The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
Dual Role of Fas/FasL-Mediated Signal in Peripheral Immune Tolerance
Open accessAbstract
Fas-mediated apoptosis contributes to physiological and pathological cellular processes, such as differentiation and survival. In particular, the roles of Fas in immune cells are complex and critical for the maintenance of immune tolerance. The precise pathways and unique functions associated with Fas/FasL-mediated signaling in the immune system are known. The dual character of Fas/FasL-mediated immune regulation that induces beneficial or harmful effects is associated with the onset or development of immune disorders. Studies on mutations in genes encoding Fas and FasL gene of humans and mice contributed to our understanding of the pathogenesis of autoimmune diseases. Here, we review the opposing functions of Fas/FasL-mediated signaling, bilateral effects of Fas/FasL on in immune cells, and complex pathogenesis of autoimmunity mediated by Fas/FasL.
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Cites
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NF-κB at the crossroads of life and death
Karin, M., & Lin, A. (2002) · Nature Immunology · doi:10.1038/ni0302-221 · Cited by 2,709
Membrane-bound Fas ligand only is essential for Fas-induced apoptosis
O’ Reilly, L. A., Tai, L., Lee, L., Kruse, E. A., Grabow, S., Fairlie, W. D., Haynes, N. M., Tarlinton, D. M., Zhang, J.-G., Belz, G. T., et al. (2009) · Nature · doi:10.1038/nature08402 · Cited by 400
The Fas counterattack: Cancer as a site of immune privilege
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Cited by
An early history of T cell-mediated cytotoxicity
Golstein, P., & Griffiths, G. M. (2018) · Nature Reviews Immunology · doi:10.1038/s41577-018-0009-3 · Cited by 284
Age-associated B cells in autoimmune diseases
Mouat, I. C., Goldberg, E., & Horwitz, M. S. (2022) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-022-04433-9 · Cited by 170
Metadata
- Authors
- Yamada, A., Arakaki, R., Saito, M., Kudo, Y., & Ishimaru, N.
- Venue
- Frontiers in Immunology
- Publisher
- Frontiers Media SA
- Published
- 2017-04-05
- Volume
- 8
- Pages
- 403-403
- ISSN
- 1664-3224 (ISSN-L)
- OpenAlex
- W2604970209
- Cited by
- 218
- References
- 4
- FWCI
- 4.19
- Type
- journal article
- Language
- en
- Open access
- gold
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- Yamada, A., Arakaki, R., Saito, M., Kudo, Y., & Ishimaru, N. (2017). Dual Role of Fas/FasL-Mediated Signal in Peripheral Immune Tolerance. Frontiers in Immunology. https://doi.org/10.3389/fimmu.2017.00403
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
