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Experimental Demyelination and Axonal Loss Are Reduced in MicroRNA-146a Deficient Mice
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In the citing paper
“We have previously shown that miR-146a is also upregulated in response to cuprizone (CPZ) exposure in mice, and that miR-146a deficiency protected against CPZ induced demyelination (16).”
From Absence of miRNA-146a Differentially Alters Microglia Function and Proteome (2020) · cites this paper as [16]
In the citing paper
“We have previously shown that miR-146a is also upregulated in response to cuprizone (CPZ) exposure in mice, and that miR-146a deficiency protected against CPZ induced demyelination (16).”
From Absence of miRNA-146a Differentially Alters Microglia Function and Proteome (2020) · cites this paper as [16]
In the citing paper
“while these mice were protected against myelin loss (16).”
From Absence of miRNA-146a Differentially Alters Microglia Function and Proteome (2020) · cites this paper as [16]
In the citing paper
“The lower level of dysregulated proteins in the KO microglia can be related to a lower demyelination damage observed in these mice (16)”
From Absence of miRNA-146a Differentially Alters Microglia Function and Proteome (2020) · cites this paper as [16]
In the citing paper
“This may contribute to the reduced demyelination induced by CPZ in miR-146a KO mice (16).”
From Absence of miRNA-146a Differentially Alters Microglia Function and Proteome (2020) · cites this paper as [16]
In the citing paper
“Gene and protein expression of two chemokines involved in MS pathology, CCL2 (MCP1) and CCL3 (MIP-1a) were induced by demyelination although with different kinetics (16, 21, 48)”
From Absence of miRNA-146a Differentially Alters Microglia Function and Proteome (2020) · cites this paper as [16]
In the citing paper
“Since miR-146a plays an important role in response to myelin damage in vivo (16)”
From Absence of miRNA-146a Differentially Alters Microglia Function and Proteome (2020) · cites this paper as [16]
In the citing paper
“it is likely that the difference in percentage of CD11c+ microglia observed in the present study is linked to the reduced demyelination damage of the miR-146a KO mice.”
From Absence of miRNA-146a Differentially Alters Microglia Function and Proteome (2020) · cites this paper as [16]
In the citing paper
“We have recently found a reduced number of microglia in the corpus callosum of miR-146a KO mice during CPZ-induced demyelination (16)”
From Absence of miRNA-146a Differentially Alters Microglia Function and Proteome (2020) · cites this paper as [16]
In the citing paper
“which may be explained by less myelin damage in the KO mice (16).”
From Absence of miRNA-146a Differentially Alters Microglia Function and Proteome (2020) · cites this paper as [16]
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Citations
Cites
Praet, J., Guglielmetti, C., Berneman, Z., Van der Linden, A., & Ponsaerts, P. (2014) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2014.10.004 · Cited by 435
Skripuletz, T., Hackstette, D., Bauer, K., Gudi, V., Pul, R., Voss, E., Berger, K., Kipp, M., Baumgärtner, W., & Stangel, M. (2013) · Brain · doi:10.1093/brain/aws262 · Cited by 376
Glial response during cuprizone-induced de- and remyelination in the CNS: lessons learned
Gudi, V., Gingele, S., Skripuletz, T., & Stangel, M. (2014) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2014.00073 · Cited by 375 · cited 1×
“However, the observed increase in miR-146a in response to CPZ exposure in the corpus callosum cannot be solely explained by an increase in infiltrating microglia and macrophages, because the number of infiltrating microglia cells declines already 1 week after CPZ suspension (49, 50), and we found the highest level of…”
BackgroundJovičić, A., Roshan, R., Moisoi, N., Pradervand, S., Moser, R., Pillai, B., & Luthi-Carter, R. (2013) · The Journal of Neuroscience · doi:10.1523/jneurosci.0600-12.2013 · Cited by 251
Thymic Atrophy and Apoptosis of CD4+CD8+ Thymocytes in the Cuprizone Model of Multiple Sclerosis
Solti, I., Kvell, K., Talaber, G., Veto, S., Acs, P., Gallyas, F., Illes, Z., Fekete, K., Zalan, P., Szanto, A., et al. (2015) · PLOS ONE · doi:10.1371/journal.pone.0129217 · Cited by 30
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Cited by
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Dynamic Responses of Microglia in Animal Models of Multiple Sclerosis
Plastini, M. J., Desu, H. L., & Brambilla, R. (2020) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2020.00269 · Cited by 48
Segaran, R. C., Chan, L. Y., Wang, H., Sethi, G., & Tang, F. R. (2020) · Current Medicinal Chemistry · doi:10.2174/0929867327666200121122910 · Cited by 42
Absence of miRNA-146a Differentially Alters Microglia Function and Proteome
Martin, N. A., Hyrlov, K. H., Elkjaer, M. L., Thygesen, E. K., Wlodarczyk, A., Elbaek, K. J., Aboo, C., Okarmus, J., Benedikz, E., Reynolds, R., et al. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.01110 · Cited by 36
Self-citationSen, M. K., Almuslehi, M. S. M., Gyengesi, E., Myers, S. J., Shortland, P. J., Mahns, D. A., & Coorssen, J. R. (2019) · Cells · doi:10.3390/cells8111314 · Cited by 35
Almuslehi, M. S. M., Sen, M. K., Shortland, P. J., Mahns, D. A., & Coorssen, J. R. (2020) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2020.00043 · Cited by 34
Metadata
- Authors
- Martin, N. A., Molnar, V., Szilagyi, G. T., Elkjaer, M. L., Nawrocki, A., Okarmus, J., Wlodarczyk, A., Thygesen, E. K., Palkovits, M., Gallyas, F., Larsen, M. R., Lassmann, H., Benedikz, E., Owens, T., Svenningsen, A. F., & Illes, Z.
- Venue
- Frontiers in Immunology
- Publisher
- Frontiers Media SA
- Published
- 2018-03-12
- Volume
- 9
- ISSN
- 1664-3224
- PMC
- PMC5857529
- Cited by
- 45
- References
- 5
- Funders
- Lundbeckfonden (R118-A11472)
- Országos Tudományos Kutatási Alapprogramok (NN109841 and K77892)
- Jascha Fonden (5589)
- Direktør Ejnar Jonasson Kaldet Johnsen og Hustrus Mindelegat (5609)
- Odense Universitetshospital (A474)
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