Endothelial to Mesenchymal Transition Represents a Key Link in the Interaction between Inflammation and Endothelial Dysfunction

Lanthanum Chloride Inhibits LPS Mediated Expressions of Pro-Inflammatory Cytokines and Adhesion Molecules in HUVECs: Involvement of NF-κB-Jmjd3 Signaling

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Endothelial Cell Dysfunction and the Pathobiology of Atherosclerosis

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The NLRP3 inflammasome instigates obesity-induced inflammation and insulin resistance

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A novel heterodimeric cysteine protease is required for interleukin-1βprocessing in monocytes

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Inflammatory links between obesity and metabolic disease

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Endothelial-to-mesenchymal transition contributes to cardiac fibrosis

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Proinflammatory Cytokines

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Phenotypic Heterogeneity of the Endothelium

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Signaling mechanisms of the epithelial-mesenchymal transition

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Endothelial-to-Mesenchymal Transition and Inflammation Play Key Roles in Cyclophilin A–Induced Pulmonary Arterial Hypertension

Xue, C., Senchanthisai, S., Sowden, M. P., Pang, J., White, R. J., & Berk, B. C. (2020) · Hypertension · doi:10.1161/hypertensionaha.119.14013 · Cited by 29

KRAS mutation-induced EndMT of brain arteriovenous malformation is mediated through the TGF-β/BMP-SMAD4 pathway

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YAP is critical to inflammation, endothelial-mesenchymal transition and subretinal fibrosis in experimental choroidal neovascularization

Yang, X., Zou, R., Dai, X., Wu, X., Yuan, F., & Feng, Y. (2022) · Experimental Cell Research · doi:10.1016/j.yexcr.2022.113221 · Cited by 27

EpiRegio: analysis and retrieval of regulatory elements linked to genes

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Mesenchymal stem cells alleviate palmitic acid-induced endothelial-to-mesenchymal transition by suppressing endoplasmic reticulum stress

Luo, R., Li, L., Liu, X., Yuan, Y., Zhu, W., Li, L., Liu, J., Lu, Y., Cheng, J., & Chen, Y. (2020) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00155.2020 · Cited by 27

Primary hypercholesterolemia and development of cardiovascular disorders: Cellular and molecular mechanisms involved in low-grade systemic inflammation and endothelial dysfunction

Collado, A., Domingo, E., Piqueras, L., & Sanz, M. (2021) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2021.106066 · Cited by 32

An antibody against L1 cell adhesion molecule inhibits cardiotoxicity by regulating persistent DNA damage

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Inhibition of BAP31 expression inhibits cervical cancer progression by suppressing metastasis and inducing intrinsic and extrinsic apoptosis

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TLR2 regulates angiotensin II-induced vascular remodeling and EndMT through NF-κB signaling

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miR-181b-5p inhibits endothelial-mesenchymal transition in monocrotaline-induced pulmonary arterial hypertension by targeting endocan and TGFBR1

Zhao, H., Wang, Y., Zhang, X., Guo, Y., & Wang, X. (2019) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2019.114827 · Cited by 24

Angiogenic lncRNAs: A potential therapeutic target for ischaemic heart disease

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SIRT6 inhibits endothelial-to-mesenchymal transition through attenuating the vascular endothelial inflammatory response

Chen, L., Wang, G., He, J., Yang, X. P., Zheng, Z., Deng, Y. J., Liu, Y., Chen, D., Lin, R., & Wang, W. (2021) · International Immunopharmacology · doi:10.1016/j.intimp.2021.108240 · Cited by 22

Decoding the transcriptome of atherosclerotic plaque at single-cell resolutionPreprint

Alsaigh, T., Evans, D., Frankel, D. A., & Torkamani, A. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.03.03.968123 · Cited by 22

Ginsenoside Rg3 protects against iE-DAP–induced endothelial-to-mesenchymal transition by regulating the miR-139-5p–NF-κB axis

Lee, A., Yun, E., Chang, W., & Kim, J. M. (2019) · Journal of Ginseng Research · doi:10.1016/j.jgr.2019.01.003 · Cited by 21

Stromal Cells Underlining the Paths From Autoimmunity, Inflammation to Cancer With Roles Beyond Structural and Nutritional Support

Honan, A. M., & Chen, Z. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.658984 · Cited by 21

Vascular dysfunction in COVID-19 patients: update on SARS-CoV-2 infection of endothelial cells and the role of long non-coding RNAs

Pelisek, J., Reutersberg, B., Greber, U. F., & Zimmermann, A. (2022) · Clinical Science · doi:10.1042/cs20220235 · Cited by 23

Inflammation and DKK1-induced AKT activation contribute to endothelial dysfunction following NR2F2 loss

Dougherty, E. J., Chen, L., Awad, K. S., Ferreyra, G. A., Demirkale, C. Y., Keshavarz, A., Gairhe, S., Johnston, K. A., Hicks, M. E., Sandler, A. B., et al. (2023) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00171.2022 · Cited by 21

Crosstalk between endothelial cell-specific calpain inhibition and the endothelial-mesenchymal transition via the HSP90/Akt signaling pathway

Sun, X., Sun, Y., Jiang, P., Qi, G., & Chen, X. (2020) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2020.109822 · Cited by 21

Knockdown of LINC00657 inhibits ox-LDL-induced endothelial cell injury by regulating miR-30c-5p/Wnt7b/β-catenin

Wu, H., Liu, T., & Hong, H. (2020) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-020-03793-9 · Cited by 21

Nutrigenomic Effect of Hydroxytyrosol in Vascular Endothelial Cells: A Transcriptomic Profile Analysis

Carluccio, M. A., Martinelli, R., Massaro, M., Calabriso, N., Scoditti, E., Maffia, M., Verri, T., Gatta, V., & Caterina, R. D. (2021) · Nutrients · doi:10.3390/nu13113990 · Cited by 21

Obesity drives depot-specific vascular remodeling in male white adipose tissue

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Gemigliptin Inhibits Interleukin-1β–Induced Endothelial-Mesenchymal Transition via Canonical-Bone Morphogenetic Protein Pathway

Hong, O., Lee, S., Yoo, S. J., Lee, M.-K., Kim, M.-K., Baek, K., Song, K., & Kwon, H. (2020) · Endocrinology and Metabolism · doi:10.3803/enm.2020.35.2.384 · Cited by 20

Co-Culture of Primary Human Coronary Artery and Internal Thoracic Artery Endothelial Cells Results in Mutually Beneficial Paracrine Interactions

Shishkova, D. K., Markova, V. E., Sinitsky, M. Y., Цепокина, А. В., Frolov, A. V., Игоревич, З. Н., Bogdanov, L. A., & Kutikhin, A. G. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21218032 · Cited by 22

ELTD1 Activation Induces an Endothelial-EMT Transition to a Myofibroblast Phenotype

Sheldon, H., Alexander, J. J., Bridges, E., Moreira, L. M., Reilly, S. N., Ang, K. H., Wang, D., Lin, S., Haider, S. A., Banham, A. H., et al. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms222011293 · Cited by 20

Immunosenescence in Aging-Related Vascular Dysfunction

Tylutka, A., Morawin, B., Wawrzyniak-Gramacka, E., Wacka, E., Nowicka, W., Hiczkiewicz, J., & Zembroń-Łacny, A. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232113269 · Cited by 20

Adipose‐Derived Circulating Exosomes Promote Protection of the Pulmonary Endothelial Barrier by Inhibiting EndMT and Oxidative Stress through Down‐Regulation of the TGF‐β Pathway: A Potential Explanation for the Obesity Paradox in ARDS

Qi, D., Deng, W., Chen, X., Fan, S., Peng, J., Tang, X., Wang, D., & Yu, Q. (2022) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2022/5475832 · Cited by 19

Combined Shikonin-Loaded MPEG-PCL Micelles Inhibits Effective Transition of Endothelial-to-Mesenchymal Cells

Li, G., Shang, C., Li, Q., Chen, L., Yue, Z., Ren, L., Yang, J., Zhang, J., & Wang, W. (2022) · International Journal of Nanomedicine · doi:10.2147/ijn.s374895 · Cited by 19

Distinct patterns of responses in endothelial cells and smooth muscle cells following vascular injury

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Epigallocatechin-3-Gallate Attenuates Myocardial Dysfunction via Inhibition of Endothelial-to-Mesenchymal Transition

Kim, S.-J., Lee, H., Moon, H., Kim, R., Kim, M., Jeong, S., Kim, H., Kim, S., Hwang, S. S., Lee, M. Y., et al. (2023) · Antioxidants · doi:10.3390/antiox12051059 · Cited by 19

Myocardial fibrosis, inflammation, and altered cardiac gene expression profiles in rats exposed to a predator-based model of posttraumatic stress disorder

Rorabaugh, B. R., Mabe, N. W., Seeley, S. L., Stoops, T. S., Mucher, K. E., Ney, C. P., Goodman, C. S., Hertenstein, B. J., Rush, A. E., Kasler, C. D., et al. (2019) · Stress · doi:10.1080/10253890.2019.1641081 · Cited by 19

Niclosamide attenuates lung vascular remodeling in experimental pulmonary arterial hypertension

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Novel Role of GPR35 (G-Protein–Coupled Receptor 35) in the Regulation of Endothelial Cell Function and Blood Pressure

Li, H., Nguyen, H. T., Venkata, S. P. M., Koh, J. Y., Kowluru, A., Li, L., Rossi, N. F., Chen, W., & Wang, J. (2021) · Hypertension · doi:10.1161/hypertensionaha.120.15423 · Cited by 19

Mechanism of Extracellular Vesicle Secretion Associated with TGF-β-Dependent Inflammatory Response in the Tumor Microenvironment

Bonowicz, K., Mikołajczyk, K., Faisal, I., Qamar, M., Steinbrink, K., Kleszczyński, K., Grzanka, A., & Gagat, M. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232315335 · Cited by 20

MicroRNA 9 Is a Regulator of Endothelial to Mesenchymal Transition in Diabetic Retinopathy

Wang, E., Feng, B., & Chakrabarti, S. (2023) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.64.7.13 · Cited by 18

Palmdelphin Deficiency Evokes NF-κB Signaling in Valvular Endothelial Cells and Aggravates Aortic Valvular Remodeling

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Morin, a matrix metalloproteinase 9 inhibitor, attenuates endothelial-to-mesenchymal transition in atherosclerosis by downregulating Notch-1 signaling

He, Y., Qin, X.-X., Liu, M., & Sun, W. (2024) · Journal of Chinese Integrative Medicine · doi:10.1016/j.joim.2024.11.002 · Cited by 17

Adipose tissue–derived stromal cells’ conditioned medium modulates endothelial‐mesenchymal transition induced by IL‐1β/TGF‐β2 but does not restore endothelial function

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Ginsenoside Rg3 attenuates pulmonary fibrosis by inhibiting endothelial to mesenchymal transition

Yun, E., Kwon, B. S., Kim, J., & Lee, A. (2023) · Animal Cells and Systems · doi:10.1080/19768354.2023.2244549 · Cited by 19

Non-coding RNA-mediated endothelial-to-mesenchymal transition in human diabetic cardiomyopathy, potential regulation by DNA methylation

Wang, E., Chen, S., Wang, H., Chen, T., & Chakrabarti, S. (2023) · Cardiovascular Diabetology · doi:10.1186/s12933-023-02039-4 · Cited by 17

The concept revolution of gut barrier: from epithelium to endothelium

Liu, S., Song, P. K., Sun, F., Ai, S., Hu, Q., Guan, W., & Wang, M. (2020) · International Reviews of Immunology · doi:10.1080/08830185.2020.1841185 · Cited by 17

Selection of goat β-casein derived ACE-inhibitory peptide SQPK and insights into its effect and regulatory mechanism on the function of endothelial cells

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Single-cell omics identifies inflammatory signaling as a trans-differentiation trigger in mouse embryos

Zhang, Y., Kang, Z., Liu, M., Wang, L., & Liu, F. (2024) · Developmental Cell · doi:10.1016/j.devcel.2024.02.010 · Cited by 15

Endothelial KLF11 is a novel protector against diabetic atherosclerosis

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Endothelial-to-Mesenchymal Transition: Potential Target of Doxorubicin-Induced Cardiotoxicity

Feng, J., & Wu, Y. (2023) · American Journal of Cardiovascular Drugs · doi:10.1007/s40256-023-00573-w · Cited by 16

IL-1 in Abdominal Aortic Aneurysms

Millar, J. K., Nasser, E. H., Ailawadi, G., & Salmon, M. (2023) · Journal of Cellular Immunology · doi:10.33696/immunology.5.163 · Cited by 15

Endothelial CD38-induced endothelial-to-mesenchymal transition is a pivotal driver in pulmonary fibrosis

Hu, M. S., Guan, X., Wang, L.-F., Xu, H., Ke, S.-F., Yuan, Q., Tan, H.-L., Wu, J., Yu, G.-H., Huang, Q., et al. (2024) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-024-05548-x · Cited by 14

Curcumol suppresses endothelial-to-mesenchymal transition via inhibiting the AKT/GSK3β signaling pathway and alleviates pulmonary arterial hypertension in rats

Nie, X., Wu, Z., Shang, J., Zhu, L., Liu, Y., & Qi, Y. (2023) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2023.175546 · Cited by 14

Endothelial to mesenchymal transition in the interleukin-1 pathway during aortic aneurysm formation

Millar, J. K., Salmon, M., Nasser, E. H., Malik, S., Kolli, P., Lu, G., Pinteaux, E., Hawkins, R. B., & Ailawadi, G. (2023) · Journal of Thoracic and Cardiovascular Surgery · doi:10.1016/j.jtcvs.2023.11.010 · Cited by 15

Role of PATJ in stroke prognosis by modulating endothelial to mesenchymal transition through the Hippo/Notch/PI3K axis

Medina-Dols, A., Cañellas, G., Capó, T., Solé, M., Mola-Caminal, M., Cullell, N., Jaume, M., Nadal-Salas, L., Llinàs, J., Gómez, L., et al. (2024) · Cell Death Discovery · doi:10.1038/s41420-024-01857-z · Cited by 14

Melatonin alleviates myocardial dysfunction through inhibition of endothelial‐to‐mesenchymal transition via the NF‐κB pathway

Kim, R., Kim, M., Jeong, S., Kim, S., Moon, H., Kim, H., Lee, M. Y., Kim, J., Kim, H., Choi, M., et al. (2024) · Journal of Pineal Research · doi:10.1111/jpi.12958 · Cited by 14

Endothelial Birc3 promotes renal fibrosis through modulating Drp1-mediated mitochondrial fission via MAPK/PI3K/Akt pathway

Chen, S., He, Q., Yang, H., & Huang, H. (2024) · Biochemical Pharmacology · doi:10.1016/j.bcp.2024.116477 · Cited by 14

The Effects of Silencing PTX3 on the Proteome of Human Endothelial Cells

Banfi, C., Brioschi, M., Vicentini, L. M., & Cattaneo, M. G. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232113487 · Cited by 14

Vascular Diseases and Gangliosides

Sasaki, N., & Toyoda, M. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20246362 · Cited by 15

Decoding Endothelial MPL and JAK2V617F Mutation: Insight Into Cardiovascular Dysfunction in Myeloproliferative Neoplasms

Zhang, H., Kafeiti, N., Masarik, K., Lee, S., Yang, X., Zheng, H., & Zhan, H. (2024) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.124.321008 · Cited by 14

Pathophysiology in Brain Arteriovenous Malformations: Focus on Endothelial Dysfunctions and Endothelial-to-Mesenchymal Transition

Jeong, J. Y., Bafor, A. E., Freeman, B. H., Chen, P. R., Park, E. S., & Kim, E. (2024) · Biomedicines · doi:10.3390/biomedicines12081795 · Cited by 15

High Glucose Induced Changes in Human VEC Phenotype in a 3D Hydrogel Derived From Cell-Free Native Aortic Root

Cecoltan, S., Ciortan, L., Macarie, R. D., Vadana, M., Mihaila, A. C., Tucureanu, M. M., Vlad, M.-L., Droc, I., Gherghiceanu, M., Simionescu, A., et al. (2021) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2021.714573 · Cited by 13

Significant decrease of von Willebrand factor and plasminogen activator inhibitor-1 by providing supplementation with selenium and coenzyme Q10 to an elderly population with a low selenium status

Alehagen, U., Alexander, J., Aaseth, J., Larsson, A. O., & Lindahl, T. L. (2020) · European Journal of Nutrition · doi:10.1007/s00394-020-02193-5 · Cited by 13

Profiling and Molecular Mechanism Analysis of Long Non-Coding RNAs and mRNAs in Pulmonary Arterial Hypertension Rat Models

Hou, S., Chen, D., Liu, J., Chen, S., Zhang, X., Zhang, Y., Li, M., Pan, W., Zhou, D., Guan, L., et al. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.709816 · Cited by 13

COL8A1 regulates endothelial phenotype in inflammatory endothelial-to-mesenchymal transition

Li, Q., Ye, L., Talapaneni, S., Meng, Y., Wang, C. R., Kalindjian, K., Phan, J., Chen, Y., Demer, L. L., Tintut, Y., et al. (2025) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00339.2025 · Cited by 12

Endothelial to mesenchymal cell transition in diabetic retinopathy: targets and therapeutics

Nijim, W., Moustafa, M., Humble, J., & Al‐Shabrawey, M. (2023) · Frontiers in Ophthalmology · doi:10.3389/fopht.2023.1230581 · Cited by 12

GDF15 affects venous thrombosis by promoting EndMT through smad2/p-smad2 pathway

Li, Y., Zhu, H., Xin, W., Wang, J., Yan, C., & Ying, K. (2023) · Thrombosis Journal · doi:10.1186/s12959-023-00547-7 · Cited by 12

Super-Enhancer–Driven HCG20 Promotes Pulmonary Hypertension Through U2AF2 Splicing

Mei, J., Huang, W., Meng, Z., Wen, S., Ou, L., Bai, J., Wang, X., Yuan, H., Li, Y., Zhang, L., et al. (2025) · Circulation Research · doi:10.1161/circresaha.125.326133 · Cited by 12

Cell surface GRP78 regulates TGFβ1-mediated profibrotic responses via TSP1 in diabetic kidney disease

Trink, J., Ahmed, U., O'Neil, K. S., Li, R., Gao, B., & Krepinsky, J. C. (2023) · Frontiers in Pharmacology · doi:10.3389/fphar.2023.1098321 · Cited by 12

A multiscale in silico model of endothelial to mesenchymal transformation in a tumor microenvironment

Chowkwale, M., Mahler, G. J., Huang, P., & Murray, B. T. (2019) · Journal of Theoretical Biology · doi:10.1016/j.jtbi.2019.08.012 · Cited by 12

Epigenetics: a new warrior against cardiovascular calcification, a forerunner in modern lifestyle diseases

Dutta, P., Sengupta, A., & Chakraborty, S. (2021) · Environmental Science and Pollution Research · doi:10.1007/s11356-021-15718-0 · Cited by 11

Peripheral vascular remodeling during ischemia

Lin, S., Lin, R., Zhang, H., Xu, Q., & He, Y. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.1078047 · Cited by 11

Endothelial periostin regulates vascular remodeling by promoting endothelial dysfunction in pulmonary arterial hypertension

Lee, D., Lee, H., Jo, H., Yun, E., Kwon, B. S., Kim, J., & Lee, A. (2024) · Animal Cells and Systems · doi:10.1080/19768354.2023.2300437 · Cited by 11

Disruption of blood-brain barrier and endothelial-to-mesenchymal transition are attenuated by Astragalus polysaccharides mediated through upregulation of ETS1 expression in experimental autoimmune encephalomyelitis

Lu, Q., Ma, J., Zhao, Y., Ding, G., Wang, Y., Qiao, X., & Cheng, X. (2024) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2024.117521 · Cited by 11

Pioglitazone and/or irbesartan ameliorate COPD-induced endothelial dysfunction in side stream cigarette smoke-exposed mice model

Abdelhafez, A. T., Gomaa, A. M. S., Ahmed, A. M., Sayed, M. M., & Ahmed, M. A. (2021) · Life Sciences · doi:10.1016/j.lfs.2021.119706 · Cited by 11

Cellular and molecular insights into the roles of visfatin in breast cancer cells plasticity programs

Rajput, P. K., Sharma, J. R., & Yadav, U. C. S. (2022) · Life Sciences · doi:10.1016/j.lfs.2022.120706 · Cited by 11

How Long Are Reperfusion Therapies Beneficial for Patients after Stroke Onset? Lessons from Lethal Ischemia Following Early Reperfusion in a Mouse Model of Stroke

Nakagomi, T., Tanaka, Y., Nakagomi, N., Matsuyama, T., & Yoshimura, S. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21176360 · Cited by 11

Myeloid differentiation protein 2 mediates angiotensin II-induced inflammation and mesenchymal transition in vascular endothelium

Qian, J., Luo, W., Dai, C., Wang, J., Guan, X., Zou, C., Chattipakorn, N., Wu, G., Huang, W., & Liang, G. (2020) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2020.166043 · Cited by 11

Differential effect of basal vitamin D status in monocrotaline induced pulmonary arterial hypertension in normal and vitamin D deficient rats: Possible involvement of eNOS/TGF-β/α-SMA signaling pathways

Shah, S. Z., Vishwakarma, V. K., Arava, S. K., Mridha, A. R., Yadav, R. K., Seth, S., Bhatia, J., Hote, M. P., Arya, D. S., & Yadav, H. N. (2022) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2022.109246 · Cited by 10

Possible molecular mechanisms underlying the development of atherosclerosis in cancer survivors

Banerjee, P., Rosales, J. E., Chau, K. M., Nguyen, M. T., Kotla, S., Lin, S. H., Deswal, A. M., Dantzer, R., Olmsted‐Davis, E. A., Nguyen, H., et al. (2023) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2023.1186679 · Cited by 10

Role of inflammation in endothelial responses in Pulmonary Hypertension

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Humanized Anti-RGMa Antibody Treatment Promotes Repair of Blood-Spinal Cord Barrier Under Autoimmune Encephalomyelitis in Mice

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