The DOI matches its Crossref record; 206 of the 209 references it cites were found in a registry or an index.
Childhood Obesity: Immune Response and Nutritional Approaches
Open accessAbstract
Childhood obesity is characterized by a low-grade inflammation status depending on the multicellular release of cytokines, adipokines, and reactive oxygen species. In particular, the imbalance between anti-inflammatory T regulatory cells and inflammatory T helper 17 cells seems to sustain such a phlogistic condition. Alterations of gut microbiota since childhood also contribute to the maintenance of inflammation. Therefore, besides preventive measures and caloric restrictions, dietary intake of natural products endowed with anti-oxidant and anti-inflammatory activities may represent a valid interventional approach for preventing and/or attenuating the pathological consequences of obesity. In this regard, the use of prebiotics, probiotics, polyphenols, polyunsaturated fatty acids, vitamins, and melatonin in human clinical trials will be described.
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“ageing and obesity are both associated with chronic low grade inflammation, immune impairment, and intestinal dysbiosis.”
From Antioxidant, Immunomodulating, and Microbial‐Modulating Activities of the Sustainable and Ecofriendly Spirulina (2017) · cites this paper as [141]
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“Obesity is associated with systemic inflammation and impaired immunity.”
From The influence of obesity on the effects of spirulina supplementation in the human metabolic response of Korean elderly (2016) · cites this paper as [30]
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“In obese individuals, visceral adipose tissue is the major source of proinflammatory cytokines [30].”
From The influence of obesity on the effects of spirulina supplementation in the human metabolic response of Korean elderly (2016) · cites this paper as [30]
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Cites
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Cited by
Sorted by citations
Cortellini, A., Bersanelli, M., Buti, S., Cannita, K., Santini, D., Perrone, F., Giusti, R., Tiseo, M., Michiara, M., Di Marino, P., et al. (2019) · Journal for ImmunoTherapy of Cancer · doi:10.1186/s40425-019-0527-y · Cited by 413
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BackgroundThe influence of diet on anti-cancer immune responsiveness
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“Overall, obesity, a diet-related disease, represents a systemic inflammatory condition characterized by an excessive production of IL-17 and IL-21, which, in turn, are strong inducers of Th17 cells [12, 13].”
BackgroundSelf-citation
Metadata
- Authors
- Magrone, T., & Jirillo, E.
- Affiliations
- University of Bari Aldo Moro (IT)
- Corresponding author
- Jirillo, Emilio
- Venue
- Frontiers in Immunology
- Publisher
- Frontiers Media SA
- Published
- 2015-02-24
- Volume
- 6
- Pages
- 76-76
- ISSN
- 1664-3224 (ISSN-L)
- PMC
- PMC4338791
- OpenAlex
- W1989401283
- Cited by
- 67
- References
- 209
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 1 · 2023: 4 · 2022: 7 · 2021: 10 · 2020: 9 · 2019: 8 · 2018: 4 · 2017: 12 · 2016: 5 · 2015: 4
- FWCI
- 1.08
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by
- Locations
- Frontiers in Immunology (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- CINECA IRIS Institutional Research Information System (University of Bari Aldo Moro) (submittedVersion, other-oa)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Obesity, Physical Activity, Diet
- Keywords
- childhood obesity, low-grade inflammation, cytokines, adipokines, reactive oxygen species, regulatory T cells, Th17 cells, gut microbiota, prebiotics, probiotics, polyphenols, polyunsaturated fatty acids, vitamins, melatonin, natural antioxidants, dietary intervention
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