, L. D., Jirillo, E., Ascierto, P. A., Marincola, F. M., & LORENZO, A. D. (2018) · Journal of Translational Medicine · doi:10.1186/s12967-018-1448-0 · Cited by 249
“Overall, obesity, a diet-related disease, represents a systemic inflammatory condition characterized by an excessive production of IL-17 and IL-21, which, in turn, are strong inducers of Th17 cells [12, 13].”
BackgroundSelf-citation
Metadata
- Authors
- Magrone, T., & Jirillo, E.
- Affiliations
- University of Bari Aldo Moro (IT)
- Corresponding author
- Jirillo, Emilio
- Venue
- Frontiers in Immunology
- Publisher
- Frontiers Media SA
- Published
- 2015-02-24
- Volume
- 6
- Pages
- 76-76
- ISSN
- 1664-3224 (ISSN-L)
- PMC
- PMC4338791
- OpenAlex
- W1989401283
- Cited by
- 67
- References
- 209
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 1 · 2023: 4 · 2022: 7 · 2021: 10 · 2020: 9 · 2019: 8 · 2018: 4 · 2017: 12 · 2016: 5 · 2015: 4
- FWCI
- 1.08
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by
- Locations
- Frontiers in Immunology (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- CINECA IRIS Institutional Research Information System (University of Bari Aldo Moro) (submittedVersion, other-oa)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Obesity, Physical Activity, Diet
- Keywords
- childhood obesity, low-grade inflammation, cytokines, adipokines, reactive oxygen species, regulatory T cells, Th17 cells, gut microbiota, prebiotics, probiotics, polyphenols, polyunsaturated fatty acids, vitamins, melatonin, natural antioxidants, dietary intervention
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