Immunobiography and the Heterogeneity of Immune Responses in the Elderly: A Focus on Inflammaging and Trained Immunity

Inflamm‐aging: An Evolutionary Perspective on Immunosenescence

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The senescence-associated secretory phenotype: the dark side of tumor suppression

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The widespread regulation of microRNA biogenesis, function and decay

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Chronic Inflammation (Inflammaging) and Its Potential Contribution to Age-Associated Diseases

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SYSTEMIC ACQUIRED RESISTANCE

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Trained immunity: A program of innate immune memory in health and– disease

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The role of senescent cells in ageing

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mTOR- and HIF-1α–mediated aerobic glycolysis as metabolic basis for trained immunity

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Inflammaging and anti-inflammaging: a systemic perspective on aging and longevity emerged from studies in humans

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Systemic Acquired Resistance.

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Age-related immunosenescence in Behçet’s disease

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Re-visiting humoral constitutive antibacterial heterogeneity in bloodstream infections

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Tobacco exposure, but not aging, shifts the frequency of peripheral blood B cell subpopulations

Pinto, T. N. C., da Silva, C. C. B. M., Carvalho‐Pinto, R. M., Duarte, A. J. D. S., Benard, G., & Fernandes, J. R. (2023) · GeroScience · doi:10.1007/s11357-023-01051-6 · Cited by 5

Endocrine Risk Factors for COVID-19 in Context of Aging

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Biological age of transplanted livers

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Multivariate analysis of immunosenescence data in healthy humans and diverse diseases

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Immune aging of men and women: Different susceptibility to infectious diseases and different response to vaccines

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Extreme MetaboHealth scores in three cohort studies associate with plasma protein markers for inflammation and cholesterol transport

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Risk of Alzheimer Dementia After High-Dose vs Standard-Dose Influenza Vaccination

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Reduced Naïve T Cell Numbers Correlate with Increased Low-Grade Systemic Inflammation During Ageing and Can be Modulated by Physical Activity

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Aging, Inflammaging and Adaptation

Franceschi, C. (2021) · Physics of Life Reviews · doi:10.1016/j.plrev.2021.07.001 · Cited by 3

RNAi Technology and Investigation on Possible Vaccines to Combat SARS-CoV-2 Infection

Talukder, P., & Chanda, S. (2021) · Applied Biochemistry and Biotechnology · doi:10.1007/s12010-021-03548-2 · Cited by 3

Editorial: Exploring impacts of combined exposures to particles and chemicals on immune reactions across living organisms

Boraschi, D., Duschl, A., Lynch, I., & Stoeger, T. (2023) · Frontiers in Toxicology · doi:10.3389/ftox.2023.1148374 · Cited by 3

Immunity and Ageing

Caruso, C., Accardi, G., Aiello, A., & Candore, G. (2024) · Elsevier eBooks · doi:10.1016/b978-0-128-24465-4.00029-6 · Cited by 3

iTRAQ-based quantitative proteomic profiling of the regulatory mechanisms on immune functions and blood lipids in aged mice fed with Lentinula edodes-derived polysaccharides

Xu, X., Liu, X., Chen, J., Guan, J., & Luo, D. (2024) · Food Science and Human Wellness · doi:10.26599/fshw.2024.9250117 · Cited by 2

Gut Microbiota Alterations in Myelodysplastic Neoplasms Are Associated With Immune Dysfunction and the Therapeutic Mechanism of Hypomethylating Agents

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Trained Immunity Induced by Vaccines: A Shifting Paradigm for Infant and Adult Immunity

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A new cellular type in invertebrates: first evidence of telocytes in leech Hirudo medicinalis

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A comprehensive insight on the COVID-19 vaccine candidates

Sharma, A. R., Sharma, R., Kaur, R. J., Sharma, R., & Singh, S. (2021) · Journal of Family Medicine and Primary Care · doi:10.4103/jfmpc.jfmpc_1570_20 · Cited by 2

Novel Technologies to Improve Vaccines for Older Adults

Laupèze, B., der Most, R. G. V., & Giudice, G. D. (2020) · Interdisciplinary topics in gerontology and geriatrics · doi:10.1159/000504485 · Cited by 2

Why we should use topological data analysis in ageing: Towards defining the “topological shape of ageing”

Fülöp, T., Desroches, M., Cohen, A. A., Santos, F. A. N., & Rodrigues, S. (2020) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2020.111390 · Cited by 9

Antibody Titers in Elderly Patients After Rabies Post-Exposure Prophylaxis

Itani, O., Hochedez, P., Benabdelmoumen, G., Jidar, K., Taieb, F., Parize, P., Consigny, P., & Poujol, P. (2023) · Clinical Infectious Diseases · doi:10.1093/cid/ciad408 · Cited by 2

Human aging reflects increases in entropy across organ networksPreprint

Meng, H., Zhang, H., Li, Y., Huang, Y., Wu, J., Zhang, S., Guo, X. A., Li, X., Hu, Z., Li, X., et al. (2025) · medRxiv · doi:10.1101/2025.05.06.25327108 · Cited by 2

Deep learning representations of human Immune Health for precision immunologyPreprint

Lee, M., Kim, J., Ionita, M., McKeague, M. L., Lee, J., Nam, Y., Jeong, C.-U., Nair, A., Moyo, E. T., Khavin, I., et al. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.07.15.724605 · Cited by 2

Aging-induced stem cell dysfunction: Molecular mechanisms and potential therapeutic avenues

Grajeda, Y., Arias, N., Barrios, A., Pervin, S., & Singh, R. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-820071-1.00005-0 · Cited by 1

Baseline TGF-β correlates with protection after immunization with Plasmodium falciparum sporozoites in the controlled human malaria infection model

de Jong, G. M., Yap, X. Z., Walk, J., Dik, W. A., McCall, M. B. B., van Genderen, P. J. J., van Hellemond, J. J., Verbon, A., & Sauerwein, R. W. (2023) · Immunology Letters · doi:10.1016/j.imlet.2023.04.005 · Cited by 1

Inflammaging and Immunosenescence

Fülöp, T., Pawelec, G., Cohen, A. A., Legault, V., Hirokawa, K., Larbi, A., Khalil, A., Franceschi, C., & Witkowski, J. M. (2024) · Springer eBooks · doi:10.1007/978-3-031-57361-3_10 · Cited by 2

Therapeutic approaches to delay lung aging: understanding cellular and immune system changes in the older adults

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Autoimmune diseases of older people are influenced by sex and gender

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Determination of aging phenotype based on the changes in spontaneous and induced interleukin-6 and interleukin-10 production in vitro

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Clinical features of patients with familial Mediterranean fever over 50 years of age: a single-center experience

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Autoimmune diseases are more common in women: insights into sex and gender differences in autoimmunity

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Development of an adjuvanted, higher-dose, cell-based influenza vaccine: combining advanced technologies to improve vaccine effectiveness

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Trained immunity in the treatment for haematological malignancy

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The Gut–Immune–Brain Axis in Aging: Integrating Immunosenescence, Inflammaging, and Neuroinflammation for Precision Medicine

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The Complex Relationship Between Nutrition and Immunosenescence

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How Are Older Adults Different Than Other Adults for Infections?

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Immunology of Ageing

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Inflammaging: Significance and intervention.

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Cellular and humoral mechanisms of immune aging

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Protocol for CHIEF (cochlear implants and inner ear inflammation) study; an observational, cross-sectional study of children and young people undergoing cochlear implantation.

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IMMUNOSENESCENCE AND LATE-ONSET FAMILIAL MEDITERRANEAN FEVER

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Immunological Changes

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Beyond Covid: Pandemics and the Economics of Aging and LongevityPreprint

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Immunomodulation by raw bovine milk and its ingredients: effects in nutritional intervention, oral vaccination and trained immunity

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The Complex Relationship Between Nutrition and Immunosenescence

Larbi, A., Lesourd, B., & Fülöp, T. (2018) · Springer eBooks · doi:10.1007/978-3-319-64597-1_65-1

Immunity and Health

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Immunology of Ageing

Pawelec, G., & Müller, L. (2021) · Springer eBooks · doi:10.1007/978-3-030-01782-8_104-1

Estudio celular de la inmunosenescencia en adultos mayores vacunados y en pacientes con cáncer de mama

Rodríguez, R., & Johanna, I. (2021)

In vitro analysis of human immune response (IgG) against salivary gland extract of dengue vector from dengue hemorrhagic fever (DHF) endemic area in Jember, Indonesia

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Faculty Opinions recommendation of Defining trained immunity and its role in health and disease.

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Modern use of biomarkers in geriatric medicine

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Cytokine-neuroendocrine peripheral signature in the context of the “accelerated ageing” phenomenon in autism spectrum and schizophrenia spectrum disorders

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Differences in anti-viral immune responses in individuals of Indian and European origin: relevance for the COVID-19 pandemicPreprint

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Current approaches of anti-age related diseases: From molecules up to whole organism

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Fatores relacionados à sarcopenia em pessoas vivendo com o vírus da imunodeficiência humana

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Can age be a modifiable risk factor? the impact of dietary patterns on the molecular mechanisms that underlie cardiovascular aging

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Perturbations in spike‐specific peripheral T follicular helper cells in SARS‐CoV2 breakthrough convalescent individuals immunized by BBV152 vaccine

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Efeito da suplementação dietética com ácido graxo ômega-3 na resposta imunológica, hepática e muscular de camundongos knockout IL-10

Campanari, D. D. (2024) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/t.17.2024.tde-13052024-155734

Immunity, Immunosenescence, Brain and Cognitive/Mental Health

Fülöp, T., & Witkowski, J. M. (2024) · Healthy ageing and longevity · doi:10.1007/978-3-031-68513-2_6

The Normal Aging Brain

Richardson, P. K. (2024) · Topics in Geriatric Care. · doi:10.1007/978-981-97-5995-8_1

Editorial: Pathogen-induced immunosenescence: where do vaccines stand?

Doroudchi, M., & Fouladseresht, H. (2025) · Frontiers in Aging · doi:10.3389/fragi.2025.1560009

Investigating Chronic Post-Infection and Post-Injury Symptom Syndromes: Clinical Outcomes, Biological Pathways, and Potential Links to Neurodegenerative Disease

Grossberg, A. N. (2024) · Digital Commons - DU (University of Denver) · doi:10.56902/etdcrp.2024.14

A life course approach to healthy longevity

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The Quantified Immune-Aging Dysregulation Index (TENSE): a Large-Language Model-powered method to annotate and quantify systems-level dysregulationPreprint

Vavougios, G. D., & Hadjigeorgiou, G. M. (2025) · Research Square · doi:10.21203/rs.3.rs-7377143/v1

Association between human herpesvirus 6 status and sarcopenia risk: a UK biobank cohort study with sex-specific patterns and telomere length modification

Liu, X., Yang, W., Chen, X., Liu, Y., Zhao, Y., Li, Y., Chen, N., & Cui, J. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1623291

The unequal effect of pandemics on aging and longevity: A health economic analysis

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Leptospirosis in the republic of guinea

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Additional file 4 of Hyperactivation of monocytes and macrophages in MCI patients contributes to the progression of Alzheimer's disease

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Additional file 3 of Hyperactivation of monocytes and macrophages in MCI patients contributes to the progression of Alzheimer's disease

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Additional file 1 of Hyperactivation of monocytes and macrophages in MCI patients contributes to the progression of Alzheimer's disease

Munawara, U., Catanzaro, M., Xu, W., Tan, C., Hirokawa, K., Bosco, N., Dumoulin, D., Khalil, A., Larbi, A., Lévesque, S., et al. (2021) · Figshare · doi:10.6084/m9.figshare.14821079

Additional file 2 of Hyperactivation of monocytes and macrophages in MCI patients contributes to the progression of Alzheimer's disease

Munawara, U., Catanzaro, M., Xu, W., Tan, C., Hirokawa, K., Bosco, N., Dumoulin, D., Khalil, A., Larbi, A., Lévesque, S., et al. (2021) · Figshare · doi:10.6084/m9.figshare.14821082

Biologically Younger Individuals, as Identified by MARK ‐ AGE Biological Age Scores, Display a Distinct Favourable Blood Chemistry Profile Regardless of Age

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INFLAMMATORY AGING OF THE PERIODONTIUM

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Orchestration of myelopoiesis, early innate myeloid responses, and long-term innate immune imprinting after vaccination

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Qualification de l'ADNcf en transplantation d'organe et en transfusion sanguine : impact dans la tolérance immunitaire

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Avaliação do perfil imunológico de adultos mais velhos segundo as regiões brasileiras: resultados do ELSI-Brasil

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Innate immune restoration after major surgery in the elderly: functional adaptation for maintaining immune reactivity

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The quantified immune-aging dysregulation index: a large-language model-powered method for annotating and quantifying systems-level dysregulation

Vavougios, G., & Hadjigeorgiou, G. M. (2026) · Frontiers in Artificial Intelligence · doi:10.3389/frai.2026.1732901

Tumor Microenvironment Hijacks and Accelerates a Physiological Myeloid Senescence Signature Associated with Pan-Cancer Immunosuppression and Prognostic Stratification

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Diabetic cardiomyopathy: Target immune cell from mechanism to treatment

Lv, J., Bao, X., Jiao, X., Jiang, Y., Lin, M., Zhang, W., & Wang, M. C. (2026) · International Immunopharmacology · doi:10.1016/j.intimp.2026.117116

Predicting susceptibility to inflammaging using a genetic inflammatory index through Prakriti-based phenotypic stratification

Bera, N., Agaje Gowri, S., Syed, N., Govinda, V., Rao, A. K., Jeeru, J., Kurthkoti, K., Narayanaswamy, K., Jakka, S. R., Raghawan, A. K., et al. (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2026.1854940

The Intersection of Immunosenescence, Cellular Senescence, and Type 1 Diabetes: Paving the Way for Future Interventions

Saavedra, D., Mittal, R., Blaschke, C. E., Tondin, A. R., Añé-Kourí, A. L., Lage, A., Frasca, D., & Skyler, J. S. (2026) · Diabetes · doi:10.2337/db26-0159

Immune senescence and exhaustion in breast cancer patients with a history of childhood maltreatment

Rodríguez, I. J., Neira-Ortíz, S. L., Llano-León, M., Lalinde-Ruiz, N., Parada-Gereda, H. M., Pedraza, R. S., & López, C. A. P. (2026) · Brain Behavior & Immunity - Health · doi:10.1016/j.bbih.2026.101345

СИГНАЛЬНЫЕ МОЛЕКУЛЫ И СТАРЕНИЕ КОЖИ: ТАРГЕТНЫЕ ПОДХОДЫ ПРОФИЛАКТИКИ В МОЛЕКУЛЯРНОЙ КОСМЕТОЛОГИИ

Хабаров, В. Н., Жукова, И. К., Кравцова, И. В., Дробинцева, А. О., Белова, Ю. И., Kvetnaia, T. V., & Подвальная, Д. К. (2026) · Успехи геронтологии · doi:10.34922/ae.2026.39.4.014

Why Some People Live Past 100: The Role of the Immune System in Centenarians, Semi-Supercentenarians and Supercentenarians

Caruso, C., Accardi, G., Aiello, A., Calabrò, A., Puleo, C., Zarcone, R., & Candore, G. (2026) · International Journal of Molecular Sciences · doi:10.3390/ijms27188420

Comprehensive profiling of phenotypic features of memory T- and B-cells from birth to the onset of old age

Brito‐de‐Sousa, J. P., Reis, L. R., da Costa-Rocha, I. A., Peruhype-Magalhães, V., Costa-Pereira, C., Martins, J. P., Antonelli, L. R. D. V., Garcia, C. C., Gomes, A. O., Coelho-dos-Reis, J. G. A., et al. (2026) · Frontiers in Aging · doi:10.3389/fragi.2026.1890974

The Effect of Chronic Inflammation on Cellular Aging Processes and Current Treatment Approaches

Başaran, A. (2026) · Uluslararası Sağlık Bilimlerinde Disiplinler Arası Etkileşim Dergisi · doi:10.65349/nxpt1964

From inflamm-aging to immune-paralysis: a slippery slope during aging for immune-adaptation

Fülöp, T., Dupuis, G., Baëhl, S., Page, A. Y. L., Bourgade, K., Frost, E. H., Witkowski, J. M., Pawelec, G., Larbi, A., & Cunnane, S. C. (2015) · Biogerontology · doi:10.1007/s10522-015-9615-7 · Cited by 166

Evolution and development of innate immune memory

Divangahi, M., & Kaufmann, E. (2026) · Science Immunology · doi:10.1126/sciimmunol.aeb7976 · Cited by 7

Overcoming immune dysfunction in the elderly: trained immunity as a novel approach

Bulut, O., Kilic, G., Domínguez-Andrés, J., & Netea, M. G. (2020) · International Immunology · doi:10.1093/intimm/dxaa052 · Cited by 99

Trained Immunity: Long-Term Adaptation in Innate Immune Responses

Tercan, H., Riksen, N. P., Joosten, L., Netea, M. G., & Bekkering, S. (2021) · Radboud Repository (Radboud University) · Cited by 3

Immunological Changes

Fülöp, T., Larbi, A., Khalil, A., Hirokawa, K., Cohen, A. A., & Witkowski, J. M. (2022) · Lessons from the ICU · doi:10.1007/978-3-030-94133-8_6 · Cited by 1