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Childhood Obesity: Immune Response and Nutritional Approaches
Open accessAbstract
Childhood obesity is characterized by a low-grade inflammation status depending on the multicellular release of cytokines, adipokines, and reactive oxygen species. In particular, the imbalance between anti-inflammatory T regulatory cells and inflammatory T helper 17 cells seems to sustain such a phlogistic condition. Alterations of gut microbiota since childhood also contribute to the maintenance of inflammation. Therefore, besides preventive measures and caloric restrictions, dietary intake of natural products endowed with anti-oxidant and anti-inflammatory activities may represent a valid interventional approach for preventing and/or attenuating the pathological consequences of obesity. In this regard, the use of prebiotics, probiotics, polyphenols, polyunsaturated fatty acids, vitamins, and melatonin in human clinical trials will be described.
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“ageing and obesity are both associated with chronic low grade inflammation, immune impairment, and intestinal dysbiosis.”
From Antioxidant, Immunomodulating, and Microbial‐Modulating Activities of the Sustainable and Ecofriendly Spirulina (2017) · cites this paper as [141]
In the citing paper
“Obesity is associated with systemic inflammation and impaired immunity.”
From The influence of obesity on the effects of spirulina supplementation in the human metabolic response of Korean elderly (2016) · cites this paper as [30]
In the citing paper
“In obese individuals, visceral adipose tissue is the major source of proinflammatory cytokines [30].”
From The influence of obesity on the effects of spirulina supplementation in the human metabolic response of Korean elderly (2016) · cites this paper as [30]
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Improvement of Colonic Immune Function with Soy Isoflavones in High-Fat Diet-Induced Obese Rats
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“Introduction Obesity is aworldwide epidemic in continuous growth,which is associated to high mortality and morbidity [1, 2].”
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Metadata
- Authors
- Magrone, T., & Jirillo, E.
- Affiliations
- University of Bari Aldo Moro (IT)
- Corresponding author
- Jirillo, Emilio
- Venue
- Frontiers in Immunology
- Publisher
- Frontiers Media SA
- Published
- 2015-02-24
- Volume
- 6
- Pages
- 76-76
- ISSN
- 1664-3224 (ISSN-L)
- PMC
- PMC4338791
- OpenAlex
- W1989401283
- Cited by
- 67
- References
- 209
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 1 · 2023: 4 · 2022: 7 · 2021: 10 · 2020: 9 · 2019: 8 · 2018: 4 · 2017: 12 · 2016: 5 · 2015: 4
- FWCI
- 1.08
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by
- Locations
- Frontiers in Immunology (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- CINECA IRIS Institutional Research Information System (University of Bari Aldo Moro) (submittedVersion, other-oa)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Obesity, Physical Activity, Diet
- Keywords
- childhood obesity, low-grade inflammation, cytokines, adipokines, reactive oxygen species, regulatory T cells, Th17 cells, gut microbiota, prebiotics, probiotics, polyphenols, polyunsaturated fatty acids, vitamins, melatonin, natural antioxidants, dietary intervention
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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